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Study the Usefulness of Bio-impedance Spectroscopy in the Early Assessment of Breast Cancer Related Lymphoedema

Conditions: Lymphedema; Breast Cancer Stage II; Early Disease Onset
Intervention:
Sponsors: Nij Smellinghe Hosptial; Nij Smellinghe Hosptial
Recruiting - verified May 2012
Duloxetine Hydrochloride in Treating Muscle, Bone, and Joint Pain in Patients With Early-Stage Breast Cancer Receiving Hormone Therapy

Conditions: Breast Cancer; Musculoskeletal Complications; Pain; Therapy-related Toxicity
Interventions: Drug: duloxetine hydrochloride; Other: placebo
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012
A DB Randomized Study of R1-R2 WaterJel / AloeVera Jell in Prevention of Radiation Dermatitis in Breast Cancer

Conditions: Breast Cancer; Radiation Dermatitis; Erythema
Intervention:
Sponsors: Water-Jel; Water-Jel
Recruiting - verified May 2012
Safety Study of Enzalutamide (MDV3100) in Patients With Incurable Breast Cancer

Condition: Breast Cancer
Intervention: Drug: enzalutamide
Sponsors: Medivation, Inc.; Medivation, Inc.; Astellas Pharma Inc
Recruiting - verified May 2012
An Observational Pilot Study Evaluating The Feasibility of Conducting Genomewide Association Studies Utilizing Subject-Provided Information in Subjects With Metastatic Breast Cancer Treated With Avastin (Bevacizumab)

Condition: Breast Cancer
Intervention:
Sponsors: Genentech; Genentech; 23andMe, Inc.
Recruiting - verified May 2012
Elderly Metastatic Breast Cancer: Pertuzumab-Herceptin vs Pertuzumab-Herceptin-Metronomic Chemotherapy, Followed by T-DM1

Condition: Elderly Metastatic Breast Cancer Population
Interventions: Drug: Pertuzumab + trastuzumab; Drug: Pertuzumab + trastuzumab + metronomic chemotherapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Not yet recruiting - verified May 2012
Phase Ib/II Study of PLX 3397 and Eribulin in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: PLX3397; Drug: Eribulin
Sponsors: University of California, San Francisco; Hope Rugo, MD; Susan G. Komen Breast Cancer Foundation; Plexxikon, Inc.; Eisai Inc.
Not yet recruiting - verified May 2012
Study to Assess Food Effect on Pharmacokinetics of Entinostat in Subjects With Breast Cancer or Non-Small Cell Lung Cancer

Conditions: Lung Cancer; Non Small Cell Lung Cancer (NSCLC); Breast Cancer; ER+ Breast Cancer
Interventions: Drug: entinostat; Drug: entinostat; Drug: Erlotinib; Drug: Erlotinib; Drug: Exemestane; Drug: Exemestane
Sponsors: Syndax Pharmaceuticals; Syndax Pharmaceuticals
Recruiting - verified May 2012
Prospective Chart-Review: Impact of Combination - Digital Breast Tomosynthesis + Digital Mammography

Condition: Breast Cancer
Intervention:
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center
Recruiting - verified May 2012
A Phase I Study of LJM716 in Squamous Cell Carcinoma of Head and Neck, or HER2+ Breast Cancer or Gastric Cancer

Conditions: HER2 + Breast Cancer; HER2 + Gastric Cancer; Squamous Cell Carcinoma of Head and Neck
Intervention: Drug: LJM716
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012
Neoadjuvant Study of Sequential Eribulin Followed by FAC Compared to Sequential Paclitaxel Followed by FEC in Early Stage Breast Cancer Not Overexpressing HER-2

Condition: Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Eribulin; Drug: 5-Fluorouracil; Drug: Epirubicin; Drug: Cyclophosphamide; Drug: Doxorubicin
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Eisai Inc.
Not yet recruiting - verified May 2012
Dual Blockage With Afatinib and Trastuzumab as Neoadjuvant Treatment for Patients With Locally Advanced or Operable Breast Cancer Receiving Taxane-anthracycline Containing Chemotherapy

Condition: Unilateral HER2 Positive Breast Cancer
Interventions: Drug: Afatinib; Drug: Trastuzumab; Drug: Paclitaxel; Drug: Epirubicin; Drug: Cyclophosphamide
Sponsors: German Breast Group; German Breast Group; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified May 2012
A Randomized Controlled Mindfulness Based Stress Reduction Intervention in Women With Breast Cancer

Condition: Breast Cancer
Intervention: Other: MBSR
Sponsors: Skaraborg Hospital; Skaraborg Hospital
Recruiting - verified May 2012
A Phase Ⅱ Study of an All-Oral Combination of Low-dose Etoposide/Capecitabine in Patients With Metastatic Breast Cancer Previously Treated With Anthracyclines and/or Taxanes

Condition: Metastatic Breast Cancer
Interventions: Drug: Capecitabine; Drug: Etoposide
Sponsors: Peking University; Tao OUYANG
Not yet recruiting - verified May 2012
Evaluation of Drug Activity in Women With Breast Cancer and no Previous Herceptin Treatment

Condition: Breast Neoplasm
Interventions: Drug: Drug-AZD8931; Drug: Drug-Placebo
Sponsors: AstraZeneca; AstraZeneca
Not yet recruiting - verified May 2012
Prospective Trial of Two Prone Breast Radiotherapy Techniques With Randomization to Concurrent Versus Weekly Boost

Condition: Breast Cancer
Intervention: Other: Radiation Therapy
Sponsors: New York University School of Medicine; New York University School of Medicine
Recruiting - verified May 2012
Cancer and Mindfulness-Based Cancer Recovery After Chemotherapy

Conditions: Cancer Survivor; Breast Cancer; Colorectal Cancer; Gynecological Cancer; Ovarian Cancer; Uterine Cancer
Intervention: Behavioral: Mindfulness Based Cancer Recovery
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Not yet recruiting - verified May 2012
A Combined GWAS and miRNA for the Identification of Bevacizumab Response Predictors in Metastatic Breast Cancer

Condition: Breast Cancer Invasive Nos
Intervention:
Sponsors: Spanish Breast Cancer Research Group; Spanish Breast Cancer Research Group; Hoffmann-La Roche; Roche Farma, S.A.
Not yet recruiting - verified May 2012
Safety Study of Topical Compound 31543 (Calcitriol, USP) in Patients Receiving Chemotherapy for Breast Cancer

Conditions: Alopecia; Breast Cancer
Intervention: Drug: compound 31543 Calcitriol
Sponsors: Berg Pharma,LLC; Berg Pharma,LLC
Not yet recruiting - verified April 2012
The Ultrasound Study of Tamoxifen

Condition: Breast Neoplasms
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified January 2012
Study Comparing Nanoparticle-based Paclitaxel With Solvent-based Paclitaxel as Part of Neoadjuvant Chemotherapy for Patients With Early Breast Cancer (GeparSepto)

Conditions: Tubular Breast Cancer Stage II; Mucinous Breast Cancer Stage II; Breast Cancer Female NOS; Invasive Ductal Breast Cancer; Tubular Breast Cancer Stage III; HER-2 Positive Breast Cancer; Inflammatory Breast Cancer Stage IV; Inflammatory Breast Cancer
Interventions: Drug: nab-Paclitaxel; Drug: Paclitaxel
Sponsors: German Breast Group; German Breast Group; Celgene GmbH; Roche Pharma AG
Not yet recruiting - verified April 2012
Home-Based Symptom Management Via Reflexology for Breast Cancer Patients

Condition: Breast Cancer
Intervention: Other: Reflexology
Sponsors: Michigan State University; Michigan State University; National Cancer Institute (NCI)
Recruiting - verified April 2012
Neoadjuvant Letrozole Plus Metformin vs Letrozole Plus Placebo for ER-positive Postmenopausal Breast Cancer

Condition: Hormone Receptor Positive Malignant Neoplasm of Breast
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: Seoul National University Hospital; Seoul National University Hospital
Not yet recruiting - verified April 2012
Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction

Conditions: Breast Cancer; Pain, Postoperative; BRCA1 Mutation; BRCA2 Mutation; Breast Diseases; Neoplasms
Interventions: Drug: Botulinum Toxin Type A; Drug: Sodium Chloride Solution
Sponsors: Mayo Clinic; Mayo Clinic
Not yet recruiting - verified May 2012
National Breast Cancer and Lymphedema Registry

Conditions: Breast Cancer; Lymphedema
Intervention:
Sponsors: Stanford University; Stanley Rockson
Recruiting - verified April 2012
Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of Sorafenib and Eribulin in Combination

Condition: Breast Neoplasms
Interventions: Drug: Sorafenib (Nexavar, BAY43-9006); Drug: Eribulin
Sponsors: Bayer; Bayer
Not yet recruiting - verified April 2012
Tivantinib in Treating Patients With Recurrent or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: tivantinib; Genetic: fluorescence in situ hybridization; Genetic: gene expression analysis; Genetic: mutation analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Dana-Farber Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified April 2012
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Conditions: Dose Escalation; Safety; Preliminary Efficacy; Advanced Solid Tumors; Metastatic Breast Cancer; Advanced Pancreatic Adenocarcinoma; Metastatic Colorectal Cancer; Recurrent Glioblastoma Multiforme
Intervention: Drug: LDE225 and BKM120
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment

Conditions: Arthralgia; Breast Cancer; Hot Flashes; Musculoskeletal Complications; Sexual Dysfunction
Interventions: Drug: therapeutic testosterone; Other: placebo
Sponsors: National Cancer Institute (NCI); North Central Cancer Treatment Group; National Cancer Institute (NCI)
Not yet recruiting - verified April 2012
A Study of the Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation

Condition: Breast Cancer
Interventions: Drug: BKM120; Drug: Paclitaxel; Drug: BKM120 matching placebo
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012
A Study of Pertuzumab in Combination With Herceptin (Trastuzumab) and A Taxane in First-Line Treatment in Patients With HER2-Positive Advanced Breast Cancer (PERUSE)

Condition: Breast Cancer
Interventions: Drug: pertuzumab; Drug: trastuzumab [Herceptin]; Drug: taxane
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified April 2012
Evaluation of RFID Localization System for Marking and Retrieving Breast Lesions

Condition: Non-palpable Breast Lesions
Intervention: Device: RFID Tag (Health Beacon)
Sponsors: Health Beacons; Health Beacons
Not yet recruiting - verified April 2012
Exercise in Breast Cancer Survivors

Conditions: Breast Cancer; Obesity
Intervention: Behavioral: Exercise
Sponsors: University of Mississippi Medical Center; University of Mississippi Medical Center
Recruiting - verified April 2012
A Prospective Study to Evaluate the Effect of Systemic Adjuvant Therapy on the Cognitive Function of Breast Cancer Patients

Condition: Breast Cancer
Intervention:
Sponsors: National University Hospital, Singapore; National University Hospital, Singapore
Not yet recruiting - verified April 2012
Breast MRI for Newly Diagnosed Breast Cancer:Impact on Re-excision Lumpectomy

Condition: Breast Cancer
Intervention: Other: MRI
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute
Recruiting - verified March 2012
A Comparison of Recall Rates Between Conventional 2d Mammography and 2d Plus 3d (Tomosynthesis) Mammography in a Screening Population

Condition: Breast Cancer
Intervention:
Sponsors: Rose Imaging Specialists, P.A.; Rose Imaging Specialists, P.A.; Hologic, Inc.
Recruiting - verified March 2012
AZD2014 and Fulvestrant in Patients With ER+ Advanced Metastatic Breast Cancer

Condition: Advanced Metastatic Breast Cancer
Interventions: Drug: AZD2014; Drug: Fulvestrant
Sponsors: AstraZeneca; AstraZeneca
Not yet recruiting - verified May 2012
Safety and Efficacy of BKM120 and Lapatinib in HER2+/PI3K-activated, Trastuzumab-resistant Advanced Breast Cancer

Condition: Breast Cancer
Intervention: Drug: BKM120 + lapatinib
Sponsors: Institut Paoli-Calmettes; Institut Paoli-Calmettes
Recruiting - verified April 2012
Effect of Breastfeeding Optimization on Early Vascular Development

Conditions: Breast Feeding; Cardiovascular Diseases
Interventions: Behavioral: Breast feeding optimization; Behavioral: Usual care
Sponsors: Indonesia University; Indonesia University; CEEBM; Julius Center; Budi Kemuliaan Hospital
Not yet recruiting - verified March 2012
A Study of Pertuzumab in Combination With Herceptin (Trastuzumab) And Vinorelbine in First Line in Patients With Metastatic or Locally Advanced HER2-Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: pertuzumab; Drug: trastuzumab [Herceptin]; Drug: pertuzumab; Drug: trastuzumab [Herceptin]; Drug: vinorelbine
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified April 2012
Combination Immunotherapy With Herceptin and the HER2 Vaccine NeuVax

Condition: Breast Cancer
Interventions: Drug: Herceptin; Drug: NeuVax vaccine; Drug: GM-CSF
Sponsors: San Antonio Military Medical Center; COL George Peoples, MD, FACS; Genentech; Galena Biopharma, Inc.
Not yet recruiting - verified April 2012
Diffusion-Weighted Magnetic Resonance Imaging in Assessing Treatment Response in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy

Condition: Breast Cancer
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: paclitaxel; Other: imaging biomarker analysis; Procedure: breast imaging study; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); American College of Radiology Imaging Network; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Diagosis of Breast Carcinoma: Characterization of Breast Lesions With CLEARPEMSONIC : Feasibility Study

Condition: Breast Carcinoma
Interventions: Device: MRI; Device: PET-CT scan; Device: PEM scan with ClearPemSonic
Sponsors: Assistance Publique Hopitaux De Marseille; Assistance Publique Hopitaux De Marseille
Not yet recruiting - verified March 2012
Adjuvant Systemic Treatment for (ER)-Positive HER2-negative Breast Carcinoma in Women Over 70 According to Genomic Grade (GG): Chemotherapy + Endocrine Treatment Versus Endocrine Treatment

Condition: Breast Cancer
Interventions: Drug: HORMONOTHERAPY; Drug: CHEMOTHERAPY then HORMONOTHERAPY
Sponsors: UNICANCER; UNICANCER
Not yet recruiting - verified March 2012
Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Condition: Advanced Solid Tumors, Excluding Breast Cancer
Interventions: Drug: caffeine; Drug: diclofenac; Drug: omeprazole; Drug: midazolam; Drug: TKI258
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012
Neoadjuvant Treatment With Nab-paclitaxel for Patients With Stage II and III Luminal Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Nab-paclitaxel
Sponsors: Spanish Breast Cancer Research Group; Spanish Breast Cancer Research Group; Celgene Corporation
Recruiting - verified April 2012
A Study of Assisted- and Self-Administered Subcutaneous Herceptin (Trastuzumab) as Adjuvant Therapy in Patients With Early HER2-Positive Breast Cancer (SafeHer)

Condition: Breast Cancer
Interventions: Drug: trastuzumab [Herceptin]; Drug: trastuzumab [Herceptin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified March 2012
HER2 Imaging Study to Identify HER2 Positive Metastatic Breast Cancer Patient Unlikely to Benefit From T-DM1

Condition: HER-2 Positive Breast Cancer
Interventions: Drug: T-DM1; Procedure: 89Zr-trastuzumab
Sponsors: Jules Bordet Institute; Jules Bordet Institute; Roche Pharma AG
Not yet recruiting - verified March 2012
Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer

Condition: Locally Advanced Malignant Neoplasm
Intervention: Drug: Metformin
Sponsors: Instituto Nacional de Cancerologia de Mexico; Instituto Nacional de Cancerologia de Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Not yet recruiting - verified March 2012
Studying Blood and DNA Samples From Patients With Breast Cancer Treated With Chemotherapy With or Without Trastuzumab

Condition: Breast Cancer
Interventions: Genetic: DNA analysis; Genetic: gene expression analysis; Genetic: polymerase chain reaction; Other: enzyme-linked immunosorbent assay; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); North Central Cancer Treatment Group; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Predictors of Response to Neoadjuvant Docetaxel-Carboplatin Chemotherapy for Patients With Stage II and III Triple Negative Breast Cancer

Conditions: Breast Cancer; Breast Cancer Stage II-III
Intervention: Drug: Docetaxel- Carboplatin
Sponsors: Hospital General Universitario Gregorio Marañon; Hospital General Universitario Gregorio Marañon; UNC Lineberger Comprehensive Cancer Center; Hospital Universitario Ramon y Cajal; Hospital San Carlos, Madrid; Centro Nacional de Investigaciones Oncologicas CARLOS III
Recruiting - verified March 2012
Ruxolitinib in Patients With Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Ruxolitinib
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute
Not yet recruiting - verified March 2012
LINE: Treatment Patterns in postmenopausaL Women With Hormone Receptor Positive Breast Cancer

Condition: Local Advanced or Metastatic Postmenopausal Breast Cancer
Intervention:
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified May 2012
Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant

Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Plasma Cell Neoplasm; Poor Prognosis Metastatic Gestational Trophoblastic Tumor; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Neuroblastoma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage II Ovarian Epithelial Cancer; Stage II Ovarian Germ Cell Tumor; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage III Small Lymphocytic Lymphoma; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Breast Cancer; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Small Lymphocytic Lymphoma
Interventions: Procedure: management of therapy complications; Procedure: musculoskeletal complications management/prevention
Sponsors: Roswell Park Cancer Institute; Roswell Park Cancer Institute
Not yet recruiting - verified May 2012
Prospective Construction and Validation of a Prognostic Score to Identify Among Patients With Metastatic Breast Cancer Those Who Benefit From a Third Line Chemotherapy in Terms of Overall Survival

Condition: Metastatic Breast Cancer Starting a Third Line Chemotherapy
Intervention: Other: Construction of a prognostic score (non-drug intervention types)
Sponsors: Institut Claudius Regaud; Institut Claudius Regaud
Not yet recruiting - verified May 2012
Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer

Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Genetic: protein expression analysis; Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery; Radiation: whole breast irradiation
Sponsors: National Cancer Institute (NCI); American College of Surgeons; National Cancer Institute (NCI)
Not yet recruiting - verified April 2012
Lapatinib With Trastuzumab in Treating Patients With HER2-Negative/HER2 Mutant Metastatic Breast Cancer

Condition: Breast Neoplasms
Interventions: Drug: lapatinib ditosylate; Biological: trastuzumab
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Not yet recruiting - verified March 2012
Prospective Observational Study in Patients With Metastatic Breast Cancer Treated With Anthracyclines

Condition: Metastatic Breast Cancer
Intervention:
Sponsors: Teva Pharma; Teva Pharma
Recruiting - verified May 2012
Melatonin as Adjuvant Therapy in Breast Cancer Patients

Condition: Stage II and III Breast Cancer
Interventions: Drug: Melatonin; Drug: match placebo
Sponsors: Khon Kaen University; Khon Kaen University; National Research Council of Thailand; Melatonin research Group Khon Kaen University; Srinagarind Hospital, Khon Kaen; Maharat Hospital, Nakhon Ratchasima; General Drug House Ltd., Bangkok
Not yet recruiting - verified March 2012
The Use of Laser-Assisted Indocyanine Green Dye Angiography to Predict Mastectomy Skin Flap Viability

Conditions: Breast Cancer; Breast Reconstruction; Mastectomy
Intervention: Device: Laser-Assisted ICG Dye Angiography (SPY System)
Sponsors: Stony Brook University; Stony Brook University
Recruiting - verified March 2012
Eribulin in Combination With Cyclophosphamide in Patients With Solid Tumor Malignancies

Conditions: Malignant Solid Tumour; Breast Cancer Nos Metastatic Recurrent; Neuropathy
Intervention: Drug: Eribulin in Combination w/ Cyclophosphamide
Sponsors: University of California, San Francisco; University of California, San Francisco; Eisai Inc.
Not yet recruiting - verified March 2012
Night-time Compression Systems for Breast Cancer Related Lymphedema

