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Patient Rheumatoid Arthritis Social Support Study

Condition: Rheumatoid Arthritis
Intervention: Behavioral: Peer Support Program
Sponsors: Brigham and Women's Hospital; Amgen
Recruiting - verified February 2012
A Pharmacokinetic/Pharmacodynamic Study Comparing PF-05280586 To Rituximab In Subjects With Active Rheumatoid Arthritis With An Inadequate Response To TNF Inhibitors (REFLECTIONS B328-01)

Condition: Rheumatoid Arthritis
Interventions: Biological: PF-05280586; Biological: MabThera; Biological: Rituxan
Sponsor: Pfizer
Not yet recruiting - verified February 2012
Health-related Quality of Life and Patient-reported Outcomes in Rheumatoid Arthritis Patients Treated With Certolizumab Pegol

Condition: Rheumatoid Arthritis
Intervention:
Sponsors: UCB, Inc.; ReSearch Pharmaceutical Services, Inc.
Recruiting - verified February 2012
Assessment of NSAID-treated Patients Adherence to Co-prescribed Proton Pump Inhibitor (PPI)

Conditions: Osteoarthritis; Rheumatoid Arthritis; Ankylosing Spondilitis
Intervention:
Sponsor: AstraZeneca
Not yet recruiting - verified January 2012
Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drug (DMARD)-Naïve Adults With Early Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Biological: Certolizumab Pegol + Methotrexate (MTX); Biological: Placebo + Methotrexate (MTX)
Sponsor: UCB, Inc.
Not yet recruiting - verified January 2012
Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drug (DMARD)-Naïve Adults With Early Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Biological: Certolizumab Pegol + Methotrexate (MTX); Biological: Placebo + Methotrexate (MTX)
Sponsor: UCB, Inc.
Not yet recruiting - verified January 2012
Safety and Efficacy Study of Botulinum Toxin Type A as Treatment for Osteoarthritis Knee Pain

Condition: Osteoarthritis
Interventions: Biological: botulinum toxin Type A; Drug: Normal Saline (Placebo)
Sponsor: Allergan
Recruiting - verified January 2012
Pharmacokinetics Of CP-690,550 In Pediatric Patients With Juvenile Idiopathic Arthritis (JIA)

Condition: Juvenile Idiopathic Arthritis
Interventions: Drug: CP-690,550; Drug: CP-690,550; Drug: CP-690,550
Sponsor: Pfizer
Not yet recruiting - verified January 2012
Study of SI000413 in Knee Osteoarthritis Patients

Condition: Osteoarthritis, Knee
Interventions: Drug: SI000413; Drug: microcrystalline cellulose
Sponsor: Dong-A Pharmaceutical Co., Ltd.
Recruiting - verified February 2012
Sirolimus Injections for Autoimmune Scleritis

Condition: Scleritis
Intervention: Drug: Sirolimus
Sponsor: National Eye Institute (NEI)
Recruiting - verified December 2011
Total Ankle Replacement Versus Ankle Arthrodesis Trial

Condition: End-stage Ankle Osteoarthritis
Interventions: Procedure: Total Ankle Replacement; Procedure: Ankle Arthrodesis
Sponsors: Razi Zaidi; University College, London; Medical Research Council
Not yet recruiting - verified January 2012
Study of Levotofisopam 50 mg Three Times a Day (TID) Administered for 7 Days on Hyperuricemia and Gout

Conditions: Hyperuricemia; Gout
Intervention: Drug: levotofisopam
Sponsor: Pharmos
Recruiting - verified January 2012
Descriptive Study in Patients Treated With Vimovo™, Including Registration of the Physicians' Prescribing Patterns

Conditions: Osteoarthritis; Rheumatoid Arthritis; Ankylosing Spondylitis
Intervention:
Sponsor: AstraZeneca
Recruiting - verified January 2012
Treatment Study Topical NSAID, PENNSAID and Effect on Coagulation Values in Patients With Osteoarthritis Knee Pain Taking Warfarin

Conditions: Osteoarthritis of the Knee; Coagulopathy
Intervention: Drug: PENNSAID (diclofenac sodium solution topical)
Sponsors: Nathan Wei, MD, FACP, FACR:; Covidien; Arthritis Treatment Center, Maryland
Not yet recruiting - verified January 2012
Zostavax in Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Varicella Zoster
Intervention: Drug: Zostavax (varicella zoster virus) vaccine
Sponsor: Oklahoma Medical Research Foundation
Recruiting - verified January 2012
A Study is to Assess Efficacy and Safety of Tacrolimus in Active Rheumatoid Arthritis Patients Who Showed Unsuccessful Response to Existing Disease Modifying Antirheumatic Drugs (DMARDs)

Condition: Rheumatoid Arthritis
Intervention: Drug: Tacrolimus
Sponsors: Astellas Pharma Inc; Astellas Pharma Korea, Inc.
Recruiting - verified January 2012
Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement

Condition: Arthritis of Knee
Intervention:
Sponsors: Athens Orthopedic Clinic, P.A.; Stryker Orthopaedics
Recruiting - verified January 2012
Outcomes After Total Knee Joint Arthroplasty : A Comparative Study Using 3 Different Analgesic Techniques

Conditions: Knee Joint Arthritis; Knee Joint Arthroplasty
Interventions: Procedure: Spinal anesthesia with periarticular infiltration; Procedure: Femoral and sciatic nerve blocks; Procedure: Periarticular infusions
Sponsor: Lawson Health Research Institute
Not yet recruiting - verified January 2012
Open-Label Study of Diclofenac Capsules to Treat Osteoarthritis Pain

Condition: Osteoarthritis
Intervention: Drug: Diclofenac
Sponsor: Iroko Pharmaceuticals, LLC
Recruiting - verified January 2012
Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases

Condition: Inflammatory Rheumatism
Intervention: Behavioral: Telenursing
Sponsors: University of Applied Sciences of Western Switzerland; Swiss National Science Foundation; Réseau d'Etudes aux Confins de la Santé et du Social (RECSS)(HES-SO); University of Lausanne Hospitals; Consultation Multisite Romande de Rhumatologie Pédiatrique; Ligue Genevoise contre le Rhumatisme
Recruiting - verified January 2012
Combination Treatment Study in Subjects With Tophaceous Gout With Lesinurad and Febuxostat

Condition: Tophaceous Gout
Interventions: Drug: Lesinurad; Drug: Lesinurad; Drug: Placebo
Sponsor: Ardea Biosciences, Inc.
Recruiting - verified January 2012
Combining Lesinurad With Allopurinol in Inadequate Responders

Condition: Gout
Interventions: Drug: Lesinurad; Drug: Lesinurad; Drug: Placebo
Sponsor: Ardea Biosciences, Inc.
Recruiting - verified January 2012
Lesinurad Monotherapy in Gout Subjects Intolerant to Xanthine Oxidase Inhibitors

Condition: Gout
Interventions: Drug: lesinurad; Drug: Placebo
Sponsor: Ardea Biosciences, Inc.
Recruiting - verified January 2012
Efficacy and Safety of LBSA0103 Versus Hyruan Plus Injection in Patients With Knee Osteoarthritis

Condition: Osteoarthritis of the Knee
Interventions: Drug: Placebo; Drug: Hyruan Plus; Drug: LBSA0103
Sponsor: LG Life Sciences
Recruiting - verified January 2012
Safety, Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Drug: placebo; Drug: SAR113945
Sponsor: Sanofi-Aventis
Recruiting - verified February 2012
Long-Term Safety Study Of CP-690,550 In Patients With Juvenile Idiopathic Arthritis

Condition: Juvenile Idiopathic Arthritis
Intervention: Drug: CP-690,550
Sponsor: Pfizer
Not yet recruiting - verified December 2011
A Long Term Study To Evaluate The Safety, Tolerability And Efficacy Of CP-690,550 In Patients With Moderate To Severe Plaque Psoriasis And/Or Psoriatic Arthritis

Conditions: Psoriasis; Arthritis, Psoriatic
Interventions: Drug: CP-690,550; Drug: CP-690, 550
Sponsor: Pfizer
Not yet recruiting - verified January 2012
Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate

Condition: Rheumatoid Arthritis
Interventions: Biological: Certolizumab pegol + Methotrexate (CZP + MTX); Biological: Adalimumab + Methotrexate (ADA + MTX)
Sponsor: UCB, Inc.
Recruiting - verified January 2012
Efficacy of Humira in Behcet Patients With Arthritis

Condition: Arthritis; Behcet
Intervention: Drug: Adalimumab (Humira)
Sponsors: Rambam Health Care Campus; Abbott
Not yet recruiting - verified December 2011
Randomized Controlled Trial Using Patient Reported Outcomes and Care Managers to Improve HIV Medication Adherence in Routine Clinical Care

Condition: HIV
Intervention: Behavioral: Care management
Sponsors: University of Washington; National Institutes of Health (NIH); National Institute of Mental Health (NIMH); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Not yet recruiting - verified January 2012
The Effects of Intra-articular Injection of Mesenchymal Stem Cells in Knee Joint Osteoarthritis

Condition: Osteoarthritis
Interventions: Biological: mesenchymal stem cell; Biological: Placebo
Sponsor: Royan Institute
Recruiting - verified March 2010
Encore Revelation Hip Stem

Conditions: Osteoarthritis of the Hip; Total Hip Arthroplasty
Intervention: Device: Revelation Hip Stem (Revelation)
Sponsor: Encore Medical, L.P.
Not yet recruiting - verified January 2012
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects

Conditions: Premature Endothelial Dysfunction; Rheumatoid Arthritis; Healthy
Intervention:
Sponsors: Orrin M Troum, M.D. and Medical Associates; Bristol-Myers Squibb
Recruiting - verified December 2011
Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms

Conditions: Chronic Low Back Pain; Degenerative Disc Disease; Depression; Anxiety
Interventions: Drug: Oxycodone; Drug: Morphine
Sponsors: Brigham and Women's Hospital; Arthritis Foundation; National Institute on Drug Abuse (NIDA)
Recruiting - verified December 2011
Benefit of Orthopedic Navigation in the ARThroplasty of the Hip

Conditions: Osteoarthritis, Hip; Arthritis, Rheumatoid; Femur Head Necrosis
Interventions: Procedure: Manual Intervention; Procedure: Navigated Intervention
Sponsor: Aesculap AG
Recruiting - verified December 2011
Active Conventional Therapy Compared to Three Different Biologic Treatments in Early Rheumatoid Arthritis With Subsequent Dose Reduction

Condition: Rheumatoid Arthritis
Interventions: Drug: Non-biological DMARD's; Biological: Cimzia, Orencia, RoActemra
Sponsor: Karolinska Institutet
Not yet recruiting - verified December 2011
Autologous Chondrocyte Intra-articular Implantation in Patients With Severe Hip Osteoarthritis

Condition: Hip Osteoarthritis
Intervention: Biological: cell injection
Sponsor: Royan Institute
Recruiting - verified January 2011
Cimzia Treatment in Rheumatoid Arthritis: Randomizing to Stop Versus Continue Disease-modifying Anti-rheumatic Drug(s)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Pope Research Corporation
Not yet recruiting - verified December 2011
Multi-center, Non-comparative Study of Primary Total Knee Arthroplasty (TKA) Functional Performance

Condition: Noninflammatory Degenerative Joint Disease
Intervention: Device: Total Knee Replacement
Sponsor: DePuy Orthopaedics
Recruiting - verified December 2011
Obesity's Impact on the Effect of Hip Arthroplasty

Condition: Hip Osteoarthritis
Intervention: Procedure: Hip arthroplasty
Sponsor: University of Aarhus
Recruiting - verified December 2011
A Crossover Study of the Safety and Tolerability of Two Formulations of Adalimumab

Condition: Rheumatoid Arthritis
Intervention: Biological: Adalimumab
Sponsor: Abbott
Not yet recruiting - verified January 2012
A Study To Evaluate The Effect Of CP-690,550 On Measures Of Kidney Function In Patients With Active Rheumatoid Arthritis

Condition: Arthritis, Rheumatoid
Interventions: Drug: CP-690,550 or Placebo; Drug: Placebo
Sponsor: Pfizer
Not yet recruiting - verified January 2012
Vascular Occlusion and Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Other: vascular occlusion with exercise trainig; Other: high intensity resistance training; Other: control
Sponsor: University of Sao Paulo
Recruiting - verified November 2011
Combining Lesinurad With Allopurinol in Inadequate Responders

Condition: Gout
Interventions: Drug: Lesinurad; Drug: Lesinurad; Drug: Placebo
Sponsor: Ardea Biosciences, Inc.
Recruiting - verified January 2012
Examination of the Effectiveness of Diffusion Weighted Magnetic Resonance Imaging for Identifying Poor Prognosis in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsors: Optimus Clinical Research; Arthritis Australia, Abbott Australia
Recruiting - verified November 2011
Minimal Invasive Surgery in Total Hip Arthroplasty Patients; Short- and Long Term Results

Condition: Hip Osteoarthritis
Interventions: Procedure: Total hip replacement; Procedure: Total hip replacement; Procedure: Total hip replacement
Sponsors: Norwegian University of Science and Technology; St. Olavs Hospital
Recruiting - verified January 2012
Knee Osteoarthritis (OA) Project Treatment Versus Conventional Physical Therapy in the Treatment of Knee OA Patients

Condition: Osteoarthritis, Knee
Interventions: Other: knee OA project; Other: conventional PT
Sponsor: Meir Medical Center
Recruiting - verified February 2012
An Observational Study on Long-Term Efficacy and Safety of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis (FAct)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Not yet recruiting - verified January 2012
Outcomes Study of the TM Reverse Shoulder System Used in Primary or Revision Reverse Total Shoulder Arthroplasty

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-traumatic Arthritis; Ununited Humeral Head Fracture; Irreducible 3-and 4-part Proximal Humeral Fractures; Avascular Necrosis; Gross Rotator Cuff Deficiency; Failed Total Shoulder Arthroplasty (Both Glenoid and Humeral Components Require Revision
Intervention: Device: Trabecular Metal Reverse Shoulder System
Sponsor: Zimmer, Inc.
Recruiting - verified January 2012
Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder Arthroplasty

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-traumatic Arthritis; Ununited Humeral Head Fracture; Irreducible 3- and 4-part Proximal Humeral Fractures; Avascular Necrosis
Intervention: Device: Trabecular Metal Humeral Stem
Sponsor: Zimmer, Inc.
Recruiting - verified November 2011
Shared Decision Making in Patients With Osteoarthritis of the Hip and Knee

Conditions: Hip Osteoarthritis; Knee Osteoarthritis
Intervention: Other: Shared Decision Making Intervention
Sponsors: University of California, San Francisco; Stanford University; Robert Wood Johnson Foundation
Recruiting - verified December 2011
Strength Training for ARthritis Trial

Condition: Knee Osteoarthritis
Interventions: Behavioral: High Intensity Strength Training; Behavioral: Low Intensity Strength Training; Behavioral: Attention Control
Sponsors: Wake Forest University; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Not yet recruiting - verified December 2011
Study of FX006 in Patients With Osteoarthritis of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: FX006; Drug: Kenalog
Sponsor: Flexion Therapeutics, Inc.
Not yet recruiting - verified December 2011
Pharmacokinetic and Pharmacodynamic Study of FX006 in Patients With Osteoarthritis of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: FX006; Drug: Kenalog-40
Sponsor: Flexion Therapeutics, Inc.
Not yet recruiting - verified December 2011
Clinical and Stereoradiological Comparison of the Results After Primary Cemented Total Knee Arthroplasty Inserted With or Without the Use of a Tourniquet

Condition: Osteoarthritis of the Knee
Interventions: Procedure: tourniquet; Procedure: no tourniquet
Sponsor: Hvidovre University Hospital
Not yet recruiting - verified December 2011
Assessment of Efficacy of Low Intensity Resistance Training in Individuals at Risk for Symptomatic Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: double leg press with partial blood flow restriction; Other: double leg press without partial blood flow restriction
Sponsor: University of Iowa
Recruiting - verified December 2011
Exercise in Sjogren

Condition: Primary Sjogren´s Syndrome
Intervention: Other: Aerobic exercise
Sponsor: University of Sao Paulo
Recruiting - verified January 2012
Multi-country Post-Marketing Observational Study on Maintenance of Effectiveness of Adalimumab (Humira®) in Patients With Ankylosing Spondylitis and Psoriatic Arthritis

Conditions: Ankylosing Spondylitis; Psoriatic Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder

Conditions: Adhesive Capsulitis; Frozen Shoulder
Interventions: Biological: collagenase clostridium histolyticum; Other: Shoulder exercises
Sponsor: Auxilium Pharmaceuticals
Recruiting - verified December 2011
Nottingham Osteoarthritis Biomarker Study 2011

Condition: Osteoarthritis
Intervention:
Sponsor: University of Nottingham
Not yet recruiting - verified January 2012
An Observational Study of RoActemra/Actemra (Tocilizumab) As Monotherapy in Rheumatoid Arthritis Patients in Routine Clinical Practice (ACT-SOLO)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Not yet recruiting - verified January 2012
Vascular Occlusion in Patients With Osteoarthritis

Condition: Osteoarthritis
Interventions: Other: Exercise training; Other: Resistance training with vascular occlusion
Sponsor: University of Sao Paulo
Recruiting - verified November 2011
Milnacipran for Chronic Pain in Knee Osteoarthritis

Conditions: Knee Osteoarthritis; Degenerative Joint Disease; Chronic Pain
Interventions: Drug: Milnacipran; Drug: Placebo
Sponsors: Dr. Norman Harden; Forest Laboratories
Recruiting - verified January 2012
Psoriatic Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to NSAIDs or Non-biologic Disease Modifying Anti-rheumatic Drugs (DMARDs) Therapy

Condition: Arthritis, Psoriatic
Interventions: Biological: Placebo matching BMS-945429; Biological: BMS-945429; Biological: BMS-945429; Biological: BMS-945429
Sponsor: Bristol-Myers Squibb
Recruiting - verified January 2012
Arthritis Research UK Gout Treatment Trial - Phase 2

Condition: Gout
Interventions: Other: Nurse intervention; Other: Standard care
Sponsors: University of Nottingham; Arthritis Research UK (funder)
Not yet recruiting - verified November 2011
Autologous Stem Cells in Osteoarthritis

Condition: Osteoarthritis, Knee
Interventions: Procedure: Bone Marrow Autologous Stem Cells Infusion; Drug: Acetaminophen
Sponsor: Hospital Universitario Dr. Jose E. Gonzalez
Recruiting - verified January 2012
Ultrasound Evaluation of Hands in Patients With Systemic Lupus Erythematosus

Conditions: Lupus Erythematosus, Systemic; Arthritis, Rheumatoid
Intervention:
Sponsor: Federal University of São Paulo
Recruiting - verified November 2011
Oral JAK1/JAK2 Selective Inhibitor Treatment in Japanese Participants With Active Rheumatoid Arthritis on Background Methotrexate Therapy

Condition: Arthritis, Rheumatoid
Interventions: Drug: LY3009104; Drug: Placebo; Drug: LY3009104; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting - verified January 2012
Effectiveness of a Knee Brace When Combined With Viscosupplementation in the Treatment of Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Other: Orthovisc; Device: DonJoy HA lite knee brace; Device: Orthovisc injections and DonJoy HA lite knee brace
Sponsor: OAD Orthopaedics
Recruiting - verified December 2011
A Study in Patients With Moderate to Severe Active Rheumatoid Arthritis Comparing Different Infusion Durations of RoActemra/Actemra (Tocilizumab) Treatment

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab; Drug: tocilizumab
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Musculoskeletal Effects of Bicarbonate

Conditions: Age-related Bone Loss; Age Related Muscle Loss; Falls; Fractures
Interventions: Dietary Supplement: potassium bicarbonate; Dietary Supplement: potassium bicarbonate; Other: placebo
Sponsors: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Tufts University
Recruiting - verified November 2011
Cost of Care for Juvenile Idiopathic Arthritis

Condition: Juvenile Idiopathic Arthritis
Intervention:
Sponsor: The Cleveland Clinic
Not yet recruiting - verified November 2011
Impact of Noninvasive Targeted Pulsed Electromagnetic Field (tPEMF) on Opioid Use, Pain, and Joint Function Following Total Knee Arthroplasty

Condition: Osteoarthritis, Knee
Interventions: Device: Ivivi Torino II; Device: Ivivi Torino II
Sponsor: Amp Orthopedics, Inc.
Recruiting - verified November 2011
A Study for Moderate Osteoarthritis of the Knee

Condition: Osteoarthritis
Interventions: Dietary Supplement: Flexsure Capsules; Dietary Supplement: Placebo Capsules
Sponsors: Vedic Lifesciences Pvt. Ltd.; VitalgNetics
Recruiting - verified November 2011
The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ)

Conditions: Temporomandibular Joint; Conservative Treatment Therapy
Intervention: Drug: PET/CT with 18-FDG
Sponsor: University of Pennsylvania
Recruiting - verified December 2011
A Post-Marketing Observational Study to Evaluate the Effectiveness of Adalimumab in Patients With Moderately to Severely Active Rheumatoid Arthritis in China

Conditions: Arthritis; Rheumatoid
Intervention:
Sponsor: Abbott
Recruiting - verified January 2012
Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure

Conditions: Prehypertension; Gout; Pulse Wave Velocity; Hypertension; 24 Hour Blood Pressure
Intervention: Drug: Febuxostat
Sponsors: University of California, San Diego; Takeda Global Research & Development Center, Inc.
Recruiting - verified November 2011
A Study of Flt3-Ligand Levels in Sjögrens Syndrome

Condition: Sjogrens Syndrome
Intervention:
Sponsor: Göteborg University
Recruiting - verified November 2011
Efficacy and Safety of Olokizumab With Rheumatoid Arthritis With Previously Failed to Anti-tumor Necrosis Factor (Anti-TNF) Therapy

Condition: Rheumatoid Arthritis
Interventions: Biological: Placebo; Biological: Olokizumab 60 mg; Biological: Olokizumab 120 mg; Biological: Olokizumab 240 mg
Sponsor: UCB, Inc.
Recruiting - verified January 2012
A Prospective Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Prospective Study Measuring Clinical Outcomes of Knee Arthroplasty Using the OrthoSensor Surgical Smart Trial

Condition: Osteoarthritis, Knee
Intervention:
Sponsor: Orthosensor, Inc.
Recruiting - verified January 2012
Efficacy and Safety Study in Patients Suffering From Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: Chondroitin sulfate and sodium hyaluronate; Drug: Hyaluronan
Sponsor: Pierre Fabre Medicament
Not yet recruiting - verified November 2011
LPS Flex Porous Femoral Components

Conditions: Osteoarthritis; Rheumatoid Arthritis; Traumatic Arthritis; Poly Arthritis; Collagen Disorders; Avascular Necrosis of Femoral Condyle
Intervention: Device: LPS Flex Porous Femoral Components
Sponsor: Zimmer, Inc.
Not yet recruiting - verified October 2011
Gender Solutions Natural Knee Post-Market Study

