Alcon - Database of Clinical Trials by Pharmaceutical Companies

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Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brimonidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Latin America

Condition: Glaucoma
Intervention: Drug: Brinzolamide/Timolol Maleate Fixed Combination (AZARGA)
Sponsor: Alcon Research
Recruiting - verified January 2012
Assessing the Efficacy and Tolerability of AZARGA® (Brinzolamide 1%/Timolol 0.5% Fixed Combination) as Replacement Therapy in Patients on COMBIGAN® (Brinomidine 0.2%/Timolol 0.5% Fixed Combination) Therapy in Brazil

Condition: Glaucoma
Intervention: Drug: Brinzolamide/Timolol Maleate Fixed Combination (AZARGA)
Sponsor: Alcon Research
Not yet recruiting - verified January 2012
Efficacy of Changing to DuoTrav® (Travoprost 0.004%/Timolol 0.5% BAK-Free Fixed Combination) From Prior Therapy

Condition: Glaucoma
Intervention: Drug: Travoprost/Timolol Maleate BAK-Free Fixed Combination
Sponsor: Alcon Research
Not yet recruiting - verified January 2012
VIGADEXA Gel Compared to VIGADEXA Solution Following Cataract Surgery

Condition: Cataracts
Interventions: Drug: Moxifloxacin 0.5%/Dexamethasone Phosphate 0.075% Ophthalmic Gel (VIGADEXA Gel); Drug: Moxifloxacin 0.5%/Dexamethasone Phosphate 0.1% Ophthalmic Solution (VIGADEXA Solution)
Sponsor: Alcon Research
Not yet recruiting - verified January 2012
Efficacy of Changing to Travatan From Prior Therapy

Conditions: Open-angle Glaucoma; Ocular Hypertension
Intervention: Drug: Travoprost 0.004% without BAK containing Polyquad (PQ) preservative
Sponsor: Alcon Research
Not yet recruiting - verified January 2012
Travacom Post Marketing Surveillance Study

Conditions: Open-angle Glaucoma; Ocular Hypertension
Intervention: Drug: Travoprost/timolol fixed combination (Travacom)
Sponsor: Alcon Research
Not yet recruiting - verified January 2012
Performance Evaluation of DAILIES® TOTAL1™ in First Time Contact Lens Wearers

Condition: Myopia
Intervention: Device: Delefilcon A contact lens
Sponsor: Alcon Research
Recruiting - verified December 2011
Evaluation of Marketed Contact Lens Disinfectant Systems on Eyelid Tissues

Condition: Contact Lens Care
Interventions: Device: Hydrogen peroxide-based contact lens care system (CLEAR CARE®/AOSEPT Plus); Device: Polyaminopropyl biguanide (PHMB) containing multipurpose system (ReNu® ); Device: Soft contact lenses
Sponsor: Alcon Research
Recruiting - verified December 2011
Efficacy of Changing to TRAVATAN® From Prior Therapy

Conditions: Open-angle Glaucoma; Ocular Hypertension
Intervention: Drug: Travoprost 0.004% without BAK containing Polyquad (PQ) preservative
Sponsor: Alcon Research
Recruiting - verified January 2012
Lens Wearing Experience and Biocompatibility of a Marketed Multi-Purpose Disinfecting Solution in Silicone Hydrogel and Soft Contact Lens Wearers

Condition: Refractive Error
Intervention: Device: FID 114675A (OPTI-FREE)
Sponsor: Alcon Research
Completed - verified December 2011
A Multicenter Study of the Pigmentation in the Trabecular Meshwork After Two Years of Treatment With TRAVATAN 0.004% Ophthalmic Solution

Condition: Open-angle Glaucoma
Intervention: Procedure: Trabecular Meshwork Tissue Collection
Sponsor: Alcon Research
Recruiting - verified December 2011
AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure

Condition: Glaucoma
Intervention: Drug: Brinzolamide/Timolol Maleate Fixed Combination (AZARGA)
Sponsor: Alcon Research
Recruiting - verified December 2011
In Vivo Measurement of Corneal Epithelial Changes in Dry Eye Patients

Condition: Dry Eye Syndrome
Intervention: Drug: SYSTANE® Gel Drop lubricant eye gel
Sponsor: Alcon Research
Active, not recruiting - verified November 2011
Lens Wearing Experience and Biocompatibility of a MPDS