Conditions: Breast Neoplasms; Lymphedema
Interventions: Behavioral: Night-time compression system garment; Behavioral: Day-time compression sleeve
Sponsors: University of Alberta; University of Alberta; Alberta Health Services; Canadian Breast Cancer Foundation
Recruiting - verified April 2012
Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: AC regimen; Drug: TAC regimen; Drug: cyclophosphamide; Drug: docetaxel; Drug: doxorubicin hydrochloride; Drug: paclitaxel
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Recruiting - verified May 2012
Efficacy Study of Herceptin to Treat HER2-positive CTC Breast Cancer

Conditions: Breast Cancer; Human Epidermal Growth Factor 2 Negative Carcinoma of Breast; Circulating Tumor Cells
Intervention: Drug: trastuzumab
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC; Hoffmann-La Roche
Not yet recruiting - verified March 2012
Cancer Symptom Data From Multiple Treatment Centers

Conditions: Breast Cancer; Colon Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified November 2011
Targeted Intraoperative Radiotherapy United States (TARGIT-US) Registry Trial

Conditions: Malignant Neoplasm of Breast; Breast Radiotherapy; Breast Diseases; Ductal Breast Carcinoma; Intraoperative Radiotherapy
Intervention: Radiation: Intraoperative radiation therapy (IORT)
Sponsors: University of California, San Francisco; University of California, San Francisco; H. Lee Moffitt Cancer Center and Research Institute; Northwestern University; Los Angeles Women's Health Clinic of California Hospital and Medical Center
Not yet recruiting - verified April 2012
Breast Cancer Recurrence - the Accuracy of Dual-time PET/CT

Condition: Breast Cancer Recurrent
Intervention: Radiation: Dual-time PET/CT (low-dose)
Sponsors: Odense University Hospital; Odense University Hospital
Recruiting - verified March 2012
A Phase 3 Comparative Study of TAP-144-SR(6M) in Postoperative and Hormone Therapy-naïve Patients With Premenopausal Breast Cancer

Condition: Premenopausal Breast Cancer
Interventions: Drug: TAP-144-SR(6M); Drug: TAP-144-SR(3M)
Sponsors: Takeda Global Research & Development Center, Inc.; Takeda Pharmaceutical Company Limited
Recruiting - verified April 2012
Pilot Study to Evaluate the Impact of Denosumab on Disseminated Tumor Cells (DTC) in Patients With Early Stage Breast Cancer

Condition: Early Stage Breast Cancer
Intervention: Drug: Denosumab
Sponsors: University of California, San Francisco; Hope Rugo, MD; University of California, San Francisco; Amgen
Not yet recruiting - verified March 2012
A Randomised Study of Docosahexaenoic Acid (DHA) in Metastatic Breast Cancer

Conditions: Metastatic Breast Cancer; Progesterone Receptor Positive Tumor; Estrogen Receptor Positive Tumor; HER-2 Negative Tumor
Interventions: Dietary Supplement: Dietary supplementation with fish oil.; Dietary Supplement: Dietary supplementation with vegetable oil
Sponsors: University Hospital, Tours; University Hospital, Tours; ICO Paul Papin
Recruiting - verified March 2012
ARQ197 in Metastatic Triple-Negative Breast Cancer

Condition: Breast Cancer
Intervention: Drug: ARQ 197
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute
Not yet recruiting - verified March 2012
A Phase II Study of Abraxane Gemcitabine Combination in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Abraxane and Gemcitabine
Sponsors: Fudan University; Fudan University
Recruiting - verified February 2012
IL-6 and IL-8 Level of Blood and Pleural Effusion During Chemotherapy in Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention:
Sponsors: Fudan University; Fudan University
Recruiting - verified February 2012
Study of Effects of Dexmedetomidine on Postoperative Nausea and Vomiting

Condition: Breast Cancer
Interventions: Drug: Dexmedetomidine; Drug: Placebo
Sponsors: Yonsei University; Yonsei University
Recruiting - verified March 2012
Collection of FUJIFILM's 3Dimensional Mammograms

Condition: Breast Cancer
Interventions: Device: 3Dimensional Mammography; Device: 2D FFDM
Sponsors: Fujifilm Medical Systems USA, Inc.; Fujifilm Medical Systems USA, Inc.
Recruiting - verified March 2012
Prophylactic Treatment of Sleep/Fatigue Before and During Chemotherapy

Condition: Stage, Breast Cancer
Interventions: Behavioral: Brief behavioral treatment for insomnia and bright light; Behavioral: treatment as usual
Sponsors: University of California, San Diego; University of California, San Diego
Not yet recruiting - verified February 2012
Tumour Necrosis Factor Release in Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Docetaxel

Condition: Breast Cancer
Intervention: Procedure: Fine needle aspiration assessing tumour TNFa levels
Sponsors: Lawson Health Research Institute; Lawson Health Research Institute
Not yet recruiting - verified February 2012
Fulvestrant With or Without Ganetespib in HR+ Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Fulvestrant; Drug: Ganetespib
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute
Not yet recruiting - verified March 2012
Impact of Body Weight on Pharmacokinetic Analysis of Doxorubicin + Cyclophosphamide in Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: University of Texas Southwestern Medical Center; University of Texas Southwestern Medical Center; Texas Tech University Health Sciences Center
Not yet recruiting - verified January 2012
Evaluation of Nutrition and Metabolism in Breast Cancer Patients

Condition: Breast Cancer
Interventions: Behavioral: Nutrition and Exercise Group; Behavioral: Yoga and Stretching Group
Sponsors: University of Waterloo; University of Waterloo; Grand River Regional Cancer Centre
Recruiting - verified February 2012
A Mindfulness Meditation-Based Intervention for Younger Breast Cancer Survivors

Condition: Younger Breast Cancer Survivors
Intervention: Behavioral: Mindful Awareness practices (MAPs)
Sponsors: Jonsson Comprehensive Cancer Center; Jonsson Comprehensive Cancer Center; Susan G. Komen Breast Cancer Foundation
Recruiting - verified March 2012
Cognitive Rehabilitation Group Intervention for Breast Cancer Survivors

Condition: Breast Cancer
Intervention: Behavioral: Improving Cognition with group intervention
Sponsors: Jonsson Comprehensive Cancer Center; Jonsson Comprehensive Cancer Center; Breast Cancer Research Foundation
Recruiting - verified April 2012
Effect of Weight on the Population Pharmacokinetic Analysis of Doxorubicin and Cyclophosphamide

Conditions: Breast Cancer; Obesity
Interventions: Drug: Doxorubicin; Drug: Cyclophosphamide
Sponsors: Texas Tech University Health Sciences Center; Texas Tech University Health Sciences Center; University of Texas
Recruiting - verified April 2012
Exploratory Study of Topical Norepinephrine in Breast Cancer Patients Receiving Radiotherapy

Condition: Radiodermatitis
Intervention: Drug: Norepinephrine
Sponsors: ProCertus BioPharm, Inc; ProCertus BioPharm, Inc; H. Lee Moffitt Cancer Center and Research Institute
Recruiting - verified March 2012
Acupuncture, Sham Acupuncture, or Wait List for Joint Symptoms Related to Aromatase Inhibitors in Patients With Early-Stage Breast Cancer

Conditions: Breast Cancer; Pain
Interventions: Procedure: acupuncture therapy; Procedure: sham intervention; Procedure: standard follow-up care
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking

Conditions: Breast Cancer; Cancer Survivor; Colorectal Cancer; Lung Cancer; Prostate Cancer; Tobacco Use Disorder
Interventions: Drug: memantine hydrochloride; Other: placebo
Sponsors: National Cancer Institute (NCI); Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Tracking & Feedback Registry to Reduce Breast Cancer Treatment Disparities

Condition: Breast Cancer
Interventions: Other: Tracking & Feedback; Other: Control
Sponsors: Mount Sinai School of Medicine; Mount Sinai School of Medicine; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Evaluation of BIS for Quantification of Lymphedema

Condition: Breast Cancer
Intervention: Other: Bioimpedance Spectroscopy
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified February 2012
Tobacco Dependence in Breast Cancer Patients Scheduled for Mastectomy/Reconstructive Surgery Trial of Varenicline (Chantix)

Conditions: Breast Cancer; Tobacco Dependence
Interventions: Drug: placebo; Drug: varenicline
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Pfizer
Recruiting - verified February 2012
BIBW 2992 (Afatinib) and Vinorelbine

Condition: Carcinoma Breast Stage IV
Intervention: Drug: BIBW 2992 in combination with vinorelbine
Sponsors: University of Magdeburg; University of Magdeburg; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified February 2012
Pilot Study of a Breast Cancer Vaccine Plus Poly-ICLC for Breast Cancer

Condition: Breast Cancer
Intervention: Biological: 9 Peptides from Her-2/neu, CEA, & CTA + poly-ICLC
Sponsors: University of Virginia; University of Virginia
Not yet recruiting - verified February 2012
Efficacy and Tolerability of Eribulin Plus Lapatinib in Patients With Metastatic Breast Cancer (E-VITA)

Condition: Metastatic Breast Cancer
Interventions: Drug: Lapatinib + 1,23 mg Eribulin; Drug: Lapatinib + 1,76 mg Eribulin
Sponsors: German Breast Group; German Breast Group
Recruiting - verified February 2012
3D Breast Ultrasound Elastography in Patients Under Neoadjuvant Chemotherapy

Condition: Malignant Breast Tumours
Intervention: Device: 3D Ultrasound elastography by means of shear wave propagation into breast tissue
Sponsors: Institut National de la Santé Et de la Recherche Médicale, France; Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified February 2012
Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients

Conditions: Hot Flashes; Breast Cancer
Interventions: Drug: solifenacin; Drug: Clonidine
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified February 2012
A Randomized Study of TH Versus THL in First Line Treatment of HER2-positive Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Trastuzumab; Drug: Paclitaxel; Drug: Lapatinib
Sponsors: All Ireland Cooperative Oncology Research Group; All Ireland Cooperative Oncology Research Group
Recruiting - verified February 2012
Donor Atorvastatin Calcium in Preventing Severe Acute Graft-Versus-Host Disease in Patients Undergoing Donor Peripheral Blood Stem Cell Transplant

Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Burkitt Lymphoma; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; High Risk Metastatic Gestational Trophoblastic Tumor; Juvenile Myelomonocytic Leukemia; Low Risk Metastatic Gestational Trophoblastic Tumor; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Plasma Cell Neoplasm; Previously Treated Childhood Rhabdomyosarcoma; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Gestational Trophoblastic Tumor; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Neuroblastoma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Small Lymphocytic Lymphoma; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage II Ovarian Epithelial Cancer; Stage II Ovarian Germ Cell Tumor; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Childhood Lymphoblastic Lymphoma; Stage III Childhood Small Noncleaved Cell Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Ovarian Epithelial Cancer; Stage III Ovarian Germ Cell Tumor; Stage III Small Lymphocytic Lymphoma; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Breast Cancer; Stage IV Childhood Hodgkin Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Childhood Lymphoblastic Lymphoma; Stage IV Childhood Small Noncleaved Cell Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Small Lymphocytic Lymphoma
Interventions: Drug: atorvastatin calcium; Procedure: peripheral blood stem cell transplantation; Procedure: allogeneic hematopoietic stem cell transplantation
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Study of Neoadjuvant Docetaxel and Cyclophosphamide in Locally Advanced or Node Positive Primary Breast Cancer With Companion Pharmacokinetic and Pharmacogenomic Analyses

Condition: Breast Cancer
Intervention: Drug: Neoadjuvant Docetaxel and Cyclophosphamide
Sponsors: National Cancer Centre, Singapore; National Cancer Centre, Singapore
Recruiting - verified August 2010
Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Dovitinib; Drug: Fulvestrant
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Trial of Eribulin/Cyclophosphamide or Docetaxel/Cyclophosphamide as Neoadjuvant Therapy in Locally Advanced HER2-Negative Breast Cancer

Condition: Locally Advanced HER2-Negative Breast Cancer
Interventions: Drug: Eribulin Mesylate; Drug: Cyclophosphamide; Drug: Docetaxel
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Eisai Inc.
Not yet recruiting - verified March 2012
A Phase II Clinical Trial of PM01183 in BRCA 1/2-Associated or Unselected Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: PM01183
Sponsors: PharmaMar; PharmaMar
Not yet recruiting - verified January 2012
Early Rehabilitation of Cancer Patients

Conditions: Breast Cancer; Colorectal Cancer; Lymphoma; Prostate Cancer; Testicle Cancer
Intervention: Other: Stressmanagement
Sponsors: Haukeland University Hospital; Haukeland University Hospital; University of Bergen; Uppsala University; University of Agder
Recruiting - verified January 2012
Digital Breast Tomosynthesis Versus Digital Mammography: A National Multicenter Trial

Condition: Breast Neoplasms
Intervention:
Sponsors: Medical University of Vienna; Medical University of Vienna
Recruiting - verified January 2012
Salvage Chemotherapy of Vinorelbine Plus Oxaliplatin in Metastatic Triple-negative Breast Cancer:a Prospective Trial

Condition: Breast Cancer
Intervention: Drug: vinorelbine plus oxaliplatin
Sponsors: Fudan University; Fudan University
Recruiting - verified February 2012
Docetaxel With or Without Metronomic Cyclophosphamide as First Line Chemotherapy in Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Docetaxel and Cyclophosphamide (TC); Drug: Docetaxel (T)
Sponsors: Fudan University; Fudan University
Recruiting - verified February 2012
Low Dose of Metronomic Cyclophosphamide and Capecitabine in Pretreated HER2-negative Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: metroCX
Sponsors: Fudan University; Fudan University
Recruiting - verified February 2012
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Locally Advanced or Inflammatory Triple Negative Breast Cancer

Conditions: Inflammatory Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-negative Breast Cancer
Interventions: Drug: carboplatin; Drug: paclitaxel albumin-stabilized nanoparticle formulation; Other: laboratory biomarker analysis
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified April 2012
Persistent Pain After Breast Cancer Treatment (PPBCT) - Risk Factors and Pathophysiological Mechanisms

Conditions: Breast Cancer; Persistent Pain; Lymphedema; Neuropathic Pain; Neuropathy
Intervention:
Sponsors: Rigshospitalet, Denmark; Rigshospitalet, Denmark; Danish Breast Cancer Cooperative Group; Danish Cancer Society
Recruiting - verified January 2012
Study to Compare Vinorelbine In Combination With the mTOR Inhibitor Everolimus vs. Vinorelbin Monotherapy for Second-line Treatment in Advanced Breast Cancer

Conditions: Her2-negative Metastatic Breast Cancer; Her2-negative Locally Advanced Breast Cancer
Interventions: Drug: Vinorebine, Everolimus; Drug: Vinorelbine
Sponsors: AIO-Studien-gGmbH; AIO-Studien-gGmbH
Not yet recruiting - verified January 2012
Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors

Conditions: Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Primary Hepatocellular Carcinoma; Chondrosarcoma; Clear Cell Sarcoma of the Kidney; Conjunctival Kaposi Sarcoma; Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; Hormone-resistant Prostate Cancer; Limited Stage Small Cell Lung Cancer; Localized Resectable Adult Primary Liver Cancer; Male Breast Cancer; Mast Cell Sarcoma; Ovarian Sarcoma; Recurrent Adult Brain Tumor; Recurrent Adult Primary Liver Cancer; Recurrent Adult Soft Tissue Sarcoma; Recurrent Bladder Cancer; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Esophageal Cancer; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Gastric Cancer; Recurrent Kaposi Sarcoma; Recurrent Melanoma; Recurrent Non-small Cell Lung Cancer; Recurrent Osteosarcoma; Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Prostate Cancer; Recurrent Rectal Cancer; Recurrent Renal Cell Cancer; Recurrent Small Cell Lung Cancer; Recurrent Uterine Sarcoma; Small Intestine Leiomyosarcoma; Stage I Colon Cancer; Stage I Rectal Cancer; Stage I Uterine Sarcoma; Stage IA Breast Cancer; Stage IA Gastric Cancer; Stage IA Ovarian Epithelial Cancer; Stage IA Ovarian Germ Cell Tumor; Stage IB Breast Cancer; Stage IB Gastric Cancer; Stage IB Ovarian Epithelial Cancer; Stage IB Ovarian Germ Cell Tumor; Stage IC Ovarian Epithelial Cancer; Stage IC Ovarian Germ Cell Tumor; Stage II Breast Cancer; Stage II Uterine Sarcoma; Stage IIA Colon Cancer; Stage IIA Gastric Cancer; Stage IIA Non-small Cell Lung Cancer; Stage IIA Ovarian Epithelial Cancer; Stage IIA Ovarian Germ Cell Tumor; Stage IIA Rectal Cancer; Stage IIB Colon Cancer; Stage IIB Esophageal Cancer; Stage IIB Gastric Cancer; Stage IIB Melanoma; Stage IIB Non-small Cell Lung Cancer; Stage IIB Ovarian Epithelial Cancer; Stage IIB Ovarian Germ Cell Tumor; Stage IIB Rectal Cancer; Stage IIC Colon Cancer; Stage IIC Melanoma; Stage IIC Ovarian Epithelial Cancer; Stage IIC Ovarian Germ Cell Tumor; Stage IIC Rectal Cancer; Stage III Uterine Sarcoma; Stage IIIA Breast Cancer; Stage IIIA Colon Cancer; Stage IIIA Esophageal Cancer; Stage IIIA Gastric Cancer; Stage IIIA Melanoma; Stage IIIA Non-small Cell Lung Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIA Rectal Cancer; Stage IIIB Breast Cancer; Stage IIIB Colon Cancer; Stage IIIB Esophageal Cancer; Stage IIIB Gastric Cancer; Stage IIIB Melanoma; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIB Rectal Cancer; Stage IIIC Breast Cancer; Stage IIIC Colon Cancer; Stage IIIC Esophageal Cancer; Stage IIIC Gastric Cancer; Stage IIIC Melanoma; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IIIC Rectal Cancer; Stage IV Bladder Cancer; Stage IV Esophageal Cancer; Stage IV Gastric Cancer; Stage IV Melanoma; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Prostate Cancer; Stage IV Renal Cell Cancer; Stage IV Uterine Sarcoma; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: sirolimus; Other: laboratory biomarker analysis; Biological: DEC-205-NY-ESO-1 fusion protein vaccine
Sponsors: Roswell Park Cancer Institute; Roswell Park Cancer Institute
Recruiting - verified March 2012
Predictive Model of Therapy Outcomes in Breast Cancer Patients

Condition: Toxicity From Medication (Endocrine Treatment and Chemotherapy) Given for Breast Cancer Treatment.
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified March 2012
A Study That Provides Long-term Access and Examines Long-term Exposure to Abiraterone Acetate

Conditions: Metastatic Castration-resistant Prostate Cancer; Metastatic Breast Cancer
Interventions: Drug: Abiraterone acetate; Drug: Abiraterone acetate
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Not yet recruiting - verified January 2012
Text-Messaging in Reducing Early Discontinuation of Aromatase Inhibitor Therapy in Women With Early-Stage Breast Cancer Who Underwent Breast Surgery

Condition: Breast Cancer
Interventions: Behavioral: telephone-based intervention; Procedure: standard follow-up care
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified January 2012
Attention and Interpretation Modification (AIM) for Fear of Breast Cancer Recurrence: An Intervention Development Study

Condition: Breast Cancer
Intervention: Behavioral: AIM materials and assessments
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Brown University; Weill Medical College of Cornell University
Recruiting - verified March 2012
Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects

Condition: Metastatic Breast Cancer
Interventions: Biological: OPT-822/OPT-821; Biological: Phosphate Buffer Saline (PBS)
Sponsors: Optimer Pharmaceuticals; Optimer Biotechnology, Inc.
Recruiting - verified January 2012
The Preoperative Health & Body Study