Conditions: Osteoarthritis; Inflammatory Arthritis; Post-traumatic Arthritis; Rheumatoid Arthritis; Osteonecrosis; Varus or Valgus Deformities
Intervention: Device: Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System
Sponsor: Zimmer, Inc.
Not yet recruiting - verified October 2011
Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients

Conditions: Systemic Sclerosis; Ulcers
Interventions: Drug: macitentan 3mg; Drug: macitentan 10mg; Drug: placebo
Sponsor: Actelion
Recruiting - verified February 2012
Web-based Support to Manage Arthritis Pain

Conditions: Osteoarthritis; Rheumatoid Arthritis; Ankylosing Spondylitis; Other Arthritic Conditions (e.g., Psoriatic Arthritis)
Intervention: Behavioral: painACTION: Arthritis
Sponsor: Inflexxion, Inc.
Recruiting - verified October 2011
Post-Market Study of the EPIK Knee System

Conditions: Osteoarthritis; Post Traumatic Degenerative Disease
Intervention: Device: EPIK™ uni-compartmental knee
Sponsor: Encore Medical, L.P.
Recruiting - verified December 2011
A Study of RoActemra/Actemra (Tocilizumab) in Patients Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: Tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Not yet recruiting - verified January 2012
Dose-finding of Multiple Dose of BT061 in Patients With Active Rheumatoid Arthritis Incompletely Controlled on Stable Methotrexate (MTX)

Condition: Rheumatoid Arthritis
Interventions: Biological: BT061; Biological: Placebo
Sponsor: Biotest
Recruiting - verified November 2011
Pain and Analgesic Consumption Compared Between the First and the Second Surgery in Staged BTKRA

Condition: Degenerative Arthritis
Intervention:
Sponsor: Seoul National University Bundang Hospital
Recruiting - verified November 2011
Influenza Vaccination in Fibromyalgia Patients

Condition: Fibromyalgia Syndrome
Interventions: Biological: Inactivated split virion Influenza vaccine; Biological: WHO recommended 2011 Influenza vacccine
Sponsor: Tel-Aviv Sourasky Medical Center
Not yet recruiting - verified October 2011
Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%

Condition: Osteo Arthritis of the Knee
Interventions: Drug: Diclofenac; Drug: Placebo
Sponsors: Anchen Pharmaceuticals, Inc; Novum Pharmaceutical Research Services
Recruiting - verified December 2011
Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients

Condition: Knee Osteoarthritis
Interventions: Drug: SAR113945; Drug: placebo
Sponsor: Sanofi-Aventis
Recruiting - verified November 2011
Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis

Condition: Osteoarthritis
Interventions: Drug: Hyaluronic Acid; Biological: Autologous bone marrow-derived mesenchymal stem cells
Sponsors: National University of Malaysia; Cytopeutics Pte. Ltd.
Recruiting - verified October 2011
Allogeneic Mesenchymal Stem Cells in Osteoarthritis

Condition: Osteoarthritis of Knee
Interventions: Biological: Ex- vivo cultured adult allogeneic MSCs; Biological: Plasmalyte-A
Sponsor: Stempeutics Research Pvt Ltd
Recruiting - verified November 2011
Intra-articular Injection of Allogeneic Platelet Rich Plasma (PRP) for Adhesive Capsulitis

Condition: Adhesive Capsulitis
Interventions: Procedure: Isotonic saline injection into the glenohumeral joint; Procedure: Allogenic PRP injection into the glenohumeral joint
Sponsor: Seoul National University Hospital
Recruiting - verified December 2011
Effectiveness Study of the Ivivi SofPulse for Pain Amelioration in Adults With Mild to Moderate Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: Ivivi SofPulse; Device: Ivivi SofPulse
Sponsor: Amp Orthopedics, Inc.
Recruiting - verified December 2011
ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee

Conditions: Osteochondritis Dissecans; Osteoarthritis; Cartilage Injury; Osteonecrosis
Intervention: Procedure: Treatment of cartilage defects in the knee
Sponsors: University Hospital of North Norway; University of Tromso
Recruiting - verified November 2011
Three Doses of Hepatitis A Vaccine in Patients With Immunomodulating Drugs

Condition: Vaccine Response Impaired
Interventions: Biological: hepatitis A vaccine; Biological: hepatitis A vaccine
Sponsor: Sormland County Council, Sweden
Recruiting - verified October 2011
Effect of Golimumab in Participants With Active Axial Spondyloarthritis (P07642)

Condition: Spondylitis, Ankylosing
Interventions: Drug: Golimumab; Drug: Placebo
Sponsors: Schering-Plough; Johnson & Johnson
Recruiting - verified January 2012
Study of the Safety and Efficacy of Long-Term Rilonacept Treatment for the Prevention of Gout Flares

Condition: Gout
Interventions: Drug: Rilonacept; Drug: Placebo; Drug: Allopurinol
Sponsor: Regeneron Pharmaceuticals
Recruiting - verified January 2012
Open Label Study to Assess the Predictability of Early Response to Certolizumab Pegol in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Biological: Certolizumab pegol
Sponsor: UCB, Inc.
Recruiting - verified January 2012
Echogenic Versus Stimulating Needle and Catheter for Sciatic Blocks

Conditions: Osteoarthritis Knee; Postoperative Pain
Interventions: Device: echogenic needle and catheter; Device: Neurostimulation to position needle and catheter
Sponsors: Lawson Health Research Institute; The Physicians' Services Incorporated Foundation
Not yet recruiting - verified January 2012
A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: ABT-652; Drug: Placebo
Sponsor: Abbott
Recruiting - verified January 2012
Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement

Condition: Ankle Osteoarthritis
Intervention: Other: Total Ankle Replacement Surgery
Sponsor: Duke University
Recruiting - verified January 2012
Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol

Condition: Intercritical Gout
Interventions: Drug: Colchicine; Drug: Placebo; Drug: Allopurinol
Sponsor: Regeneron Pharmaceuticals
Recruiting - verified October 2011
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy

Condition: Duchenne Muscular Dystrophy
Intervention:
Sponsors: University of Florida; University of Pennsylvania; Oregon Health and Science University; Children's Hospital of Philadelphia; Shriners Hospitals for Children; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified October 2011
Efficacy Confirmation Study of CDP870 in Early Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: placebo of CDP870; Drug: CDP870
Sponsors: Otsuka Pharmaceutical Co., Ltd.; UCB Japan Co., LTD.
Recruiting - verified October 2011
Natural Course of Adhesive Capsulitis of Hip

Condition: Adhesive Capsulitis
Intervention:
Sponsor: Seoul National University Hospital
Recruiting - verified October 2011
Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty

Conditions: Pain; Osteoarthritis
Interventions: Procedure: Canal Block and Capsular Injection; Procedure: Femoral Nerve Block with Tibial Nerve Block
Sponsor: Saint Francis Care
Recruiting - verified October 2011
Guided Imagery Response in Total Knee Replacement

Condition: Osteoarthritis
Interventions: Behavioral: GUIDED IMAGERY; Behavioral: PLACEBO
Sponsors: Kent State University; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified December 2011
Impact Of RA Therapy Compliance On Patient-Reported Outcomes

Condition: Rheumatoid Arthritis
Interventions: Drug: tDMARDs; Drug: biodmards
Sponsor: Pfizer
Not yet recruiting - verified September 2011
Effects of Foot Center of Pressure Manipulation on Hip Osteoarthritis Patients During Gait

Condition: Hip Osteoarthritis
Interventions: Device: AposTherapy Biomechanical System; Other: Control
Sponsor: HaEmek Medical Center, Israel
Not yet recruiting - verified October 2011
TIV and High Dose TIV in Subjects With Rheumatoid Arthritis

Condition: Influenza
Interventions: Biological: 2011-2012 Sanofi Pasteur Fluzone®; Biological: 2011-2012 Sanofi Pasteur Fluzone® High Dose
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Functional and Quality of Life Outcomes Following Viscosupplementation for Knee Osteoarthritis

Condition: Knee Osteoarthritis
Intervention: Other: Subject outcomes following viscosupplementation of the knee
Sponsor: University of Florida
Recruiting - verified October 2011
Clinical Evaluation on the Use of the X-pander Device

Conditions: Osteoarthrosis; Total Hip Arthroplasty
Intervention: Procedure: x-pander
Sponsors: Northern Orthopaedic Division, Denmark; Medichanical Engineering
Recruiting - verified November 2011
Allogeneic Mesenchymal Stem Cells for Osteoarthritis

Condition: Osteoarthritis of Knee Joint
Interventions: Biological: Ex- vivo cultured adult allogeneic MSCs; Biological: Plasmalyte-A
Sponsors: Stempeutics Research Pvt Ltd; Stempeutics Research Malaysia SDN BHD
Recruiting - verified December 2011
Metal Ions in Ceramic on Metal Total Hip Arthroplasty

Conditions: Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis; Developmental Dysplasia of the Hip
Intervention:
Sponsor: Hussain Kazi
Not yet recruiting - verified September 2011
Study of Antibodies to Anti-TNF Agents in Juvenile Idiopathic Arthritis

Condition: Juvenile Idiopathic Arthritis
Intervention:
Sponsors: Blood Transfusion Centre of Slovenia; University Medical Centre Ljubljana
Not yet recruiting - verified September 2011
Anakinra for Behcet's Disease

Conditions: Autoimmune/Connective Tissue Diseases; Immune System Diseases; Behcet's Disease
Interventions: Drug: Anakinra; Other: Placebo
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Sleep Patterns in Children With and Without Juvenile Idiopathic Arthritis

Condition: Juvenile Idiopathic Arthritis
Intervention: Behavioral: comparison of types of sleep disordered breathing
Sponsor: University of Washington
Recruiting - verified September 2011
A Clinical Trial to Study the Effects of Revamilast in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Revamilast; Drug: Revamilast; Drug: Revamilast; Drug: Placebo Comparator
Sponsors: Glenmark Pharmaceuticals Ltd. India; Glenmark Pharmaceuticals SA
Recruiting - verified December 2011
The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease

Conditions: Cat-scratch Disease; Bartonella Infections
Interventions: Drug: prednison and azithromycin; Drug: prednison, azithromycin; Drug: prednison, Azenil
Sponsor: Tel-Aviv Sourasky Medical Center
Not yet recruiting - verified November 2011
Long-Term Safety and Tolerability of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients

Condition: Acute Gouty Arthritis
Intervention: Drug: Canakinumab 150mg in prefilled syringe
Sponsor: Novartis Pharmaceuticals
Recruiting - verified September 2011
Effect of Exercise on Disease Activity and Cardiovascular Risk Factors in Patients With Ankylosing Spondylitis

Condition: Ankylosing Spondylitis
Intervention: Behavioral: Exercise
Sponsors: Diakonhjemmet Hospital; University of Oslo
Recruiting - verified October 2011
Patient and Provider Interventions for Managing Osteoarthritis in Primary Care

Condition: Osteoarthritis
Interventions: Behavioral: Patient Behavioral Intervention for OA; Behavioral: Provider Intervention for OA; Behavioral: Combined Patient and Provider Interventions for OA
Sponsors: Duke University; National Institutes of Health (NIH); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified September 2011
Exploration of TNF-alpha Blockade With Golimumab in the Induction of Clinical Remission in Patients With Early Peripheral Spondyloarthritis (SpA) According to ASAS-criteria

Condition: Peripheral Spondylarthritis
Interventions: Drug: Placebo; Drug: Golimumab
Sponsors: University Hospital, Ghent; Janssen Biologics B.V.
Not yet recruiting - verified August 2011
Weight Loss Intervention Before Total Knee Replacement

Conditions: Osteoarthritis, Knee; Obesity
Intervention: Behavioral: 8 weeks weight loss program, Cambridge.
Sponsor: University of Aarhus
Recruiting - verified November 2011
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: Meloxicam; Drug: Placebo
Sponsor: Pfizer
Recruiting - verified January 2012
Natural History and Development of Spondyloarthritis

Conditions: Arthritis; Spondylitis, Ankylosing
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified July 2011
Extracorporeal Shock Wave Treatment - Can the Pain be Reduced?

Conditions: Fasciitis, Plantar; Achillodynia; Periarthritis Calcarea; Epikondylopathia Humeri /Radii
Intervention:
Sponsor: University of Zurich
Recruiting - verified August 2011
Extension Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis

Condition: Juvenile Idiopahtic Arthritis
Intervention: Drug: etanercept
Sponsor: Pfizer
Not yet recruiting - verified August 2011
AMG 827 in Subjects With Psoriatic Arthritis

Condition: Psoriatic Arthritis
Interventions: Drug: AMG 827; Drug: Placebo; Drug: AMG 827
Sponsor: Amgen
Recruiting - verified January 2012
Correlation Between Beliefs About Medicine and Objective Measures of Efficacy and Safety in Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Intervention: Other: SC anti-TNF
Sponsor: Pfizer
Recruiting - verified January 2012
Evaluating N-Acetylcysteine in CTD-ILD Treatment

Conditions: Interstitial Lung Disease; Connective Tissue Disease
Intervention: Drug: N-Acetylcysteine
Sponsor: University of Michigan
Recruiting - verified December 2011
A Comparison of Manual Physical Therapy and Corticosteroid Injections for Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Procedure: Orthopaedic manual physical therapy; Procedure: Corticosteroid Injection
Sponsors: Madigan Army Medical Center; Brooke Army Medical Center; Wilford Hall Medical Center
Not yet recruiting - verified August 2011
Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis

Conditions: Cytokine Environment; Kinetics of Bone Cells Differentiation and Activity in Untreated RA and AS Patients.
Intervention:
Sponsors: Instituto de Medicina Molecular; Merck
Not yet recruiting - verified December 2011
Rosehip Powder for Knee Osteoarthritis

Condition: Osteoarthritis
Intervention: Dietary Supplement: Rosehip powder
Sponsors: Frederiksberg University Hospital; Axellus A/S, Ishøj, Denmark; Oak Foundation, Geneva
Recruiting - verified September 2011
An Open-label Extension Study With Canakinumab on the Treatment and Prevention of Gout Flares up to 3 Years

Condition: Chronic Gouty Arthritis
Intervention: Biological: canakinumab
Sponsor: Novartis Pharmaceuticals
Not yet recruiting - verified November 2011
The Pathogenesis and Natural History of Sjogren's Syndrome

Conditions: Pathogenesis; Sjogren's Syndrome; Salivary Gland
Intervention:
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified April 2011
Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities

Condition: Relapsing Remitting Multiple Sclerosis
Intervention:
Sponsors: University of Southern California; Teva Pharmaceuticals USA
Recruiting - verified November 2011
A Biomarker Study of Secukinumab in Rheumatoid Arthritis Patients

Condition: Rheumatoid Arthritis
Interventions: Biological: Placebo to Secukinumab (AIN457); Biological: Secukinumab
Sponsor: Novartis Pharmaceuticals
Recruiting - verified August 2011
A Study to Determine the Safety and Efficacy of LX3305 in Subjects With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: 50 mg LX3305 QD; Drug: 100 mg LX3305 QD; Drug: 150 mg LX3305 QD; Drug: 200 mg LX3305 QD; Drug: 250 mg LX3305 QD; Drug: 300 mg LX3305 QD; Drug: 400 mg LX3305 QD; Drug: 250 mg LX3305 BID; Drug: 500 mg LX3305 QD; Drug: Placebo
Sponsor: Lexicon Pharmaceuticals
Recruiting - verified September 2011
The Metaphyseal Hip Prosthesis - Total Hip

Condition: Osteoarthritis of the Hip
Interventions: Device: Metaphyseal Hip Prosthesis; Device: Stanmore hip prosthesis
Sponsor: Biomet, Inc.
Not yet recruiting - verified December 2011
Bovine Intestinal Alkaline Phosphatase (bIAP) Modulating Rheumatoid Arthritis

Condition: Acute Rheumatoid Arthritis
Intervention: Drug: s.c. injections of bovine intestinal Alkaline Phosphatase
Sponsors: Alloksys Life Sciences B.V.; Aix Scientifics
Recruiting - verified August 2011
Study on the Efficacy and Safety of Chondroitin Sulfate and Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis Treatment

Condition: Knee Osteoarthritis
Interventions: Drug: Chondroitin sulfate/ Glucosamine hydrochloride; Drug: Celecoxib
Sponsor: Bioiberica
Recruiting - verified October 2011
Methotrexate (Rheumatrex) High Dose Special Investigation (Regulatory Post Marketing Commitment Plan)

Conditions: Arthritis; Rheumatoid; High Dose
Intervention: Drug: Methotrexate (MTX)
Sponsor: Pfizer
Recruiting - verified January 2012
Dexamethasone for Pain After Shoulder Surgery

Conditions: Shoulder Impingement Syndrome; Arthritis
Intervention: Drug: Dexamethasone
Sponsors: University of Aarhus; Horsens Hospital; Central Denmark Region; The Family Hede Nielsens Fund; The Danish Rheumatism Association
Recruiting - verified January 2012
Special Investigation (All Case Survey) in Patients With Juvenile Idiopathic Arthritis

Condition: Arthritis, Juvenile Rheumatoid
Intervention:
Sponsor: Abbott
Recruiting - verified November 2011
Changes Of Sleep on the Sensoriomotor and Cytokine In Patients With Osteoarthritis

Condition: Osteoathritis and Sleep
Intervention: Behavioral: Balance and muscle strength
Sponsors: Universidade Federal de Sao Carlos; Federal University of São Paulo
Recruiting - verified August 2011
Ceramic-on-Ceramic Total Hip Arthroplasty and Squeaking: Influence of Component Design

Condition: Hip Arthrosis
Interventions: Device: THA with ABG II / Trident; Device: THA with CLS / Trilogy
Sponsor: Vejle Hospital
Recruiting - verified November 2011
Efficacy and Safety of Masitinib in Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis (RA)
Interventions: Drug: masitinib; Drug: masitinib; Drug: methotrexate
Sponsor: AB Science
Recruiting - verified May 2011
A Study of Two Doses of MRC375 in Moderate to Severe Rheumatoid Arthritis Patients With a 12 Week Open-label Extension

Condition: Rheumatoid Arthritis
Interventions: Drug: MRC375; Drug: Matching Placebo; Drug: MRC375 150mg
Sponsors: Molecular Research Center, Inc.; Camargo Pharmaceutical Services; Rho; Clin Data Services; Harrison Clinical Research; BARC Global Central Laboratory; Bilcare Global Clinical Supplies
Recruiting - verified January 2012
Maxi-Analgesic Osteoarthritis (OA) Study

Condition: Moderate to Severe Pain Associated With Osteoarthritis of the Hip or Knee
Interventions: Drug: Acetaminophen; Drug: Maxigesic USA; Drug: Ibuprofen; Drug: Placebo
Sponsor: AFT Pharmaceuticals, Ltd.
Not yet recruiting - verified August 2011
A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral BCX4208 Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency

Conditions: Gout; Hyperuricemia; Arthritis; Joint Disease; Renal Insufficiency
Interventions: Drug: BCX4208; Drug: Allopurinol 200mg
Sponsor: BioCryst Pharmaceuticals
Recruiting - verified November 2011
The Efficacy of Platelets Rich Plasma Injection With PRGF Method in the Treatment for Osteoarthritis of the Subtalar Joint

Condition: Osteoarthritis of Subtalar Joint
Intervention: Biological: Platelet Rich Plasma
Sponsor: Meir Medical Center
Not yet recruiting - verified August 2011
Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Ankylosing Spondylitis (AS)

Condition: Ankylosing Spondylitis
Intervention: Biological: Human umbilical cord-derived MSCs
Sponsor: Shandong University
Recruiting - verified April 2011
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene

Condition: Rheumatoid Arthritis
Intervention: Other: No intervetion
Sponsor: Rigshospitalet, Denmark
Recruiting - verified July 2011
Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Placebo; Drug: BMS-817399; Drug: BMS-817399
Sponsor: Bristol-Myers Squibb
Recruiting - verified November 2011
Use of Pulsed Electromagnetic Fields for Postoperative Knee Pain

Condition: Osteoarthritis
Interventions: Device: Active Device (Torino II); Device: Sham Device (Torino II)
Sponsor: Center for Joint Surgery and Sports Medicine, Maryland
Recruiting - verified August 2011
INFUSE®Bone Graft in Transforaminal Lumbar Interbody Fusion for Degenerative Disease of Lumbosacral Spine

Condition: Lumbar Spine Degeneration
Interventions: Device: INFUSE Bone Graft; Other: Iliac Crest Bone Graft
Sponsor: Medtronic Spinal and Biologics
Recruiting - verified January 2012
Pilot and Feasibility Study of Hematopoietic Stem Cell Gene Transfer for the Wiskott-Aldrich Syndrome

Condition: Wiskott-Aldrich Syndrome
Intervention: Biological: Retrovirus-mediated gene transfer
Sponsor: Children's Hospital Boston
Recruiting - verified August 2011
Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: Methotrexate
Sponsor: Postgraduate Institute of Medical Education and Research
Recruiting - verified August 2011
Sigma CR150 Versus Sigma CR Knee

Condition: Osteoarthritis
Interventions: Device: PFC Sigma CR150; Device: PFC Sigma CR; Device: PFC Sigma CR150; Device: PFC Sigma CR
Sponsor: DePuy International
Recruiting - verified August 2011
The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis

Condition: Psoriasis
Intervention:
Sponsor: National Taiwan University Hospital
Recruiting - verified July 2011
Teriparatide for Joint Erosions in Rheumatoid Arthritis: The TERA Trial

Condition: Rheumatoid Arthritis
Intervention: Drug: Teriparatide
Sponsors: Brigham and Women's Hospital; Eli Lilly and Company
Recruiting - verified January 2012
Safety, Tolerability, and Pharmacodynamic Study of ISIS CRP Rx in Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: ISIS CRP Rx or Placebo
Sponsor: Isis Pharmaceuticals
Recruiting - verified November 2011
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: methotrexate; Drug: methotrexate; Drug: placebo
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Pharmacovigilance in Juvenile Idiopathic Arthritis Patients Treated With Biologic Agents and/or Methotrexate

Condition: Juvenile Idiopathic Arthritis
Intervention:
Sponsors: Istituto Giannina Gaslini; Members of the PRINTO network (PRINTO at www.printo.it)
Not yet recruiting - verified May 2011
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement

Condition: Osteoarthritis of the Knee
Interventions: Other: Neuromuscular training (NEMEX-TJR); Drug: Paracetamol; Drug: Burana; Drug: Pantoprazol; Behavioral: Dietary counseling; Behavioral: Patient education; Procedure: TKR; Other: Insoles
Sponsors: Northern Orthopaedic Division, Denmark; The Danish Rheumatism Association; Obel Family Foundation; Spar Nord Foundation; The Bevica Foundation; Aalborg University; The Association of Danish Physiotherapists Research Fund; Formthotics
Recruiting - verified December 2011
Agricultural Health Study Follow-up