Condition: Healthy
Intervention: Device: Alcon MPDS
Sponsor: Alcon Research
Completed - verified November 2011
Efficacy and Safety of AL-4943A Ophthalmic Solution in Patients With Allergic Conjunctivitis Using the Conjunctival Allergen Challenge (CAC) Model

Condition: Allergic Conjunctivitis
Interventions: Drug: AL-4943A Ophthalmic Solution; Drug: AL-4943A Ophthalmic Solution Vehicle; Drug: Pataday
Sponsor: Alcon Research
Recruiting - verified January 2012
Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma

Condition: Glaucoma
Interventions: Drug: Brinzolamide/Timolol Maleate Fixed Combination (AZARGA); Drug: Dorzolamide/timolol Maleate Fixed Combination (COSOPT)
Sponsor: Alcon Research
Completed - verified November 2011
Assessment of Intraocular Pressure (IOP) Control in Subjects With Open-angle Glaucoma or Ocular Hypertension Treated With Travoprost 0.004% (TRAVATAN® Z) or Bimatoprost 0.01%

Conditions: Glaucoma; Intraocular Hypertension
Interventions: Drug: travoprost 0.004% (TRAVATAN®Z); Drug: bimatoprost 0.01% (LUMIGAN)
Sponsor: Alcon Research
Recruiting - verified November 2011
Elongation of Foveal Tissue After Macular Hole Surgery

Condition: Macular Holes
Intervention: Procedure: pars plana vitrectomy and fluid gas exchange
Sponsor: Samsung Medical Center
Completed - verified November 2011
Safety and Efficacy of AL-53817 Nasal Spray Solution

Conditions: Healthy Subjects; Allergy
Interventions: Drug: AL-53817 Nasal Spray Solution; Drug: Vehicle Nasal Spray Solution
Sponsor: Alcon Research
Recruiting - verified October 2011
Travoprost 3-Month Safety and Efficacy Study

Conditions: Open Angle Glaucoma; Ocular Hypertension
Interventions: Drug: Travoprost (New Formulation); Drug: TRAVATAN
Sponsor: Alcon Research
Recruiting - verified November 2011
Retinal Layers and Visual Rehabilitation After Epiretinal Membrane Removal

Condition: Epiretinal Membrane
Intervention: Procedure: Pars plana vitrectomy and removal of epiretinal membrane
Sponsor: Samsung Medical Center
Completed - verified November 2011
LASIK Using the Alcon Allegretto Wavefront-Guided Excimer Laser vs AMO Visx Wavefront-Guided Excimer Laser

Conditions: Myopia; Astigmatism
Interventions: Procedure: Wavefront-guided LASIK - Allegretto; Procedure: Wavefront-guided LASIK - AMO
Sponsor: Stanford University
Recruiting - verified October 2011
Three Month Safety and Efficacy Study of TRAVATAN® Versus Travoprost Ophthalmic Solution, 0.004%

Conditions: Open Angle Glaucoma; Ocular Hypertension
Interventions: Drug: Travoprost Ophthalmic Solution, 0.004% (New Formulation); Drug: TRAVATAN®
Sponsor: Alcon Research
Not yet recruiting - verified October 2011
Nepafenac Compared to Placebo for Ocular Pain and Inflammation

Condition: Cataract
Interventions: Drug: Nepafenac; Other: Nepafenac Vehicle
Sponsor: Alcon Research
Recruiting - verified August 2011
A Comfort Study of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination, Brinzolamide 1% and Brimonidine 0.2%

Conditions: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: Brinzolamide / Brimonidine Fixed Combination; Drug: Brinzolamide; Drug: Brimonidine
Sponsor: Alcon Research
Completed - verified December 2011
Comparative Efficacy of SYSTANE® ULTRA vs Optive™ in Improving Tear Film Break-up Time

Condition: Dry Eye
Interventions: Other: Systane Ultra; Other: Optive
Sponsor: Alcon Research
Recruiting - verified January 2012
Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada

Condition: Glaucoma
Intervention: Drug: Brinzolamide 1% / timolol 0.5% maleate fixed combination (AZARGA®)
Sponsor: Alcon Research
Recruiting - verified January 2012
Clinical Study of Clariti Monthly Contact Lens