Condition: Breast Cancer
Interventions: Behavioral: Exercise; Behavioral: Surgical preparation program
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Yale University; Susan G. Komen Breast Cancer Foundation
Recruiting - verified January 2012
Etude Tomos- Apport de la Tomosynthèse Dans le Bilan d'Extension locorégional préthérapeutique d'Une Tumeur du Sein : Recherche de multicentricité Tomos Study- Contribution of Tomosynthesis In Locoregional Pretherapeutic Staging of a Breast Tumor: Multicentricity Search

Condition: Mammary Tumor
Interventions: Other: Evaluation of the Tomosynthesis; Other: Avaluation of a medical device: the tomosynthesis
Sponsors: Centre Jean Perrin; Centre Jean Perrin
Recruiting - verified January 2012
Tumor Suppressor Status as a Predictor of Chemotherapy Response in Triple Negative Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Thomas Jefferson University; Thomas Jefferson University
Recruiting - verified January 2012
Relevance of T Lymphocytes Tumor Infiltrates CD8 and Foxp3 as Immune Prognostic Biomarker in Breast Cancer Treated by Neo Adjuvant Chemotherapy

Condition: Breast Cancer
Intervention: Other: immunohistochemical dectection of lymphocytes T CD8+/Foxp3 ratio
Sponsors: Centre Georges Francois Leclerc; Centre Georges Francois Leclerc
Not yet recruiting - verified January 2012
A Study of Trastuzumab Emtansine in Patients With HER2-Positive Metastatic Breast Cancer and Normal or Reduced Hepatic Function

Condition: Breast Cancer
Intervention: Drug: trastuzumab emtansine
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Phase III Study Comparing the Efficacy and Safety of LA-EP2006 and Peg-Filgrastim

Conditions: Chemotherapy-induced Neutropenia; Breast Cancer
Interventions: Drug: LA-EP2006; Drug: Peg-Filgrastim
Sponsors: Sandoz; Sandoz
Recruiting - verified January 2012
Phase III Study Comparing the Efficacy and Safety of EP2006 and Filgrastim

Conditions: Chemotherapy Associated Neutropenia; Breast Cancer
Interventions: Drug: EP2006; Drug: Filgrastim
Sponsors: Sandoz; Sandoz
Recruiting - verified March 2012
The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk (SHAPE-2)

Condition: Breast Cancer Risk
Interventions: Behavioral: Diet; Behavioral: Combined exercise- + diet-induced weight loss
Sponsors: UMC Utrecht; UMC Utrecht
Not yet recruiting - verified January 2012
External-Beam Partial-Breast Irradiation for Early Breast Cancer 40 Gy QD Over 2 Weeks

Condition: Breast Cancer
Intervention: Radiation: External Beam Partial-Breast Irradiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Brigham and Women's Hospital
Recruiting - verified May 2012
The Efficacy of Health Partnership Program for Cancer Patients

Conditions: Breast Cancer; Colon Cancer; Gastric Cancer; Lung Cancer
Interventions: Behavioral: Tailored health partnership program; Behavioral: Usual care and health education workshop
Sponsors: National Cancer Center, Korea; National Cancer Center, Korea; Samsung Medical Center; Seoul National University Hospital; Korea University Anam Hospital; Asan Medical Center; Ajou University School of Medicine; Kyunghee University Medical Center
Recruiting - verified February 2012
Phase 1b/2 Study of U3-1287 in Combination With Trastuzumab Plus Paclitaxel in Newly Diagnosed Metastatic Breast Cancer (MBC)

Condition: Metastatic Breast Cancer
Interventions: Drug: U3-1287; Drug: Trastuzumab; Drug: Paclitaxel; Drug: U3-1287; Drug: Trastuzumab; Drug: Paclitaxel; Drug: Placebo
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.; ACTIVA
Recruiting - verified January 2012
Lifestyle Intervention for High Risk Cancer Survivors

Condition: Breast Cancer
Interventions: Behavioral: Exercise Program; Behavioral: Telephone Counseling Calls; Behavioral: Standard Care; Behavioral: Health Behavior Survey
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012
Suction Drain Versus the Use of Adaptive Skin Sutures After Mastectomy ± Axillary Lymphadenectomy; a Prospective Randomised Study

Conditions: in Situ Breast Cancer; Invasive Breast Cancer
Interventions: Procedure: Insertion of suction drain(s) following mastectomy; Procedure: Adaptive skin sutures.
Sponsors: National Institute of Oncology, Hungary; National Institute of Oncology, Hungary
Recruiting - verified February 2012
The Study Evaluating Efficacy And Tolerability Of Veliparib in Combination With Temozolomide or In Combination With Carboplatin and Paclitaxel Versus Placebo in Subjects With BRCA1 and BRCA2 Mutation and Metastatic Breast Cancer.

Condition: Metastatic Breast Cancer
Interventions: Drug: Veliparib; Drug: Temozolomide; Drug: Carboplatin; Drug: Paclitaxel; Drug: Placebo
Sponsors: Abbott; Abbott
Recruiting - verified March 2012
Real Time Optical Coherence Tomography (OCT) of Human Tissue

Condition: Breast Cancer
Intervention: Device: Optical Coherence Tomography
Sponsors: Diagnostic Photonics, Inc.; Diagnostic Photonics, Inc.; University of Illinois
Not yet recruiting - verified March 2012
Effects of Web-based, Stage-matched Exercise and Diet Intervention Among Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Behavioral: Web-based Health Planner on diet and exercise; Behavioral: Non-tailored booklet on exercise and diet
Sponsors: National Cancer Center, Korea; National Cancer Center, Korea; Seoul National University; Asan Medical Center; Korea University Anam Hospital
Recruiting - verified February 2012
Integrated Molecular Profiling in Advanced Cancers Trial

Conditions: Breast Cancer; Non-small Cell Lung Cancer; Colorectal Cancer; Ovarian Cancer
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto; Princess Margaret Hospital, Canada
Recruiting - verified March 2012
Weight Variation During Chemotherapy in Breast Cancer Patients

Condition: Breast Cancer
Intervention: Other: blood test/ additional measurement
Sponsors: Centre Jean Perrin; Centre Jean Perrin
Recruiting - verified January 2012
The Role of the Novel 99mTc-NC100692 Tracer in Patients at High Risk or Known Breast Cancer

Conditions: Breast Cancer; Tumor Angiogenesis
Intervention:
Sponsors: Tel-Aviv Sourasky Medical Center; Tel-Aviv Sourasky Medical Center
Not yet recruiting - verified January 2012
Pregnant Women With a Breast Cancer Diagnosed Between 2000 and 2006

Conditions: Pregnant Women; Patients With Breast Cancer
Intervention:
Sponsors: Centre Oscar Lambret; Centre Oscar Lambret
Recruiting - verified December 2011
The Immune System's Response to Young Women's Breast Cancer

Conditions: Breast Cancer; Young Women Breast Cancer; Pregnancy Associated Breast Cancer
Intervention:
Sponsors: University of Colorado, Denver; University of Colorado, Denver
Recruiting - verified December 2011
Pre-Operative, Single-Dose Ipilimumab and/or Cryoablation in Early Stage/Resectable Breast Cancer

Conditions: Breast Cancer; Invasive Adenocarcinoma of the Breast
Interventions: Procedure: Cryoablation; Biological: Ipilimumab
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2012
Neoadjuvant Chemotherapy for Operable Premenopausal Breast Cancer Patients

Condition: Breast Cancer Nos Premenopausal
Interventions: Drug: Docetaxel; Drug: epirubicin; Drug: cyclophosphamide; Procedure: Modified radical mastectomy or breast-conserving Surgery; Drug: Docetaxel (post-operative); Drug: Epirubicin (post-operative); Drug: Cyclophosphamide (post-operative); Radiation: Radiation therapy; Drug: Herceptin （post-operative); Drug: Tamoxifen (post-operative)
Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Recruiting - verified December 2011
Part II: Exercise in Hispanic Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Behavioral: Baseline Fitness Test; Behavioral: Questionnaires; Behavioral: Individualized Exercise Program; Behavioral: Written Materials
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Irinotecan/Capecitabine Versus Capecitabine in Patients Treated With A/T for HER2 Negative Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Irinotecan, Capecitabine
Sponsors: National Cancer Center, Korea; National Cancer Center, Korea; Asan Medical Center; Chung-Ang University; Inha University Hospital; Korea University Anam Hospital; Samsung Medical Center; Severance Hospital; Seoul National University Hospital; Seoul National University Bundang Hospital
Recruiting - verified March 2012
Epigenetic Testing for Breast Cancer Risk Stratification

Condition: Breast Cancer
Intervention:
Sponsors: University of Texas Southwestern Medical Center; University of Texas Southwestern Medical Center; Department of Defense
Not yet recruiting - verified September 2011
Faslodex Specific Clinical Experience Investigation

Condition: Breast Cancer
Intervention:
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
BKM120 in Cancers With PIK3CA Activating Mutations

Conditions: Lung Cancer; Breast Cancer; Colorectal Cancer; Cholangiocarcinoma; Solid Tumors
Intervention: Drug: BKM120
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Novartis Pharmaceuticals
Recruiting - verified April 2012
Predictive Clinical and Biological Parameters in Breast Cancer

Condition: Breast Cancer
Intervention: Genetic: molecular alteration
Sponsors: Institut Paoli-Calmettes; Institut Paoli-Calmettes
Recruiting - verified January 2012
The Involvement of Breast Cancer Patients During Oncological Consultations

Condition: Breast Cancer
Interventions: Behavioral: prompt-sheet; Behavioral: control group
Sponsors: Azienda Ospedaliera Universitaria Integrata Verona; Azienda Ospedaliera Universitaria Integrata Verona
Recruiting - verified December 2011
VEGF-targeted Fluorescent Tracer Imaging in Breast Cancer

Condition: Breast Cancer
Intervention: Drug: bevacizumab-IRDye800CW
Sponsors: University Medical Centre Groningen; University Medical Centre Groningen; UMC Utrecht
Recruiting - verified March 2012
MINT I Multi- Institutional Neo-adjuvant Therapy MammaPrint Project I

Condition: Breast Cancer
Interventions: Drug: TAC chemotherapy; Drug: TC chemotherapy; Drug: Dose Dense AC or FEC100 followed by paclitaxel or docetaxel chemotherapy; Drug: TCH chemotherapy
Sponsors: Agendia; Agendia; University of South Florida; University of Miami
Recruiting - verified January 2012
Therapy to Prevent Sexual Pain in Breast Cancer Survivors

Conditions: Vulvodynia; Dyspareunia; Breast Cancer; Menopause
Intervention: Drug: Topical liquid lidocaine
Sponsors: Oregon Health and Science University; Oregon Health and Science University
Recruiting - verified February 2012
Pharmacodynamic Study of BKM120 and BEZ235 in Breast Cancer

Condition: Breast Cancer
Interventions: Drug: BKM120; Drug: BEZ235
Sponsors: Grupo Hospital de Madrid; Sofia Perea, PharmD, PhD; Novartis
Not yet recruiting - verified January 2012
Feasibility Study for the Determination of Oxysterols in Patients With Breast Cancer Receiving Hormonal Therapy With Tamoxifen or Not

Condition: Breast Cancer
Interventions: Drug: Tamoxifen,; Drug: Exemestane; Drug: Anastrozole; Drug: Letrozole
Sponsors: Institut Claudius Regaud; Institut Claudius Regaud
Recruiting - verified March 2012
Effect of Diet and Exercise in Breast Cancer Survivors

Conditions: Breast Cancer; Obesity
Intervention: Behavioral: aerobic exercise
Sponsors: West Virginia University; West Virginia University
Recruiting - verified February 2012
The Myocet/Lapatinib Study

Condition: Her2 Positive Metastatic Breast Cancer
Interventions: Drug: Myocet; Drug: Lapatinib
Sponsors: All Ireland Cooperative Oncology Research Group; All Ireland Cooperative Oncology Research Group
Recruiting - verified December 2011
Effect of a Tailored Program of Physical Activity and Nutritional Counseling on Fatigue Reduction in Breast Cancer Patients Receiving an Adjuvant Treatment

Condition: Breast Cancer
Intervention: Behavioral: Tailored program of PA and nutritional counseling
Sponsors: Centre Val d'Aurelle - Paul Lamarque; Centre Val d'Aurelle - Paul Lamarque
Recruiting - verified December 2011
Study of How Well Letrozole Works in Combination With Lapatinib Followed by an Addition of Everolimus in Postmenopausal Women With Advanced Endocrine Resistant Breast Cancer

Conditions: Breast Neoplasms; Endocrine Breast Diseases; Neoplasm Metastasis
Interventions: Drug: letrozole; Drug: lapatinib; Drug: everolimus
Sponsors: University of Maryland; University of Maryland; Novartis Pharmaceuticals; GlaxoSmithKline
Not yet recruiting - verified December 2011
HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

Condition: Breast Cancer
Interventions: Drug: HKI-272; Drug: HKI-272; Procedure: Surgical Resection
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Translational Breast Cancer Research Consortium
Recruiting - verified February 2012
A Study of Capecitabine Rapid Disintegrating Tablets (RDT) Versus Commercial Xeloda in Patients With Solid Tumours

Condition: Breast Cancer, Colorectal Cancer
Interventions: Drug: capecitabine RTD; Drug: capecitabine [Xeloda]; Drug: capecitabine [Xeloda]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified April 2012
The BEACON Study (Breast Cancer Outcomes With NKTR-102)

Conditions: Locally Recurrent Breast Cancer; Metastatic Breast Cancer
Interventions: Drug: NKTR-102; Drug: Treatment of Physician's Choice (TPC)
Sponsors: Nektar Therapeutics; Nektar Therapeutics
Recruiting - verified April 2012
Cosmetic and Functional Outcomes After Breast Conserving Surgery

Condition: Breast Cancer
Interventions: Procedure: Lumpectomy, axillary block dissection, breast conserving surgery; Other: Radiotherapy
Sponsors: National Institute of Oncology, Hungary; National Institute of Oncology, Hungary
Recruiting - verified December 2011
Study of Etoposide in Treating Patients With Recurrent or Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Etoposide
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified January 2012
Study of TS-1 as 2nd Line Treatment in Patients With Advanced Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Tegafur Gimeracil Oteracil Potassium Capsule
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified January 2012
Quantitative Subharmonic Breast Imaging

Condition: Breast Cancer
Intervention: Other: 3D HI and SHI of ultrasound contrast agent
Sponsors: Thomas Jefferson University; Thomas Jefferson University; National Cancer Institute (NCI); Lantheus Medical Imaging; University of California, San Diego
Recruiting - verified December 2011
A Study of Pertuzumab in Combination With Trastuzumab Plus an Aromatase Inhibitor in Patients With Hormone Receptor-Positive, Metastatic HER2-positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: pertuzumab; Drug: trastuzumab; Drug: Aromatase Inhibitor; Drug: Induction Chemotherapy
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
The Memorial Sloan-Kettering Cancer Center (MSKCC

Condition: Breast Cancer
Intervention: Other: no intervention : measure of score
Sponsors: Assistance Publique - Hôpitaux de Paris; Assistance Publique - Hôpitaux de Paris
Recruiting - verified December 2011
Alkaline Water in Reducing Skin Toxicity in Women With Breast Cancer Undergoing Radiation Therapy

Conditions: Radiation Toxicity; Recurrent Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Dietary Supplement: alkaline water; Dietary Supplement: distilled water; Radiation: external beam radiation therapy (EBRT)
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Integrative Approaches for Cancer Survivorship

Condition: Breast Cancer
Intervention: Behavioral: Individualized manualized Ayurvedic intervention
Sponsors: University of California, San Francisco; University of California, San Francisco; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified March 2012
Intrapartum Epidural Fentanyl and Breast-feeding in the Immediate Postpartum Period: a Prospective Cohort Study

Conditions: Maternal Anaesthesia and Analgesia Affecting Fetus or Newborn; Breast Feeding; Fentanyl; Bupivacaine; Nalbuphine
Intervention:
Sponsors: University Hospital Case Medical Center; University Hospital Case Medical Center
Recruiting - verified February 2012
Nab-paclitaxel (Abraxane) With or Without Mifepristone in Patients With Advanced Breast Cancer

Conditions: Male Breast Cancer; Recurrent Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: mifepristone; Drug: placebo; Drug: nab-paclitaxel
Sponsors: University of Chicago; Rita Nanda
Recruiting - verified December 2011
A Phase II Neo-adjuvant Study Assessing TCH (Docetaxel, Carboplatin and Trastuzumab), TCL (Docetaxel, Carboplatin and Lapatinib) and the Combination of TCHL (Docetaxel,Carboplatin, Trastuzumab and Lapatinib) in HER-2 Positive Breast Cancer Patients.

Condition: Breast Cancer
Interventions: Drug: Docetaxel, Carboplatin and Trastuzumab; Drug: Docetaxel, Carboplatin and Lapatinib; Drug: Docetaxel, Carboplatin, Trastuzumab and Lapatinib
Sponsors: All Ireland Cooperative Oncology Research Group; All Ireland Cooperative Oncology Research Group
Recruiting - verified December 2011
The Significance of MRI in the Development of Diagnostics and Treatment of Breast Cancer

Condition: Mammary Ductal Carcinoma
Intervention:
Sponsors: Turku University Hospital; Turku University Hospital
Recruiting - verified November 2011
Patient Factors Impacting Adherence to Oral Chemotherapy

Conditions: Breast Cancer; Gastrointestinal Cancer
Intervention: Behavioral: questionnaire and interview
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2012
Understanding Patient Perspectives on the Risks of Ionizing Radiation Used for Medical Imaging

Conditions: Breast Cancer; Colon Cancer; Lung Cancer; Neuroblastoma; Testicular Cancer
Interventions: Behavioral: Focus Group Sessions; Behavioral: Focus Group Sessions; Behavioral: Focus Group Sessions; Behavioral: Focus Group Sessions; Behavioral: Focus Group Sessions; Behavioral: Focus Group Sessions
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2012
Effectiveness and Toxicity of Gemcitabine/Lobaplatin Versus Gemcitabine/Cisplatin as Second-line Treatment in Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: lobaplatin; Drug: cisplatin
Sponsors: Harbin Medical University; Harbin Medical University
Recruiting - verified January 2012
Study of Vitamin D Supplementation Tailored to Vitamin D Deficiency in Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: calcium and cholecalciferol; Drug: calcium and cholecalciferol
Sponsors: Centre Val d'Aurelle - Paul Lamarque; Centre Val d'Aurelle - Paul Lamarque
Recruiting - verified November 2011
A Study of Oral Rucaparib in Patients With gBRCA Mutation Breast or Ovarian Cancer, or Other Solid Tumor

Conditions: Metastatic Solid Tumor; Breast Cancer; Ovarian Cancer
Intervention: Drug: Rucaparib
Sponsors: Clovis Oncology, Inc.; Clovis Oncology, Inc.
Recruiting - verified May 2012
Imaging Study for FdCyd and THU Cancer Treatment

Conditions: Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms
Interventions: Drug: Tetrahydrouridine (THU); Drug: [F-18]-5-FLUORO-2'-DEOXYCYTIDINE
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified October 2011
Trastuzumab in Combination With AMG 479 in HER-2 Overexpressing MBC Progressing on Trastuzumab

Condition: Breast Cancer
Interventions: Drug: AMG 479; Drug: Trastuzumab
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Amgen
Not yet recruiting - verified November 2011
Efficacy and Safety Study of NeuVax(TM) Vaccine to Prevent Breast Cancer Recurrence

Condition: HER2 Negative Breast Cancer
Interventions: Biological: NeuVax vaccine; Biological: Leukine (sargramostim, GM-CSF) and water for injection
Sponsors: Galena Biopharma, Inc.; Galena Biopharma, Inc.
Recruiting - verified May 2012
Veliparib With Radiation Therapy in Patients With Inflammatory or Loco-regionally Recurrent Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Veliparib; Radiation: Standard radiation treatment
Sponsors: University of Michigan Cancer Center; University of Michigan Cancer Center
Not yet recruiting - verified November 2011
NBRST: Prospective Neo-adjuvant REGISTRY Trial