Conditions: Rheumatoid Arthritis; Lupus Erythematosus, Systemic; Sjogren's Syndrome
Intervention:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified June 2011
Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty

Conditions: Knee Replacement Surgery; Osteoarthritis
Interventions: Other: Standard of Care; Drug: FLOSEAL Hemostatic Matrix
Sponsor: Baxter Healthcare Corporation
Recruiting - verified September 2011
Ascension® MCP Post-Approval Study

Conditions: Rheumatoid Arthritis; Systemic Lupus Erythematosus; Osteoarthritis; Post-traumatic Arthritis
Intervention: Device: Ascension MCP Finger Implant
Sponsor: Ascension Orthopedics, Inc.
Recruiting - verified July 2011
Regulating Urine pH Levels to Alleviate Chronic Joint Pain

Condition: Arthritis
Intervention: Drug: sodium citrate and citric acid
Sponsor: Texas Tech University Health Sciences Center
Recruiting - verified August 2011
Biomechanics of Gait Pattern Adaptation in Patients After Total Knee Arthroplasty

Conditions: Knee Arthroplasty; Knee Arthritis Osteoarthritis; Osteoarthritis; Osteoarthritis, Knee; Musculoskeletal Diseases
Interventions: Device: AposTherapy Biomechanical System; Other: Physical Therapy Program
Sponsor: Tel-Aviv Sourasky Medical Center
Recruiting - verified August 2011
An Observational Study on RoActemra/Actemra (Tocilizumab) in Clinical Practice in Patients With Rheumatoid Arthritis (TRUST)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Diagnostic Value of Oral Prednisolone Test for Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: Prednisolone
Sponsor: Rheumazentrum Ruhrgebiet
Not yet recruiting - verified July 2011
Comparison of Two Etanercept Regimens (REUMATOCEPT® Versus ENBREL®) for Treatment of Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Reumatocept (etanercept); Drug: Enbrel (etanercept)
Sponsor: EMS
Not yet recruiting - verified July 2011
The Influence of Mindfulness Based Intervention on Pain Perception in Chronic Pain Patients

Conditions: Low Back Pain; Osteoarthritis
Intervention: Behavioral: mindfulness group meetings with psychologist
Sponsor: Meir Medical Center
Not yet recruiting - verified August 2011
Study of Tocilizumab to Treat Polymyalgia Rheumatica

Condition: Polymyalgia Rheumatica (PMR)
Intervention: Drug: Tocilizumab
Sponsors: Hospital for Special Surgery, New York; Genentech
Recruiting - verified January 2012
Glucocorticoid Use in Patients With Rheumatoid Arthritis on Treatment With RoActemra/Actemra (Tocilizumab)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified July 2011
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)

Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: Tetrahydrobiopterin (BH4); Drug: non-acetylated salicylate; Dietary Supplement: High Fat Meal; Drug: L-NMMA; Dietary Supplement: Antioxidant Cocktail
Sponsors: Georgia Health Sciences University; American Heart Association
Recruiting - verified July 2011
Efficacy at 24 Weeks and Long Term Safety, Tolerability and Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Psoriatic Arthritis (PsA)

Condition: Psoriatic Arthritis
Interventions: Biological: Secukinumab (75 mg); Biological: Secukinumab (150 mg); Biological: Placebo Comparator
Sponsor: Novartis Pharmaceuticals
Recruiting - verified September 2011
A Study of the Pharmacokinetics and Safety of MK-8808 (MK-8808-002 AM2)

Condition: Rheumatoid Arthritis
Interventions: Biological: MK-8808; Biological: Rituximab; Drug: Methotrexate
Sponsor: Merck
Recruiting - verified December 2011
Gait Retraining to Reduce Knee Osteoarthritis Pain

Condition: Osteoarthritis, Knee
Intervention: Behavioral: Gait retraining
Sponsor: Stanford University
Recruiting - verified July 2011
An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye

Conditions: Dry Eye; Sjogren's Syndrome; Graft vs. Host Disease
Intervention: Drug: Thymosin Beta 4 eye drops vs. vehicle
Sponsors: Michigan Cornea Consultants, PC; Kresge Eye Institute
Recruiting - verified July 2011
A Study of Rheumatoid Arthritis Patients on Adalimumab to Evaluate Quality of Life Variables, Effects on Work Productivity and Functional Outcomes in Malaysia

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
REstore Working Ability in RheumatoiD Arthritis

Condition: Rheumatoid Arthritis
Intervention: Biological: adalimumab
Sponsors: The Rheumatological Center of Helsinki; Abbott
Recruiting - verified July 2011
Oxford Partial Knee Comparative Instrument Pilot Study

Condition: Osteoarthritis, Knee
Interventions: Procedure: Conventional Instrumentation; Procedure: Signature Custom Guides
Sponsor: Biomet, Inc.
Not yet recruiting - verified October 2011
Standard Disease Activity Parameters and Step Activity in Patients With Rheumatoid Arthritis Receiving Etanercept

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: University Hospital Muenster
Recruiting - verified July 2011
An Observational Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis (ACTIVATE)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Observational Study to Research the Effectiveness of Adalimumab Treatment in Conjunction With Utilization of a Patient Support Program (PSP)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Ankylosing Spondylitis

Condition: Ankylosing Spondylitis
Intervention:
Sponsors: Abbott; JSS Medical Research Inc.; CATO Research Canada
Recruiting - verified January 2012
A Multi-centre Study to Assess the Long-term Performance of the Silent Hip™ in Primary Total Hip Replacement Surgery

Conditions: Primary Arthritis; Secondary Arthritis
Intervention: Device: Silent™ Hip
Sponsor: DePuy International
Recruiting - verified September 2011
A Study on The Safety of Administering MabThera/Rituxan (Rituximab) at A More Rapid Rate in Patients With Rheumatoid Arthritis (RATE-RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: rituximab [MabThera/Rituxan]; Drug: methotrexate
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Canadian Humira Post Marketing Observational Epidemiological Study: Assessing Effectiveness in Psoriasis

Condition: Psoriasis
Intervention:
Sponsors: Abbott; CATO Research Canada; JSS Medical Research Inc.
Recruiting - verified November 2011
An Analysis of Potential Sex Differences in Knee Osteoarthritis

Conditions: Degenerative Joint Disease; Osteoarthritis
Intervention: Other: musculoskeletal
Sponsors: Mary O'Connor; Society of Women's Health Research; University of Calgary; Florida State University; Georgia Institute of Technology
Recruiting - verified September 2011
Epsilon Aminocaproic Acid (EACA) for the Reduction of Blood Loss in Total Hip Arthroplasty (THA)

Conditions: Degenerative Joint Disease; Osteoarthritis
Interventions: Other: EACA; Other: Placebo arm
Sponsor: Mayo Clinic
Recruiting - verified September 2011
Allopurinol Outcome Study

Condition: Gout
Intervention: Drug: Allopurinol
Sponsor: Ardea Biosciences, Inc.
Recruiting - verified January 2012
A Modified Rehabilitation Intervention for Working Persons With Arthritis

Condition: Arthritis
Intervention: Behavioral: Vocational Rehabilitation Intervention
Sponsors: Boston University; U.S. Department of Education
Recruiting - verified July 2011
Exercise in Patients With Osteoarthritis of the Hip

Condition: Hip Osteoarthritis
Interventions: Procedure: Strength training; Procedure: Nordic Walking; Procedure: Unsupervised home based exercise
Sponsor: Bispebjerg Hospital
Recruiting - verified June 2011
Cannabidiol for Graft Versus Host Disease (GVHD) Prophylaxis in Allogeneic Stem Cell Transplantation

Condition: Graft Versus Host Disease
Intervention: Drug: Oral Cannabidiol
Sponsor: Rabin Medical Center
Not yet recruiting - verified April 2011
Effectiveness of Adalimumab in Moderate to Severe Plaque Psoriasis Patients With Distinct Co-morbidities

Conditions: Moderate to Severe Plaque Psoriasis; Antibodies; Monoclonals
Intervention:
Sponsors: Abbott; Mag. Andreas Raffeiner GMBH
Recruiting - verified December 2011
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents

Condition: Rheumatoid Arthritis
Interventions: Drug: Secukinumab (75 mg); Drug: Secukinumab (150 mg); Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting - verified September 2011
Basal Joint Arthritis Prospective

Condition: Osteoarthritis of the Basal Joint of the Thumb
Intervention:
Sponsors: Columbia University; Arthritis Foundation; American Society for Surgery of the Hand
Recruiting - verified January 2012
An Observational Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified October 2011
Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee

Conditions: Chronic Pain; Osteoarthritis
Intervention: Device: Transcranial Direct Current Stimulation
Sponsors: Spaulding Rehabilitation Hospital; Highland Instruments
Recruiting - verified November 2011
Rheumatoid Arthritis Treatment and Biopsy Study Assessing Certolizumab Pegol (Cimzia)

Condition: Rheumatoid Arthritis
Interventions: Drug: Open Label Drug Certolizumab Pegol (CZP); Procedure: Arthroscopic synovial tissue biopsy
Sponsors: Nathan Wei, MD, FACP, FACR:; University of California, San Diego
Recruiting - verified September 2011
Study Comparing Doses Of An Experimental Glucocorticoid Compound To Prednisone And Placebo In Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: PF-04171327; Drug: PF-04171327; Drug: PF-04171327; Drug: PF-04171327; Drug: prednisone; Other: prednisone; Other: placebo
Sponsor: Pfizer
Recruiting - verified December 2011
Phase IIB Rheumatoid Arthritis Dose Ranging Study for BMS-945429 in Subjects Who Are Not Responding to Methotrexate

Condition: Rheumatoid Arthritis
Interventions: Drug: BMS-945429 Placebo; Biological: BMS-945429; Biological: BMS-945429; Biological: BMS-945429; Biological: BMS-945429; Drug: Methotrexate; Drug: Methotrexate; Drug: Methotrexate Placebo; Drug: Methotrexate; Drug: Adalimumab Placebo; Drug: Adalimumab
Sponsor: Bristol-Myers Squibb
Recruiting - verified January 2012
Long-Term Multicenter Evaluation of the E1® Tibial Bearing

Conditions: Osteoarthritis of the Knee; Traumatic Arthritis of the Knee
Intervention: Procedure: Total knee arthroplasty
Sponsor: Massachusetts General Hospital
Not yet recruiting - verified June 2011
Platelet-rich Plasma Intra-articular Knee Injections for Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Biological: platelet-rich plasma; Drug: Corticosteroid
Sponsor: Hospital Universitari Vall d'Hebron Research Institute
Recruiting - verified September 2011
Monitoring of Acute Knee Injuries to Understand Osteoarthritis Development

Conditions: Traumatic Knee Injury; Knee Osteoarthritis
Intervention:
Sponsor: Lund University
Not yet recruiting - verified January 2011
The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis

Condition: Knee Osteoarthritis
Intervention: Drug: Voltaren
Sponsors: Brigham and Women's Hospital; Endo Pharmaceuticals
Recruiting - verified June 2011
A Phase II Trial Comparing Z-102 With Placebo In Patients With Moderate To Severe Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Prednisolone; Drug: dipyridamole; Drug: Prednisone; Drug: prednisolone-dipyridamole; Other: placebo
Sponsor: Zalicus
Recruiting - verified June 2011
Efficacy of Spearmint Tea in Relieving Osteoarthritis of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Other: Commercially spearmint tea; Other: High Rosmarinic Acid Spearmint Tea
Sponsors: University of Guelph; Ontario Ministry of Agriculture and Rural Affairs
Recruiting - verified April 2011
Can Computer-based Telephone Counseling Improve Long-term Adherence to Strength Training in Elders With Knee OA?

Condition: Osteoarthritis of the Knee
Intervention: Behavioral: TLC
Sponsors: Boston University; U.S. Department of Education
Not yet recruiting - verified July 2011
Comparison of Clinical Outcomes and Performance of Total Knee Replacement Patients Before and After Surgery

Conditions: Degenerative Joint Disease; Osteoarthritis; Knee Injury, Trauma; Connective Tissue Disorder; Pain; Loss of Function
Intervention:
Sponsor: Loma Linda University
Not yet recruiting - verified June 2011
Agility LP Ankle Arthroplasty Outcomes

Conditions: Rheumatoid Arthritis of Ankle; Osteoarthritis of Ankle; Traumatic Arthritis of Ankle
Intervention:
Sponsor: Orthopaedic Associates of Michigan, PC
Recruiting - verified June 2011
Assess Structural Damage in Rheumatoid Arthritis Using Biomarkers and Radiography

Condition: Rheumatoid Arthritis
Intervention: Other: Observational study
Sponsors: Canadian Research & Education in Arthritis; Abbott
Recruiting - verified November 2011
INBONE Total Ankle Arthroplasty(TAA)Using Calcaneal Stem Fixation

Conditions: Arthrodesis; Degenerative Arthritis; Rheumatoid Arthritis; Complications; Arthroplasty, Mechanical
Intervention:
Sponsors: Wright Medical Technology; Duke University
Recruiting - verified June 2011
Safety and Tolerability of NNC0141-0000-0100 in Subjects With Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Inflammation
Interventions: Drug: NNC 0141-0000-0100; Drug: placebo; Drug: NNC 0141-0000-0100; Drug: placebo; Drug: NNC 0141-0000-0100; Drug: placebo
Sponsor: Novo Nordisk
Recruiting - verified January 2012
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection

Conditions: Osteoarthritis; Knee Infection; Prosthetic Joint Infection; Complications; Arthroplasty, Infection or Inflammation; Complications; Arthroplasty
Interventions: Procedure: Static Spacer; Procedure: Articulating Spacer
Sponsors: Rush University Medical Center; Central DuPage Hospital
Recruiting - verified June 2011
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement

Conditions: Osteoarthritis; Hip Infection; Prosthetic Joint Infection; Complications; Arthroplasty, Infection or Inflammation; Complications; Arthroplasty
Interventions: Procedure: Implantation of a static, non-articulating cement spacer.; Procedure: Implantation of an articulating spacer.
Sponsors: Rush University Medical Center; Thomas Jefferson University; Central DuPage Hospital
Recruiting - verified June 2011
Hymovis™ Versus Placebo in Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: Hymovis Intra-articular Injection; Procedure: Phosphate Buffered Saline Injection
Sponsor: Fidia Farmaceutici s.p.a.
Recruiting - verified June 2011
Effect of Interleukin-1 Receptor Antagonist on Inhalation of 20,000 EU Clinical Ctr Reference Endotoxin in Normal Volunteers

Condition: Healthy Control Subjects
Interventions: Drug: Anakinra; Drug: Placebo
Sponsors: Michelle Hernandez, MD; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2011
An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biologic DMARD and/or Anti-TNF Therapy

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Efficacy and Safety of Subcutaneous Secukinumab for Moderate to Severe Chronic Plaque-type Psoriasis for up to 1 Year

Condition: Moderate to Severe Plaque-type Psoriasis
Interventions: Drug: secukinumab 150 mg; Drug: secukinumab 150 mg; Drug: placebo to secukinumab 150 mg
Sponsor: Novartis Pharmaceuticals
Recruiting - verified October 2011
Arthroscopic Ankle Arthrodesis: Measuring Post-operative Pain to Assess the Potential for Outpatient Surgery.

Condition: Osteoarthritis
Intervention:
Sponsor: Hammond, Allan, M.D.
Recruiting - verified June 2011
Effect of Adalimumab for the Treatment of Uveitis in Juvenile Idiopathic Arthritis

Conditions: Uveitis; Juvenile Arthritis
Interventions: Drug: Anti-tumor necrosis factor alpha monoclonal antibody; Drug: placebo
Sponsors: Assistance Publique - Hôpitaux de Paris; Abbott
Recruiting - verified July 2011
Safety & Efficacy of Canakinumab (ACZ885) in Patients With Frequent Flares for Whom Nonsterodial Anti-Inflammatory Drug (NSAIDs) and/ or Colchicine Are Contraindicated, Not Tolerated or Ineffective

Condition: Gouty Arthritis
Interventions: Biological: Canakinumab, ACZ885; Drug: Triamcinolone acetonide
Sponsor: Novartis
Not yet recruiting - verified May 2011
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

Conditions: Acute Blood Loss Anemia; Osteoarthritis, Knee
Interventions: Drug: Tranexamic Acid; Drug: Placebo
Sponsor: Henry Ford Health System
Recruiting - verified April 2011
Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate

Condition: Rheumatoid Arthritis
Interventions: Biological: secukinumab; Biological: secukinumab; Biological: placebo
Sponsor: Novartis Pharmaceuticals
Recruiting - verified October 2011
An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis

Condition: Juvenile Idiopathic Arthritis
Intervention:
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified January 2012
A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: ARRY-371797, p38 inhibitor; oral; Drug: Oxycodone hydrochloride (HCl) extended release (ER), opioid agonist; oral; Drug: Placebo; oral
Sponsor: Array BioPharma
Recruiting - verified December 2011
Prediction of Outcomes Following Total Knee Replacement

Condition: Osteoarthritis
Intervention:
Sponsor: Brigham and Women's Hospital
Recruiting - verified June 2011
Safety and Tolerability of MORAb-022 in Healthy and Rheumatoid Arthritis Subjects

Condition: Rheumatoid Arthritis
Intervention: Drug: MORAb-022
Sponsor: Eisai Inc.
Recruiting - verified May 2011
Effects of Green Tea on Level of Serum Uric Acid in Healthy Individuals

Conditions: Hyperuricemia; Gout
Interventions: Dietary Supplement: green tea extracts 2 gm/day; Dietary Supplement: green tea extracts 4 gm/day; Dietary Supplement: green tea extracts 6 gm/day
Sponsor: Chiang Mai University
Recruiting - verified October 2011
Effect of TENS for Pain and Function After Total Knee Replacement

Conditions: Unilateral Primary Osteoarthritis of Knee; Primary Osteoarthritis of Knee Nos
Interventions: Device: Placebo TENS; Device: Intense TENS (EMPI Select TENS)
Sponsor: University of Iowa
Recruiting - verified May 2011
Safety and Efficacy of an Injectable Medical Device to Treat Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: MM-II; Device: DurolaneTM
Sponsor: Moebius Medical Ltd.
Not yet recruiting - verified June 2011
Safety and Efficacy of Canakinumab Prefilled Syringes in Frequently Flaring Acute Gouty Arthritis Patients

Condition: Acute Gouty Arthritis
Interventions: Drug: Canakinumab pre-filled syringe; Drug: Canakinumab lyophilized cake; Drug: Triamcinolone Acetonide
Sponsor: Novartis Pharmaceuticals
Recruiting - verified August 2011
Assessment of Pharmacokinetics of a Single Oral Dose of VIMOVO in Healthy Adult Volunteers

Condition: Juvenile Idiopathic Arthritis
Interventions: Drug: naproxen; Drug: esomeprazole
Sponsor: AstraZeneca
Recruiting - verified June 2011
A Study of Rheumatoid Arthritis Treatment With Enbrel in Adult Patient in Outpatient Department

Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis
Intervention: Drug: Enbrel
Sponsor: Pfizer
Recruiting - verified January 2012
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDs

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: methotrexate
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis (AutoDECRA)

Condition: Rheumatoid Arthritis
Interventions: Drug: TolDC; Drug: Arthroscopy & saline irrigation alone
Sponsors: Newcastle University; Arthritis Research UK (funder); Newcastle-upon-Tyne Hospitals NHS Trust
Not yet recruiting - verified May 2011
A Study To Assess the Immune Response Following Administration Of Influenza and Pneumococcal Vaccines To Subjects With Rheumatoid Arthritis Receiving CP-690,550 Or Placebo

Condition: Rheumatoid Arthritis
Interventions: Drug: CP-690,550; Drug: placebo
Sponsor: Pfizer
Recruiting - verified January 2012
Bisphosphonate Users Radiographic Characteristics of the Hip (BURCH) Study

Conditions: Osteoporosis; Bone Diseases, Metabolic; Hip Fractures
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2011
Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 1 Year of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Anti-Tumor Necrosis Factor α (Anti-TNFα) Agents

Condition: Rheumatoid Arthritis
Interventions: Biological: Secukinumab (75 mg); Biological: Secukinumab (150 mg); Biological: Placebo; Biological: Abatacept
Sponsor: Novartis Pharmaceuticals
Recruiting - verified September 2011
Efficacy and Safety of Oxycodone/Naloxone Controlled-release Tablets (OXN) Compared to Placebo in Opioid-experienced Subjects With Moderate to Severe Chronic Low Back Pain

Condition: Low Back Pain
Interventions: Drug: Oxycodone/Naloxone Controlled-release; Drug: Placebo
Sponsor: Purdue Pharma LP
Recruiting - verified January 2012
Femoral Remodeling Following Total Hip Arthroplasty With Omni Apex Modular™, OMNI Apex ARC™ Stem, and Omni Apex "Conical Stem" Compared to Competitive Designs

Condition: Osteoarthritis of the Hip
Intervention:
Sponsor: Spokane Joint Replacement Center
Recruiting - verified May 2011
Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis

Conditions: Knee Osteoarthritis; Knee Injuries
Interventions: Other: Intra-articular ultrasound imaging of knee joint during arthroscopy; Other: Non-invasive ultrasound imaging of knee; Other: Quantitative MRI imaging of knee; Other: Contrast-enhanced CT imaging of knee
Sponsors: University of Oulu; Oulu University Hospital; University of Eastern Finland; Kuopio University Hospital
Recruiting - verified May 2011
Clinical Outcomes With OK Knee System

Condition: Osteoarthritis of the Knee
Intervention:
Sponsor: Spokane Joint Replacement Center
Recruiting - verified June 2011
Dual Energy X-rayY Absorptiometry (DXA) Comparison Hip Resurfacing Versus Total Hip Arthroplasty (THA)

Conditions: Total Hip Replacement; Osteoarthritis; Bone Loss
Intervention:
Sponsor: Spokane Joint Replacement Center
Recruiting - verified May 2011
Balancing Lupus Experiences With Stress Strategies

Condition: Systemic Lupus Erythematosus
Intervention: Behavioral: Arthritis Self Management Program
Sponsors: Medical University of South Carolina; Pfizer
Recruiting - verified April 2011
Benefits of Injectable Abatacept Using Magnetic Resonance Imaging (MRI) in Rheumatoid Arthritis (RA) Patients

Condition: Rheumatoid Arthritis
Intervention: Biological: abatacept
Sponsors: Arthritis & Rheumatic Disease Specialties Research; Bristol-Myers Squibb
Not yet recruiting - verified May 2011
Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis

Condition: Osteoarthritis, Knee
Interventions: Behavioral: Exercise Cycle; Behavioral: Land-based Treadmill; Behavioral: Water-based Treadmill
Sponsor: Penn State University
Recruiting - verified May 2011
Pulmozyme for Sjogren's Associated Cough

Conditions: Sjogren's Syndrome; Cough
Interventions: Drug: Dornase alfa; Drug: Saline
Sponsor: University of Connecticut Health Center
Recruiting - verified May 2011
Maintenance After Initiation of Nutrition TrAINing