Conditions: Hyperopia; Myopia
Interventions: Device: Air Optix Aqua; Device: Clariti
Sponsor: Sauflon Pharmaceuticals Ltd
Completed - verified July 2011
Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome

Condition: Dry Eye Syndrome
Interventions: Drug: Sodium hyaluronate ophthalmic solution, 0.18%; Other: Vehicle
Sponsor: Alcon Research
Recruiting - verified August 2011
Effects of Latanoprost, Bimatoprost and Travoprost in Patients With Latanoprost-resistant Glaucoma

Conditions: Ocular Hypertension; Primary Glaucoma
Interventions: Drug: Latanoprost, bimatoprost, travoprost; Drug: travoprost, latanoprost and bimatoprost
Sponsor: Centre Hospitalier Universitaire de Sherbrooke
Recruiting - verified December 2010
Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-angle Glaucoma or Ocular Hypertension

Conditions: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: Brinzolamide 1% +Timolol 0.5% fixed combination; Drug: Brinzolamide 1% and Timolol 0.5%
Sponsor: Alcon Research
Recruiting - verified November 2011
Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa

Conditions: Otitis Externa; Otorhinolaryngologic Diseases; Ear Diseases; Otitis
Interventions: Drug: Ciprodex Otic Suspension; Drug: Ciprodexa Otic Foam
Sponsor: Otic Pharma
Completed - verified November 2011
Evaluation of Extended Tear Film Break Up Time (TFBUT) With an Ocular Emulsion

Condition: Dry Eye
Interventions: Other: Systane Balance Lubricating Eye Drops; Other: OPTIVE™
Sponsors: Alcon Research; Optometric Technology Group Ltd
Completed - verified January 2012
Patient Preference Comparison of AZARGA Versus COSOPT

Condition: Glaucoma
Interventions: Drug: Brinzolamide/Timolol Maleate Fixed Combination (Azarga); Drug: Dorzolamide/Timolol Maleate Fixed Combination (Cosopt)
Sponsor: Alcon Research
Recruiting - verified November 2011
ESBA105 in Patients With Severe Dry Eye

Condition: Severe Dry Eye
Interventions: Biological: ESBA105; Other: Vehicle
Sponsor: Alcon Research
Active, not recruiting - verified December 2011
Safety and Efficacy of Changing to Duo-Travatan in Patients Uncontrolled on Timolol

Condition: Glaucoma
Intervention: Drug: Travoprost/Timolol Maleate Fixed Combination
Sponsor: Alcon Research
Recruiting - verified January 2012
Study of Corneas Undergoing Balanced Salt Solution(BSS ®) Versus Glucose-bicarbonate-Ringer Lactate in Cataract Surgery

Condition: Cataract
Interventions: Procedure: Phacoemulsification cataract surgery; Drug: Glucose-bicarbonate-Ringer Lactate (GBRL); Drug: Balanced Salt Solution (BSS®)
Sponsors: Grupo de Estudos em Oftalmologia Clínica e Cirúrgica; CLIHON
Completed - verified April 2011
Efficacy of Changing to DuoTrav From Prior Therapy

Condition: Glaucoma
Intervention: Drug: Travoprost/Timolol Maleate BAK-Free Fixed Combination
Sponsor: Alcon Research
Recruiting - verified January 2012
Safety and Comfort of AL-4943A Ophthalmic Solution

Condition: Ocular Discomfort
Interventions: Drug: AL-4943A Ophthalmic Solution (Treatment A); Drug: AL-4943A Ophthalmic Solution Vehicle (Treatment B); Drug: Ketotifen Fumarate Ophthalmic Solution (Treatment C)
Sponsor: Alcon Research
Completed - verified August 2011
AL-54478 Proof of Concept Study

Condition: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: AL-54478 0.005%; Drug: Latanoprost 0.005%; Drug: AL-54478 Vehicle
Sponsor: Alcon Research
Completed - verified December 2011
Nepafenac 0.3% Two Study

Condition: Cataract
Interventions: Drug: Nepafenac Ophthalmic Suspension, 0.3%; Drug: Nepafenac Ophthalmic Suspension, 0.1% (NEVANAC); Drug: Nepafenac 0.3% Vehicle
Sponsor: Alcon Research
Completed - verified December 2011
Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID and Brimonidine BID in Patients With Open Angle Glaucoma or Ocular Hypertension