Condition: Breast Cancer
Interventions: Device: MammaPrint; Device: BluePrint; Device: TargetPrint; Device: TheraPrint
Sponsors: Agendia; Agendia
Recruiting - verified April 2012
GRN1005 Alone or in Combination With Trastuzumab in Breast Cancer Patients With Brain Metastases

Conditions: Breast Cancer; Brain Metastases
Interventions: Drug: GRN1005; Drug: Trastuzumab
Sponsors: Geron Corporation; Geron Corporation
Recruiting - verified May 2012
Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Lapatinib; Drug: Metformin
Sponsors: Fondazione Michelangelo; Fondazione Michelangelo
Recruiting - verified November 2011
Omega-3 Fatty Acids in Preventing Joint Symptoms in Patients With Stage I-III Breast Cancer Receiving Anastrozole, Exemestane, or Letrozole

Conditions: Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Dietary Supplement: omega-3 fatty acid; Other: placebo; Procedure: quality-of-life assessment; Procedure: assessment of therapy complications; Procedure: magnetic resonance imaging; Other: laboratory biomarker analysis; Other: questionnaire administration
Sponsors: Ohio State University Comprehensive Cancer Center; Maryam Lustberg; Cancer and Leukemia Group B; Alliance
Recruiting - verified May 2012
Electrochemotherapy For The Treatment Of Breast Cancer That Has Spread to the Skin

Conditions: Breast Cancer; Skin Metastases
Intervention: Drug: Electrochemotherapy
Sponsors: Uppsala University Hospital; Uppsala University Hospital
Recruiting - verified November 2011
Vitamin D and Breast Cancer in Obesity: Therapeutic Trials

Condition: Breast Cancer
Interventions: Drug: Vitamin D3; Drug: Vitamin D3
Sponsors: Stanford University; Robert Carlson
Recruiting - verified December 2011
Examining a Common Complaint of Women Who Receive Chemotherapy for Breast Cancer- Cognitive Difficulty

Conditions: Breast Cancer; Neurocognitive Impairment; Quality of Life
Intervention: Other: Neurocognitive impairment observation
Sponsors: Virginia Commonwealth University; Virginia Commonwealth University; National Institute of Nursing Research (NINR)
Not yet recruiting - verified March 2012
Neuropsychologic and Electrophysiological Features of Cancer-Related Cognitive Side Effects in Racial and Ethnic Minority Breast Cancer Patients

Condition: Breast Cancer
Interventions: Other: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire; Other: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire; Other: EEG, Neuropsychological Evaluation, Psychological Questionnaires, Medical Questionnaire
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; The City College of New York; Ralph Lauren Center for Cancer Care and Prevention; Lincoln Hospital
Recruiting - verified November 2011
Evaluation of Specific Biomarkers in Primary Invasive Breast Cancer

Condition: Primary Invasive Breast Cancer
Intervention:
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Not yet recruiting - verified May 2012
Phase II Short-term Adjuvant Therapy and Biomarker Studies With Targeted Agents in Women With Estrogen Receptor Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Metformin; Other: Placebo
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Susan G. Komen Breast Cancer Foundation
Not yet recruiting - verified February 2012
The Young Women's Breast Cancer Study

Condition: Breast Cancer
Intervention:
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute
Recruiting - verified November 2011
Health Information Technology (HIT) Enhanced Family History Documentation and Management in Primary Care

Conditions: Colorectal Cancer; Breast Cancer; Coronary Heart Disease; Diabetes
Intervention: Other: risk assessment survey; decision support for providers for prevention based on risk
Sponsors: Brigham and Women's Hospital; Brigham and Women's Hospital
Not yet recruiting - verified May 2012
Donepezil Hydrochloride in Treating Cognitive Dysfunction After Chemotherapy in Female Breast Cancer Survivors

Conditions: Anxiety Disorder; Breast Cancer; Cancer Survivor; Cognitive/Functional Effects; Depression; Fatigue; Sleep Disorders
Interventions: Drug: donepezil hydrochloride; Other: placebo
Sponsors: National Cancer Institute (NCI); Wake Forest University; National Cancer Institute (NCI)
Not yet recruiting - verified November 2011
Clinical and Biological Predictors of Chemotherapy Toxicity in Older Adults

Condition: Breast Cancer
Intervention:
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Institutes of Health (NIH); National Institute on Aging (NIA)
Recruiting - verified November 2011
Trial of Neoadjuvant Endostar, Docetaxel and Epirubicin for Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: docetaxel and epirubicin; Drug: docetaxel and epirubicin plus endostatin
Sponsors: Xijing Hospital; Xijing Hospital
Recruiting - verified November 2011
Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Older Patients With Metastatic Breast Cancer

Conditions: Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: paclitaxel albumin-stabilized nanoparticle formulation; Other: questionnaire administration
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Reversing Hormone Resistance in Advanced Breast Cancer With Pazopanib

Conditions: Breast Cancer; Breast Neoplasm
Intervention: Drug: Pazopanib
Sponsors: University of California, San Francisco; Hope Rugo, MD; GlaxoSmithKline
Recruiting - verified April 2012
An Observational Study of Avastin (Bevacizumab) in Patients With HER2-metastatic or Locally Advanced Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified October 2011
Evaluation of Beauty Care Before Chemotherapy in Women With Breast Cancer

Condition: Breast Cancer
Intervention: Other: beauty care
Sponsors: Institut Gustave Roussy; Institut Gustave Roussy
Recruiting - verified October 2011
Breast and Abdominal Related Morbidity of DIEP and SIEA Flaps

Conditions: DIEP Flap Breast Reconstruction; SIEA Flap Breast Reconstruction
Interventions: Procedure: DIEP flap breast reconstruction; Procedure: SIEA flap breast reconstruction
Sponsors: University of Manitoba; University of Manitoba; Keeping Abreast Charity
Recruiting - verified April 2012
Vascular and Cognitive Assessments in Patients With Breast Cancer Undergoing Chemotherapy After Surgery

Conditions: Cognitive/Functional Effects; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Procedure: ultrasound imaging; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: quality-of-life assessment; Procedure: magnetic resonance imaging
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified February 2012
Neoadjuvant Paclitaxel Versus BIBF 1120 Priming Followed by BIBF 1120 Plus Paclitaxel in Early HER-2 Negative Breast Cancer With Proteomic and Dynamic Imaging Correlates

Condition: Breast Cancer
Interventions: Drug: BIBF + Paclitaxel; Drug: Paclitaxel
Sponsors: Centro Nacional de Investigaciones Oncologicas CARLOS III; Centro Nacional de Investigaciones Oncologicas CARLOS III; Hospital Universitario Fuenlabrada; M.D. Anderson Cancer Center; Hospital Universitari de Bellvitge; Grupo Espanol de Investigacion del Cancer de Mama
Recruiting - verified November 2011
Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia

Conditions: Adult Acute Lymphoblastic Leukemia; Adult Acute Myeloid Leukemia; Adult Burkitt Lymphoma; Adult Diffuse Large Cell Lymphoma; Adult Diffuse Mixed Cell Lymphoma; Adult Diffuse Small Cleaved Cell Lymphoma; Adult Hodgkin Lymphoma; Adult Immunoblastic Large Cell Lymphoma; Adult Lymphoblastic Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Breast Cancer; Chronic Eosinophilic Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Cutaneous T-cell Non-Hodgkin Lymphoma; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Grade 1 Follicular Lymphoma; Grade 2 Follicular Lymphoma; Grade 3 Follicular Lymphoma; Malignant Testicular Germ Cell Tumor; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Multiple Myeloma; Mycosis Fungoides/Sezary Syndrome; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neutropenia; Nodal Marginal Zone B-cell Lymphoma; Ovarian Epithelial Cancer; Ovarian Germ Cell Tumor; Plasma Cell Neoplasm; Poor Prognosis Metastatic Gestational Trophoblastic Tumor; Primary Myelofibrosis; Prolymphocytic Leukemia; Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma
Intervention: Drug: cefepime hydrochloride
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified November 2011
An Open-Label, Multicenter, Extension Study of NKTR-102 in Subjects Previously Enrolled in NKTR-102 Studies

Conditions: Malignant Solid Tumour; Breast Cancer; Ovarian Cancer; Colorectal Cancer
Intervention: Drug: NKTR-102
Sponsors: Nektar Therapeutics; Nektar Therapeutics
Available - verified April 2012
Exercise, Diet, and Counseling in Improving Weight Loss in Overweight Women Who Are Breast or Colorectal Cancer Survivors

Conditions: Anxiety Disorder; Breast Cancer; Cancer Survivor; Cognitive/Functional Effects; Colorectal Cancer; Depression; Fatigue; Pain; Psychosocial Effects of Cancer and Its Treatment; Weight Changes
Interventions: Behavioral: behavioral dietary intervention; Behavioral: compliance monitoring; Behavioral: exercise intervention; Genetic: DNA methylation analysis; Other: counseling intervention; Other: laboratory biomarker analysis; Other: preventative dietary intervention; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Neoadjuvant Trial of Eribulin Followed by Dose Dense Doxorubicin and Cyclophosphamide for Her2-negative, Locally Advanced Breast Cancer

Conditions: Breast Neoplasms; Breast Cancer; Breast Tumors; Cancer of the Breast; Neoplasms, Breast; Tumors, Breast
Interventions: Drug: Eribulin; Drug: Doxorubicin; Drug: Cyclophosphamide
Sponsors: Emory University; Emory University; Eisai Inc.
Recruiting - verified December 2011
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212

Condition: Breast Cancer
Intervention: Drug: GSK1120212
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; GlaxoSmithKline
Recruiting - verified February 2012
Patient Preferences for Breast Reconstruction After Mastectomy

Condition: Breast Cancer
Intervention:
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI); North Carolina TraCS Institute
Not yet recruiting - verified December 2011
Lipo-dox and Cyclophosphamide /5-Fluorouracil in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Lipo-Dox
Sponsors: TTY Biopharm; TTY Biopharm
Recruiting - verified October 2011
Effects of a Supervised Progressive Resistance Training With Breast Cancer Patients During Adjuvant Radiotherapy

Conditions: Breast Cancer; Cancer-related Fatigue
Interventions: Other: Supervised progressive resistance training; Other: Supervised progressive muscle relaxation training (Jacobsen method)
Sponsors: German Cancer Research Center; German Cancer Research Center; Heidelberg University Hospital; National Center for Tumor Diseases, Heidelberg
Recruiting - verified November 2011
A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab

Conditions: Locally Advance Breast Cancer (LABC); Metastatic Breast Cancer (MBC)
Interventions: Drug: BEZ235 + Trastuzumab Phase l/Phase ll); Drug: Lapatinib + Capecitabine (Phase II)
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Resource-sparing Post-mastectomy Radiotherapy in Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: Radiotherapy; Radiation: Irradiation of the chest-wall and supraclavicular fossa
Sponsors: International Atomic Energy Agency; International Atomic Energy Agency; International Network for Cancer Treatment and Research
Recruiting - verified October 2011
A Safety Study of MM-121 With Cetuximab and Irinotecan in Patients With Advanced Cancers

Conditions: Colorectal Cancer; Squamous Cell Head and Neck Cancer; Non-small Cell Lung Cancer; Triple Negative Breast Cancer; Other Tumors With EGFR Dependence
Interventions: Drug: MM-121 (SAR256212); Drug: Irinotecan; Drug: Cetuximab
Sponsors: Merrimack Pharmaceuticals; Merrimack Pharmaceuticals; Sanofi-Aventis
Recruiting - verified January 2012
Peer Navigator Education in Improving Survivorship Care in African American Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Other: educational intervention; Other: questionnaire administration; Other: counseling intervention; Other: survey administration; Procedure: quality-of-life assessment
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified May 2012
Intestine Bacteria and Breast Cancer Risk

Conditions: Breast Cancer; Microbiota; Estrogens
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified July 2011
Neoviderm in the Prevention of Radiation Dermatitis

Conditions: Breast Cancer; Head and Neck Cancer
Interventions: Other: Aveeno cream and Flamazine cream; Other: Neoviderm cream; Other: Aveeno cream and Flamazine cream; Other: Neoviderm cream
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Sir Mortimer B. Davis - Jewish General Hospital; Avario Healthcare Inc.
Recruiting - verified April 2012
Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer

Conditions: Inoperable Locally Advanced Breast Cancer; Metastatic Breast Cancer (MBC)
Intervention: Drug: BEZ235 + Paclitaxel
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer

Conditions: Breast Cancer; Ovarian Cancer
Interventions: Drug: AZ2281; Drug: Carboplatin
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified July 2011
Phase IV Trial to Evaluate Breast Brachytherapy Using the Mammosite-Ml®

Conditions: Breast Cancer; Ductal Carcinoma in Situ
Interventions: Device: Mammosite ML; Device: Mammosite ML
Sponsors: St. John's Mercy Research Institute, St. Louis; St. John's Mercy Research Institute, St. Louis
Recruiting - verified October 2011
111 Indium CHX-A DTPA Trastuzumab (Indium-Herceptin) for Imaging Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: 111 Indium CHX-A DTPA-Trastuzumab; Drug: 111Indium Trastuzumab
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified April 2012
Efficacy and Safety of Chloroquine in Combination With Taxane or Taxane-like Chemotherapy in the Treatment of Advanced or Metastatic Breast Cancer Patients Who Have Failed an Anthracycline

Conditions: Breast Neoplasms; Breast Cancer
Interventions: Drug: Taxane; Drug: Taxotere; Drug: Abraxane; Drug: Ixabepilone
Sponsors: The Methodist Hospital System; The Methodist Hospital System
Recruiting - verified September 2011
Post-marketing Surveillance for the Clinical Safety and Effectiveness of Eribulin Mesilate in Patients With Inoperable or Recurrent Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Eribulin Mesylate
Sponsors: Eisai Inc.; Eisai Co., Ltd.
Recruiting - verified October 2011
A Randomized Controlled Trial of Routine Shave Margins Versus Standard Partial Mastectomy in Breast Cancer Patients

Condition: Breast Cancer
Interventions: Procedure: Shave margins; Procedure: No Shave Margins
Sponsors: Yale University; Yale University
Recruiting - verified November 2011
Assessment of Quality of Life in Patients With Symptomatic Chemotherapy-induced Anaemia

Conditions: Anemia; Breast Cancer; Cancer; Colorectal Cancer; Lung Cancer; Ovarian Cancer; Prostate Cancer; Solid Tumors
Intervention:
Sponsors: Amgen; Amgen
Recruiting - verified April 2012
A Study of Adoptive Immunotherapy With Autologous Tumor Infiltrating Lymphocytes in Solid Tumors

Conditions: Nasopharyngeal Carcinoma; Hepatocellular Carcinoma; Breast Carcinoma
Intervention: Biological: tumor infiltrating lymphocytes, IL-2
Sponsors: Sun Yat-sen University; Sun Yat-sen University
Recruiting - verified November 2011
Lux-Breast 3; Afatinib Alone or in Combination With Vinorelbine in Patients With Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer Suffering From Brain Metastases

Conditions: Breast Neoplasms; Neoplasm Metastasis
Interventions: Drug: afatinib; Drug: afatinib; Drug: Vinorelbine; Drug: Investigator's choice of treatment
Sponsors: Boehringer Ingelheim Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified May 2012
Dose Finding Study of RAD001 (Everolimus, Afinitor®) in Combination With BEZ235 in Patients With Advanced Solid Tumors

Conditions: Advanced Solid Tumors; Metastatic Breast Cancer; Metastatic Renal Cell Carcinoma
Intervention: Drug: RAD001 + BEZ235
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
Collection of Blood From Cancer Patients for Genetic Analysis

Conditions: Prostate Cancer; Breast Cancer; Lung Cancer; Ovarian Cancer; Lymphoma
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Rural Women Connecting for Better Health

Conditions: Breast Cancer; Obesity
Interventions: Behavioral: Group phone counseling; Behavioral: Newsletter
Sponsors: University of Kansas; Christie Befort, PhD; National Cancer Institute (NCI)
Recruiting - verified April 2012
TARGeted Intraoperative radioTherapy With INTRABEAM as a Boost for Breast Cancer - A Quality Control Registry

Condition: Breast Cancer
Intervention: Radiation: IORT with 50 kV x-rays, 20 Gy
Sponsors: University Hospital Mannheim; University Hospital Mannheim
Recruiting - verified September 2011
Cabozantinib in Women With Metastatic Hormone-Receptor-Positive Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Cabozantinib
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Exelixis
Recruiting - verified January 2012
Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer

Conditions: Breast Cancer; Cancer Survivor; Hot Flashes
Interventions: Drug: magnesium oxide; Other: placebo
Sponsors: National Cancer Institute (NCI); North Central Cancer Treatment Group; National Cancer Institute (NCI)
Not yet recruiting - verified January 2012
Decision Support for Women With Breast Cancer

Condition: Breast Neoplasms
Intervention: Behavioral: Decision control preference scale
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified October 2011
Pilot Study of Patient's Adherence to TYKERB™/TYVERB™ + Capecitabine in Metastatic Breast Cancer

Condition: Neoplasms, Breast
Intervention: Other: non-drug intervention educational programme
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Not yet recruiting - verified November 2011
Letrozole in Treating Postmenopausal Women With Ductal Carcinoma in Situ

Condition: Breast Cancer
Interventions: Drug: letrozole; Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: breast imaging study; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: neoadjuvant therapy; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Trial of Neoadjuvant EndoTAG-1 in Combination With Paclitaxel in HER2-negative Breast Cancer

Condition: Breast Cancer
Intervention: Drug: EndoTAG-1
Sponsors: Jules Bordet Institute; Jules Bordet Institute
Recruiting - verified February 2012
An Observational Study to Register the Incidence of Breast Cancer and Current Clinical Care Patterns in Kenya

Condition: Breast Cancer
Intervention:
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Eribulin in Combination With Capecitabine for Adjuvant Treatment in Estrogen Receptor-Positive Early Stage Breast Cancer

Conditions: Estrogen Receptor Positive Tumor; Breast Cancer
Intervention: Drug: E7389 (eribulin mesylate) and capecitabine
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified April 2012
TKM 080301 for Primary or Secondary Liver Cancer

Conditions: Colorectal Cancer With Hepatic Metastases; Pancreas Cancer With Hepatic Metastase; Gastric Cancer With Hepatic Metastase; Breast Cancer With Hepatic Metastase; Ovarian Cancer With Hepatic Metastase
Intervention: Drug: TKM-080301
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified February 2012
Early Detection of Cardiac Toxicity of Trastuzumab (Herceptin ®) in Patients Treated for Breast Carcinoma: Value of Magnetic Resonance Imaging

Conditions: Cancer, Breast; LV Dysfunction
Intervention: Other: Cardiac MRI
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse
Recruiting - verified May 2012
Comparison of Diagnostic Performance of an Algorithm and a High Definition Classical Iterative Algorithm Positron Emission Tomography (PET) to 18Fluoro-deoxy-glucose (18FDG) in the Evaluation of Axillary Lymph Node Invasion of Breast Tumors

Condition: Breast Cancer
Intervention:
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse
Recruiting - verified May 2012
Study of the Response to a Neoadjuvant Chemotherapy Based on the Antitumor Immune Response in Localized Breast Cancer

Condition: Breast Cancer
Intervention: Biological: Blood and tumor sample
Sponsors: Centre Leon Berard; Centre Leon Berard
Recruiting - verified April 2012
Entinostat and Lapatinib Ditosylate in Patients With Locally Recurrent or Distant Relapsed Metastatic Breast Cancer Previously Treated With Trastuzumab

Condition: Breast Cancer
Interventions: Drug: entinostat; Drug: lapatinib ditosylate; Genetic: protein expression analysis; Other: circulating tumor cell analysis; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Triple Negative Breast Cancer: Study of Molecular and Genetic Factors

Condition: Breast Cancer
Intervention: Genetic: BRCA1 BRCA2 PTEN PALB2 mutation
Sponsors: Institut Paoli-Calmettes; Institut Paoli-Calmettes
Recruiting - verified April 2012
A Study of Eribulin Mesylate With Trastuzumab for Advanced or Recurrent Human Epiderma Growth Factor Receptor 2-Positive (HER2+) Breast Cancer