Condition: Obesity
Intervention: Behavioral: Interventions
Sponsor: Department of Veterans Affairs
Not yet recruiting - verified October 2011
Efficacy at 16 Weeks and Long Term Safety, Tolerability and Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Ankylosing Spondylitis (AS)

Condition: Ankylosing Spondylitis
Interventions: Biological: Secukinumab (75 mg); Biological: Secukinumab (150 mg); Biological: Placebo
Sponsor: Novartis Pharmaceuticals
Recruiting - verified October 2011
Neuromuscular Electrical Stimulation and Strength Training in Patients With Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Other: Neuromuscular Electrical Stimulation; Other: ECR
Sponsor: Universidade Gama Filho
Recruiting - verified May 2011
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain

Conditions: Autoimmune Diseases; Systemic Inflammation; Knee Pain; Osteoarthritis; Rheumatoid Arthritis
Interventions: Drug: Fish Oil; Drug: Vitamin D; Other: placebo pill
Sponsors: Brigham and Women's Hospital; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified May 2011
Effect of Artronat on the Quality of Life of Patient With Osteoarthritis

Condition: Osteoarthritis
Interventions: Dietary Supplement: ARTRONAT; Dietary Supplement: PLACEBO
Sponsors: Lescuyer Laboratory; RDVC Produit de Santé.; Association Nationale de Prévention Médicale.
Recruiting - verified November 2011
Extension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis Patients

Condition: Rheumatoid Arthritis
Intervention: Drug: Tocilizumab+Methotrexate(MTX)
Sponsor: Chugai Pharma Taiwan
Not yet recruiting - verified May 2011
Effect of Denosumab on Inflammatory Osteolytic Lesion Activity in Total Hip Arthroplasty

Condition: Revision Surgery of Total Hip Arthroplasty
Interventions: Drug: Denosumab; Other: Placebo
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Amgen; NIHR Musculoskeletal BRU
Not yet recruiting - verified December 2011
Peer to Peer Mentoring For Individuals With Early Inflammatory Arthritis: An Effectiveness Study (Pilot RCT)- Peer Mentoring Program

Condition: Early Inflammatory Arthritis
Interventions: Behavioral: One-on-one peer support; Behavioral: Standard of care
Sponsors: Sunnybrook Health Sciences Centre; Canadian Rheumatology Association; Mount Sinai Hospital, Toronto; The Arthritis Society, Canada; St. Michael's Hospital, Toronto; University of Toronto
Recruiting - verified December 2011
Peer to Peer Mentoring For Individuals With Early Inflammatory Arthritis: An Effectiveness Study (Pilot RCT)- Peer Mentor Training

Condition: Early Inflammatory Arthritis
Intervention: Behavioral: Peer Mentor Training
Sponsors: Sunnybrook Health Sciences Centre; Canadian Rheumatology Association; The Arthritis Society, Canada; Mount Sinai Hospital, Toronto; St. Michael's Hospital, Toronto; University of Toronto
Recruiting - verified December 2011
Comparison of Three Tourniquet Application Methods in Primary Total Knee Arthroplasty Surgery

Condition: Knee Osteoarthritis
Intervention: Procedure: Total knee arthroplasty performed under tourniquet
Sponsors: Vilnius University; Karolinska Institutet
Recruiting - verified May 2011
Special Investigation in Patients With Rheumatoid Arthritis (Working Productivity Activity Impairment)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Special Investigation in Patients With Rheumatoid Arthritis (HOPE3 Study Follow up Survey (P12-069))

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Study of the Effect of Chondroitin Sulfate(CONDROSAN) on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI

Condition: Knee Osteoarthritis
Intervention: Drug: Chondroitin sulfate
Sponsor: Bioiberica
Recruiting - verified August 2011
Outcomes Following Anterior Approach to Total Hip Arthroplasty

Condition: Osteoarthritis, Hip
Intervention:
Sponsors: McMaster University; DePuy Orthopaedics
Not yet recruiting - verified July 2011
Resistance Training Exercise Using the Swiss Ball in Ankylosing Spondylitis

Condition: Ankylosing Spondylitis
Intervention: Other: Exercise
Sponsors: Federal University of São Paulo; Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting - verified May 2011
Finding Early Rheumatoid Arthritis

Conditions: Joint Pain; Stiffness
Intervention:
Sponsor: Brigham and Women's Hospital
Recruiting - verified April 2011
An Observational Study of Dosage Patterns in Routine Clinical Practice in Patients With Rheumatoid Arthritis (ACT-LIFE)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified October 2011
An Observational Study of RoActemra/Actemra (Tocilizumab) in Smoking Versus Non-Smoking Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified October 2011
The Effectiveness of 8-weeks Progressive Strength Training to Patients With Unicompartmental Knee Replacement, Initiated Within the First Postoperative Week

Condition: Knee Osteoarthritis
Intervention: Other: Resistance training
Sponsor: University of Aarhus
Recruiting - verified November 2011
The Difference Between Rehabilitation With or Without Strength Training After Total Knee Replacement

Condition: Osteoarthritis, Knee
Interventions: Other: Rehabilitation with strength training; Other: Rehabilitation without strength training
Sponsor: Copenhagen University Hospital, Hvidovre
Recruiting - verified October 2011
Preconceptional Counselling in Active Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Pregnancy; TNFalfa Inhibitors; Preconceptional Counselling; Disease Activity
Intervention:
Sponsors: Erasmus Medical Center; Dutch Association of Rheumatology NVR
Recruiting - verified November 2011
The Functional Neuroanatomy of Catastrophizing: an fMRI Study

Condition: Fibromyalgia
Interventions: Behavioral: Cognitive Behavioral Therapy; Behavioral: Education
Sponsors: Brigham and Women's Hospital; Massachusetts General Hospital; Arthritis Foundation
Recruiting - verified April 2011
Treatment of Pemphigus Patients With Rituximab 1000mgX2 and Assessment of Immune Status Via Cylex

Condition: Pemphigus
Intervention: Drug: Rituximab
Sponsors: Rabin Medical Center; Leumit Health Services
Recruiting - verified March 2011
Study of CG100649 Versus Celecoxib in Osteoarthritis Patients

Condition: Osteoarthritis
Interventions: Drug: CG100649; Drug: Celecoxib; Drug: CG100649
Sponsor: CrystalGenomics, Inc.
Recruiting - verified April 2011
Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage

Condition: Rheumatoid Arthritis
Intervention: Biological: Subcutaneous Abatacept
Sponsors: Orrin M Troum, M.D. and Medical Associates; Bristol-Myers Squibb
Recruiting - verified December 2011
A Study of RoActemra/Actemra (Tocilizumab) in Comparison to Etanercept in Patients With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors

Condition: Cardiovascular Disease, Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: etanercept
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Effect of Footwear on the Clinical, Functional, and Biomechanical Aspects in Elderly Women With Knee Osteoarthritis (OA)

Condition: Knee Osteoarthritis
Intervention: Procedure: Flexible footwear
Sponsor: University of Sao Paulo General Hospital
Recruiting - verified March 2011
Total or Partial Knee Arthroplasty Trial

Condition: Knee Osteoarthritis
Interventions: Procedure: Unicompartmental Knee Replacement; Procedure: Total Knee Replacement
Sponsors: University of Oxford; University of Aberdeen
Recruiting - verified May 2011
Transcutaneous Electrical Nerve Stimulation in Relation to Central Sensitization in Osteoarthritis of the Knee

Condition: Osteoarthritis, Knee
Interventions: Device: Transcutaneous electric nerve stimulation; Device: sham transcutaneous electrical nerve stimulation
Sponsor: Vrije Universiteit Brussel
Not yet recruiting - verified April 2011
Evaluation of the Effect of Adding Corticosteroid to Viscosupplementation

Condition: Osteoarthritis
Interventions: Drug: Hylan GF-20 alone; Drug: Triamcinolone
Sponsors: University of Sao Paulo General Hospital; Fundação de Amparo à Pesquisa do Estado de São Paulo
Recruiting - verified March 2011
Efficacy and Safety Study of Lumbar Interbody Fusion With MatriTMBONE Associated With Autologous Bone Marrow

Conditions: Degenerative Osteoarthritis; Degenerative Lumbar Vertebra
Intervention: Procedure: The Transforaminal Lumbar Interbody Fusion (TLIF) surgery
Sponsors: University Hospital, Bordeaux; Biom'up
Recruiting - verified May 2011
Ustekinumab for the Treatment of Patients With Active Ankylosing Spondylitis

Condition: Ankylosing Spondylitis
Intervention: Drug: Ustekinumab
Sponsor: Charite University, Berlin, Germany
Recruiting - verified October 2011
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis

Condition: Osteoarthritis
Interventions: Drug: Milnacipran; Drug: Placebo
Sponsors: Analgesic Solutions; Forest Laboratories
Recruiting - verified August 2011
A Study of RoActemra/Actemra and, if Initially Inadequately Responded to RoActemra/Actemra, Followed by MabThera/Rituxan in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: rituximab [MabThera/Rituxan]; Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
A Study to Determine if Aquamin Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects

Condition: Osteoarthritis
Interventions: Dietary Supplement: AquaCal; Dietary Supplement: AquaPT
Sponsors: University College Cork; Marigot Ltd.
Recruiting - verified March 2011
National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

Conditions: Marfan Syndrome; Turner Syndrome; Ehlers-Danlos Syndrome; Loeys-Dietz Syndrome; FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation; Bicuspid Aortic Valve Without Known Family History; Bicuspid Aortic Valve With Family History; Bicuspid Aortic Valve With Coarctation; Familial Thoracic Aortic Aneurysm and Dissections; Shprintzen-Goldberg Syndrome; Other Aneurysms and Dissections of the Thoracic Aorta Not Due to Trauma, <50yo; Other Congenital Heart Disease
Intervention:
Sponsors: National Heart, Lung, and Blood Institute (NHLBI); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
10 Year Clinical Evaluation of Primoris Hip Component

Condition: Coxarthrosis
Intervention: Device: Primoris
Sponsors: Biomet, Inc.; Biomet Denmark A/S
Recruiting - verified December 2011
A Study to Investigate the Use of Simponi® in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)

Conditions: Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing
Intervention: Drug: Simponi®
Sponsor: Schering-Plough
Recruiting - verified January 2012
Moderate Rheumatoid Arthritis (RA) With Enbrel

Condition: Rheumatoid Arthritis
Intervention: Drug: etanercept
Sponsor: Amgen
Recruiting - verified January 2012
Interest of a Standardized Monitoring of Rheumatoid Arthritis: The COMEDRA Trial

Condition: Rheumatoid Arthritis
Interventions: Behavioral: Comorbidities treatment; Behavioral: Auto-DAS
Sponsors: Assistance Publique - Hôpitaux de Paris; 1 French Society of Rheumatology; 2 ROCHE-CHUGAI France
Recruiting - verified March 2011
PET/CT Scanning for the Follow-up of Antibiotic Treatment of Infectious Osteoarthritis in the Diabetic Foot

Conditions: Diabetic Foot; Osteoarthritis
Interventions: Procedure: Bone scintigraphy; Procedure: Leukoscan; Procedure: PET / CT
Sponsor: Centre Hospitalier Universitaire de Nīmes
Not yet recruiting - verified July 2011
General vs. Intrathecal Anesthesia for Total Knee Arthroplasty

Condition: Arthritis
Interventions: Procedure: General anesthesia; Procedure: Regional anesthesia
Sponsor: Region Skane
Not yet recruiting - verified June 2011
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Who Have an Inadequate Response to DMARDs or Anti-TNF

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
A Study of LY2828360 in Patients With Osteoarthritic Knee Pain

Condition: Osteoarthritis, Knee
Interventions: Drug: LY2828360; Drug: Placebo
Sponsor: Eli Lilly and Company
Recruiting - verified August 2011
Creating a Tissue Bank of Knee Capsules

Conditions: Osteoarthritis; Knee Joint Contractures
Intervention:
Sponsors: Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified May 2011
An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Sero-Positive Rheumatoid Arthritis Who Are Non-Reponders or Intolerant to a Single TNF-Inhibitor (PORTSMAB)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Special Investigation in Patients With Ankylosing Spondylitis (All Patients Investigation)

Condition: Ankylosing Spondylitis
Intervention:
Sponsor: Abbott
Recruiting - verified January 2012
Dexamethasone Irrigation of the Parotid Glands in Primary Sjogren's Syndrome Subjects

Conditions: Sjogren's Syndrome; Xerostomia
Intervention: Drug: Dexamethasone
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified November 2011
Single- vs. Double-Bundle ACL Reconstruction

Condition: Anterior Cruciate Ligament Injury
Interventions: Procedure: Anatomic Double-Bundle ACL Reconstruction; Procedure: Anatomic Single-Bundle ACL Reconstruction
Sponsors: University of Pittsburgh; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified March 2011
Impact of Environmental Factors on Disease Activity in Spondyloarthritis (SPA): Results of the Prospective Co-Env Cohort

Conditions: Spondylarthritis; Primary Systemic Vasculitis
Intervention:
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified November 2010
A Study to Evaluate the Effectiveness of Infliximab and Changes in Hand and Wrist Magnetic Resonance Imaging (MRI) in Participants With Active Rheumatoid Arthritis (RA) (P08136)

Condition: Arthritis, Rheumatoid
Interventions: Drug: Infliximab; Drug: Placebo
Sponsor: Schering-Plough
Recruiting - verified November 2011
Augment™ Injectable Bone Graft Compared to Autologous Bone Graft as a Bone Regeneration Device in Hindfoot Fusions

Conditions: Degenerative Joint Disease; Congenital Deformity; Arthritis; Osteoarthritis; Rheumatoid Arthritis
Interventions: Device: Augment(tm) Injectable Bone Graft; Procedure: Autologous bone graft
Sponsor: BioMimetic Therapeutics
Recruiting - verified July 2011
Measures of Pain Relevant to Knee Osteoarthritis

Condition: Osteoarthritis of the Knee
Intervention: Other: Questionnaires
Sponsors: University of Nottingham; Arthritis Research Campaign
Recruiting - verified January 2012
Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Biological: Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed)
Sponsor: Tel-Aviv Sourasky Medical Center
Not yet recruiting - verified February 2010
Ultrasound Scores as Indication of Response to Subcutaneous Abatacept in Subjects With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: abatacept
Sponsor: University of California, Los Angeles
Not yet recruiting - verified February 2011
A Trial to Evaluate the Safety and Tolerability of MT203 in Patients With Mild to Moderate Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: MT203; Drug: Placebo
Sponsor: Nycomed
Recruiting - verified September 2011
Clinical Evaluation of Daptomycin Bone Penetration

Condition: Bone and Joint Infections
Intervention:
Sponsor: University Hospital, Strasbourg, France
Recruiting - verified March 2011
Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Degenerative Arthritis

Condition: Degenerative Arthritis
Intervention: Procedure: Autologous Adipose Tissue derived MSCs Transplantation
Sponsor: RNL Bio Company Ltd.
Recruiting - verified February 2011
An Efficacy and Safety Study of Periarticular Parecoxib Sodium for Pain Management in Total Knee Arthroplasty

Condition: Unilateral Primary Osteoarthritis of Knee
Interventions: Procedure: parecoxib sodium; Procedure: parecoxib sodium
Sponsor: Ministry of Health, Malaysia
Not yet recruiting - verified March 2011
Validation Study of RA-INF-Dx, a Multigene Molecular Test Used to Predict Non-Response to INfliximab Therapy

Condition: Rheumatoid Arthritis
Intervention:
Sponsors: TcLand Expression S.A.; Premier Research Group plc; Theradis pharma; Medpharmgene Inc.
Recruiting - verified October 2011
Prevalence and Incidence of Articular Symptoms and Signs Related to Psoriatic Arthritis in Patients With Psoriasis Severe or Moderate With Adalimumab Treatment

Conditions: Psoriasis; Psoriatic Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Open-label Study to Assess the Safety and Efficacy of CDP6038 in Patients Who Completed RA0056

Condition: Rheumatoid Arthritis
Intervention: Biological: CDP6038
Sponsor: UCB, Inc.
Recruiting - verified January 2012
SWITCH Clinical Trial for Patients With Rheumatoid Arthritis Who Have Failed an Initial TNF-blocking Drug.

Condition: Rheumatoid Arthritis
Interventions: Drug: Etanercept; Drug: Abatacept; Biological: Rituximab; Drug: Adalimumab; Drug: Certolizumab Pegol; Drug: Infliximab
Sponsor: University of Leeds
Not yet recruiting - verified December 2010
A Study to Determine the Number of Participants With Rheumatoid Arthritis (RA) Who Meet the Requirements for Treatment With Anti‐Tumor Necrosis Factor α (TNFα) in a General Hospital Setting in Korea (MK-2155-171)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Merck
Not yet recruiting - verified May 2011
Enhancing the Effectiveness of Physical Therapy for People With Knee Osteoarthritis

Condition: Osteoarthritis
Interventions: Other: Exercise; Other: manual therapy
Sponsor: Agency for Healthcare Research and Quality (AHRQ)
Not yet recruiting - verified November 2010
Assessment of Central Pain in Patients Who Undergo Spinal Surgery and Influence in Surgery Outcome

Conditions: Spinal Surgery; Pain
Intervention:
Sponsor: Tel-Aviv Sourasky Medical Center
Not yet recruiting - verified February 2011
Ankylosing Spondylitis and Spondyloarthritis Evaluation Tool Study

Conditions: Ankylosing Spondylitis; Spondylarthritis
Intervention:
Sponsors: Stanford University; University of California, San Francisco; Oregon Health and Science University; Cedars-Sinai Medical Center
Not yet recruiting - verified February 2011
Effect of TNF-Inhibition Combined With Conventional DMARDs on Cervical Pannus in Patients With RA and Cervical Spine Involvement

Condition: Rheumatoid Arthritis
Intervention: Drug: therapy with disease-modifying anti rheumatic drugs (DMARD)
Sponsor: University of Zurich
Not yet recruiting - verified February 2011
Efficacy Study of Adalimumab to Treat Interstitial Cystitis

Condition: Interstitial Cystitis
Interventions: Drug: Adalimumab; Other: inactive drug
Sponsors: ICStudy, LLC; Abbott
Recruiting - verified November 2011
To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use

Conditions: Barrett's Esophagus; Erosive Esophagitis; Gastroesophageal Reflux Disease(GERD)
Intervention:
Sponsors: University of Pennsylvania; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Institutes of Health (NIH)
Recruiting - verified November 2011
A Study to Evaluate the NSAIDS Sparing Effect of Etanercept in Subjects With Axial Spondyloarthritis

Condition: Axial Spondyloarthritis
Interventions: Drug: etanercept; Drug: etanercept; Drug: placebo
Sponsor: Pfizer
Recruiting - verified January 2012
Efficacy of Monthly Ibandronate in Women With RA and Reduced Bone Mineral Density Receiving Long-term Steroids

Conditions: Rheumatoid Arthritis; Osteoporosis; Osteopenia
Interventions: Biological: Ibandronate; Biological: Placebo
Sponsor: Yeong-Wook Song
Recruiting - verified January 2012
Coiled Catheters for Regional Anesthesia

Condition: Arthritis
Intervention: Device: Placement of different catheters for continuous nerve block
Sponsor: Sunnybrook Health Sciences Centre
Recruiting - verified January 2011
Comparative Study of Safety and Efficacy of Two Hyaluronic Acids for the Treatment of Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Device: Hyaluronic acid, stabilized; Device: Hyaluronic acid
Sponsor: Smith & Nephew, Inc.
Recruiting - verified August 2011
A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: AK106-001616; Drug: AK106-001616; Drug: Active comparator
Sponsor: Asahi Kasei Pharma Corporation
Recruiting - verified January 2011
A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One TNF-Inhibitor

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: adalimumab; Drug: Placebo; Drug: Placebo; Drug: methotrexate; Drug: folate
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
An Observational Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Use of Forteo (Teriparatide) in Posterolateral Lumbar Spine Fusion

Conditions: Lumbar Spondylosis; Lumbar Spondylolisthesis; Adult Degenerative Lumbar Scoliosis
Intervention: Biological: teriparatide
Sponsors: University of California, San Francisco; Eli Lilly and Company
Recruiting - verified September 2011
Greek Study on Work Productivity and Sleep in Patients With Rheumatic Diseases Treated With Adalimumab

Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Study to Assess Safety and Efficacy of Anti-Interleukin 6-receptor (IL6R) Nanobody in Rheumatoid Arthritis (RA) Patients

Condition: Rheumatoid Arthritis
Interventions: Biological: ALX-0061; Biological: Placebo
Sponsor: Ablynx
Recruiting - verified January 2012
Study of Evaluating the Duration of Efficacy of One Intra Articular Injection of Sodium Hyaluronate 2.0% in Patients With Painful Osteoarthritis of the Knee

Condition: Osteoarthritis Patient
Intervention: Drug: Ostenil plus
Sponsor: TRB Chemedica
Recruiting - verified October 2011
Effectiveness of Hemi- Versus Total Shoulder Arthroplasty Using Implants of the "Epoca" System

Condition: Osteoarthritis
Interventions: Procedure: Hemiarthroplasty; Procedure: Total arthroplasty
Sponsors: AO Clinical Investigation and Documentation; Synthes GmbH
Not yet recruiting - verified February 2011
An Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Effects of Denosumab on the Pharmacokinetics of Etanercept

Conditions: Postmenopausal Osteoporosis; Rheumatoid Arthritis
Interventions: Drug: Etanercept; Drug: Denosumab
Sponsor: Amgen
Recruiting - verified November 2011
Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female Subjects

Conditions: Scientific Terminology Rheumatoid Arthritis, Healthy Female Volunteers, Pharmacokinetics, Oral Contraceptive, Drug-drug Interaction; Laymen Terminology Level of Oral Contraceptive in Blood, Oral Contraceptive, Rheumatoid Arthritis, Drug -Drug Interaction
Interventions: Drug: fostamatinib; Drug: Microgynon® 30 (Oral contraceptive); Drug: Placebo
Sponsor: AstraZeneca
Recruiting - verified March 2011
GP2013 in the Treatment of RA Patients Refractory to or Intolerant of Standard Therapy

Condition: Rheumatoid Arthritis
Interventions: Biological: GP2013; Biological: rituximab
Sponsors: Sandoz; Novartis Pharmaceuticals
Recruiting - verified November 2011
Assessment of Pain Management in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Patients Who Are About to be Treated With Adalimumab

Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis
Intervention:
Sponsors: Abbott; Raffeiner GmbH
Recruiting - verified November 2011
Ultrasonography in Juvenile Idiopathic Arthritis

Conditions: Juvenile Idiopathic Arthritis, Oligoarthritis; Polyarticular Juvenile Rheumatoid Arthritis; Systemic Onset Juvenile Chronic Arthritis
Intervention: Device: Ultrasonography
Sponsors: University of Aarhus; Aarhus University Hospital
Recruiting - verified February 2011
Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate

Condition: Rheumatoid Arthritis
Intervention: Drug: Adalimumab
Sponsors: Keio University; Saitama Medical University
Recruiting - verified December 2010
Total Knee Arthroplasty - Accelerated Recovery Without Tourniquet

Condition: Osteoarthrosis in Knee-joint
Intervention: Procedure: Total Knee Arthroplasty
Sponsor: Northern Orthopaedic Division, Denmark
Recruiting - verified August 2011
Hydroxychloroquine in Previously Treated Patients With Metastatic Pancreatic Cancer

Condition: Pancreatic Cancer
Interventions: Drug: Hydroxychloroquine; Drug: Hydroxychloroquine
Sponsors: Dana-Farber Cancer Institute; Brigham and Women's Hospital; Massachusetts General Hospital
Recruiting - verified June 2011
Norspan Efficacy and Safety Among Elderly Subjects

Condition: Osteoarthritis Pain of the Hip and or Knee
Intervention: Drug: Buprenorphine transdermal patch
Sponsor: Mundipharma AB
Recruiting - verified October 2011
Study Of A Controlled Release Formulation Of Pregabalin In Fibromyalgia Patients

Condition: Fibromyalgia
Interventions: Drug: pregabalin; Drug: placebo
Sponsor: Pfizer
Recruiting - verified January 2012
Radiostereometric Analysis (RSA) and DEXA to Evaluate Fixation and Wear of the Restoration ADM Acetabular System

Condition: Osteoarthritis
Intervention: Device: ADM Cup
Sponsor: Dalhousie University
Recruiting - verified January 2012
Evaluation of Efficacy and Safety of Fostamatinib Monotherapy Compared With Adalimumab Monotherapy in Patients With Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: Fostamatinib and placebo injections; Drug: Fostamatinib and placebo injections; Drug: Fostamatinib and placebo injections; Drug: Adalimumab and placebo of fostamatinib; Drug: Placebo of fostamatinib, fostamatinib, and placebo injections
Sponsor: AstraZeneca
Recruiting - verified December 2011
Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Biological: PDA001
Sponsors: Celgene Corporation; Celgene Cellular Therapeutics
Recruiting - verified January 2012
Efficacy and Safety Dose Finding Study of Givinostat to Treat Polyarticular Course Juvenile Idiopathic Arthritis

Condition: Polyarticular Course Juvenile Idiopathic Arthritis
Intervention: Drug: Givinostat
Sponsor: Italfarmaco
Recruiting - verified January 2012
The Benefit of Arthroscopic Partial Meniscectomy in Middle-Aged Patients

Condition: Degenerative Meniscus Tear
Interventions: Procedure: Arthroscopic partial meniscectomy; Procedure: Sham procedure
Sponsors: Slagelse Hospital; University of Southern Denmark
Recruiting - verified November 2010
Desflurane or Propofol Anesthesia in Elderly Obese Patients Undergoing Total Knee Replacement

Conditions: Obesity; Arthritis
Intervention: Drug: propofol or desflurane
Sponsors: Stanford University; Baxter Healthcare Corporation
Recruiting - verified July 2011
Cross-sectional Characterization of Idiopathic Bronchiectasis

Conditions: Idiopathic Bronchiectasis; Nontuberculous Mycobacterium (NTM) Infection
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2011
Tai Chi and Physical Therapy for Knee Osteoarthritis

Condition: Knee Osteoarthritis
Interventions: Behavioral: Tai Chi; Behavioral: Physical Therapy
Sponsors: Tufts Medical Center; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified August 2011
Survey of the Relieve of Symptoms of Osteoarthritis of the Knee According to Standard Medical Guidelines or Clinical Practice Standards (MK-0663-140)

Condition: Osteoarthritis
Intervention: Drug: Standard of care for treatment of OA of knee(s)
Sponsor: Merck
Recruiting - verified December 2011
Quality of Life in Chronic Arthritis

Conditions: Ankylosing Spondylitis; Rheumatoid Arthritis
Intervention:
Sponsor: Far Eastern Memorial Hospital
Recruiting - verified November 2010
Platelet Rich Plasma (PRP) as a Treatment for Knee Osteoarthritis PRP as a Treatment for Knee Osteoarthritis

Condition: Osteoarthritis of the Knee
Interventions: Biological: Platelet Rich Plasma (Preparation Rich in Growth Factors); Drug: Hyaluronic acid
Sponsor: Meir Medical Center
Not yet recruiting - verified July 2011
An Open-label Study With Tocilizumab in Patients With Rheumatoid Arthritis in a Local Environment

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra]
Sponsor: Hoffmann-La Roche
Not yet recruiting - verified January 2012
Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA)

Condition: Rheumatoid Arthritis
Intervention: Biological: adalimumab
Sponsor: University Hospital, Tours
Recruiting - verified June 2011
Post-op Treatment With Hyaluronic Acid Injections

Conditions: Meniscus Tear; Chondropathy/Degenerative Joint Disease (DJD)
Interventions: Device: Euflexxa; Other: Saline
Sponsors: The Hawkins Foundation; Ferring Pharmaceuticals
Recruiting - verified July 2011
Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa

Conditions: Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa
Intervention: Genetic: LZRSE-Col7A1 Engineered Autologous Epidermal Sheets (LEAES)
Sponsors: Stanford University; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified January 2012
A Study of RoActemra/Actemra (Tocilizumab) in Combination With DMARDs Versus Current Best Practice DMARD Therapy in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: DMARD
Sponsor: Hoffmann-La Roche
Not yet recruiting - verified January 2012
Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis [PSA, PALACE 4]

Condition: Psoriatic Arthritis
Interventions: Drug: Apremilast; Drug: • Placebo
Sponsor: Celgene Corporation
Recruiting - verified June 2011
Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System

Condition: Osteoarthritis
Interventions: Procedure: OtisMed; Procedure: Computer Assisted Surgery (CAS)
Sponsor: Dalhousie University
Recruiting - verified January 2012
Study Comparing Etanercept (ETN) Against a Placebo for Etanercept on a Background Nonsteroidal Anti Inflammatory Drug (NSAIDs) in the Treatment of Early Spondyloarthritis (SpA) Patients Who do Not Have X-ray Structural Changes

Condition: Spondylitis, Ankylosing
Interventions: Biological: etanercept; Drug: Background NSAID; Other: PLACEBO; Drug: Background NSAID
Sponsor: Pfizer
Recruiting - verified January 2012
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty

Condition: Osteoarthritis, Knee
Intervention: Other: Instrument
Sponsor: DePuy Orthopaedics
Recruiting - verified December 2011
Group Exercise After Hip Replacement Surgery

Conditions: Hip Osteoarthritis; Exercise; Hydrotherapy
Intervention: Other: Group training
Sponsor: Norwegian University of Science and Technology
Recruiting - verified October 2011
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Effects Of CP-690,550 (Tasocitinib) On Cholesterol Metabolism In Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: CP-690,550 (tasocitinib); Other: No intervention
Sponsor: Pfizer
Recruiting - verified January 2012
Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

Condition: Rheumatoid Arthritis
Interventions: Biological: CDP6038; Biological: CDP6038; Biological: CDP6038; Biological: Tocilizumab (Actemra or RoActemra); Biological: CDP6038; Biological: CDP6038; Biological: CDP6038; Other: Placebo sc; Other: Placebo sc; Other: Placebo iv
Sponsor: UCB, Inc.
Recruiting - verified January 2012
Ilaris (Canakinumab) in the Schnitzler Syndrome

Condition: Schnitzler Syndrome
Intervention: Drug: Ilaris
Sponsor: Universitaire Ziekenhuizen Leuven
Recruiting - verified November 2010
Preoperative Alignment of Total Knee Replacement

Condition: Knee Arthritis
Interventions: Procedure: customized knee instruments; Procedure: total knee replacement
Sponsors: VA Palo Alto Health Care System; DePuy Orthopaedics
Recruiting - verified October 2011
Evaluation of Long-term Safety and Effectiveness of Fostamatinib in the Treatment of Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: Fostamatinib; Drug: Fostamatinib; Drug: Fostamatinib
Sponsor: AstraZeneca
Recruiting - verified December 2011
Thigh Swelling, Hip-muscle Strength, and Functional Performance Following Total Hip Arthroplasty

Condition: Osteoarthrosis Patients With Total Hip Arthroplasty
Intervention:
Sponsors: Hvidovre University Hospital; Lundbeck Foundation
Recruiting - verified November 2010
Efficacy Study of Pre-emptive Etoricoxib for Postoperative Pain and Functional Outcome in Total Knee Arthroplasty

Condition: Knee Osteoarthritis
Interventions: Drug: Control; Drug: Etoricoxib
Sponsors: Singapore General Hospital; Merck
Not yet recruiting - verified June 2011
The MUST Hand Osteoarthritis (OA) Exercise Trial

Condition: Hand Osteoarthritis
Intervention: Other: Hand exercise program
Sponsors: Diakonhjemmet Hospital; Norwegian Fund for Postgraduate Training in Physiotherapy
Recruiting - verified January 2010
Magnetic Resonance Image Verified Early Response to Certolizumab Pegol in Subjects With Active Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Other: Placebo, then certolizumab pegol (CZP); Biological: Certolizumab pegol (CZP)
Sponsor: UCB, Inc.
Recruiting - verified January 2012
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use

Conditions: Primary Arthrosis; Post Traumatic Arthritis; Rheumatoid Arthritis; Osteoarthritis
Intervention: Device: Scandinavian Total Ankle Replacement System (STAR Ankle)
Sponsors: Small Bone Innovations, Inc.; Musculoskeletal Clinical Regulatory Advisers LLC
Recruiting - verified January 2012
A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: placebo; Drug: tocilizumab [RoActemra/Actemra]; Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Post-Approval Study to Investigate the Long Term (8 Year) Survivorship of STAR Ankle Among Continued Access Study Patients

Condition: Primary Arthrosis
Intervention: Device: Scandinavian Total Ankle Replacement System (STAR Ankle)
Sponsor: Small Bone Innovations, Inc.
Recruiting - verified January 2012
A Study of the Safety and Efficacy of CNTO 148 (Golimumab) in Children With Juvenile Idiopathic Arthritis (JIA) and Multiple Joint Involvement Who Have Poor Response to Methotrexate (GO KIDS)

Condition: Juvenile Idiopathic Arthritis
Interventions: Biological: CNTO 148 (Golimumab); Biological: CNTO 148 (golimumab) or placebo
Sponsors: Centocor, Inc.; Schering-Plough (Ireland) Company
Recruiting - verified January 2012
Analysis of Neutrophil Response in Chronic Periodontitis

Condition: Chronic Periodontitis
Intervention:
Sponsors: NHS South Birmingham; University of Birmingham
Not yet recruiting - verified July 2010
Effect of Steroid Injections in a Knee With Osteoarthritis

Condition: Osteoarthritis (OA) of the Knee
Interventions: Drug: Triamcinolone Acetonide; Drug: 0.9% Sodium Chloride Injection as Placebo
Sponsor: Tufts Medical Center
Not yet recruiting - verified February 2011
Safety and Efficacy of MRgFUS for the Treatment of Low Back Pain

Condition: Lower Back Pain, Facets Joints Osteoarthritis
Intervention: Device: Exablate treatment
Sponsor: InSightec
Recruiting - verified June 2011
Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover

Condition: Knee Osteoarthritis
Interventions: Other: normal activities and clinical care; Other: Concentric Focused Resistance Exercise; Other: Eccentric Focused Resistance Exercise
Sponsor: University of Florida
Recruiting - verified September 2011
Hydroxychloroquine for Discordant CD4 Responders on Highly Active Antiretroviral Therapy (HAART)

Condition: HIV Infection
Intervention: Drug: Hydroxychloroquine
Sponsor: St Stephens Aids Trust
Recruiting - verified December 2011
A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: adalimumab; Drug: leflunomide; Drug: methotrexate; Drug: MLTA3698A; Drug: placebo
Sponsor: Genentech
Recruiting - verified May 2011
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: methotrexate
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
A Multiple Dose Trial of NNC 0151-0000-0000 in Subjects With Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Inflammation
Interventions: Drug: NNC 0151-0000-0000; Drug: placebo
Sponsor: Novo Nordisk
Recruiting - verified December 2011
Use of Etoricoxib Compared to Diclofenac in the Perioperative Treatment of Patients After Total Hip Arthroplasty

Conditions: Coxarthrosis; Arthroplasties Hip Replacement; Perioperative Blood Loss
Interventions: Drug: Etoricoxib; Drug: Diclofenac
Sponsors: University of Regensburg; Merck
Recruiting - verified September 2010
A Study of Glucocorticoid Use to Evaluate Systematic Methylprednisolone Reduction in Patients With Rheumatoid Arthritis on Background RoActemra/Actemra (Tocilizumab) (ACT-ALONE)

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: methylprednisolone
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Influence of Oxidative Dysbalance on Secondary Osteoarthritis

Condition: Osteoarthritis
Intervention:
Sponsor: Heinrich-Heine University, Duesseldorf
Recruiting - verified July 2011
One-Time DNA Study for Vasculitis

Conditions: Churg-Strauss Syndrome; Giant Cell Arteritis; Granulomatosis With Polyangiitis (Wegener's); Microscopic Polyangiitis; Polyarteritis Nodosa; Takayasu's Arteritis
Intervention:
Sponsors: Boston University; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Office of Rare Diseases (ORD); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Antidepressant Treatment at an Inner City Asthma Clinic

Conditions: Depression; Asthma
Interventions: Drug: Escitalopram; Drug: Placebo
Sponsors: University of Texas Southwestern Medical Center; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2011
An Open Label Study for Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: LY2127399
Sponsor: Eli Lilly and Company
Recruiting - verified January 2012
A Study of RoActemra/Actemra (Tocilizumab) Plus DMARDs in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified October 2011
Complex Āyurvedic Treatment in Osteoarthritis of the Knee Compared to Standard Care.

Condition: Osteoarthritis
Interventions: Other: Complex Ayurvedic Treatment; Other: Conventional Care
Sponsors: Charite University, Berlin, Germany; Ministry of Health & Family Welfare, India
Recruiting - verified November 2011
Randomized Trial to Compare Axial Alignment in TKA With Use of Standard Instruments or Visionaire Cutting Block System.

Condition: Osteoarthritis of the Knee
Intervention: Device: Total Knee Arthroplasty
Sponsor: Smith & Nephew Orthopaedics AG
Recruiting - verified June 2011
Study of TG-C in Patients With Grade 3 Degenerative Joint Disease of the Knee

Condition: Osteoarthritis, Knee
Interventions: Biological: TissueGene-C; Drug: Normal Saline
Sponsor: TissueGene, Inc.
Recruiting - verified June 2011
Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Biological: Rituximab; Drug: Placebo
Sponsor: Johann Wolfgang Goethe University Hospitals
Recruiting - verified June 2011
Biomarkers of Anti-TNF-α Therapy Efficacy in Rheumatoid Arthritis to Define Unresponsive Patients

Condition: Arthritis, Rheumatoid
Intervention:
Sponsors: Biogen Idec; Crescendo
Recruiting - verified February 2012
A Study to Evaluate BioMarkers in Blood Samples in Subjects With Rheumatoid Arthritis

Condition: Arthritis
Interventions: Other: Blood samples; Other: Synovial fluid aspiration; Other: Synovial tissue sample
Sponsors: MedImmune LLC; AstraZeneca
Recruiting - verified January 2012
The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery

Conditions: Patients Age 20-90; Osteoarthritis
Intervention: Drug: Evicel fibrin sealant
Sponsors: Hospital for Special Surgery, New York; Ethicon, Inc.
Recruiting - verified June 2011
Assessment of the Effects of Chondroitin Sulphate in Patients With Knee Osteoarthritis With Functional Magnetic Resonance Imaging (fMRI)

Condition: Knee Osteoarthritis
Interventions: Drug: Chondroitin sulphate (Condrosan®); Drug: Placebo
Sponsor: Bioiberica
Recruiting - verified August 2011
A Two-Part, 12-Week Study of Etoricoxib as a Treatment for Rheumatoid Arthritis (RA) (MK-0663-107)

Condition: Arthritis, Rheumatoid
Interventions: Drug: Part 1: Etoricoxib 60 mg; Drug: Part 1: Etoricoxib 90 mg; Drug: Part 2: Etoricoxib 60 mg; Drug: Part 2: Etoricoxib 90 mg; Drug: Part 1: Placebo to Etoricoxib 60 mg; Drug: Part 1: Placebo to Etoricoxib 90 mg; Drug: Part 2: Placebo to Etoricoxib 60 mg; Drug: Part 2: Placebo to Etoricoxib 90 mg
Sponsor: Merck
Recruiting - verified December 2011
Biological Response of Stage IV Knee Osteoarthritis to Serial 12.5% Dextrose

Condition: Knee Osteoarthritis
Intervention: Drug: Dextrose intraarticularly administered
Sponsor: Universidad Nacional de Rosario
Recruiting - verified September 2010
Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis

Condition: Arthritis, Rheumatoid
Intervention: Drug: Milnacipran
Sponsors: Brigham and Women's Hospital; Forest Laboratories; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified June 2011
Double Blind Combination of Rituximab by Intravenous and Intrathecal Injection Versus Placebo in Patients With Low-Inflammatory Secondary Progressive Multiple Sclerosis (RIVITaLISe)

Condition: Multiple Sclerosis
Intervention: Drug: Rituximab
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2011
Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial

Condition: Rheumatoid Arthritis
Intervention: Device: Ultrasonography
Sponsors: Espen A. Haavardsholm; The Research Council of Norway; Smerud Medical Research International AS; Oslo University Hospital, Section for GCP; Innovest; Abbott; UCB NORDIC A/S; Pfizer; MSD Norway AS; Roche Pharma AG; The Norwegian Rheumatism Association
Recruiting - verified December 2011
A Migration and Bone Density Study Comparing Hi-Fatigue Bone Cement and Palacos Bone Cement

Condition: Hip Arthritis
Interventions: Device: Hi-Fatigue Bone Cement; Device: Palacos Bone Cement
Sponsors: University of Aarhus; Aarhus University Hospital; Zimmer, Inc.
Recruiting - verified September 2011
A Study in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: LY2127399; Drug: Placebo every 4 weeks; Drug: Placebo every 2 weeks
Sponsor: Eli Lilly and Company
Recruiting - verified January 2012
A Rheumatoid Arthritis Study in Patients

Condition: Rheumatoid Arthritis
Interventions: Drug: LY2127399; Drug: Placebo every 4 weeks; Drug: Placebo every 2 weeks
Sponsor: Eli Lilly and Company
Recruiting - verified January 2012
Longitudinal ULtrasonographic Study of Patients With Spondylarthritis Starting Biological Therapy

Conditions: Spondyloarthritis; Ultrasonography
Intervention: Biological: Anti-TNF alpha therapy
Sponsor: Diakonhjemmet Hospital
Not yet recruiting - verified September 2010
A Study of RO5310074 in Patients With Psoriatic Arthritis

Condition: Arthritis, Psoriatic
Interventions: Drug: RO5310074; Drug: Placebo
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
A Rheumatoid Arthritis Study in Patients on a Background Treatment of Methotrexate

Condition: Rheumatoid Arthritis
Interventions: Drug: LY2127399; Drug: Placebo every 2 weeks; Drug: Placebo every 4 weeks
Sponsor: Eli Lilly and Company
Recruiting - verified January 2012
Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Disease Modifying Anti-rheumatic Drug (DMARD) But Not Responding.

Condition: Rheumatoid Arthritis
Interventions: Drug: fostamatinib; Drug: fostamatinib; Drug: placebo, fostamatinib
Sponsor: AstraZeneca
Recruiting - verified December 2011
Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha Antagonist

Condition: Rheumatoid Arthritis
Interventions: Drug: fostamatinib; Drug: fostamatinib; Drug: placebo
Sponsor: AstraZeneca
Recruiting - verified January 2012
A Two-Part 26-Week Study of Etoricoxib as Treatment for Ankylosing Spondylitis (AS) (MK-0663-108)

Condition: Spondylitis, Ankylosing
Interventions: Drug: Part I - etoricoxib 60 mg; Drug: Part I - etoricoxib 90 mg; Drug: Part I- naproxen 1000 mg; Drug: Part I - Placebo to etoricoxib 60 mg; Drug: Part I - Placebo to etoricoxib 90 mg; Drug: Part I - Placebo to naproxen 500 mg; Drug: Part II- etoricoxib 60 mg; Drug: Part II- etoricoxib 90 mg; Drug: Part II- naproxen 1000 mg; Drug: Part II - Placebo to etoricoxib 60 mg; Drug: Part II - Placebo to etoricoxib 90 mg; Drug: Part II - Placebo to naproxen 500 mg
Sponsor: Merck
Recruiting - verified December 2011
An Observational Study of MabThera/Rituxan (Rituximab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Anti-TNF Therapy (REPEAT)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Early Rehabilitation After Total Hip Replacement

Condition: Osteoarthritis, Hip
Interventions: Other: Supervised progressive resistance training; Other: Control group
Sponsors: University of Aarhus; Regionshospitalet Silkeborg
Recruiting - verified November 2011
Pain Modulation in Rheumatoid Arthritis (RA) - Influence of Adalimumab

Conditions: Arthritis, Rheumatoid; Pain; Fatigue
Interventions: Drug: adalimumab; Drug: Placebo
Sponsors: Karolinska Institutet; Abbott; Swedish Foundation for Strategic Research; The Swedish Research Council
Recruiting - verified August 2011
A Study to Compare Subcutaneous Versus Intravenous Administration of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: tocilizumab [RoActemra/Actemra]; Drug: placebo; Drug: placebo; Drug: Disease-modifying antirheumatic drugs (DMARDs)
Sponsor: Hoffmann-La Roche
Recruiting - verified April 2011
An Observational Study on Long-Term Effectiveness and Safety of RoActemra/Actemra (Tocilizumab) in Daily Practice in Patients With Rheumatoid Arthritis (ICHIBAN)

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
The Controlled Trial of Apremilast for Rheumatoid Arthritis Treatment (CARAT)

Condition: Rheumatoid Arthritis
Interventions: Biological: apremilast; Other: Placebo
Sponsor: Baylor Research Institute
Recruiting - verified April 2011
Canakinumab in the Treatment of Acute Gout Flares and Prevention of New Flares in Patients Unable to Use NSAIDs and/or Colchicine.