Conditions: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: Brinzolamide 1% / brimonidine 0.2% ophthalmic suspension; Drug: Brinzolamide 1% Eye drops, suspension BID (AZOPT); Drug: Brimonidine Tartrate
Sponsor: Alcon Research
Recruiting - verified November 2011
Efficacy and Safety of Brinzolamide 1% / Brimonidine 0.2% Fixed Combination BID vs. Brinzolamide 1% BID Plus Brimonidine 0.2% BID

Condition: Open-angle Glaucoma or Ocular Hypertension
Interventions: Drug: Brinzolamide 1% / brimonidine 0.2% ophthalmic suspension; Other: Vehicle for masking purposes; Drug: Brinzolamide 1% ophthalmic suspension (AZOPT); Drug: Brimonidine 0.2% ophthalmic solution
Sponsor: Alcon Research
Recruiting - verified November 2011
Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C

Conditions: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: AL-59412C Concentration 1; Drug: Travoprost; Other: Vehicle; Drug: AL-59412C Concentration 2
Sponsor: Alcon Research
Active, not recruiting - verified November 2011
A Multi-Site Post Marketing Surveillance Study for Systane in Indian Patients

Condition: Moderate to Severe Dry Eye
Intervention: Other: Systane
Sponsor: Alcon Research
Completed - verified January 2012
Effects of Anti-Glaucoma Medications on the Ocular Surface

Condition: Glaucoma
Interventions: Drug: Travoprost; Drug: Latanoprost
Sponsors: Massachusetts Eye and Ear Infirmary; Alcon Research
Recruiting - verified October 2011
ESBA1008 Safety, Tolerability and Effects in Wet Age-related Macular Degeneration (AMD) Patients

Condition: Exudative Age-related Macular Degeneration
Interventions: Biological: ESBA1008; Biological: Ranibizumab
Sponsor: Alcon Research
Recruiting - verified August 2011
A Comparison of Visual Function After Bilateral Implantation of Presbyopia Correcting Intraocular Lenses

Condition: Cataract
Interventions: Device: ReSTOR +3; Device: LENTIS MPlus
Sponsor: Alcon Research
Completed - verified October 2011
Divided Dose of Travatan

Condition: Open-angle Glaucoma and Ocular Hypertension
Interventions: Drug: Travoprost Ophthalmic Solution, 0.00033%; Drug: Travoprost Ophthalmic Solution, 0.00013%; Drug: Travoprost Ophthalmic Solution, 0.001%; Drug: Travoprost Ophthalmic Solution, 0.00267%; Drug: Travatan 0.004%; Drug: Travoprost Ophthalmic Solution Vehicle
Sponsor: Alcon Research
Completed - verified November 2011
Three Month Efficacy/Safety Study With a 3 Month Safety Extension of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% or Brimonidine 0.2%

Conditions: Open Angle Glaucoma; Ocular Hypertension
Interventions: Drug: Brinzolamide 1% / Brimonidine Tartrate 0.2%; Drug: Brinzolamide ophthalmic suspension, 1%; Drug: Brimonidine Tartrate 0.2%
Sponsor: Alcon Research
Active, not recruiting - verified November 2011
Efficacy and Safety Study of Brinzolamide 1% / Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2%

Conditions: Open-angle Glaucoma; Ocular Hypertension
Interventions: Drug: Brinzolamide 1% / brimonidine 0.2% ophthalmic suspension; Drug: Brinzolamide ophthalmic suspension, 1% (Azopt); Drug: Brimonidine ophthalmic solution, 0.2%
Sponsor: Alcon Research
Active, not recruiting - verified January 2012
Patient Perception Study for AL-4943A

Condition: Allergic Conjunctivitis
Intervention: Drug: AL-4943A
Sponsor: Alcon Research
Completed - verified October 2011
A Clinical Evaluation of an Investigational Lubricant Eye Gel (FID 115958D)

Condition: Dry Eye
Interventions: Other: Lubricant Eye Drop; Other: Refresh Liquigel
Sponsor: Alcon Research
Completed - verified January 2012
Comparison of a New Abbott Medical Optics (AMO) Multi-Purpose Solution (MPS) to Existing Contact Lens Regimens

Condition: Normal Contact Lens Wearers.
Interventions: Device: Multi-purpose disinfecting solution; Device: Clear Care; Device: Opti-Free RepleniSH
Sponsor: Abbott Medical Optics
Completed - verified September 2011