Condition: Breast Cancer
Intervention: Drug: E7389
Sponsors: Eisai Inc.; Eisai Co., Ltd.
Recruiting - verified March 2012
Study of MEDI-573 Plus Standard Endocrine Therapy for Women With Hormone-sensitive Metastatic Breast Cancer

Condition: Hormone-sensitive, HER-2 Negative Metastatic Breast Cancer
Interventions: Drug: MEDI-573; Drug: Aromatase Inhibitor
Sponsors: MedImmune LLC; MedImmune LLC
Recruiting - verified April 2012
Efficacy and Safety of DLBS1425 as Neoadjuvant in Stage II or III Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: DLBS1425; Drug: Placebo DLBS1425
Sponsors: Dexa Medica Group; Dexa Medica Group
Recruiting - verified April 2012
Dual-energy Contrast-enhanced (2D and 3D Mammography Versus Contrast-enhanced MRI)- A Pilot Study

Condition: Breast Cancer
Intervention:
Sponsors: Hologic, Inc.; Hologic, Inc.
Recruiting - verified September 2011
Primary Chemotherapy With Anthracycline Followed by Nab-paclitaxel and Trastuzumab

Conditions: Breast Cancer; HER-2 Positive Breast Cancer; Effects of Chemotherapy
Intervention: Drug: Nab-paclitaxel
Sponsors: Osaka Medical College; Osaka Medical College
Recruiting - verified September 2011
Systemic Dickkopf-related Protein 1 (DKK1)During Estrogen Level Changes in Post-menopausal Breast Cancer Patients Treated With Aromatase Inhibitors

Condition: Breast Cancer
Intervention:
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified March 2012
Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Patients Resistant to Aromatase Inhibitor Therapy

Condition: Breast Cancer
Interventions: Drug: fulvestrant; Drug: GDC-0941; Drug: GDC-0980; Drug: placebo
Sponsors: Genentech; Genentech
Recruiting - verified April 2012
Inflammatory Response and Tissue Fibrosis/ Lymphatico-venous Bypass

Conditions: Breast Cancer; Genitourinary Cancer; Malignant Female Reproductive System Neoplasm; Melanoma; Sarcoma
Intervention: Procedure: Punch Biopsy
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Department of Defense
Recruiting - verified March 2012
Study of Aspirin in the Exemestane to Adjuvant Treatment of Breast Cancer

Condition: Breast Neoplasms
Interventions: Drug: aspirin; Drug: Exemestane
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified September 2011
Prospective Analysis of Symptoms and Lymphedema in Patients Following Treatment for Breast Cancer

Condition: Lymphedema
Intervention:
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified January 2012
Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy

Conditions: Breast Cancer; Heart Failure
Interventions: Drug: Metoprolol; Drug: Placebo; Drug: Candesartan; Drug: Placebo
Sponsors: University Hospital, Akershus; University Hospital, Akershus; University of Oslo; Norwegian Cancer Society; AstraZeneca
Recruiting - verified September 2011
FDG-PET/CT for Simulation and Radiation Treatment Planning of Early Breast Cancer

Condition: Breast Neoplasm
Intervention:
Sponsors: University Hospital, Geneva; University Hospital, Geneva
Recruiting - verified September 2011
A Study of Ramucirumab (IMC-1121B) in Combination With Eribulin Versus Eribulin Alone in Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Biological: Ramucirumab (IMC-1121B); Drug: Eribulin
Sponsors: ImClone LLC; ImClone LLC
Recruiting - verified May 2012
Breast Cancer and Exercise Trial in Alberta

Condition: Breast Neoplasms
Interventions: Other: Volume of Exercise; Moderate or High Volume; Other: Aerobic Exercise; Other: Aerobic Exercise
Sponsors: Alberta Health Services; Alberta Health Services
Recruiting - verified September 2011
Multi-level Evaluation of Chemotherapy-induced Febrile Neutropenia Prophylaxis, Outcomes, and Determinants With Granulocyte-colony Stimulating Factor

Conditions: Febrile Neutropenia; Cancer; Breast Cancer; Ovarian Cancer; Lung Cancer; Prostate Cancer; Multiple Myeloma; Bladder Cancer; B-cell Lymphoma
Intervention:
Sponsors: Sandoz; Sandoz
Recruiting - verified October 2011
Efficacy and Safety Study of Trastuzumab and Paclitaxel Based Regimens to Treat HER2-positive Breast Cancer

Condition: HER-2 Positive Breast Cancer
Interventions: Drug: Trastuzumab; Drug: Paclitaxel; Drug: Epirubicin; Drug: Carboplatin
Sponsors: Fudan University; Zhimin Shao; Roche Pharma AG
Recruiting - verified September 2011
Patient Controlled Tissue Expansion for Breast Reconstruction

Condition: Breast Cancer
Interventions: Device: AeroForm Patient Controlled Tissue Expander; Procedure: Implantation of Saline Tissue Expander
Sponsors: AirXpanders, Inc.; AirXpanders, Inc.
Recruiting - verified April 2012
Non-Invasive Imaging for Cording in Breast Cancer Patients

Condition: Breast Cancer
Intervention: Other: Non invasive venous ultrasound
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified April 2012
A Prospective Cohort Study to Evaluate the Oncotype DX® Test in Early Stage Breast Cancer

Condition: Breast Cancer
Intervention: Genetic: ONCOTYPEDX Test
Sponsors: Ontario Clinical Oncology Group (OCOG); Ontario Clinical Oncology Group (OCOG); Ontario Ministry of Health and Long Term Care
Recruiting - verified May 2012
Fluocinonide Cream in Treating Symptoms of Vaginal Dryness and Painful Sexual Intercourse In Patients With Breast Cancer Undergoing Hormone Therapy

Condition: Breast Cancer
Interventions: Other: questionnaire administration; Drug: fluocinonide cream; Procedure: management of therapy complications
Sponsors: OHSU Knight Cancer Institute; OHSU Knight Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified April 2012
A Trial of Preoperative MM-121 With Paclitaxel in HER2-negative Breast Cancer

Conditions: ER Positive, Her2 Negative Breast Cancer Patients; Triple Negative Breast Cancer Patients
Interventions: Drug: MM-121 (SAR256212) plus paclitaxel; Drug: Paclitaxel
Sponsors: Merrimack Pharmaceuticals; Merrimack Pharmaceuticals; Sanofi-Aventis
Recruiting - verified April 2012
Combination of Weekly Paclitaxel With Neratinib and Trastuzumab in Women With Metastatic HER2-positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Paclitaxel; Biological: trastuzumab; Drug: Neratinib
Sponsors: National Surgical Adjuvant Breast and Bowel Project (NSABP); National Surgical Adjuvant Breast and Bowel Project (NSABP); Pfizer
Recruiting - verified March 2012
Collection of Efficacy and Safety Data of Chinese Patients Who Have Received Faslodex 250mg Treatment

Condition: Breast Cancer
Intervention:
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012
Pre-Operative Study of PF-4691502 With Letrozole Compared To Letrozole Alone In Patients With Early Breast Cancer

Conditions: Early Breast Cancer (Phase 2); Advanced Breast Cancer (Phase 1b)
Interventions: Drug: PF-04691502; Drug: PF-04691502 in combination with Letrozole; Drug: Letrozole
Sponsors: Pfizer; Pfizer
Not yet recruiting - verified May 2012
The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction

Conditions: Breast Neoplasms; Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases
Interventions: Drug: Botulinum Toxin Type A; Drug: 0.9% Sodium Chloride
Sponsors: University of British Columbia; University of British Columbia; Vancouver Coastal Health; Providence Health & Services
Recruiting - verified January 2012
Identification of Genes That Predict Local Recurrence in Samples From Patients With Breast Cancer Treated on NSABP-B-28

Condition: Breast Cancer
Interventions: Genetic: RNA analysis; Genetic: gene expression analysis; Genetic: microarray analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Not yet recruiting - verified August 2011
High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma

Condition: Breast Fibroadenoma
Intervention: Device: Ultrasonic ablation device
Sponsors: Theraclion; Theraclion
Recruiting - verified April 2012
Addition of Carboplatin to Neoadjuvant Therapy for Triple-negative and HER2-positive Early Breast Cancer

Conditions: Tubular Breast Cancer Stage II; Mucinous Breast Cancer Stage II; Breast Cancer Female NOS; Invasive Ductal Breast Cancer; Tubular Breast Cancer Stage III; HER-2 Positive Breast Cancer; Inflammatory Breast Cancer Stage IV; Inflammatory Breast Cancer
Interventions: Drug: Carboplatin; Drug: background treatment according to standards fpr triple negative and Her2pos breast cancer patients
Sponsors: German Breast Group; German Breast Group; Cephalon; Roche Pharma AG; GlaxoSmithKline
Recruiting - verified February 2012
Toll-like Receptor (TLR) 7 Agonist and Radiotherapy for Breast Cancer With Skin Metastases

Conditions: Breast Cancer; Metastatic Breast Cancer; Recurrent Breast Cancer
Interventions: Radiation: Radiation; Drug: Imiquimod
Sponsors: New York University School of Medicine; New York University School of Medicine; National Cancer Institute (NCI)
Recruiting - verified April 2012
Promoting a Healthier Lifestyle Among Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Behavioral: Motivational Interviewing; Behavioral: Counseling
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Department of Defense
Recruiting - verified January 2012
A Study of Trastuzumab Emtansine in Comparison With Treatment of Physician's Choice in Patients With HER2-Positive Breast Cancer Who Have Received at Least Two Prior Regimens of HER2-Directed Therapy (TH3RESA)

Condition: Breast Cancer
Interventions: Drug: trastuzumab emtansine; Drug: anti-cancer therapy
Sponsors: Genentech; Genentech
Recruiting - verified March 2012
A Study of LY2523355 in Patients With Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: LY2523355; Drug: Ixabepilone; Drug: pegfilgrastim; Drug: filgrastim
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012
Nab-paclitaxel in Metastatic Breast Cancer Patients Failing Solvent Based Taxane (Tiffany)

Condition: Metastatic Breast Cancer
Intervention: Drug: Nab-Paclitaxel
Sponsors: German Breast Group; German Breast Group
Recruiting - verified August 2011
A Clinical Trial in Patients With BRCA Defective Tumours

Conditions: Breast Cancer; Ovarian Cancer
Interventions: Drug: 6-Mercaptopurine; Drug: Methotrexate
Sponsors: University of Oxford; University of Oxford
Recruiting - verified September 2011
Randomized Study of Hypofractionated and Conventional Fractionation Radiotherapy After Breast Conservative Surgery

Condition: Breast Cancer
Intervention: Radiation: radiotherapy
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified February 2012
AX Versus AC as Adjuvant Treatment for Node-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Doxorubicin, Cyclophosphamide; Drug: doxorubicin, Capecitabine
Sponsors: Peking Union Medical College Hospital; Peking Union Medical College Hospital
Recruiting - verified August 2011
Pilot Imaging Study With 89Zr-Trastuzumab in HER2-positive Metastatic Breast Cancer Patients

Conditions: Breast Neoplasms; Secondary; HER2 Positive Carcinoma of Breast
Intervention: Drug: Zr89-trastuzumab
Sponsors: Jules Bordet Institute; Jules Bordet Institute
Recruiting - verified August 2011
Trastuzumab Administered Concurrently or Sequentially to Anthracycline-containing Adjuvant Regimen for Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Trastuzumab, Anthracycline; Drug: Trastuzumab, anthracycline
Sponsors: Peking Union Medical College Hospital; Peking Union Medical College Hospital
Recruiting - verified August 2011
Safety and Aesthetic Outcomes of Breast Conserving Surgery With Peri-areolar Incision Approach

Condition: Breast Cancer
Interventions: Procedure: peri-areolar incision; Procedure: traditional incision
Sponsors: Peking Union Medical College Hospital; Peking Union Medical College Hospital
Recruiting - verified August 2011
Biomarkers in Tissue Samples From Patients With Newly Diagnosed Breast Cancer Treated With Zoledronic Acid

Conditions: Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; Invasive Ductal Breast Carcinoma; Progesterone Receptor-negative Breast Cancer; Progesterone Receptor-positive Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer
Interventions: Drug: zoledronic acid; Other: laboratory biomarker analysis; Procedure: therapeutic conventional surgery
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Epigenetics and Psychoneurologic Symptoms in Women With Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Virginia Commonwealth University; Virginia Commonwealth University
Recruiting - verified August 2011
Cook for Your Life

Condition: Breast Cancer
Interventions: Other: Arm A; Behavioral: Arm B
Sponsors: Columbia University; Columbia University; National Cancer Institute (NCI)
Recruiting - verified October 2011
Accelerated Radiation Therapy After Surgery in Treating Patients With Breast Cancer

Conditions: Inflammatory Breast Cancer; Invasive Ductal Breast Carcinoma; Invasive Lobular Breast Carcinoma; Mucinous Ductal Breast Carcinoma; Papillary Ductal Breast Carcinoma; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Tubular Ductal Breast Carcinoma
Intervention: Radiation: External beam radiation therapy
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; National Cancer Institute (NCI)
Recruiting - verified August 2011
Evaluation of the Predictive and Prognostic Value of Germ-line Polymorphisms in Patients With Metastatic Breast Cancer

Conditions: Breast Cancer; Metastasis
Intervention: Other: Blood sample for genetic analysis (Identification of germ line genetic factors that influence the risk of metastatic breast cancer)
Sponsors: Centre Leon Berard; Centre Leon Berard; Centre de Recherche en Cancérologie de Lyon
Recruiting - verified May 2012
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer

Conditions: Breast Cancer; Cognitive/Functional Effects; Depression; Fatigue; Pain; Psychosocial Effects of Cancer and Its Treatment; Radiation Toxicity; Skin Reactions Secondary to Radiation Therapy
Interventions: Genetic: DNA analysis; Genetic: gene expression analysis; Other: enzyme-linked immunosorbent assay; Other: flow cytometry; Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: adjuvant therapy; Procedure: assessment of therapy complications; Procedure: quality-of-life assessment; Radiation: 3-dimensional conformal radiation therapy; Radiation: breast irradiation; Radiation: external beam radiation therapy; Radiation: hypofractionated radiation therapy; Radiation: intensity-modulated radiation therapy; Radiation: whole breast irradiation
Sponsors: National Cancer Institute (NCI); Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified May 2012
Study of Arimidex and Radiotherapy Sequencing

Condition: Breast Cancer
Interventions: Drug: Pre-radiotherapy commencement of Arimidex; Drug: Post radiotherapy commencement of Arimidex; Radiation: Radiotherapy; Radiation: Radiotherapy
Sponsors: Fudan University; Fudan University; AstraZeneca
Recruiting - verified July 2011
A Study on Patients' Preference of Herceptin (Trastuzumab) Subcutaneous Versus Intravenous Administration in Patients With HER2-Positive Early Breast Cancer

Condition: Breast Cancer
Interventions: Drug: trastuzumab [Herceptin]; Drug: trastuzumab [Herceptin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Partial Breast Irradiation Using Non Invasive Machine for Early Stage Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: Accelerated partial breast irradiation
Sponsors: Brown University; Jaroslaw Hepel; The Miriam Hospital; Rhode Island Hospital
Recruiting - verified May 2012
Comparative Evaluation of Ostepathy Treatment Efficacy in Pain Support After Breast Surgery in Oncology

Condition: Breast Cancer
Interventions: Other: OSTEOPATHY + conventional analgesic treatments; Other: Conventional analgesic treatments
Sponsors: Centre Leon Berard; Centre Leon Berard
Recruiting - verified February 2012
Cosmetic Evaluation of Lumpectomy Versus Oncolytic Mammoplasty With Bilateral Breast Reduction for Early Stage Breast Cancer

Condition: Breast Carcinoma
Intervention:
Sponsors: New Hanover Regional Medical Center; New Hanover Regional Medical Center; National Cancer Institute (NCI); Coastal Carolina Radiation Oncology (CCRO)
Recruiting - verified August 2011
Factors Influencing Decision-Making About the Use of Chemoprevention in Women at Increased Risk for Breast Cancer

Condition: Breast Cancer
Interventions: Behavioral: telephone-based intervention; Drug: raloxifene; Drug: tamoxifen citrate; Other: communication analysis; Other: communication intervention; Other: counseling intervention; Other: educational intervention; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: psychosocial assessment and care
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Not yet recruiting - verified August 2011
Fresolimumab and Radiotherapy in Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: fresolimumab (GC1008); Drug: fresolimumab (GC1008); Radiation: Radiation Therapy
Sponsors: New York University School of Medicine; New York University School of Medicine; University of California, Los Angeles
Recruiting - verified May 2012
Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy

Condition: Metastatic Breast Cancer
Interventions: Drug: eribulin mesylate; Drug: eribulin mesylate; Drug: eribulin mesylate, trastuzumab
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Eisai Inc.
Recruiting - verified March 2012
Study of Pazopanib, Paclitaxel, and Carboplatin in Patients With Advanced Solid Tumors

Conditions: Unspecified Adult Solid Tumor - Protocol Specific; Breast Cancer - Female
Interventions: Drug: Pazopanib; Drug: Paclitaxel; Drug: Carboplatin
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; National Cancer Institute (NCI); GlaxoSmithKline
Recruiting - verified September 2011
Experience of the Patient Treated With Trastuzumab (Herceptin ®) as Adjuvant for Breast Cancer

Condition: Breast Cancer
Interventions: Other: questionnaires; Other: questionnaires
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse
Recruiting - verified July 2011
Prospective Non-randomized Evaluation of Oncoplastic Surgery

Conditions: Breast Image Scale Index for Self Esteem Evaluation; Breast Symmetry Index; Quality of Life; Morbidity; Oncological Outcome
Interventions: Procedure: Breast Surgery; Procedure: Breast Surgery
Sponsors: Medical University of Vienna; Medical University of Vienna
Recruiting - verified April 2011
Radiofrequency Ablation After Breast Lumpectomy (ABLATE)

Condition: Breast Cancer
Intervention: Procedure: Radiofrequency Ablation
Sponsors: University of Kansas; University of Kansas; Angiodynamics, Inc.
Recruiting - verified October 2011
Study of Chemotherapy With Adoptive Cellular Therapy With DC-CIK Cells in Triple Negative Breast Cancer Patients

Conditions: Breast Neoplasms; Neoplasm Metastasis
Intervention:
Sponsors: Beijing Cancer Hospital; Beijing Cancer Hospital
Recruiting - verified January 2012
ICG Fluorescence Technique for the Detection of Sentinel Lymph Nodes

Condition: Malignant Neoplasm of Breast
Intervention: Procedure: ICG Fluorescence technique
Sponsors: Pulsion Medical Systems SE; Pulsion Medical Systems SE
Not yet recruiting - verified July 2011
Effects of Controlled Ovarian Hyperstimulation (COH) With Letrozole and Gonadotropin

Conditions: Infertility; Breast Cancer
Intervention: Procedure: Random Peri-Areolar Fine Needle Aspiration (RPFNA)
Sponsors: University of Kansas; University of Kansas
Recruiting - verified July 2011
Whole Breast Irradiation With Intensity Modulated Radiotherapy and Simultaneously Integrated Boost for Early Stage Breast Cancer Patients

Condition: Breast Cancer
Intervention: Radiation: IMRT with an simultaneous integrated boost
Sponsors: Fudan University; Fudan University
Recruiting - verified June 2011
A Novel Prosocial Online Support Group for Distressed Breast Cancer Survivors

Condition: Breast Neoplasms
Interventions: Behavioral: prosocial online support group; Behavioral: Standard Online Support Group
Sponsors: Temple University; Temple University; Cancer Support Community
Not yet recruiting - verified July 2011
Diffuse Optical Tomography (DOT) for Monitoring Response to Neoadjuvant (Preoperative) Chemotherapy in Breast Cancer