Condition: Acute Gout
Intervention: Drug: ACZ885
Sponsor: Novartis Pharmaceuticals
Recruiting - verified June 2011
Study to Determine the Effects of Different Doses of Methotrexate (MTX) When Taken With Adalimumab in Subjects With Early Rheumatoid Arthritis (RA)

Condition: Early Rheumatoid Arthritis
Interventions: Biological: adalimumab; Drug: methotrexate
Sponsor: Abbott
Recruiting - verified November 2011
A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA)

Condition: Rheumatoid Arthritis
Interventions: Biological: Humira (adalimumab); Drug: Methotrexate (MTX)
Sponsor: Abbott
Recruiting - verified December 2011
Changes of the Single Limb Standing Balance After Total Knee Arthroplasty in Degenerative Osteoarthritis

Condition: Knee Osteoarthritis
Intervention:
Sponsor: Ulsan University Hospital
Recruiting - verified December 2011
Assessment of Knee Arthrosis After Bariatric Surgery

Condition: Bariatric Surgery Candidate
Intervention: Other: knee MRI
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified May 2009
Effectiveness of Tailored Activity Pacing for Symptomatic Osteoarthritis

Conditions: Osteoarthritis; Pain
Interventions: Behavioral: Tailored Activity Pacing; Behavioral: General Activity Pacing
Sponsor: Department of Veterans Affairs
Recruiting - verified December 2011
Late Cardial Assessment in Children Who Were Diagnosed With Post Streptococcal Reactive Arthritis - a Long Term Study

Condition: Post Streptococcal Reactive Arthritis
Intervention: Device: echocardiogram
Sponsor: Meir Medical Center
Recruiting - verified July 2011
Spinal Cord Injury Energy Management Program

Condition: Spinal Cord Injury
Interventions: Behavioral: Energy Management Program; Behavioral: Energy Management Program
Sponsors: University of British Columbia; Canadian Institutes of Health Research (CIHR)
Recruiting - verified August 2011
The Biodistribution of 1-L-(2 Deoxy-2,- 18 Fluoroarabinofuranosyl) Cytosine ([18F]L-FAC) in Healthy Subjects and Patients With Cancer, Autoimmune and Inflammatory Diseases

Conditions: Autoimmune Diseases; Cancer
Intervention:
Sponsor: University of California, Los Angeles
Recruiting - verified June 2011
Effectiveness in Daily Practice of Different Treatment Strategies for Early Rheumatoid Arthritis.

Condition: Rheumatoid Arthritis
Intervention: Other: randomisation
Sponsors: P. Verschueren; Het agentschap voor Innovatie door Wetenschap en Technologie (IWT)
Recruiting - verified October 2011
Roentgen Stereophotogrammetric Analysis (RSA) Trial Comparing Trabecular Metal Monoblock and Modular Tibial Components

Condition: Osteoarthritis
Intervention: Device: Trabecular Metal Modular Tibial Total Knee Component
Sponsors: Dalhousie University; Zimmer, Inc.
Recruiting - verified January 2012
Clinical Outcome of Birmingham Hip Resurfacing (BHR) Using VISIONAIRE Femoral Alignment Guide

Condition: Osteoarthritis
Intervention:
Sponsors: Smith & Nephew, Inc.; Jason Jones, MS, Group Director, Clinical Affairs, Smith&Nephew
Recruiting - verified August 2011
R3® Acetabular System in Patients With Degenerative Hip Disease

Condition: Osteoarthritis
Intervention:
Sponsor: Smith & Nephew, Inc.
Recruiting - verified July 2011
Psoriasis Inflammation and Systemic Co Morbidities

Condition: Psoriasis
Intervention:
Sponsors: Rockefeller University; Weill Medical College of Cornell University
Recruiting - verified October 2011
A Study of the Efficacy and Safety of Adalimumab in Pediatric Subjects With Enthesitis Related Arthritis.

Condition: Enthesitis Related Arthritis (ERA)
Interventions: Biological: adalimumab - blinded; Biological: placebo for adalimumab - blinded; Drug: Adalimumab - open label
Sponsor: Abbott
Recruiting - verified November 2011
Jointstrong Intervention for Juvenile Arthritis

Condition: Juvenile Arthritis
Interventions: Behavioral: CD-ROM; Behavioral: Wait-list Control Group
Sponsor: University of Kansas
Recruiting - verified April 2011
Investigating Genes in Patients With Polymyositis and Dermatomyositis

Condition: Myositis
Intervention: Procedure: Venepuncture
Sponsor: Salford Royal NHS Foundation Trust
Recruiting - verified September 2011
Effects of Tasocitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA).

Condition: Rheumatoid Arthritis
Interventions: Drug: Tasocitinib plus Methotrexate; Drug: Tasocitinib plus placebo methotrexate; Drug: Placebo tasocitinib plus Methotrexate
Sponsor: Pfizer
Recruiting - verified January 2012
A Study of the Effects of Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)

Condition: Rheumatoid Arthritis
Interventions: Drug: methotrexate; Drug: pneumovax; Drug: tetanus toxoid adsorbed; Drug: tocilizumab [Actemra]
Sponsor: Genentech
Recruiting - verified June 2011
Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing

Conditions: Spondyloarthritis; Intestinal Inflammation
Intervention: Drug: Adalimumab
Sponsors: Regionshospitalet Silkeborg; Abbott; European Capsule Endoscopy Group; The Central Denmark Region
Recruiting - verified July 2011
Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Osteoarthritis; Periodontal Disease
Intervention:
Sponsors: University of Nebraska; Dallas VA Medical Center; Washington D.C. Veterans Affairs Medical Center; VA Salt Lake City Health Care System
Recruiting - verified April 2011
Special Investigation in Patients With Psoriasis Vulgaris and Psoriatic Arthritis (All Patients Investigation)

Condition: Psoriasis
Intervention:
Sponsor: Abbott
Recruiting - verified January 2012
Preoperative Resistance Training in Patients Scheduled for Total Hip Arthroplasty

Conditions: Osteoarthritis; Hip Arthroplasty
Intervention: Other: Preoperative resistance training
Sponsors: University of Southern Denmark; University of Copenhagen
Recruiting - verified January 2012
Safety and Efficacy of the Combination of Diacerein 100 mg Daily and MTX Versus MTX Alone in the Treatment of Early Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: Diacerein; Drug: Placebo
Sponsor: TRB Chemedica
Recruiting - verified October 2011
Genes and Phenotype (GAP) A National Resource for Genotype-Phenotype Studies of Immunological and Inflammatory Pathways

Condition: Immune System
Intervention:
Sponsors: North Shore Long Island Jewish Health System; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); University of Alabama at Birmingham
Recruiting - verified January 2012
A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Current Non-Biologic and/or Biologic DMARDS

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsors: Hoffmann-La Roche; Clalit Health Services
Recruiting - verified January 2012
Clinical Effectiveness and Impact on Health-related Quality of Life in Peruvian Patients With Psoriasis After 16 Weeks of Adalimumab Therapy

Condition: Moderate to Severe Psoriasis
Intervention:
Sponsor: Abbott
Recruiting - verified December 2011
Pharmacological Treatment In Osteoarthritis

Condition: Osteoarthritis
Interventions: Drug: Hydroxychloroquine; Drug: cellulose
Sponsor: Maasstad Hospital
Recruiting - verified July 2011
Exploratory Study on Quality of Life in Patient With Moderate Psoriasis and Moderate Psoriatic Arthritis

Conditions: Psoriatic Arthritis; Psoriasis
Intervention:
Sponsors: Innovaderm Research Inc.; Amgen
Recruiting - verified October 2011
Genotype-Phenotype Study of Patients With Plaquenil(Registered Trademark)-Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene

Conditions: Genotype; Retinal Disease
Intervention:
Sponsor: National Eye Institute (NEI)
Recruiting - verified May 2011
Searching for Persistence of Infection in Lyme Disease

Conditions: Lyme Disease; Borrelia Burgdorferi
Interventions: Procedure: Skin Biopsy; Device: Xenodiagnosis; Procedure: Blood Drawing
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2011
Efficacy and Safety of Abatacept Subcutaneous (SC) in Combination With Methotrexate in Adults With Very Early Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Interventions: Drug: Abatacept; Drug: Methotrexate; Drug: Abatacept Placebo; Drug: Methotrexate Placebo
Sponsor: Bristol-Myers Squibb
Recruiting - verified July 2011
Rehabilitation After Total Knee Arthroplasty (TKA) - PFC Rotating Versus Fixed Bearing

Condition: Osteoarthritis
Intervention: Device: P.F.C. Sigma knee arthroplasty
Sponsors: University of Aarhus; Regionshospitalet Silkeborg; Gigtforeningen; Protesekompagniet
Recruiting - verified February 2011
Reversing Corticosteroid Induced Memory Impairment

Condition: Memory Impairment
Interventions: Drug: Lamotrigine; Drug: Placebo
Sponsors: University of Texas Southwestern Medical Center; National Institute of Mental Health (NIMH)
Recruiting - verified August 2011
The Impact of Thumb Carpometacarpal Osteoarthritis on General Health

Condition: Thumb Arthritis
Intervention:
Sponsors: Washington University School of Medicine; University of Rochester
Recruiting - verified March 2011
A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid Arthritis

Condition: Arthritis, Rheumatoid
Interventions: Biological: adalimumab; Drug: Methotrexate
Sponsors: Abbott; Mount Sinai Hospital, Canada
Recruiting - verified December 2011
Comparative Analysis of Intra-articular Injection of Steroid and/or Sodium Hyaluronate in Adhesive Capsulitis

Condition: Adhesive Capsulitis
Interventions: Procedure: isotonic saline injection into the glenohumeral joint; Procedure: steroid injection into the glenohumeral joint; Procedure: sodium hyaluronate injection into the glenohumeral joint; Procedure: steroid and hyaluronate injection into the glenohumeral joint; Procedure: intra-articular injection of the glenohumeral joint
Sponsor: Seoul National University Hospital
Recruiting - verified October 2011
Phase 1 Trial of CII APL A12 in Rheumatoid Arthritis Patients

Condition: Rheumatoid Arthritis
Intervention: Drug: APL A12
Sponsor: Department of Veterans Affairs
Recruiting - verified October 2011
Knee Arthroplasty Registry

Condition: Osteoarthritis, Knee
Intervention: Device: any knee joint arthroplasty implant
Sponsors: Heekin Orthopedic Research Institute; DePuy Orthopaedics; Stryker Orthopaedics; ConforMIS, Inc.
Recruiting - verified June 2011
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study

Condition: Psoriatic Arthritis
Interventions: Drug: Methotrexate; Drug: Anti-TNF
Sponsors: University of Rochester; National Psoriasis Foundation
Recruiting - verified October 2011
Patient and Provider Interventions for Managing Osteoarthritis in Primary Care

Condition: Osteoarthritis
Intervention: Behavioral: Osteoarthritis Intervention
Sponsor: Department of Veterans Affairs
Recruiting - verified September 2011
Real Life Evaluation of Rheumatoid Arthritis in Canadians Taking HUMIRA

Condition: Rheumatoid Arthritis
Intervention:
Sponsors: Abbott; University Health Network, Toronto
Recruiting - verified November 2011
A Pilot Study Using Anakinra/Kineret for the Treatment of Patients With Severe Atopic Dermatitis

Conditions: Anakinra; Kineret; Atopic Dermatitis; Eczema; Allergic Disease
Intervention: Drug: Anakinra
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified August 2011
Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains

Condition: Ankle Sprain
Interventions: Other: Mobilization therapy in addition to standard therapy; Other: Sham intervention
Sponsors: University of Virginia; American Physical Therapy Association
Recruiting - verified May 2011
A Cooperative Clinical Study of Abatacept in Multiple Sclerosis

Condition: Multiple Sclerosis, Relapsing-Remitting
Interventions: Biological: abatacept; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance Network (ITN)
Recruiting - verified January 2012
Low Density Lipoprotein Cholesterol (CLDL) as a Cardiovascular Disease Risk Factor in Rheumatoid Arthritis

Conditions: Rheumatoid Arthritis; Cardiovascular Disease
Intervention:
Sponsor: University of Arkansas
Recruiting - verified December 2011
A Randomised Trial Comparing Anterior Versus Posterior Approach in Total Hip Replacement

Conditions: Osteoarthritis; Rheumatoid Arthritis
Interventions: Procedure: Minimally Invasive Anterior Approach; Procedure: Standard postero-lateral approach
Sponsor: Medacta International SA
Recruiting - verified January 2012
AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study

Conditions: Osteoarthritis; Arthritis; Avascular Necrosis; Fracture of the Femoral Neck or Head; Congenital Hip Dysplasia
Intervention: Device: AMIStem Hip System
Sponsor: Medacta International SA
Recruiting - verified January 2012
The Effects of the Electro, Heat and Cold -Therapy During Physiotherapy Treatment in Osteoarthritis(OA) of KNEE

Conditions: Knee Pain; Osteoarthritis
Interventions: Device: Elf care; Other: control group
Sponsor: Meir Medical Center
Recruiting - verified August 2011
Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

Condition: Osteoarthritis of the Knee
Interventions: Biological: Apitox, purified honeybee toxin, lyophilized in saline; Biological: histamine
Sponsor: Apimeds, Inc.
Not yet recruiting - verified September 2011
Suture Fixation System Versus Tendonous Reconstruction in Carpometacarpal (CMC) Arthroplasty

Condition: Thumb Carpometacarpal Arthritis
Interventions: Procedure: Ligament reconstruction with suture fixation system; Procedure: Ligament Reconstruction with Tendon Interposition (LRTI)
Sponsor: J&M Shuler
Recruiting - verified June 2011
Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA)

Condition: Rheumatoid Arthritis
Intervention: Drug: Certolizumab
Sponsor: University of Rochester
Recruiting - verified October 2011
Study Evaluating the Safety and Effectiveness of Etanercept for the Treatment of Pediatric Psoriasis

Condition: Psoriasis
Intervention: Drug: Etanercept
Sponsor: Pfizer
Recruiting - verified January 2012
Assessment of the Response to Etoricoxib in Patients With Ankylosing Spondylitis (AS) and Inadequate Response to ≥2 NSAIDs

Condition: Ankylosing Spondylitis (AS) and Inadequate Response to ≥2 NSAIDs.
Intervention: Drug: Etoricoxib
Sponsor: Spanish Foundation of Rheumatology
Recruiting - verified October 2010
Golimumab Plus UVB-311nm in Psoriasis

Condition: Psoriasis
Intervention: Radiation: UVB-311nm radiation
Sponsor: Medical University of Graz
Recruiting - verified August 2011
The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis

Conditions: Psoriasis; Cardiovascular Diseases; Diabetes Mellitus, Type 2
Interventions: Drug: Adalimumab treatment arm; Drug: Fumaric acid esters treatment group; Other: Narrow band UVB radiation
Sponsor: Medical University of Vienna
Recruiting - verified January 2012
Laquinimod Study in Systemic Lupus Erythematosus (SLE) Patients With Active Lupus Arthritis

Condition: Lupus Arthritis
Interventions: Drug: Laquinimod; Drug: Laquinimod; Other: Placebo
Sponsor: Teva Pharmaceutical Industries
Recruiting - verified January 2012
A Study of Tocilizumab as Monotherapy or in Combination With DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified December 2011
Draining PLN and Synovial Inflammation in RA Knee Joints Pre and Post Anti-TNF or B Cell Depletion Therapy

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: University of Rochester
Recruiting - verified June 2011
Golimumab Safety and Surveillance Program Using the Ingenix NHI Database

Conditions: Rheumatoid Arthritis; Arthritis, Psoriatic; Ankylosing Spondylitis
Interventions: Biological: anti-TNF biologics; Biological: non-anti-TNF biologics; Other: general population; Biological: golimumab; Drug: systemic non-biological treatments
Sponsor: Centocor Ortho Biotech Services, L.L.C.
Not yet recruiting - verified July 2011
An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement

Conditions: Rheumatoid Arthritis; Osteoarthritis; Post-traumatic Arthritis; Avascular Necrosis; Traumatic Femoral Fractures; Congenital Hip Dysplasia
Intervention: Device: DePuy Proxima™ Hip
Sponsor: DePuy International
Recruiting - verified September 2011
Rituximab for Autoimmune Retinopathy

Condition: Autoimmune Disease
Intervention: Drug: Rituximab
Sponsor: National Eye Institute (NEI)
Recruiting - verified January 2012
Belgian Registry of HUMIRA (Adalimumab) in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

Conditions: Rheumatoid Arthritis; Psoriatic Arthritis; Ankylosing Spondylitis
Intervention: Biological: HUMIRA (adalimumab)
Sponsors: Abbott; Veeda Clinical Research, Brussels
Recruiting - verified December 2011
A Study on the Prevalence of the Anti-MCV Anti-body in an Irish Rheumatoid Arthritis (RA) Population and the Impact of Biomarker Status on the Management of Irish Patients With Early RA

Condition: Rheumatoid Arthritis
Intervention: Other: This is a non-drug study. No treatment is mandated by the protocol. Routine blood draws (as per normal clinical care) will be taken through the study.
Sponsors: Abbott; Clinical Trial End-Point (CTEP) Ltd; JSS Medical Research Inc.
Recruiting - verified November 2011
Evaluation of the Role of Adalimumab on Extraarticular Manifestation - Bone Metabolism and Bone Mineral Density in Patients With Active Rheumatoid Arthritis

Conditions: Active Rheumatoid Arthritis; Osteoporoses
Intervention:
Sponsors: Abbott; Centre of Biostatistics and Analyses, Faculty of Medicine, Masaryk University Brno, Czech Republic
Recruiting - verified October 2011
Efficacy and Safety of Humira in Patients With Psoriatic Arthritis in Normal Medical Practice

Condition: Psoriatic Arthritis
Intervention: Biological: adalimumab (Humira)
Sponsor: Abbott
Recruiting - verified December 2011
Safety and Effectiveness and Effect on Quality of Life and Work Productivity of Humira in Patients With Psoriatic Arthritis in Clinical Routine

Condition: Psoriatic Arthritis
Intervention: Biological: adalimumab (Humira)
Sponsor: Abbott
Not yet recruiting - verified January 2012
Efficacy and Safety of Adalimumab in Rheumatoid Arthritis Patients in Routine Clinical Practice

Condition: Rheumatoid Arthritis
Intervention: Biological: adalimumab (Humira)
Sponsor: Abbott
Recruiting - verified October 2011
Efficacy and Safety of Adalimumab in Patients With Rheumatoid Arthritis in Routine Clinical Practice

Condition: Rheumatoid Arthritis
Intervention: Biological: adalimumab (Humira)
Sponsor: Abbott
Recruiting - verified December 2011
Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid Arthritis

Condition: Arthritis, Rheumatoid
Interventions: Drug: Otelixizumab; Drug: Matching placebo
Sponsor: GlaxoSmithKline
Recruiting - verified November 2011
A Study of the Safety and Efficacy of Ustekinumab in Patients With Psoriatic Arthritis With and Without Prior Exposure to Anti-TNF Agents

Condition: Arthritis, Psoriatic
Interventions: Drug: placebo; Drug: ustekinumab; Drug: ustekinumab; Drug: placebo; Drug: placebo; Drug: ustekinumab; Drug: ustekinumab; Drug: ustekinumab
Sponsor: Centocor, Inc.
Recruiting - verified December 2011
Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction

Conditions: Anterior Cruciate Ligament Injury; Osteoarthritis
Interventions: Biological: MSB-CAR001 Combined With Hyaluronan; Drug: Hyaluronan
Sponsor: Mesoblast, Ltd.
Recruiting - verified March 2010
Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Biological: adalimumab (Humira)
Sponsor: Abbott
Recruiting - verified October 2011
An Observational Study on Patients With Rheumatoid Arthritis Trated With MabThera (Rituximab)

Condition: Rheumatoid Arthritis
Intervention: Drug: rituximab [Mabthera/Rituxan]
Sponsor: Hoffmann-La Roche
Recruiting - verified December 2011
An Observational Study on The Safety and Effectiveness of Mabthera (Rituximab) in The First Six Months of Treatment in Patients With Severe Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: rituximab [Mabthera/Rituxan]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Effect of Febuxostat on Joint Damage in Hyperuricemic Subjects With Early Gout

Condition: Joint Damage
Interventions: Drug: Febuxostat; Drug: Placebo
Sponsor: Takeda Global Research & Development Center, Inc.
Recruiting - verified December 2011
Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)

Condition: Degenerative Arthritis of Knee
Interventions: Other: Total Knee Arthroplasty; Other: Total Knee Arthroplasty
Sponsor: Smith & Nephew, Inc.
Recruiting - verified November 2011
Treatment Efficacy and Toxicity in Rheumatoid Arthritis Database and Repository

Condition: Rheumatoid Arthritis
Intervention:
Sponsors: University of Alabama at Birmingham; Brigham and Women's Hospital; Duke University; Johns Hopkins University; North Shore Medical Center; Stanford University; University of California, San Francisco; University of Colorado, Denver; University of Nebraska; University of Pittsburgh
Recruiting - verified January 2011
Safety and Effectiveness of Adalimumab (Humira) in Patients With Ankylosing Spondylitis in Clinical Routine

Condition: Ankylosing Spondylitis
Intervention: Drug: adalimumab (Humira)
Sponsor: Abbott
Recruiting - verified November 2011
Hydroxychloroquine Efficacy in Chronic Urticaria

Condition: Chronic Urticaria
Interventions: Drug: Placebo; Drug: Hydroxychloroquine
Sponsor: Vanderbilt University
Not yet recruiting - verified April 2011
Effects of Glucosamine on Joint Fluid in Osteoarthritis Patients

Condition: Knee Osteoarthritis
Interventions: Dietary Supplement: Glucosamine sulphate; Other: Placebo
Sponsor: University of British Columbia
Not yet recruiting - verified August 2011
Vanguard CR vs. AGC

Conditions: Osteoarthritis; Rheumatoid Arthritis; Traumatic Arthritis
Interventions: Device: Vanguard CR; Device: AGC knee
Sponsors: Biomet, Inc.; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK); Biomet U.K. Ltd.
Recruiting - verified December 2011
Evaluation of SAR153191(REGN88)(Sarilumab) on Top of Methotrexate in Rheumatoid Arthritis Patients

Condition: Rheumatoid Arthritis
Interventions: Drug: SAR153191 (REGN88); Drug: placebo
Sponsors: Sanofi-Aventis; Regeneron Pharmaceuticals
Recruiting - verified February 2012
Study Evaluating Long-Term Safety Of ATN-103 In Subjects With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: ATN-103; Drug: ATN-103
Sponsors: Pfizer; Ablynx
Recruiting - verified January 2012
Tritanium® Primary Acetabular Shell Study

Conditions: Osteoarthritis; Traumatic Arthritis; Avascular Necrosis
Interventions: Device: Tritanium® Primary Acetabular Shell; Device: Tritanium® Primary Acetabular Shell with Periapatite
Sponsor: Stryker Orthopaedics
Recruiting - verified August 2011
T Cells and TNF: The Impact of TNF Blockade

Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis
Intervention: Drug: anti-TNF therapy (etanercept or adalimumab)
Sponsor: Imperial College London
Recruiting - verified September 2011
Safety and Efficacy of AMG 827 in Subjects With RA

Condition: Rheumatoid Arthritis
Intervention: Drug: AMG 827
Sponsor: Amgen
Not yet recruiting - verified July 2011
Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee

Condition: Osteoarthritis of the Hip or Knee
Interventions: Drug: Dexibuprofen; Drug: Ibuprofen
Sponsor: Gebro Pharma GmbH
Recruiting - verified June 2011
Mini Stem DEXA (Dual Energy X-ray Absorptiometry)