Condition: Breast Neoplasms
Intervention:
Sponsors: National Cancer Centre, Singapore; National Cancer Centre, Singapore; National University, Singapore
Recruiting - verified May 2012
Diindolylmethane in Treating Patients With Breast Cancer

Conditions: Ductal Breast Carcinoma in Situ; Lobular Breast Carcinoma in Situ; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer
Interventions: Drug: diindolylmethane; Other: placebo; Other: questionnaire administration; Procedure: digital mammography; Procedure: magnetic resonance imaging; Other: biomarker analysis of blood and urine
Sponsors: University of Arizona; University of Arizona; National Cancer Institute (NCI)
Recruiting - verified May 2011
Cryoablation for Invasive Breast Carcinoma Following Neoadjuvant Therapy

Condition: Breast Cancer
Interventions: Device: Visica 2™ Treatment System; Procedure: Cryoablation; Procedure: Surgical Resection
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified January 2012
Psychosocial Adjustment of Patients and Their Partners Following Breast Cancer Diagnosis

Condition: Breast Cancer
Intervention: Behavioral: questionnaire
Sponsors: University of Southern Denmark; University of Southern Denmark; Danish Cancer Society; University Medical Centre Groningen; Rigshospitalet, Copenhagen University; University Hospital Herlev
Recruiting - verified February 2012
Study of Neoadjuvant Carboplatin, Eribulin and Trastuzumab for Operable HER2 Positive Breast Cancer

Condition: HER-2 Positive Breast Cancer
Interventions: Drug: eribulin; Drug: carboplatin; Drug: trastuzumab
Sponsors: ACORN Research, LLC; ACORN Research, LLC; Eisai Inc.
Recruiting - verified January 2012
Systemic Therapy With or Without Upfront Surgery in Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Procedure: upfront breast surgery; Other: systemic therapy
Sponsors: Jeroen Bosch Ziekenhuis; Jeroen Bosch Ziekenhuis; Borstkanker Onderzoek Groep; Comprehensive Cancer Centre The Netherlands
Recruiting - verified May 2012
Effect of Yoga in Reducing Chemotherapy Induced Nausea and Vomiting

Conditions: Breast Cancer; Malignant Female Reproductive System Neoplasm; Lymphomas; Chemotherapy-induced Nausea and Vomiting
Interventions: Behavioral: yoga; Behavioral: Jacobsons PMRT group
Sponsors: Bharath Charitable Cancer Hospital and Institute; Bharath Charitable Cancer Hospital and Institute; HCG BANGALORE INSTITUTE OF ONCOLOGY; CENTRAL COUNCIL FOR RESEARCH IN YOGA AND NATUROPATHY
Recruiting - verified December 2011
Real-Time Near-infrared (NIR) Mapping of Sentinel Lymph Nodes in Breast Cancer

Condition: Breast Cancer
Intervention: Device: NIR Imaging with FLARE and Mini-FLARE Imaging System
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center; Brigham and Women's Hospital; Dana-Farber Cancer Institute
Recruiting - verified February 2012
HYPAZ: Hypertension Induced by Pazopanib

Conditions: Renal Cell Carcinoma; Soft Tissue Sarcoma; Glioblastoma; Ovarian Cancer; Cervical Cancer; Breast Cancer; Non-small Cell Lung Cancer; Small Cell Lung Cancer; Pancreatic Cancer; Melanoma; Gastrointestinal Cancer
Intervention: Drug: Pazopanib
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; University of Cambridge; GlaxoSmithKline; Cambridge Experimental Cancer Medicine Centre
Recruiting - verified June 2011
Understanding Decision Making Processes for Undergoing Genetic Testing Among Women With Newly Diagnosed Breast Cancer

Condition: Breast Cancer
Intervention: Genetic: BRCA testing and questionnaire assessments
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified January 2012
Vaccination of High Risk Breast Cancer Patients

Condition: Stage IV Breast Cancer
Intervention: Biological: Vaccination with Mimotope P10s-PADRE/MONTANIDE ISA 51 VG
Sponsors: University of Arkansas; University of Arkansas; Department of Defense
Recruiting - verified January 2012
Omega-3-Fatty Acid Supplements in Treating Muscle and Bone Pain and Stiffness in Patients With Stage I, Stage II, or Stage III Breast Cancer Receiving Hormone Therapy

Conditions: Arthralgia; Breast Cancer; Pain
Interventions: Dietary Supplement: omega-3 fatty acid; Other: placebo
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Exercise Training in Postmenopausal Patients With Breast Cancer

Condition: Physical Activity
Interventions: Behavioral: Counseling; Behavioral: physical activity
Sponsors: Arbeitsgemeinschaft medikamentoese Tumortherapie; Arbeitsgemeinschaft medikamentoese Tumortherapie; Roche Pharma AG
Recruiting - verified June 2011
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

Conditions: Brain Metastases; Lung Cancer; Breast Cancer; Melanoma; Malignant Glioma
Intervention: Drug: 2B3-101
Sponsors: to-BBB technologies B.V.; to-BBB technologies B.V.
Recruiting - verified April 2012
Safety Study of ²¹²Pb-TCMC-Trastuzumab Radio Immunotherapy

Conditions: Breast Neoplasms; Peritoneal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Stomach Neoplasms
Interventions: Other: ²¹²Pb-TCMC-Trastuzumab; Biological: trastuzumab
Sponsors: Areva Med LLC; Areva Med LLC
Recruiting - verified January 2012
Evaluation of Effectiveness of Cell Phone Technology as Community Based Intervention to Improve Exclusive Breast Feeding

Conditions: Malnutrition in Pregnancy; Other Disorders of Breast and Lactation Associated With Childbirth
Intervention: Behavioral: Lactational Counseling by Cell phone
Sponsors: Lata Medical Research Foundation, Nagpur; Lata Medical Research Foundation, Nagpur
Recruiting - verified June 2011
Distinction Between Lung Cancer and Gynecological Cancers by Canine Scent Detection

Conditions: Lung Cancer; Breast Cancer; Ovarian Cancer
Intervention: Other: exhalation analysis of breath sample
Sponsors: Schillerhoehe Hospital; Schillerhoehe Hospital; Robert Bosch Gesellschaft für Medizinische Forschung mbH
Recruiting - verified November 2011
Investigating the Impact of Tamoxifen Therapy on Ovarian Aging

Conditions: Breast Cancer; Fertility
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified February 2012
Can Methylprednisoloneacetate Prevent Seroma After Mastectomy for Primary Breast Cancer

Condition: Breast Cancer
Intervention: Drug: methylprednisoloneacetate
Sponsors: Copenhagen University Hospital at Herlev; Copenhagen University Hospital at Herlev; University Hospital, Gentofte, Copenhagen
Recruiting - verified June 2011
Assessment of Cognitive Function in Breast Cancer and Lymphoma Patients Receiving Chemotherapy

Conditions: Breast Cancer; Lymphoma
Intervention:
Sponsors: University of Rochester; University of Rochester
Recruiting - verified July 2011
A Study of Abiraterone Acetate Plus Prednisone With or Without Exemestane in Postmenopausal Women With Estrogen Receptor-Positive (ER+) Metastatic Breast Cancer Progressing After Letrozole or Anastrozole Therapy

Conditions: Metastatic ER+ Her2- Breast Cancer; Postmenopausal
Interventions: Drug: Exemestane; Drug: Abiraterone acetate + Prednisone/ Prednisolone + Exemestane; Drug: Abiraterone acetate + Prednisone or Prednisolone
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified April 2012
Therapeutic Estradiol and Exemestane in Treating Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast Cancer

Conditions: Estrogen Receptor-positive Breast Cancer; Progesterone Receptor-positive Breast Cancer; Recurrent Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Biological: therapeutic estradiol; Drug: exemestane; Other: laboratory biomarker analysis; Other: enzyme-linked immunosorbent assay
Sponsors: University of Arizona; University of Arizona; National Cancer Institute (NCI)
Recruiting - verified May 2012
Test Uniformity of Transdermal Drug Delivery to Breast Using Diclofenac Epolamine

Condition: Breast Cancer
Intervention: Other: Diclofenac epolamine patch
Sponsors: Northwestern University; Northwestern University
Recruiting - verified May 2012
The Jewels in Our Genes Study - an African American Family Study of Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: University at Buffalo; University at Buffalo; Susan G. Komen Breast Cancer Foundation
Recruiting - verified June 2011
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study

Conditions: Colon Cancer; Breast Cancer; Trauma; Inflammatory Bowel Disease; Hernia
Intervention:
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified July 2011
High Throughput Technologies to Drive Breast Cancer Patients to Specific Phase I/II Trials of Targeted Agents

Condition: Metastatic Breast Cancer
Intervention: Other: Biopsy
Sponsors: UNICANCER; UNICANCER; Ministry of Health, France; Institut Gustave Roussy
Recruiting - verified August 2011
The Trial Comparing Dose-dense AC-T With PC as Adjuvant Therapy for TNBC

Condition: Breast Cancer
Intervention: Drug: epirubicin, cyclophosphamide, paclitaxel, carboplatin, G-CSF
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified December 2011
Exercise Controls Tumor Cell Growth Through AMPK Activation

Condition: Breast Cancer
Intervention:
Sponsors: Rigshospitalet, Denmark; Rigshospitalet, Denmark
Recruiting - verified June 2011
Allogenic Haematopoietic Cell Transplantation for Patients With Refractory "Triple Negative" Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: Radiotherapy; Biological: Anti-Thymocyte Globulin
Sponsors: European Institute of Oncology; European Institute of Oncology; Istituto Clinico Humanitas
Recruiting - verified June 2011
Doxorubicin With or Without Sildenafil, With Analysis of Cardiac Markers

Conditions: Breast Cancer; Gastrointestinal Cancer; Genitourinary Cancer; Sarcoma; Gynecologic Cancer
Interventions: Drug: Doxorubicin; Drug: Sildenafil
Sponsors: Virginia Commonwealth University; Virginia Commonwealth University
Recruiting - verified April 2012
Evaluating AlloMax in Immediate Expander-Based Breast Reconstruction Study

Conditions: Malignant Neoplasm of the Breast; Acquired Absence of the Breast
Intervention:
Sponsors: National Center for Plastic Surgery, Virginia; National Center for Plastic Surgery, Virginia; Inova Health Care Services; Ohio State University Comprehensive Cancer Center; Walter Reed Army Medical Center; C. R. Bard
Recruiting - verified August 2011
Evaluation of the Efficacy of Digital Breast Tomosynthesis Imaging

Condition: Digital Breast Tomosynthesis
Intervention: Device: SIEMENS INSPIRATION DIGITAL BREAST TOMOSYNTHESIS (DBT) SYSTEM
Sponsors: Siemens Medical Solutions USA - CSG; Siemens Medical Solutions USA - CSG
Recruiting - verified June 2011
A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins

Condition: Breast Cancer
Intervention:
Sponsors: Duke University; Duke University; National Institutes of Health (NIH)
Recruiting - verified February 2012
Multi-Compression Spot Mammography

Condition: Breast Diseases
Intervention:
Sponsors: State University of New York - Upstate Medical University; State University of New York - Upstate Medical University
Recruiting - verified December 2010
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors

Conditions: Malignant Solid Tumour; Breast Cancer; Malignant Tumor of Colon; GIST; Ovarian Cancer
Intervention: Biological: HER-2 vaccine
Sponsors: Ohio State University Comprehensive Cancer Center; Ohio State University Comprehensive Cancer Center
Recruiting - verified February 2012
Axillary Reverse Mapping

Condition: Breast Cancer
Interventions: Procedure: Injection of isotope; Procedure: Axillary lymph node dissection
Sponsors: University of Kansas; University of Kansas
Recruiting - verified October 2011
Investigation of High Resolution Nuclear Breast Imaging Camera (MBI) in Patients Administered Tc-99m Sestamibi (ROSE)

Condition: Breast Lesions
Intervention:
Sponsors: Hamilton Health Sciences Corporation; Hamilton Health Sciences Corporation
Recruiting - verified April 2012
Study Evaluating Impact of IL-7 on CD4 Lymphopenia, Risks of Severe Haematological Toxicity and Tumor Progression in Metastatic Breast Cancer Patients

Condition: Metastatic Breast Cancer
Interventions: Drug: placebo; Drug: interleukin 7; Drug: interleukin 7; Drug: interleukin 7
Sponsors: Centre Leon Berard; Centre Leon Berard; Ministry of Health, France
Recruiting - verified June 2011
Nuevo Amanecer: Promoting the Psychosocial Health of Latinas

Conditions: Breast Neoplasms; Psychology, Social
Intervention: Behavioral: Peer Support Program
Sponsors: University of California, San Francisco; University of California, San Francisco; California Breast Cancer Research Program; Circulo de Vida Cancer Support and Resource Center
Recruiting - verified January 2012
Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast Cancer

Conditions: Estrogen Receptor-positive Breast Cancer; HER2-negative Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Drug: goserelin acetate; Drug: letrozole; Drug: anastrozole; Procedure: therapeutic conventional surgery; Genetic: DNA analysis; Other: immunohistochemistry staining method; Procedure: positron emission tomography; Genetic: comparative genomic hybridization; Procedure: biopsy; Other: laboratory biomarker analysis; Drug: chemotherapy
Sponsors: Washington University School of Medicine; Washington University School of Medicine; National Cancer Institute (NCI)
Recruiting - verified March 2012
An Evaluation of a Self-contained Direct Digital Radiography System for Breast Specimen Imaging

Condition: Breast Cancer
Interventions: Device: Trident Specimen Radiography System; Device: Bioptics, Faxitron, and Full Field Digital Mammography (FFDM) Selenia
Sponsors: Levine, Gary M. , M.D.; Levine, Gary M. , M.D.; Hologic, Inc.
Recruiting - verified March 2012
Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients

Conditions: Estrogen Receptor-negative Breast Cancer; HER2-negative Breast Cancer; Male Breast Cancer; Progesterone Receptor-negative Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-negative Breast Cancer
Interventions: Drug: eribulin mesylate; Drug: carboplatin; Procedure: biopsy
Sponsors: Northwestern University; Northwestern University; Eisai Inc.
Not yet recruiting - verified June 2011
Prediction of Pain After Breast Cancer Surgery With EEG

Conditions: Breast Cancer; Postoperative Pain; Chronic Pain
Intervention:
Sponsors: Maastricht University Medical Center; Maastricht University Medical Center
Recruiting - verified August 2011
A Phase II Study of Neoadjuvant Trastuzumab+Docetaxel+NPLD+/-Bevacizumab in Her2-pos. Early Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Trastuzumab, Docetaxel; Drug: Trastuzumab, Docetaxel, Bevacizumab; Drug: Trastuzumab+Docetaxel+NPLD; Drug: Trastuzumab+Docetaxel+NPLD+Bevacizumab
Sponsors: Austrian Breast & Colorectal Cancer Study Group; Austrian Breast & Colorectal Cancer Study Group; Hoffmann-La Roche; Cephalon
Recruiting - verified April 2012
Intra-hepatic Chemotherapy in Patient With Non-resectable Liver Metastases From Breast Cancer

Conditions: Metastatic Breast Cancer; Liver Metastases
Intervention: Drug: oxaliplatin, capecitabine, trastuzumab
Sponsors: Herlev Hospital; Herlev Hospital; Odense University Hospital; Aarhus University Hospital
Recruiting - verified April 2010
Intra-hepatic Chemotherapy in Patients With Liver Metastases From Breast Cancer and Limited Extrahepatic Disease

Conditions: Metastatic Breast Cancer; Liver Metastases
Intervention: Drug: oxaliplatin, capecitabine, trastuzumab
Sponsors: Herlev Hospital; Herlev Hospital; Odense University Hospital; Aarhus University Hospital
Recruiting - verified April 2010
Integrative Oncology Outcomes Study in Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Bastyr University; Bastyr University; Fred Hutchinson Cancer Research Center; National Institutes of Health (NIH); National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified April 2012
A Study of Herceptin (Trastuzumab) in Combination With Whole Brain Radiotherapy in Patients With HER-2 Positive Breast Cancer

Condition: Breast Cancer
Intervention: Drug: trastuzumab [Herceptin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Biodistribution and Safety of the PET Probes [18F]FPRGD2 and [18F]FPPRGD2

Conditions: Breast Cancer; Non-Small-Cell Lung Cancer; Glioblastoma; Other Cancers
Intervention: Drug: FPPRGD2
Sponsors: Stanford University; Stanford University
Recruiting - verified February 2012
Treatment of Advanced Breast Cancer With Anti-Lewis Humanized mAB - Hu3S193

Condition: Breast Cancer
Intervention: Biological: Hu3S193
Sponsors: University of Sao Paulo; University of Sao Paulo; Fundação Faculdade de Medicina; Recepta Biopharma
Not yet recruiting - verified April 2011
AUY922 With Lapatinib and Letrozole for ER+ HER2+ Advanced Breast Cancer

Conditions: Breast Cancer; Metastatic Breast Cancer; HER-2 Positive Breast Cancer; ER Positive Breast Cancer
Intervention: Drug: AUY922
Sponsors: Texas Tech University Health Sciences Center; Texas Tech University Health Sciences Center
Recruiting - verified May 2012
Intrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous Meningitis

Conditions: Metastatic Breast Cancer; Carcinomatous Meningitis
Intervention: Drug: Trastuzumab
Sponsors: Institut Curie; Institut Curie; Hoffmann-La Roche; Institut Gustave Roussy; Centre Leon Berard; Groupe Hospitalier Pitie-Salpetriere; Centre Oscar Lambret; Centre Francois Baclesse; Institut Bergonié; ICO Paul Papin
Recruiting - verified June 2011
Hand in Hand. Psychological Support and Counseling to Breast Cancer Patients and Their Partners

Condition: Breast Cancer
Intervention: Behavioral: Psychological intervention
Sponsors: University of Southern Denmark; University of Southern Denmark; Odense University Hospital; Ringsted Hospital; Herlev University Hospital; Region of Southern Denmark; Danish Cancer Society
Recruiting - verified May 2012
A Study of Pertuzumab in Addition to Chemotherapy and Herceptin (Trastuzumab) as Adjuvant Therapy in Patients With HER2-Positive Primary Breast Cancer

Condition: Breast Cancer
Interventions: Drug: pertuzumab; Drug: placebo; Drug: trastuzumab [Herceptin]; Drug: Chemotherapy
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche; Breast International Group; Genentech
Recruiting - verified February 2012
Proton Therapy for Lymph Nodes in Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: Photon; Radiation: 3D-Proton/Conventional plan
Sponsors: University of Florida; University of Florida
Recruiting - verified May 2012
Molecular Imaging of Fulvestrant Effects on Availability of ER Binding Sites

Condition: Metastatic Breast Cancer
Intervention: Other: Diagnostic intervention: Positron Emission Tomography with 16-alpha-[18-fluoro]-17betaestradiol
Sponsors: University Medical Centre Groningen; University Medical Centre Groningen
Recruiting - verified May 2011
Vaccine Therapy in Combination With Ampligen® and/or Sargramostim in Patients With Stage II-IV HER2-Positive Breast Cancer

Conditions: HER2-positive Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: Ampligen; Biological: synthetic HER-2/neu peptide vaccine; Biological: GM-CSF; Other: laboratory biomarker analysis; Other: immunoenzyme technique
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients

Conditions: Breast Cancer; Depression
Interventions: Drug: Melatonin (N-acetyl-5-methoxytryptamine); Drug: Placebo
Sponsors: Herlev Hospital; Melissa Voigt Hansen; University of Copenhagen; Rigshospitalet, Denmark; Pharma Nord
Recruiting - verified March 2012
Exploratory, Phase I,Open Label,Non-randomized Study of [F18]CP-18 PET in Normal and Breast Cancer Subjects

Condition: Breast Cancer
Intervention: Radiation: [F18]CP-18 Injection
Sponsors: Siemens Molecular Imaging; Siemens Molecular Imaging
Recruiting - verified June 2011
Benefits of Breast MRI for Predicting of Histopathologic Cell Type of Small Breast Cancer

Condition: Invasive Breast Cancer
Intervention: Radiation: MRI
Sponsors: Mahidol University; Mahidol University
Recruiting - verified May 2012
Study to Assess Safety and Tolerability of Oral CC-115 for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Multiple Myeloma

Conditions: Multiple Myeloma; Non-Hodgkin's Lymphoma; Glioblastoma Multiforme; Head and Neck Squamous Cell Cancer; Triple Negative Breast Cancer; Hormone Receptor-Positive Breast Cancer; Castration-Resistant Prostate Cancer; Ewing's Family of Sarcomas
Intervention: Drug: CC-115
Sponsors: Celgene Corporation; Celgene Corporation
Recruiting - verified May 2012
The CEASE Study: Computer Based Educational Module for the Reduction of Arthralgia Syndrome Associated With Endocrine Therapy for Breast Cancer

Conditions: Breast Cancer; Arthralgia
Interventions: Behavioral: Education and exercise intervention; Behavioral: Education and General Exercise
Sponsors: Georgetown University; Georgetown University
Recruiting - verified May 2011
Capecitabine and Pseudomonas Aeruginosa Combination in Metastatic Breast Cancer (MBC)

Condition: Metastatic Breast Cancer
Intervention: Drug: capecitabine and pseudomonas aeruginosa combination
Sponsors: Fudan University; Fudan University
Recruiting - verified May 2011
LLLT Combined With CDT in Breast Cancer-Related Lymphedema

Conditions: Breast Cancer; Lymphedema
Interventions: Device: Low Level Laser Therapy; Device: Low Level Laser
Sponsors: New York University School of Medicine; New York University School of Medicine; Hunter College
Recruiting - verified January 2012
TAC Versus TCX as Adjuvant Treatment for Node-Positive Her2-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Docetaxel, Doxorubicin, Cyclophosphamide; Drug: Docetaxel, Cyclophosphamide, Capecitabine
Sponsors: Peking Union Medical College Hospital; Peking Union Medical College Hospital
Recruiting - verified January 2012
Breast Cancer Registry

Condition: Breast Cancer
Intervention:
Sponsors: iOMEDICO AG; iOMEDICO AG; Arbeitskreis Klinische Studien; Arbeitsgemeinschaft fur Internistische Onkologie
Recruiting - verified January 2012
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: azacitidine; Drug: entinostat; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified May 2012
Higher-Dose Radiation Therapy or Standard Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

Condition: Breast Cancer
Interventions: Radiation: 3-dimensional conformal radiation therapy; Radiation: accelerated radiation therapy; Radiation: hypofractionated radiation therapy; Radiation: intensity-modulated radiation therapy; Radiation: whole breast irradiation
Sponsors: National Cancer Institute (NCI); Radiation Therapy Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer

Conditions: Breast Cancer; Metastatic Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: Ixabepilone; Drug: Capecitabine; Drug: Motesanib
Sponsors: Thomas Jefferson University; Thomas Jefferson University; Susan G. Komen Breast Cancer Foundation; Amgen
Not yet recruiting - verified January 2012
A Study of Oral LGK974 in Patients With Melanoma and Lobular Breast Cancer

Conditions: Melanoma; Breast Neoplasms; Lobular Carcinoma
Intervention: Drug: LGK974
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Risk Education and Assessment for Cancer Heredity

Conditions: Breast Cancer; Ovarian Cancer; Genetic Predisposition
Intervention: Behavioral: BRCA1/BRCA2 Genetic Counseling
Sponsors: University of Utah; University of Utah; National Cancer Institute (NCI); Huntsman Cancer Institute
Recruiting - verified November 2011
MK2206 and Anastrozole, Letrozole, Exemestane, or Fulvestrant in Treating Postmenopausal Women With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Akt inhibitor MK2206; Drug: anastrozole; Drug: exemestane; Drug: fulvestrant; Drug: letrozole
Sponsors: National Cancer Institute (NCI); Washington University Siteman Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012
Blood Test for Breast Cancer Associated Auto Antibodies

Condition: Breast Cancer
Intervention:
Sponsors: Eventus Diagnostics Ltd; Eventus Diagnostics Ltd
Recruiting - verified November 2011
A Pilot Study of Tumor-Derived Exosomes as Diagnostic and Prognostic Markers in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

Condition: Breast Neoplasms
Intervention:
Sponsors: Leo W. Jenkins Cancer Center; Leo W. Jenkins Cancer Center
Recruiting - verified January 2012
Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors

Condition: Breast Cancer
Interventions: Drug: Celecoxib; Drug: Placebo; Drug: Cholecalciferol
Sponsors: University of North Dakota; University of North Dakota; Department of Defense
Recruiting - verified August 2011
Proton Radiation Therapy for Invasive Breast Cancer Following Mastectomy

Condition: Invasive Breast Cancer
Intervention: Radiation: Proton Radiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2011
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy

Conditions: Breast Cancer; Colon Cancer; Bladder Cancer
Interventions: Drug: Glycosylated Recombinant Human Interleukin-7; Biological: Diphtheria-Tetanus Vaccine; Biological: Polio Vaccine; Biological: Pneumaococcal Vaccine; Biological: Hepatitis A Vaccine; Biological: Hepatitis B Vaccine; Biological: Influenza Vaccine; Biological: PhiX 174
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified January 2012
Radioactive Iodide (131I) Treatment of 124I PET/CT Detected Breast Cancers

Conditions: Breast Cancer; Metastatic Breast Cancer
Interventions: Procedure: 124 PET/CT imaging; Drug: Na134I; Drug: Tri-iodothyronine; Drug: Tri-iodothyronine
Sponsors: Stanford University; Stanford University
Recruiting - verified May 2011
Trial of MEK Inhibitor and PI3K/mTOR Inhibitor in Subjects With Locally Advanced or Metastatic Solid Tumors

Conditions: Locally Advanced Solid Tumor; Metastatic Solid Tumor; Breast Cancer; Non Small Cell Lung Cancer; Melanoma; Colorectal Cancer
Intervention: Drug: MSC1936369B and SAR245409
Sponsors: EMD Serono; EMD Serono; Sanofi
Recruiting - verified April 2012
Phase I Study of LFA102 in Patients With Prolactin Receptor-positive Castration-resistant Prostate Cancer or Prolactin Receptor-positive Metastatic Breast Cancer

Conditions: Castration-resistant Prostate Cancer,; Metastatic Breast Cancer
Intervention: Drug: LFA102
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
Effectiveness of a Decision Support System in Improving the Diagnosis and Screening Rate of Breast Cancer

Condition: Breast Cancer
Intervention: Other: SEBASTIAN Clinical Decision Support System (CDSS)
Sponsors: Hospital Italiano de Buenos Aires; Hospital Italiano de Buenos Aires; Duke University
Recruiting - verified April 2012
BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancer

Conditions: Estrogen Receptor-positive Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: PI3K inhibitor BKM120; Drug: fulvestrant; Procedure: biopsy
Sponsors: Washington University School of Medicine; Washington University School of Medicine; National Cancer Institute (NCI)
Not yet recruiting - verified October 2011
Genomic Testing for Primary Breast Cancer

Condition: Breast Cancer
Interventions: Procedure: Tumor Biopsy; Other: Breast Cancer Registry
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Susan G. Komen Breast Cancer Foundation; Kellogg Company
Recruiting - verified March 2012
Impact on Cognitive Function and Quality of Life of Adjuvant Chemotherapy in Patients Aged Over 65 Years: Application to Breast Cancer or Colon

Condition: Breast Cancer
Intervention:
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse; National Cancer Institute, France; Sanofi-Aventis
Recruiting - verified December 2011
Maximum Tolerated Dose (MTD) of Liposomal Doxorubicin in Combination With Seliciclib for Patients With Metastatic Triple Negative Breast Cancer (TNBC)

Condition: Breast Cancer
Interventions: Drug: Liposomal Doxorubicin; Drug: Seliciclib
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Institutes of Health (NIH)
Not yet recruiting - verified March 2012
A Clinical Trial Comparing Gemcitabine and Carboplatin With and Without P276-00 in Subjects With Metastatic Triple Negative Breast Cancer, With a Run-in of Escalating Dose of P276-00 Added to Gemcitabine and Carboplatin

Condition: Breast Cancer
Interventions: Drug: Gemcitabine and Carboplatin; Drug: P276-00 along with Gemcitabine and carboplatin
Sponsors: Piramal Healthcare Limited; Piramal Healthcare Limited
Recruiting - verified January 2012
Impact of Cancer on Memory Functioning: Understanding Disorders Using Approaches in Neuropsychology and Neuroimaging

Conditions: Breast Cancer; Healthy
Interventions: Procedure: cognitive tests and cerebral IRM; Procedure: cognitive tests and cerebral IRM
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse
Recruiting - verified April 2011
Promoting Breast Cancer Screening in Non-adherent Women

Condition: Breast Cancer
Interventions: Behavioral: reminder letter; Behavioral: reminder call; Behavioral: Counselor Call; Behavioral: Booster reminder; Behavioral: Booster reminder; Behavioral: Booster reminder
Sponsors: University of Massachusetts, Worcester; University of Massachusetts, Worcester; Reliant Medical Group; Fallon Community Health Plan; National Cancer Institute (NCI)
Recruiting - verified April 2012
Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU)

Condition: Breast Fibroadenoma
Intervention: Device: Ultrasonic ablation device
Sponsors: Theraclion; Theraclion
Recruiting - verified April 2012
Impact of Art Therapy on Fatigue and Quality of Life of Patients Treated With Adjuvant Radiotherapy for Breast Cancer

Condition: Breast Cancer
Intervention: Other: ART-THERAPIE
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse; Ligue contre le cancer, France
Recruiting - verified February 2012
Impact of Nutritional Intervention in Women With Breast Cancer Under Adjuvant Chemotherapy

Conditions: Breast Cancer; Adequate Physical Condition
Interventions: Other: Control arm; Other: Intervention arm
Sponsors: Centre Leon Berard; Centre Leon Berard; National Cancer Institute, France; Ligue du Rhône; Fondation de France; CLARA; Lions Club Bourg-en-Bresse et Pérouges; Association Lyonnaise de Logistique Post hospitalière; Ministère de la Recherche
Recruiting - verified May 2012
Study of ABT-767 in Subjects With Breast Cancer 1 and Breast Cancer 2 (BRCA 1 and BRCA 2) Mutations and Solid Tumors or High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Conditions: Solid Tumors (e.g. Breast, Ovarian, Prostate, or Pancreatic) and Ovarian; Fallopian Tube; or Primary Peritoneal Cancer
Intervention: Drug: ABT-767
Sponsors: Abbott; Abbott
Recruiting - verified April 2012
Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

Condition: Hereditary Breast and Ovarian Cancer Syndrome
Interventions: Genetic: blood collection; Genetic: blood collection
Sponsors: Centre Francois Baclesse; Centre Francois Baclesse
Recruiting - verified February 2012
Trial With Autologous Dendritic Cell Vaccination in Patients With Stage II-III HER2 Negative Breast Cancer

Conditions: Stage II Breast Cancer; Stage III Breast Cancer
Intervention: Biological: Autologous dendritic cell vaccination. Dendritic cells are pulsed with their own tumor antigens
Sponsors: Instituto Cientifico y Tecnologico de Navarra, Universidad de Navarra; Instituto Cientifico y Tecnologico de Navarra, Universidad de Navarra; CAIBER (Spanish Clinical Research Network); Ministerio de Sanidad de España (Spanish Institute of Health)
Recruiting - verified September 2011
Z-Endoxifen Hydrochloride in Treating Patients With Metastatic or Locally Recurrent Estrogen Receptor-Positive Breast Cancer

Conditions: Breast Cancer; Hot Flashes
Interventions: Drug: Z-endoxifen hydrochloride; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study; Other: questionnaire administration
Sponsors: National Cancer Institute (NCI); Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified August 2011
Patient Empowerment by Group Medical Consultations

Conditions: Breast Cancer; BRCA Mutation
Interventions: Behavioral: individual consult; Behavioral: group medical consult
Sponsors: Radboud University; Radboud University
Recruiting - verified October 2011
Afatinib (BIBW2992) in HER2-overexpressing Inflammatory Breast Cancer

Condition: Breast Neoplasms
Interventions: Drug: Vinorelbine Weekly; Drug: Afatinib once daily (OD)
Sponsors: Boehringer Ingelheim Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified May 2012
Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: TRC105
Sponsors: Tracon Pharmaceuticals Inc.; Tracon Pharmaceuticals Inc.; Roswell Park Cancer Institute; Department of Defense
Recruiting - verified March 2012
Enumeration and Molecular Characterization of Circulating Tumour Cells in Women With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention:
Sponsors: Lund University Hospital; Lund University Hospital
Recruiting - verified October 2011
A Phase 1b/2, Multicenter, Randomized, Open-Label, Dose-Escalation and Confirmation Study of Eribulin in Combination With Capecitabine

Condition: Metastatic Breast Cancer
Interventions: Drug: Eribulin mesylate administration as a 2 to 5 minute IV infusion at 1.4 mg/m2 on Day 1 and Day 14; Drug: Eribulin mesylate administration as a 2 to 5 minute IV infusion at 1.4 mg/m2 on Day 1 and Day 8
Sponsors: Eisai Inc.; Eisai Limited
Recruiting - verified April 2012
Dose Dense Doxorubucin and Cyclophosphamide Followed by Eribulin Mesylate for the Adjuvant Treatment of Early Stage Breast Cancer

Condition: Her2normal
Intervention: Drug: eribulin mesylate
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified February 2012
18-F-Fluoroacetate as PET Imaging Agent

Conditions: Brain Cancer; Breast Cancer; Prostate Cancer
Intervention: Drug: 18F-fluoroacetate
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Not yet recruiting - verified December 2011
Breast Cancer Study: Paclitaxel Versus Paclitaxel Plus Sorafenib in Second- or Third-line Treatment

Condition: Metastatic Breast Cancer
Interventions: Drug: Paclitaxel and Sorafenib; Drug: Paclitaxel
Sponsors: Gesellschaft fur Medizinische Innovation – Hamatologie und Onkologie mbH; Gesellschaft fur Medizinische Innovation – Hamatologie und Onkologie mbH; iOMEDICO AG
Recruiting - verified March 2011
PD0332991/Paclitaxel in Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: PD0332991; Drug: Paclitaxel
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified February 2012
Diet Composition, Weight Control, and Breast Carcinogenesis

Condition: Breast Cancer
Intervention: Other: Weight Loss Dietary Pattern
Sponsors: Colorado State University; Colorado State University
Recruiting - verified February 2012
SPY Intra-Operative Angiography & Skin Perfusion in Immediate Breast Reconstruction w/ Implants

Condition: Breast Cancer
Intervention: Procedure: SPY Intra-Operative Angiography
Sponsors: Stanford University; Stanford University
Recruiting - verified July 2011
Evaluation of the Use of AZD6244 to Induce Increased ER Expression and Anti-Estrogen Response in ER-Negative/Low Breast Cancer

Condition: Breast Cancer
Intervention: Drug: AZ6244
Sponsors: University of Miami Sylvester Comprehensive Cancer Center; University of Miami Sylvester Comprehensive Cancer Center
Recruiting - verified March 2012
Intrathecal Trastuzumab for Leptomeningeal Metastases in HER2+ Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: Trastuzumab
Sponsors: Northwestern University; Northwestern University
Recruiting - verified May 2012
Effectiveness of Using Biomarkers to Detect and Identify Cardiotoxicity and Describe Treatment (PREDICT)

Conditions: Breast Cancer; Gastrointestinal Cancer; Genitourinary Cancer; Leukemia; Lung Cancer
Intervention: Other: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Biosite
Recruiting - verified December 2011
The Combination of GnRh Analogue and Aromatase Inhibitor in Receptor Positive Premenopausal Women With Advanced Breast Cancer

Condition: Advanced Breast Cancer
Intervention: Other: GnRh Analogue and Aromatase Inhibitor
Sponsors: King Faisal Specialist Hospital & Research Center; King Faisal Specialist Hospital & Research Center
Recruiting - verified December 2011
Telephone Counseling-Mailed Materials Versus Internet Interventions in Overweight Cancer Survivors

Conditions: Breast Cancer; Colorectal Cancer; Prostate Cancer
Interventions: Behavioral: Standard Arm (mail/telephone); Behavioral: Internet Arm; Behavioral: Surveys and Questionnaires; Behavioral: Exercise and Diet
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified April 2012
Bioprosthetic Mesh to Expand the Lower Pole in Tissue Expander Reconstruction

Condition: Breast Cancer
Interventions: Device: Alloderm; Device: Surgimend
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified April 2012
Prognostic Value of Divpenia and CD4 Count in Relapsed Breast or Lung Cancer Patients

Conditions: Breast Cancer; Lung Cancer
Interventions: Biological: Breast cancer cohort; Biological: Lung cancer cohort
Sponsors: Centre Leon Berard; Centre Leon Berard; UBET (Biostatistic and Therapeutic Evaluation Unit); BEC (Department of Clinical Sciences)
Recruiting - verified May 2012
ABT-888 With Cyclophosphamide in Refractory BRCA-Positive Ovarian, Primary Peritoneal or Ovarian High-Grade Serous Carcinoma, Fallopian Tube Cancer, Triple-Negative Breast Cancer, and Low-Grade Non-Hodgkin's Lymphoma

Conditions: Ovarian; Primary Peritoneal; Serous Carcinoma; Triple-Negative Breast; Fallopian Tube
Interventions: Drug: ABT-888 with Cyclophospharmide; Drug: Cyclophosphamide
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified November 2011
A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases

Condition: HER-2 Positive Breast Cancer
Interventions: Drug: Everolimus; Drug: Vinorelbine; Drug: Trastuzumab
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; Novartis Pharmaceuticals
Recruiting - verified April 2012
Safety and Pharmacokinetic Study of MM-302 in Patients With Advanced Breast Cancer

Condition: Breast Cancer
Intervention: Drug: MM-302
Sponsors: Merrimack Pharmaceuticals; Merrimack Pharmaceuticals
Recruiting - verified November 2011
Dasatinib In Combination With Trastuzumab And Paclitaxel In The First Line Treatment Of Her2-Positive Metastatic Breast Cancer (MBC) Patients

Condition: Breast Cancer
Intervention: Drug: dasatinib plus trastuzumab plus paclitaxel
Sponsors: Spanish Breast Cancer Research Group; Spanish Breast Cancer Research Group; Bristol-Myers Squibb
Recruiting - verified October 2011
1st Line Treatment of Bevacizumab-Taxane vs Bevacizumab-Exemestane in Metastatic Breast Cancer

Condition: First Line Metastatic Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Bevacizumab; Drug: Exemestane
Sponsors: ARCAGY/ GINECO GROUP; ARCAGY/ GINECO GROUP
Recruiting - verified June 2011
Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors

Condition: Breast Neoplasms
Interventions: Drug: Metformin; Drug: Placebo; Behavioral: Lifestyle intervention; Behavioral: Standard printed dietary guidelines
Sponsors: University of California, San Diego; University of California, San Diego
Recruiting - verified February 2012
Contrast-Enhanced Digital Mammography (CEDM) for Identifying a Change in Management of Women With Newly Diagnosed Breast Cancer

Condition: Breast Cancer
Intervention: Other: DE-CEDM and CE-BMRI
Sponsors: GE Healthcare; GE Healthcare
Recruiting - verified January 2012
A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: University Health Network, Toronto; University Health Network, Toronto; Breast Cancer Research Foundation
Recruiting - verified July 2011
Early Cardiac Toxicity of Adjuvant CT in Elderly BC.