Condition: Osteoarthritis, Hip
Intervention:
Sponsor: Smith & Nephew, Inc.
Recruiting - verified July 2011
Mini Stem Radiostereometric Analysis Study

Condition: Osteoarthritis, Hip
Intervention:
Sponsor: Smith & Nephew, Inc.
Recruiting - verified July 2011
A Study to Evaluate the Efficacy and Safety of CAM-3001 (Drug) in Subjects With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: CAM3001; Drug: CAM3001; Drug: CAM3001; Drug: CAM3001
Sponsors: MedImmune LLC; MedImmune Ltd
Recruiting - verified November 2011
The Relation Between Dedicated Extremity MRI Synovitis and Structural Deterioration Radiographic in Patients With Rheumatoid Arthritis in Clinical Remission. Preliminary Study

Condition: Rheumatoid Arthritis
Intervention: Other: MRI
Sponsor: Centre Hospitalier Universitaire de Nice
Recruiting - verified December 2011
Group Physical Therapy for Knee Osteoarthritis

Condition: Osteoarthritis
Interventions: Other: Group Physical Therapy for Knee OA; Other: Individual Physical Therapy for Knee OA
Sponsor: Department of Veterans Affairs
Recruiting - verified October 2011
Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo

Condition: Polyarthritis
Interventions: Drug: Methotrexate; Drug: Placebo
Sponsor: Centre Hospitalier Universitaire de Nice
Recruiting - verified December 2011
Botulism Toxin Injection as a Treatment for Arthritis of the Basal Thumb Joint

Conditions: Basilar Joint Arthritis; Basal Thumb Joint Arthritis; Trapeziometacarpal Arthritis; Carpometacarpal Arthritis
Interventions: Drug: Botulinum Toxin Type A; Drug: Triamcinolone Acetonide; Drug: Lidocaine
Sponsor: University of Missouri-Columbia
Recruiting - verified March 2011
A Study of Tocilizumab in Combination With an Oral Contraceptive in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: tocilizumab [RoActemra/Actemra]
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Aromatase Inhibitor-Associated Musculoskeletal Symptoms in Non-Metastatic, Post Menopausal Breast Cancer Patients

Condition: Breast Cancer
Interventions: Other: History and Physical Exam; Other: Grip Strength Measurement; Behavioral: Surveys; Other: Blood Collection; Procedure: Ultrasound of Hand/Wrist
Sponsor: University of California, Los Angeles
Recruiting - verified June 2011
Use of Thermal and 3D Imaging to Quantify Arthritis

Conditions: Rheumatoid Arthritis; Juvenile Rheumatoid Arthritis
Intervention: Other: 3D and thermal imaging
Sponsors: University of Pittsburgh; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified February 2011
Development of Knee Osteoarthritis After Arthroscopic Partial Resection of Degenerative Meniscus Tear

Conditions: Osteoarthritis of the Knee; Arthroscopy; Meniscal Tear
Interventions: Procedure: Arthroscopic partial meniscectomy; Procedure: Arthroscopy (diagnostic)
Sponsors: University of Tampere; Helsinki University Central Hospital; Turku University Hospital; Kuopio University Hospital; Central Finland Hospital District
Recruiting - verified January 2012
Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis Patients

Condition: Osteoarthritis
Intervention:
Sponsor: Biomet, Inc.
Recruiting - verified September 2011
Treatment of Medial Compartmental Osteoarthritis Grade 1-4 (According to Kellgren-Lawrence) or Osteonecrosis With TomoFix™ Small or Conservatively

Conditions: Osteoarthritis, Knee; Osteonecrosis
Intervention:
Sponsors: AO Clinical Investigation and Documentation; Synthes Inc.
Recruiting - verified October 2011
Distal Clavicle Resection With Rotator Cuff Repair

Condition: Acromioclavicular Joint Arthritis
Intervention: Procedure: distal clavicle resection
Sponsor: Samsung Medical Center
Recruiting - verified June 2011
Combination Disease-Modifying Antirheumatic Drugs (DMARDs) Versus Sulfasalazine in Inflammatory Back Pain

Condition: Seronegative Spondyloarthropathies
Interventions: Drug: Methotrexate, Hydroxychloroquine; Drug: Placebo
Sponsor: Sanjay Gandhi Postgraduate Institute of Medical Sciences
Recruiting - verified April 2011
Cannabis for Inflammatory Bowel Disease

Conditions: Crohn's Disease; Ulcerative Colitis
Interventions: Drug: smoking of cannabis; Drug: smoking cigarettes with placebo
Sponsor: Meir Medical Center
Recruiting - verified December 2011
Oral CF101 Tablets Treatment in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: CF101; Drug: Placebo control
Sponsor: Can-Fite BioPharma
Recruiting - verified August 2011
A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: methotrexate; Drug: placebo TCZ; Drug: placebo MTX
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arhtritis and an Inadequate Response to Non-biological DMARDs

Condition: Rheumatoid Arthritis
Interventions: Drug: tocilizumab [RoActemra/Actemra]; Drug: placebo; Drug: non-biological DMARDs
Sponsor: Hoffmann-La Roche
Recruiting - verified December 2011
Disability and Self-rated Health Following Primary Knee Replacement

Conditions: Osteoarthritis; Knee Replacement
Intervention:
Sponsors: Coxa, Hospital for Joint Replacement; University of Tampere; Seinajoki Central Hospital
Recruiting - verified August 2011
Adalimumab in Axial Spondyloarthritis (ASIM) - MRI and Biomarkers in Patients With Spondyloarthritis

Condition: Spondyloarthritis
Interventions: Drug: Adalimumab; Drug: Placebo
Sponsor: Glostrup University Hospital, Copenhagen
Recruiting - verified February 2011
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms

Conditions: Pain; Weakness; Cramps; Myalgia; Side Effects of Statins
Interventions: Dietary Supplement: Coenzyme Q10; Other: Placebo
Sponsors: Beth Israel Deaconess Medical Center; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified June 2011
Ultrasound (US)-Guided Versus Sham Ultrasound Corticosteroid (CS) Knee Injections

Condition: Osteoarthritis
Interventions: Procedure: Ultrasound; Procedure: Sham ultrasound
Sponsor: VA Connecticut Healthcare System
Recruiting - verified July 2011
A Study of the Safety and Preliminary Efficacy of MOR103, a Human Antibody to Granulocyte Macrophage Colony-stimulating Factor (GM-CSF), in Patients With Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: MOR103; Drug: MOR103; Drug: MOR103
Sponsor: MorphoSys AG
Recruiting - verified January 2012
A Trial Comparing Mini-posterior Approach and Direct Anterior Approach

Condition: Osteoarthritis
Interventions: Procedure: Mini-Posterior surgical approach for total hip arthroplasty; Procedure: Direct Anterior surgical approach for total hip arthroplasty
Sponsor: OrthoCarolina Research Institute, Inc.
Recruiting - verified January 2012
Determination of New Biomarkers of Septic Arthritis by Surface-Enhanced Laser Desorption/Ionization Time-Of-Flight (SELDI-TOF)

Condition: Acute Arthritis
Intervention:
Sponsor: University Hospital, Grenoble
Recruiting - verified December 2011
Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis

Condition: Active Rheumatoid Arthritis
Intervention: Drug: SBI-087
Sponsors: Pfizer; Emergent Product Development Seattle LLC
Recruiting - verified January 2012
Acupuncture in Treating Women With Stage I, Stage II, or Stage III Breast Cancer With Aromatase Inhibitor-Related Joint Pain

Conditions: Breast Cancer; Recurrent Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Procedure: acupuncture therapy; Procedure: sham intervention
Sponsor: Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified February 2011
Golimumab in Rheumatoid Arthritis Patients With an Inadequate Response to Etanercept (ENBREL) or Adalimumab (HUMIRA)

Conditions: Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases
Interventions: Drug: golimumab or placebo; Drug: golimumab; Drug: golimumab or placebo
Sponsors: Centocor, Inc.; Schering-Plough
Recruiting - verified July 2011
A Study on M2a Magnum Total Hip Arthroplasty

Conditions: Degenerative Joint Disease; Avascular Necrosis
Interventions: Device: Metal-on-Metal Articulation; Device: Metal-on-Metal Acetabular System
Sponsors: Biomet, Inc.; Biomet Japan, Inc.
Recruiting - verified July 2011
Study Evaluating The Prevalence Of Undiagnosed Psoriatic Arthritis In Patients With Plaque Psoriasis

Conditions: Arthritis, Psoriatic; Psoriasis
Intervention: Other: questionnaire
Sponsor: Pfizer
Recruiting - verified January 2012
Bone Mineral Density (BMD) in Cemented Versus Cementless Hip Resurfacing

Condition: Osteoarthritis
Interventions: Device: Cormet; Device: Conserve
Sponsors: Ottawa Hospital Research Institute; Corin
Recruiting - verified December 2011
A Comparison of Stainless Steel and Bioabsorbable Screw Fixation of Lisfranc Foot Injuries

Condition: Unstable Lisfranc Fracture-dislocations of the Midfoot
Interventions: Procedure: Steel screw fixation of Lisfranc fracture-dislocation.; Procedure: Absorbable screw fixation of Lisfranc fracture-dislocations.
Sponsor: Rothman Institute Orthopaedics
Recruiting - verified July 2011
Comparison of a Metal Backed Fixed-Bearing Tibial Baseplate and an All-Polyethylene Tibia in Total Knee Arthroplasty

Condition: Osteoarthritis, Knee
Interventions: Procedure: TKA surgery with modular polished tibial baseplate/XLK design; Procedure: TKA surgery with the nonmodular APT/GVF design; Device: P.F.C.® Sigma Knee System; Device: P.F.C.® Sigma Knee System
Sponsors: Minneapolis Veterans Affairs Medical Center (VAMC); Depuy, Inc.
Recruiting - verified July 2011
Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis

Conditions: Wegener's Granulomatosis; Microscopic Polyangiitis (MPA)
Interventions: Procedure: Plasma Exchange; Drug: Glucocorticoids
Sponsors: Boston University; Food and Drug Administration (FDA); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Birmingham Clinical Trials Unit
Recruiting - verified March 2011
Erlotinib With or Without Hydroxychloroquine in Chemo-Naive Advanced NSCLC and (EGFR) Mutations

Condition: Non-small Cell Lung Cancer
Interventions: Drug: Erlotinib; Drug: Hydroxychloroquine
Sponsors: Massachusetts General Hospital; Stanford University; Yale University; Genentech
Recruiting - verified September 2011
Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients

Conditions: Chronic Allograft Nephropathy; Chronic Kidney Disease; Chronic Renal Failure; Disordered Mineral Metabolism; End Stage Renal Disease; Hyperparathyroidism; Hypophosphatemia; Kidney Disease; Kidney Transplantation; Post Renal Transplantation
Interventions: Drug: Cinacalcet; Drug: Placebo
Sponsor: Amgen
Recruiting - verified January 2012
Bone Graft Materials Observational Registry

Conditions: Degenerative Disc Disease; Herniated Disc; Spinal Stenosis; Spondylolithesis; Spinal Deformity; Cervical Myelopathy; Failed Back Surgery Syndrome; Spinal Cord Neoplasms
Intervention: Device: Bone graft substitute, autograft or allograft
Sponsor: Apatech, Inc.
Recruiting - verified May 2011
Triathlon® PKR Outcomes Study

Conditions: Osteoarthritis; Post Traumatic Arthritis
Intervention: Device: Triathlon PKR
Sponsor: Stryker Orthopaedics
Recruiting - verified May 2011
Treatment of TNFa Naive Patients With Poor Prognosis Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: Rituximab
Sponsors: University of Manitoba; Hoffmann-La Roche
Recruiting - verified March 2011
A 24 Week Open Label Study of the Utility of Adalimumab in Active Axial Forms of Psoriatic Arthritis

Condition: Psoriatic Arthritis
Intervention: Drug: Adalimumab (HUMIRA®)
Sponsor: Instituto de Investigacion Biomedica de A Coruna
Recruiting - verified April 2011
A Study to Evaluate the Effectiveness and Safety of an Implant in the Treatment of Osteoarthritis of the Great Toe

Condition: First MTP Joint Osteoarthritis
Interventions: Device: Arthrodesis; Device: Cartiva
Sponsor: Carticept Medical, Inc
Recruiting - verified August 2011
Study Evaluating Etanercept in 3 Subtypes of Childhood Arthritis

Condition: Arthritis, Juvenile Idiopathic
Intervention: Drug: Etanercept
Sponsor: Pfizer
Recruiting - verified August 2011
Motion Analysis of EMP Knee Versus Posterior Stabilized Knee Arthroplasty for Osteoarthritis

Condition: Arthropathy of Knee Joint
Interventions: Procedure: Total Knee Arthroplasty; Procedure: Motion analysis
Sponsors: Ottawa Hospital Research Institute; Wright Medical Technology
Not yet recruiting - verified December 2011
Falls and Cardiovascular Events in Pacemaker Patients

Condition: Bradycardia
Intervention: Other: Fill out Questionnaire
Sponsor: Medtronic Bakken Research Center
Recruiting - verified January 2012
Gait Analysis of Anterior Versus Posterior Approach in Performance of Total Hip Arthroplasty

Condition: Osteoarthritis
Interventions: Procedure: Anterior Approach; Procedure: Posterior Approach
Sponsors: Medacta USA; Medacta International SA
Recruiting - verified November 2011
Long-term Intervention With Weight Loss in Patients With Concomitant Obesity and Knee Osteoarthritis. The LIGHT Study

Conditions: Osteoarthritis, Knee; Obesity
Intervention: Dietary Supplement: day formula diet
Sponsors: Henning Bliddal; Velux Fonden; Oak Foundation; The Danish Rheumatism Association; Cambridge Health & Weight Plan, UK
Recruiting - verified January 2012
Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors

Condition: Schnitzler Syndrome
Intervention:
Sponsor: University Hospital, Strasbourg, France
Recruiting - verified August 2011
The Use of Neuromuscular Electrical Stimulation to Reverse Muscle Atrophy in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Other: Neuromuscular electrical stimulation; Other: Volitional exercises
Sponsor: University of Pittsburgh
Recruiting - verified September 2011
Efficacy of Etoricoxib 60 mg in Modifying Pain Hypersensitivity in People With Knee Osteoarthritis

Conditions: Osteoarthritis; Pain
Interventions: Drug: Etoricoxib (Arcoxia); Drug: Sugar pill
Sponsors: Curtin University of Technology; Merck
Recruiting - verified June 2011
A Broad Multi-histology Phase II Study of the Multi-Kinase Inhibitor R935788 (Fostamatinib Disodium) in Advanced Colorectal, Non-small Cell Lung, Head and Neck Hepatocellular and Renal Cell Carcinomas, and Pheochromocytoma and Thyroid Tumors (Multi-H...

Conditions: Head and Neck Neoplasms; Pheochromocytoma; Colorectal Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell
Intervention: Drug: Fostamatinib disodium (R9355788)
Sponsor: National Cancer Institute (NCI)
Recruiting - verified January 2011
RCT Comparing Ion Levels and Clinical Outcomes of A-Class BFH to Metal on Polyethylene Total Hip Replacement

Conditions: Hip Joint; Osteoarthritis; Arthroplasty
Interventions: Device: A Class BFH; Device: Metal on Polyethylene
Sponsors: Ottawa Hospital Research Institute; Wright Medical Technology
Recruiting - verified October 2011
Endothelial Function, Inflammatory Disease Activity, and Bone and Cartilage Markers in Rheumatic Patients: The Influence of Antirheumatic Treatment

Conditions: Rheumatoid Arthritis; Psoriatic Arthritis; Ankylosing Spondylitis; Endothelial Dysfunction; Inflammatory Disease Activity
Intervention:
Sponsors: Revmatismesykehuset AS; Abbott
Recruiting - verified May 2009
Study of Knee Replacements for Patellofemoral Osteoarthritis

Condition: Osteoarthritis, Knee
Intervention: Device: Knee arthroplasty
Sponsors: University of Aarhus; Stryker Nordic; DePuy Orthopaedics
Recruiting - verified March 2011
Premature Coronary Artery Disease (CAD) in Severe Psoriasis

Conditions: Psoriasis; Coronary Artery Disease
Intervention: Procedure: CCTA Scan (Coronary CT Angiogram)
Sponsor: University of Michigan
Recruiting - verified August 2011
Effect of Pre-surgery Neuromuscular Physiotherapy (PT)

Condition: Knee Osteoarthritis
Interventions: Other: preoperative neuromuscular training; Behavioral: knee OA School
Sponsors: University of Zurich; Kantonsspital Olten; Kantonsspital Aarau; Lund University; Maastricht University
Recruiting - verified October 2011
Registry of Etanercept Use in Patients With Rheumatoid Arthritis in Clinical Practice in Taiwan

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Pfizer
Recruiting - verified October 2011
Nutritional and Contractile Regulation of Muscle Growth

Condition: Sarcopenia
Interventions: Drug: Rapamycin; Other: Amino acid supplementation; Other: Low-intensity resistance exercise; Drug: Sodium nitroprusside; Device: Blood flow restriction cuff; Other: Low-intensity resistance exercise
Sponsors: The University of Texas, Galveston; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Study to Evaluate The Safety and Efficacy of Abatacept in Subjects With Chronic Urticaria Who Have Had an Inadequate Response to Anti-histamine Therapy

Condition: Urticaria
Intervention: Drug: abatacept (Orencia ®)
Sponsors: Johns Hopkins University; Bristol-Myers Squibb
Recruiting - verified October 2011
Strategic Timing of Antiretroviral Treatment

Condition: HIV Infection
Intervention: Drug: All licensed antiretroviral medications
Sponsors: University of Minnesota - Clinical and Translational Science Institute; National Institute of Allergy and Infectious Diseases (NIAID); Copenhagen HIV Programme (CHIP) -- Copenhagen, Denmark; Medical Research Council (MRC) Clinical Trials Unit -- London, United Kingdom; Kirby Institute; The Institute for Clinical Research at the Veterans Affairs Medical Center -- Washington, D.C., USA; Agence Nationale de Recherche sur le SIDA (ANRS), France; German Federal Ministry of Education and Research; NEAT - European AIDS Treatment Network; National Health and Medical Research Council, Australia; National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI); National Heart, Lung, and Blood Institute (NHLBI); National Institute of Mental Health (NIMH); National Institute of Neurological Disorders and Stroke (NINDS); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Abbott; Bristol-Myers Squibb; Gilead Sciences; GlaxoSmithKline; Merck; Tibotec Pharmaceutical Limited
Recruiting - verified January 2012
Periosteal Stimulation for Knee Osteoarthritis

Condition: Osteoarthritis, Knee
Interventions: Other: Periosteal stimulation; Other: Control-Periosteal Stimulation
Sponsor: Department of Veterans Affairs
Recruiting - verified October 2011
Obesity and the Initiation of Knee Osteoarthritis

Condition: Obesity
Intervention:
Sponsor: Department of Veterans Affairs
Recruiting - verified October 2011
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

Conditions: Osteoarthritis; Traumatic Arthritis; Avascular Necrosis of the Femoral Condyle; Moderate Varus; Valgus; Flexion Deformities
Intervention: Device: NexGen LPS-Flex Mobile Bearing Knee
Sponsor: Zimmer, Inc.
Recruiting - verified September 2011
Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica

Conditions: Polymyalgia Rheumatica; Rheumatoid Arthritis; Rheumatic Disease
Intervention:
Sponsor: Lahey Clinic
Recruiting - verified April 2011
A Multicenter Prospective Study of Quality of Life in Adult Scoliosis

Condition: Scoliosis
Interventions: Procedure: Surgical intervention; Other: Non operative intervention
Sponsors: Washington University School of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Northwestern University; New York University; University of Virginia; University of Louisville; Maryland Spine Center; Hospital for Special Surgery, New York; University Health Network, Toronto; Hopital du Sacre', Montreal University; Dartmouth-Hitchcock Medical Center
Recruiting - verified October 2011
Role of Bone in Knee Osteoarthritis (OA)

Condition: Osteoarthritis, Knee
Interventions: Radiation: MRI; Procedure: Primary Total Knee Replacement
Sponsors: The New England Baptist Hospital; Genzyme
Recruiting - verified June 2011
Minimally Invasive Versus Conventional Approaches in Navigated Total Knee Arthroplasty (TKA)

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-traumatic Arthritis
Interventions: Procedure: Navigated TKA with a minimally invasive approach; Procedure: Navigated TKA with a conventional approach
Sponsor: Aesculap AG
Recruiting - verified July 2011
Anti-TNF Agents for the Treatment of Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Etanercept; Drug: Adalimumab
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2011
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study

Conditions: Chronic Sinusitis; Rhinosinusitis; Nasal Polyps
Intervention: Drug: Prednisone
Sponsors: Northwestern University; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2011
Capsular and Intra-articular Corticosteroid Injection for Frozen Shoulder

Condition: Adhesive Capsulitis
Interventions: Drug: lidocaine; Drug: triamcinolone
Sponsor: Oslo University Hospital
Recruiting - verified June 2011
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee

Condition: Osteoarthritis of the Knee
Interventions: Drug: CF101; Drug: Placebo
Sponsor: Can-Fite BioPharma
Not yet recruiting - verified June 2011
Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease

Conditions: Juvenile Idiopathic Arthritis; Systemic Lupus Erythematosus; Juvenile Dermatomyositis
Intervention: Drug: Human papilloma virus vaccine (cervarix)
Sponsors: N.M. Wulffraat; National Institute for Public Health and the Environment (RIVM)
Recruiting - verified August 2011
A Phase 4, 6-Week, Randomized Double-Blind, Multicenter, Active-Controlled Trial To Evaluate The Effects Of Celecoxib (Celebrex®) Or Naproxen On Blood Pressure In Pediatric Subjects

Condition: Arthritis, Juvenile Rheumatoid
Interventions: Drug: Celecoxib; Drug: Naproxen
Sponsor: Pfizer
Recruiting - verified December 2011
Determining Predictors of Safe Discontinuation of Anti-TNF Treatment in JIA

Condition: Juvenile Idiopathic Arthritis
Intervention: Other: Withdrawal of anti-TNF therapy
Sponsors: Children's Hospital Medical Center, Cincinnati; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified November 2011
The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen in Knee Osteoarthritis

Condition: Osteoarthritis
Interventions: Drug: Curcuma domestica extracts; Drug: Ibuprofen
Sponsors: Mahidol University; National Research Council of Thailand
Recruiting - verified May 2011
Juvenile Idiopathic Arthritis (JIA) Registry

Condition: Juvenile Idiopathic Arthritis
Interventions: Biological: adalimumab; Drug: Methotrexate
Sponsor: Abbott
Recruiting - verified October 2011
Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

Condition: Osteoarthritis
Interventions: Dietary Supplement: Essential amino acids; Dietary Supplement: Alanine
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2012
ReCap Total Hip Resurfacing Prospective Data Collection

Condition: Arthritis
Intervention: Device: ReCap Total Hip Resurfacing
Sponsors: Biomet, Inc.; Biomet U.K. Ltd.
Recruiting - verified September 2011
Comparison of Balloon Kyphoplasty and Vertebroplasty in Subacute Osteoporotic Vertebral Fractures

Conditions: Osteoporotic Vertebral Fracture; Between T5 and L5; Chronic Arthritis, Longer Than Six Weeks Duration
Interventions: Device: balloon kyphoplasty; Procedure: vertebroplasty
Sponsors: Assistance Publique - Hôpitaux de Paris; Ministry of Health, France
Recruiting - verified April 2011
Systemic Lupus Erythematosus in Gullah Health

Condition: Systemic Lupus Erythematosus
Intervention:
Sponsors: Medical University of South Carolina; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Biologic Rheumatology Registry Across Canada (P02843 AM5)

Conditions: Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic
Intervention: Drug: infliximab or golimumab
Sponsor: Schering-Plough
Recruiting - verified August 2011
Use of MRI and PET for Assessing Disease Activity in Takayasu's Arteritis

Condition: Takayasu Arteritis
Intervention:
Sponsors: Peter A. Merkel; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Uniglide™ Mobile Bearing Unicondylar Knee System vs the Uniglide™ Fixed Bearing Unicondylar Knee System

Condition: Osteoarthritis
Interventions: Device: Uniglide Mobile Bearing Unicondylar Knee System; Device: Uniglide Fixed Bearing Unicondylar Knee System
Sponsor: Corin
Recruiting - verified June 2011
Hormone Function in Men Treated for Pain With Opioids or Placebo

Conditions: Chronic Pain; Osteoarthritis
Intervention: Drug: MS Contin
Sponsor: National Institute of Nursing Research (NINR)
Recruiting - verified June 2011
Study Comparing Peri-articular Injection of Bupivacaine With and Without Epinephrine

Condition: Osteoarthritis
Interventions: Procedure: Peri-articular injection of marcaine/epinephrine; Procedure: Peri-articular injection of marcaine alone
Sponsor: Rush University Medical Center
Recruiting - verified March 2011
Remicade Infusion Management Program (Study P04466)

Conditions: Crohn Disease; Rheumatoid Arthritis
Intervention: Biological: Infliximab
Sponsors: Schering-Plough; Centocor, Inc.
Recruiting - verified August 2011
Post PMA-Approval Study: New Enrollment Post PMA-Approval Study Post-approval Study Group (New Enrollment)

Conditions: Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis
Intervention: Device: Cormet Hip Resurfacing
Sponsor: Corin
Recruiting - verified June 2011
Post Marketing Surveillance of Remicade (Study P05224)

Conditions: Crohn's Disease; Ankylosing Spondylitis
Intervention: Biological: Infliximab
Sponsor: Schering-Plough
Recruiting - verified August 2011
Trilogy AB Acetabular Hip System Post Approval Study

Conditions: Osteoarthritis; Avascular Necrosis; Congenital Hip Dysplasia; Traumatic Arthritis
Intervention: Device: Trilogy AB Acetabular Ceramic Hip System
Sponsor: Zimmer, Inc.
Recruiting - verified September 2011
Global® AP™ Total Shoulder Arthroplasty

Condition: Osteoarthritis
Intervention: Device: Total shoulder arthroplasty (Global® AP™ Shoulder)
Sponsor: DePuy Orthopaedics
Recruiting - verified September 2011
Post Approval Study: NOVATION Ceramic Articulation Hip System

Condition: Total Hip Replacement (Non-inflammatory)
Intervention: Device: Novation Ceramic
Sponsor: Exactech
Recruiting - verified November 2011
Use of Cold and Compression Therapy With Total Knee Replacement Patients

Conditions: Osteoarthritis; Total Knee Arthroplasty
Interventions: Device: Game Ready Injury Treatment System (CoolSystems Inc.); Other: Ice with compressive bandages
Sponsor: CoolSystems, Inc.
Recruiting - verified May 2011
CMC (Carpometacarpal) OA (Osteoarthritis) Thumb Splint Study

Condition: Osteoarthritis, Carpometacarpal
Interventions: Device: Comfort Cool thumb splint by North Coast Medical; Device: Custom made thermoplastic & neoprene splint
Sponsors: University of British Columbia; Vancouver Foundation
Recruiting - verified September 2011
Naturalistic Safety Registry Of Celecoxib (CELEBREX(R)) And NSAIDs In Juvenile Idiopathic Arthritis

Condition: Arthritis, Juvenile Rheumatoid
Interventions: Drug: Celecoxib; Drug: nsNSAIDs
Sponsor: Pfizer
Recruiting - verified December 2011
Oxford Partial Knee Replacement. A Randomized Clinical Trial of Three Implant Types

Condition: Osteoarthritis, Knee
Interventions: Device: Oxford Uni Knee; Device: Oxford Uni Knee; Device: Oxford Uni Knee
Sponsors: University of Aarhus; Aarhus University Hospital; Vejle Hospital; Biomet, Inc.
Recruiting - verified June 2011
Followup of Glenoid Fix Utilizing Auto Bone Graft in Shoulder Replacement

Condition: Arthritis
Intervention: Procedure: X-rays and CT scan
Sponsor: University of Nebraska
Recruiting - verified April 2011
Digital Sizing for Orthopaedic Hip Implants

Condition: Hip Arthritis
Intervention:
Sponsor: Ottawa Hospital Research Institute
Recruiting - verified October 2011
PRCT: Comparing Ligament Reconstruction and Tendon Interposition (LRTI) With a Joint Spacer for Trapeziometacarpal (TMC) Osteoarthritis (OA) (TMC/PyroDisk Study)

Condition: Joint Disease
Interventions: Procedure: LRTI; Procedure: Ascension PyroDisk
Sponsor: Simon Fraser Orthopaedic Fund
Recruiting - verified June 2011
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica

Condition: Sciatica
Interventions: Drug: Prednisone; Drug: Placebo
Sponsors: Kaiser Permanente; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Mobility Assessment of Patients With Total Hip Arthroplasty

Conditions: Osteoarthritis; Arthroplasty; Hip Replacement
Interventions: Procedure: Motion analysis; Procedure: Motion analysis; Procedure: Motion analysis
Sponsors: Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified December 2011
ARTHRO Distension Plus Intensive Mobilisation in Shoulder Capsulitis

Condition: Shoulder Capsulitis
Interventions: Procedure: infiltration intra articular; Procedure: ARTHRO distension plus intensive mobilisation
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting - verified May 2008
Study Evaluating Single Doses Of SBI-087 in Subjects With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention: Drug: SBI-087
Sponsors: Pfizer; Emergent Product Development Seattle LLC
Recruiting - verified June 2011
Long-Term, Open-Label Study Of CP-690,550 For Treatment Of Rheumatoid Arthritis In Japan

Condition: Rheumatoid Arthritis
Intervention: Drug: CP-690,550
Sponsor: Pfizer
Recruiting - verified January 2012
A Safety and Efficacy Study of the Birmingham Hip Resurfacing System

Condition: Arthritis
Intervention: Device: Birmingham Hip Resurfacing System
Sponsor: Smith & Nephew, Inc.
Recruiting - verified November 2011
Lateral Versus Anterior Spanning External Fixator for Tibial Plateau Fractures

Condition: Fractures, Closed
Interventions: Device: Anterior pin placement; Device: Lateral pin placement
Sponsor: University of Missouri-Columbia
Recruiting - verified March 2011
Rheumatoid Arthritis Comorbidity: Bone Health in Men and African Americans

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: University of Nebraska
Recruiting - verified March 2011
Progressive Exercise After Total Knee Arthroplasty (TKA)

Condition: Osteoarthritis
Intervention: Other: Knee muscle exercises
Sponsor: Jyväskylä Central Hospital
Recruiting - verified March 2011
Zurich Multiple Endpoint Vitamin D Trial in Knee OA Patients

Condition: Knee Osteoarthritis
Intervention: Dietary Supplement: Vitamin D3 (cholecalciferol)
Sponsors: University of Zurich; Harvard School of Public Health; Tufts University; Boston University
Recruiting - verified December 2011
Use of Teriparatide to Accelerate Fracture Healing

Condition: Pelvic Fracture
Interventions: Drug: Teriparatide; Drug: Placebo
Sponsors: University of Rochester; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Institutes of Health (NIH)
Recruiting - verified January 2012
A Prospective Clinical Study On A Total Hip Resurfacing System

Conditions: Arthritis; Avascular Necrosis
Intervention: Device: ReCap Total Hip Resurfacing System
Sponsor: Biomet, Inc.
Recruiting - verified August 2011
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor.

Condition: Rheumatoid Arthritis
Interventions: Drug: rituximab [MabThera/Rituxan]; Drug: Methotrexate
Sponsor: Hoffmann-La Roche
Recruiting - verified January 2012
Safety and Efficacy of Gardasil in Females With Juvenile Idiopathic Arthritis (JIA)/Seronegative Arthritis

Condition: Arthritis
Interventions: Biological: Gardasil; Biological: Gardasil; Biological: Gardasil
Sponsors: University Hospitals of Cleveland; Merck
Recruiting - verified October 2011
PPAR-gamma Agonists, Rheumatoid Arthritis and Cardiovascular Disease

Condition: Rheumatoid Arthritis
Intervention: Drug: pioglitazone
Sponsors: University of Michigan; National Institutes of Health (NIH)
Recruiting - verified October 2011
Evaluation of the Wear of Vitamin E Treated Polyethylene Components in Primary THA Using RSA

Conditions: Osteoarthritis of Hip; Traumatic Arthritis of Hip
Intervention: Procedure: Hip replacement
Sponsors: Massachusetts General Hospital; Biomet, Inc.
Recruiting - verified June 2011
Comparing Total Hip Arthroplasty and Hemi-Arthroplasty on Revision Surgery and Quality of Life in Adults With Displaced Hip Fractures (The HEALTH Study)

Conditions: Hip Fractures; Femoral Neck Fractures
Interventions: Device: Total hip arthroplasty; Device: Hemi-arthroplasty
Sponsors: Boston University; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Hamilton Health Sciences Corporation; ZonMw: The Netherlands Organisation for Health Research and Development; Canadian Institutes of Health Research (CIHR)
Recruiting - verified October 2011
Long-Term Multi-center Evaluation of E-Poly and Regenerex

Conditions: Osteoarthritis of Hip; Traumatic Arthritis of Hip
Intervention: Procedure: Total Hip Arthroplasty
Sponsors: Massachusetts General Hospital; Biomet, Inc.
Recruiting - verified June 2011
Study of Veltuzumab (hA20) at Different Doses in Patients With ITP

Conditions: Purpura, Thrombocytopenic, Idiopathic; Autoimmune Thrombocytopenic Purpura; Purpura, Thrombocytopenic, Autoimmune
Intervention: Biological: veltuzumab
Sponsor: Immunomedics, Inc.
Recruiting - verified January 2012
Study Evaluating The Use Of Etanercept In Patients With Ankylosing Spondylitis

Condition: Ankylosing Spondylitis
Intervention: Drug: Etanercept
Sponsor: Pfizer
Recruiting - verified January 2012
Psoriasis Longitudinal Assessment and Registry (PSOLAR)

Conditions: Psoriasis; Arthritis, Psoriatic
Interventions: Biological: infliximab; Biological: ustekinumab; Biological: Biological therapies other than infliximab and ustekinumab; Drug: conventional systemic agents
Sponsor: Centocor Ortho Biotech Services, L.L.C.
Recruiting - verified July 2011
Ankle Joint Replacement Outcomes Study

Conditions: Osteoarthritis; Rheumatoid Arthritis; Post-Traumatic Arthritis; Septic Arthritis; Prior Ankle Fusion
Intervention: Device: ankle joint replacement
Sponsor: Tornier
Recruiting - verified June 2010
Exercise and Respiratory Therapy in Patients With Rheumatoid Arthritis / Collagenosis and Pulmonary Hypertension

Conditions: Pulmonary Hypertension; Connective Tissue Disease
Intervention: Behavioral: exercise training
Sponsor: University of Heidelberg
Recruiting - verified May 2007
Pre-operative Rehabilitation Exercise Program for Total Knee Arthroplasty

Conditions: Osteoarthritis; Rheumatoid Arthritis
Intervention: Behavioral: Exercise
Sponsors: University of Alberta; Alberta Heritage Foundation for Medical Research; Canadian Institutes of Health Research (CIHR)
Recruiting - verified July 2011
Observational Trial With Enbrel

Condition: Rheumatoid Arthritis
Intervention: Drug: etanercept
Sponsor: Pfizer
Recruiting - verified January 2012
Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Condition: Antiphospholipid Syndrome
Intervention:
Sponsor: Duke University
Recruiting - verified August 2011
A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency

Condition: Growth Hormone Disorders
Intervention:
Sponsor: Ipsen
Recruiting - verified November 2011
Efficacy of Preoperative Education and Mini-invasive Surgery for Total Hip Replacement

Condition: Osteoarthritis of the Hip
Intervention: Procedure: -preoperative education and total hip replacement
Sponsors: Assistance Publique - Hôpitaux de Paris; Cochin Hospital
Recruiting - verified March 2007
CMC Arthritis - Neoprene Vs. Thermoplast Short Opponens Splinting

Condition: Carpometacarpal Thumb Arthritis
Intervention:
Sponsor: Massachusetts General Hospital
Recruiting - verified July 2011
Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

Condition: Arthritis, Rheumatoid
Interventions: Drug: CP-690,550; Drug: CP-690,550
Sponsor: Pfizer
Recruiting - verified January 2012
Clinical Orthopaedic Data Bank (Acute and Chronic)

Conditions: Osteoarthritis; Osteosarcoma; Scoliosis; Cerebral Palsy
Intervention:
Sponsor: University of Florida
Recruiting - verified September 2011
Comparison of Two Resurfacing Prostheses in the Treatment of Osteoarthritis of the Shoulder

Condition: Osteoarthritis
Intervention: Procedure: Copeland or Global CAP resurfacing prosthesis
Sponsor: University of Aarhus
Recruiting - verified June 2011
Pharmacist-initiated Intervention Trial in OsteoArthritis (PhIT-OA)

Condition: Knee Osteoarthritis
Intervention: Procedure: Pharmacist-Initiated Intervention in OsteoArthritis (PhIT-OA)
Sponsors: University of British Columbia; Canadian Institutes of Health Research (CIHR); Canadian Arthritis Network; Michael Smith Foundation for Health Research
Not yet recruiting - verified November 2011
Sirolimus for Autoimmune Disease of Blood Cells

Conditions: Autoimmune Pancytopenia; Autoimmune Lymphoproliferative Syndrome (ALPS); Evans Syndrome; Idiopathic Thrombocytopenic Purpura; Anemia, Hemolytic, Autoimmune; Autoimmune Neutropenia; Lupus Erythematosus, Systemic; Inflammatory Bowel Disease; Rheumatoid Arthritis
Intervention: Drug: sirolimus
Sponsor: Children's Hospital of Philadelphia
Recruiting - verified August 2011
Treatment Outcomes for Ankle Arthritis

Condition: Osteoarthritis
Intervention: Procedure: Gait analysis
Sponsors: Department of Veterans Affairs; Orthopaedic Associates of Michigan, PC; Orthopedic & Fracture Clinic (Portland, OR); Minnesota Orthopedic Sports Medicine Institute Twin Cities Orthopedics (Edina, MN)
Recruiting - verified October 2011
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery

Conditions: Hip Fracture; Osteoarthritis; Femur Head Necrosis
Interventions: Drug: Essential amino acid supplement; Drug: Ketoconazole; Drug: Whey protein
Sponsors: University of Arkansas; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Computer-Assisted Total Knee Replacement Kinematics: DePuy Sigma Posterior Cruciate Substituting Knee and the DePuy Sigma RP Rotating Platform Knee

Condition: Osteoarthritis, Knee
Intervention: Device: DePuy P.F.C.® Sigma Rotating Platform Knee
Sponsors: Queen's University; DePuy Orthopaedics
Recruiting - verified June 2011
Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

Conditions: Arthritis, Rheumatoid; Osteoarthritis
Interventions: Drug: celecoxib; Drug: Ibuprofen; Drug: Naproxen
Sponsors: Pfizer; The Cleveland Clinic
Recruiting - verified February 2012
Pharmacogenomics of Anti-TNF (Anti-tumor Necrosis Factor) Treatment in Patients With Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: Radboud University
Recruiting - verified November 2011
Determining Disease Activity Biomarkers in Individuals With Churg-Strauss Syndrome

Condition: Churg-Strauss Syndrome
Intervention:
Sponsors: Boston University; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis

Condition: Takayasu's Arteritis
Intervention:
Sponsors: Boston University; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Longitudinal Protocol for Granulomatosis With Polyangiitis (Wegener's) and Microscopic Polyangiitis

Conditions: Granulomatosis With Polyangiitis; Microscopic Polyangiitis; Wegener's
Intervention:
Sponsors: Boston University; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Determining Disease Activity Biomarkers in Individuals With Giant Cell Arteritis

Condition: Temporal Arteritis
Intervention:
Sponsors: Peter A. Merkel; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Determining Disease Activity Biomarkers in Individuals With Polyarteritis Nodosa

Condition: Polyarteritis Nodosa
Intervention:
Sponsors: Boston University; Office of Rare Diseases (ORD); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Rare Diseases Clinical Research Network
Recruiting - verified February 2012
Lovastatin for the Treatment of Mildly Active Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Interventions: Drug: Lovastatin; Device: Lovastatin placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Autoimmunity Centers of Excellence
Recruiting - verified September 2011
A Randomized Study of Sulindac in Oral Premalignant Lesions

Conditions: Leukoplakia, Oral; Benign Neoplasms
Interventions: Drug: sulindac; Drug: Placebo
Sponsors: Memorial Sloan-Kettering Cancer Center; Amrita Institute of Sciences, AIMS, Cochin, India; Weill Medical College of Cornell University; Regional Cancer Center(RCC), Trivandrum, India; Narayana Hrudayalaya Hospitals
Recruiting - verified January 2012
Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Rheumatologists

Conditions: Arthritis, Psoriatic; Psoriasis; Skin Diseases, Papulosquamous
Intervention: Drug: Etanercept
Sponsor: Pfizer
Recruiting - verified January 2012
Study Evaluating the Safety and Efficacy of Etanercept in Patients With Psoriatic Arthritis Treated by Dermatologists

Conditions: Arthritis, Psoriatic; Psoriasis; Skin Diseases, Papulosquamous
Intervention: Drug: etanercept
Sponsor: Pfizer
Recruiting - verified January 2012
Rheumatoid Arthritis:Tolerance Induction by Mixed Chimerism

Condition: Rheumatoid Arthritis
Intervention: Procedure: Hematopoietic Stem Cell Transplantation
Sponsor: Richard Burt
Recruiting - verified August 2011
Stem Cell Support in Patients With Rheumatoid Arthritis

Condition: RHEUMATOID ARTHRITIS
Intervention: Procedure: Immune ablation and hematopoietic stem cell transplant
Sponsor: Richard Burt
Recruiting - verified August 2011
Functional Outcomes Following Shoulder Surgery: A Prospective Database

Conditions: Rotator Cuff Tear; Osteoarthritis; Shoulder Instability
Intervention:
Sponsor: Ottawa Hospital Research Institute
Recruiting - verified July 2011
Long-term Observation of Patients With Early Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: University of California, Los Angeles
Recruiting - verified August 2011
Alemtuzumab to Treat Severe Aplastic Anemia

Conditions: Relapsed or Refractory Severe Aplastic Anemia; Severe Aplastic Anemia
Intervention: Drug: Alemtuzumab (Campath(Registered Trademark))
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2011
Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)

Conditions: Systemic Lupus Erythematosus; Antiphospholipid Syndrome
Intervention:
Sponsors: Hospital for Special Surgery, New York; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified December 2011
Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis

Condition: Vasculitis
Intervention: Drug: azathioprine
Sponsors: University Medical Centre Groningen; ZonMw: The Netherlands Organisation for Health Research and Development; Dutch Arthritis Association; Dutch Kidney Foundation
Recruiting - verified November 2011
Progression of Spinal Fusion in Ankylosing Spondylitis

Condition: Spondylitis, Ankylosing
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified March 2011
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease

Conditions: Nervous System Malformations; Arthropathy, Neurogenic; Urticaria; Papilledema
Intervention: Drug: Anakinra
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified November 2011
Studies of the Natural History and Pathogenesis and Outcome of Neonatal Onset Multisystem Inflammatory Disease (NOMID/CAPS, DIRA, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases)

Conditions: Urticaria; Arthropathy; Lymphadenopathy; Nervous System Anomalies
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified January 2012
Genetic Determinants of Ankylosing Spondylitis Severity

Condition: Ankylosing Spondylitis
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified July 2010
Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study

Condition: Ankylosing Spondylitis
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2011
Clinically Important Changes in Rheumatoid Arthritis

Condition: Rheumatoid Arthritis
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2011
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders

Conditions: Rheumatic Diseases; Rheumatoid Arthritis; Systemic Lupus Erythematosus; Scleroderma; Dermatomyositis; Myositis
Intervention:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified November 2011
Blood Component Collection From Patients With Rheumatic Disease and Healthy Volunteers

Conditions: Rheumatic Diseases; Healthy
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2011
Natural History of Rheumatic Diseases in Minority Communities

Condition: Rheumatic Disease
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified October 2011
Treatment of Hemochromatosis

Condition: Hemochromatosis
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified August 2011
Study of Arthritis and Related Conditions

Conditions: Arthritis; Synovitis
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified October 2011
Study of Alkaptonuria

Condition: Alkaptonuria
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified March 2011
Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics

Conditions: Chronic Disease; Healthy; Lyme Arthritis; Lyme Disease; Multiple Sclerosis
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Evaluation of Salivary Gland Dysfunction

Conditions: Sjogren's Syndrome; Xerostomia
Intervention:
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified October 2011
Genetic Analysis of Immune Disorders

Conditions: Healthy; Immunologic Deficiency Syndrome; Job's Syndrome; Severe Combined Immunodeficiency
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2011
Studies of Blood and Reproductive Fluids in HIV-Infected and Non-HIV-Infected Persons

Condition: HIV Infection
Intervention:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Washington Hospital Center
Recruiting - verified February 2011
Study and Treatment of Inflammatory Muscle Diseases

Conditions: Autoimmune Disease; Dermatomyositis; Inclusion Body Myositis; Myositis; Polymyositis
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified August 2011
Study of Systemic Lupus Erythematosus

Conditions: Lupus Nephritis; Systemic Lupus Erythematosus
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified April 2011
Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

Condition: Periodic Disease
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified June 2011
Genetic Basis of Primary Immunodeficiencies

Condition: Immunologic Deficiency Syndrome
Intervention:
Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified October 2011