Condition: Breast Cancer
Intervention: Drug: epirubicin, cyclophosphamide, docetaxel
Sponsors: Jules Bordet Institute; Jules Bordet Institute; Sanofi-Aventis
Recruiting - verified February 2011
Study of the P16 Gene as a Predictor of Myelosuppression in Breast Cancer Patients

Condition: Breast Cancer
Intervention:
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center
Recruiting - verified April 2012
Comparing the Efficacy and Tolerability of Fulvestrant 500 mg Versus 250 mg in Postmenopausal Women With Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Fulvestrant; Drug: Fulvestrant /placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012
MRI Evaluation of the Breast Areolar Margin and Paryenchyma

Condition: Breast Cancer
Intervention: Other: MRI
Sponsors: Piedmont Healthcare; Piedmont Healthcare
Recruiting - verified June 2011
Study of BKM120 or BEZ235 and Capecitabine in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: BMK120; Drug: Capecitabine; Drug: BEZ235
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; Novartis Pharmaceuticals
Recruiting - verified April 2012
Rosuvastatin to Lower Circulating Tissue Factor Bearing Microparticles in Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: rosuvastatin
Sponsors: Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Massachusetts General Hospital; National Institutes of Health (NIH)
Recruiting - verified February 2012
Prospective Analysis of Changes in Background Parenchymal Enhancement (BPE) and Amount of Fibroglandular Tissue on Breast MRI

Condition: Breast Cancer
Intervention: Other: MRI
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2012
Incidence of Chemotherapy-Induced Nausea and Vomiting (CINV) Associated With the Docetaxel-Cyclophosphamide Regimen in Early Breast Cancer Patients

Condition: Breast Cancer
Intervention: Drug: Aprepitant
Sponsors: Spanish Breast Cancer Research Group; Spanish Breast Cancer Research Group; Merck
Recruiting - verified October 2011
Intraoperative Boost Radiotherapy With Electrons (IOERT) Followed By Hypofractionated Whole-Breast Irradiation (WBRT)

Condition: Invasive Lobular and Ductal Carcinoma
Interventions: Radiation: Hypofractionated Whole Breast Radiation Therapy; Radiation: Intraoperative Electron Radiation Therapy
Sponsors: St. Joseph Hospital of Orange; St. Joseph Hospital of Orange
Recruiting - verified March 2012
The Use of Bioimpedance to Determine Pre-Clinical Lymphedema in the Post-Operative Breast Cancer Patient

Condition: Breast Cancer
Intervention: Device: Garment Sleeve
Sponsors: Main Line Health; Main Line Health; Sharpe Strumia Foundation
Recruiting - verified January 2012
A Study of Herceptin (Trastuzumab) in Combination With a Taxane in Patients With HER2-Positive Breast Cancer Who Relapsed After (Neo)Adjuvant Herceptin Treatment

Condition: Breast Cancer
Interventions: Drug: trastuzumab [Herceptin]; Drug: paclitaxel; Drug: docetaxel
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Effects of High Dose Calcitriol in Breast Cancer Patients

Condition: Breast Cancer
Intervention: Drug: Calcitriol
Sponsors: University of Rochester; University of Rochester
Recruiting - verified August 2011
Can Exercise Improve Cancer Associated Cognitive Dysfunction?

Condition: Breast Cancer
Intervention: Behavioral: Exercise
Sponsors: University of British Columbia; University of British Columbia; Canadian Breast Cancer Foundation
Recruiting - verified February 2012
Hormone Therapy Or Chemotherapy Before Surgery Based on Gene Expression Analysis in Treating Patients With Breast Cancer

Conditions: Ductal Breast Carcinoma in Situ; Lobular Breast Carcinoma in Situ; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer
Interventions: Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery; Other: laboratory biomarker analysis; Other: enzyme-linked immunosorbent assay; Genetic: gene expression analysis; Drug: systemic chemotherapy; Drug: tamoxifen citrate; Drug: aromatase inhibition therapy
Sponsors: Virginia Commonwealth University; Virginia Commonwealth University; National Cancer Institute (NCI)
Recruiting - verified April 2012
Breath Testing for Breast and Colon Cancer Diagnosis- NaNose Study

Conditions: Breast Cancer; Colon Cancer
Intervention:
Sponsors: Rambam Health Care Campus; Rambam Health Care Campus; Technion, Israel Institute of Technology
Recruiting - verified August 2011
A Study of Herceptin (Trastuzumab) in Combination With Xeloda (Capecitabine) in Patients With Metastatic or Recurrent HER2-positive Breast Cancer After First-Line or (Neo)Adjuvant Therapy.

Condition: Breast Cancer
Interventions: Drug: capecitabine [Xeloda]; Drug: trastuzumab [Herceptin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery

Conditions: Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer
Interventions: Drug: azacitidine; Other: laboratory biomarker analysis; Other: immunohistochemistry staining method; Genetic: polymerase chain reaction; Genetic: western blotting; Genetic: nucleic acid sequencing; Procedure: therapeutic conventional surgery
Sponsors: USC/Norris Comprehensive Cancer Center; USC/Norris Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Gemcitabine Plus Cisplatin Versus Gemcitabine Plus Paclitaxel in Triple Negative Breast Cancer (TNBC)

Condition: Breast Cancer
Interventions: Drug: Gemcitabine,cisplatin; Drug: Gemcitabine, Paclitaxel
Sponsors: Fudan University; Fudan University; 307 Hospital of PLA; The Affiliated Hospital of the Chinese Academy of Military Medical Sciences; Sun Yat-sen University; Tianjin Medical University Cancer Institute and Hospital; Zhejiang Cancer Hospital; Changhai Hospital
Recruiting - verified January 2011
Concurrent Adjuvant Carboplatin and Accelerated Radiotherapy for Triple Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Carboplatin; Radiation: 3D-RT or IMRT
Sponsors: New York University School of Medicine; New York University School of Medicine
Recruiting - verified March 2012
Study of Cipatinib in Patients With HER2 Positive or Uncertain Advanced Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Cipatinib
Sponsors: Jiangsu HengRui Medicine Co., Ltd.; Jiangsu HengRui Medicine Co., Ltd.; Chinese Academy of Medical Sciences
Recruiting - verified February 2011
Paclitaxel and Bavituximab in Treating Patients With HER2-Negative Metastatic Breast Cancer

Conditions: HER2-negative Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: paclitaxel; Biological: bavituximab; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: University of Arizona; University of Arizona; National Cancer Institute (NCI)
Recruiting - verified May 2012
Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32

Conditions: Breast Cancer; Depression; Fatigue; Sleep Disorders
Interventions: Drug: metformin hydrochloride; Genetic: DNA analysis; Genetic: RNA analysis; Genetic: polymerase chain reaction; Genetic: polymorphism analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: enzyme-linked immunosorbent assay; Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Recruiting - verified February 2012
Trial of Drain Antisepsis After Tissue Expander Breast Reconstruction

Conditions: Nonmalignant Breast Conditions; Breast Cancer
Interventions: Device: sodium hypochlorite (Dakins Soln); Drug: Chlorhexidine gluconate disk
Sponsors: Mayo Clinic; Mayo Clinic; University of California, San Francisco
Recruiting - verified April 2012
Dietary Fish and Omega 3 Fatty Acids for Breast Cancer Prevention

Condition: Breast Cancer
Intervention: Other: Dietary fish versus omega 3 fatty acid supplement capsules
Sponsors: Ohio State University Comprehensive Cancer Center; Ohio State University Comprehensive Cancer Center
Recruiting - verified May 2012
Lapatinib Ditosylate and MK2206 in Treating Women With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Akt inhibitor MK2206; Drug: lapatinib ditosylate; Genetic: cytogenetic analysis; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Barbara Ann Karmanos Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified July 2011
Study of Changes in Estrogen Levels and Grip Strength in Postmenopausal Women Who Have Received 4 to 6 Years of Hormone Therapy for Breast Cancer and Are Currently Receiving Letrozole on Clinical Trial IBCSG-35-07

Condition: Breast Cancer
Interventions: Genetic: polymorphism analysis; Other: laboratory biomarker analysis; Procedure: quality-of-life assessment
Sponsors: International Breast Cancer Study Group; International Breast Cancer Study Group
Recruiting - verified March 2012
This Trial is a Prospective Observational Study of Newly Diagnosed Diffuse Large B Cell Primary Breast Lymphomas

Condition: Diffuse Large B Cell Lymphoma of the Breast.
Intervention:
Sponsors: International Extranodal Lymphoma Study Group (IELSG); International Extranodal Lymphoma Study Group (IELSG)
Not yet recruiting - verified November 2011
Akt Inhibitor MK-2206 in Patients With Advanced Breast Cancer Who Have Tumors With a PIK3CA Mutation and/or PTEN Loss

Condition: Breast Cancer
Intervention: Drug: MK2206
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Institutes of Health (NIH)
Recruiting - verified April 2012
Pilot Study of Secondary Causes of Osteopenia/Osteoporosis in Adults With Breast and Prostate Cancer

Conditions: Breast Cancer; Prostate Cancer; Osteopenia; Osteoporosis
Intervention:
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified February 2012
An Observational Study on The Correlation Between Time of Initiation of Avastin (Bevacizumab) Treatment And Progression-Free Survival in Patients With Metastatic Breast Cancer (CRONOS 2)

Condition: Breast Cancer
Intervention:
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: accelerated hypofractionated radiotherapy (AHF-RT)
Sponsors: James Graham Brown Cancer Center; James Graham Brown Cancer Center; University of Louisville
Recruiting - verified December 2011
Cilengitide and Paclitaxel in Treating Patients With Advanced Solid Tumors

Conditions: Breast Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: cilengitide; Drug: paclitaxel; Other: enzyme-linked immunosorbent assay; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified May 2012
Predicting Pathological Response Within the 1st Week of Chemotherapy Using Diffuse Optical Spectroscopic Imaging

Condition: Breast Cancer
Intervention: Device: Diffuse Optical Spectroscopy Imaging
Sponsors: University of California, Irvine; Montana Compton
Recruiting - verified December 2011
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer

Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: cyclophosphamide; Drug: docetaxel; Drug: doxorubicin hydrochloride; Drug: paclitaxel
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Recruiting - verified February 2012
Lapatinib and RAD-001 for HER2 Positive Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Lapatinib and RAD-001
Sponsors: University of Kansas; University of Kansas
Recruiting - verified October 2011
Endoxifen in Adults With Hormone Receptor-Positive Solid Tumors

Conditions: Hormone Receptor-Positive Breast; Gynecologic; Desmoid; Hormone Receptor-Positive Neoplasms
Interventions: Drug: z-Endoxifen; Drug: [(18)F] Fluoroestradiol
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
A Study of Lapatinib in Combination With Everolimus in Patients With Advanced, Triple Negative Breast Cancer

Conditions: Breast Neoplasms; Breast Cancer; Cancer of the Breast
Intervention: Drug: Lapatinib and Everolimus
Sponsors: Emory University; Emory University
Recruiting - verified January 2012
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer

Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: exemestane; Drug: letrozole; Drug: systemic chemotherapy; Drug: tamoxifen citrate
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified February 2012
Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Metastatic Breast Cancer

Conditions: Breast Neoplasms; HER2 Protein, Human; Geriatric Health Services
Interventions: Drug: Lapatinib; Drug: Trastuzumab
Sponsors: City of Hope Medical Center; City of Hope Medical Center; GlaxoSmithKline; Genentech
Recruiting - verified January 2012
Paclitaxel, Trastuzumab, and Pertuzumab in the Treatment of Metastatic HER2-Positive Breast Cancer

Condition: Breast Cancer
Intervention: Drug: pertuzumab in combination with trastuzumab and paclitaxel
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Genentech; University of Pennsylvania
Recruiting - verified April 2012
LUX-Breast 2; Afatinib in HER2 (Human Epidermal Growth Factor Receptor)-Treatment Failures

Condition: Breast Neoplasms
Interventions: Drug: Afatinib 40mg once daily (OD); Drug: Vinorelbine 25 mg/m2 weekly; Drug: Paclitaxel 80 mg/m2 weekly
Sponsors: Boehringer Ingelheim Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified May 2012
Prevention Strategy for Pre-Menopausal Women at High Risk for Development of Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Placebo; Drug: secoisolariciresinol
Sponsors: University of Kansas; Carol Fabian, MD; Lignan Research, Inc.
Recruiting - verified February 2012
Eribulin With Trastuzumab as First-line Therapy for Locally Recurrent or Metastatic HER2 Positive Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Eribulin Mesylate
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified March 2012
Effect of Metformin on Breast Cancer Metabolism

Condition: Breast Cancer
Intervention: Drug: Metformin
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust; Cancer Research UK
Recruiting - verified December 2011
Engaging Diverse Underserved Communities to Bridge the Mammography Divide

Condition: Breast Cancer Screening
Interventions: Other: MI2 intervention arm; Other: Control
Sponsors: University of Kansas; University of Kansas
Recruiting - verified May 2012
Cognition in Breast Cancer Patients: The Impact of Cancer-related Stress

Condition: Breast Cancer
Intervention:
Sponsors: Ludwig-Maximilians - University of Munich; Ludwig-Maximilians - University of Munich; Deutsche Krebshilfe e.V., Bonn (Germany)
Recruiting - verified December 2011
Hypofractionation Trial

Condition: Breast Cancer
Interventions: Radiation: Hypofractionated Whole Breast Irradiation; Radiation: Conventionally Fractionated Whole Breast Irradiation
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified December 2011
Fulvestrant (F)/Goserelin (G) vs Anastrozole (A)/G vs G for Premenopausal Women

Conditions: Metastatic Breast Cancer; Estrogen Receptor Positive Tumor; Breast Cancer Nos Premenopausal
Interventions: Drug: Fulvestrant plus Goserelin; Drug: Anastrozole plus Goserelin; Drug: Goserelin
Sponsors: Samsung Medical Center; Samsung Medical Center; Asan Medical Center; Seoul National University Hospital; Severance Hospital; Ulsan University Hospital; Kosin University Gospel Hospital; Korea University Guro Hospital; Korea University Anam Hospital
Recruiting - verified July 2011
Feasibility Study of Biomarkers of Response to Neoadjuvant Paclitaxel in Locally Advanced Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: tumor biopsy and blood draw
Sponsors: University of Wisconsin, Madison; University of Wisconsin, Madison
Recruiting - verified February 2012
Exploratory Study of Norepinephrine to Prevent Radiodermatitis in Breast Cancer Patients

Condition: Radiodermatitis
Intervention: Drug: Norepinephrine
Sponsors: ProCertus BioPharm, Inc; ProCertus BioPharm, Inc; University of Wisconsin, Madison
Recruiting - verified January 2012
TKI258 for Metastatic Inflammatory Breast Cancer Patients

Condition: Breast Cancer
Intervention: Drug: Dovitinib
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Novartis
Recruiting - verified January 2012
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients

Condition: Breast Cancer
Intervention: Drug: Hydrochloroquine
Sponsors: Radboud University; Radboud University
Recruiting - verified January 2012
Randomized Phase II Trial of Anastrozole Plus Metronomic Tegafur-uracil as Neo-adjuvant Therapy in Postmenopausal Breast Cancer

Condition: Breast Neoplasms
Interventions: Drug: Anastrozole; Drug: Anastrozole plus tegafur-uracil
Sponsors: Translational Research Informatics Center, Kobe, Hyogo, Japan; Translational Research Informatics Center, Kobe, Hyogo, Japan; Osaka University Hospital
Recruiting - verified February 2012
Comparison Study of Neoadjuvant Paclitaxel Plus Carboplatin/Epirubicin Treatment in Triple-negative Breast Cancer

Condition: Triple Negative Breast Cancer
Interventions: Drug: Paclitaxel plus carboplatin; Drug: Paclitaxel and epirubicin
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified November 2011
Monitoring and Predicting Breast Cancer Neoadjuvant Chemotherapy Response Using Diffuse Optical Spectroscopic Imaging

Condition: Breast Cancer
Intervention: Device: Diffuse Optical Spectroscopy Imaging
Sponsors: University of California, Irvine; Montana Compton; American College of Radiology Imaging Network; Massachusetts General Hospital; University of Pennsylvania; Dartmouth-Hitchcock Medical Center; Brown University; University of San Francisco
Recruiting - verified October 2011
Screening MRI for Cancer Recurrence in Patients Treated With Breast Conserving Therapy

Conditions: Breast Neoplasms; Magnetic Resonance Imaging; Neoplasm Recurrence, Local
Intervention:
Sponsors: Seoul National University Hospital; Seoul National University Hospital
Recruiting - verified July 2011
A Study of Ramucirumab (IMC-1121B) in Patients With Breast Cancer

Conditions: Breast Cancer; Metastatic Breast Cancer
Interventions: Biological: Ramucirumab; Drug: Docetaxel
Sponsors: ImClone LLC; ImClone LLC
Recruiting - verified December 2011
Delayed-Delayed Breast Reconstruction

Condition: Breast
Intervention: Procedure: Delayed Breast Reconstruction
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified March 2012
Evaluating and Comparing Two Surgical Methods for Treatment of Early Stage Breast Cancer

Conditions: Breast Neoplasms; Breast Cancer; Breast Tumors; Cancer of Breast; Cancer of the Breast; Human Mammary Carcinoma; Neoplasms, Breast
Interventions: Procedure: Remove tumor only; Procedure: Removal of tumor and tissue
Sponsors: Emory University; Emory University
Recruiting - verified March 2012
A Study Inhibiting Telomerase to Reverse Trastuzumab Resistance in HER2+ Breast Cancer

Condition: Breast Neoplasms
Intervention: Drug: GRN163L in combination with trastuzumab
Sponsors: Indiana University; Indiana University; Breast Cancer Research Foundation; Geron Corporation
Recruiting - verified May 2012
Veliparib and Carboplatin in Treating Women With HER2-Negative Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: carboplatin; Drug: veliparib; Other: 3'-deoxy-3'-[18F]fluorothymidine; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Arthur G. James Cancer Hospital & Richard J. Solove Research Institute; National Cancer Institute (NCI)
Recruiting - verified April 2012
Study of the Safety and Pharmacology of GDC-0980 in Combination With Paclitaxel With or Without Bevacizumab in Patients With Locally Recurrent or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab; Drug: GDC-0980; Drug: paclitaxel
Sponsors: Genentech; Genentech
Recruiting - verified May 2012
BRCA Mutations in Latinas

Condition: Breast Neoplasms
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified August 2011
Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery

Condition: Breast and Abdomen Morbidities After TRAM Flap Surgery
Interventions: Device: Sham PEMF Device; Device: Ivivi Torino II PEMF Device
Sponsors: Columbia University; Columbia University; Ivivi Health Sciences, LLC
Recruiting - verified February 2012
Safety and Efficacy Study of Femara(Letrozole) as an Extended Adjuvant Treatment in Breast Cancer Patients

Conditions: Breast Cancer; Letrozole
Intervention:
Sponsors: Novartis Korea Ltd.; Novartis Korea Ltd.
Recruiting - verified June 2011
A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Patients With Breast Cancer Progressing After First-Line Therapy With Avastin and Chemotherapy (TANIA)

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: Chemotherapy
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Vorinostat in Combination With Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors and HIV Infection

Conditions: Anal Cancer; Breast Cancer; Esophageal Cancer; Gastric Cancer; Head and Neck Cancer; Lung Cancer; Nonneoplastic Condition; Ovarian Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: carboplatin; Drug: paclitaxel; Drug: vorinostat; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); AIDS Associated Malignancies Clinical Trials Consortium; National Cancer Institute (NCI)
Recruiting - verified April 2012
Histologic Assessment of the Difference Between 18F-2-fluoro-2-deoxy_D-glucose Positron Emission Mammography(PEM) and Magnetic Resonance Imaging (MRI) of the Breast

Condition: Breast Cancer
Intervention: Device: Positron Emission Mammography (PEM) and Magnetic Resonance Imaging (MRI)
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2012
Tomosynthesis in the Oslo Breast Cancer Screening Program

Conditions: Recall Rate; Cancer Detection Rate; False Positive Rate; Positive Predictive Value
Intervention: Procedure: Digital breast tomosynthesis
Sponsors: Oslo University Hospital; Oslo University Hospital; The Norwegian Cancer Registry; Hologic, Inc.
Recruiting - verified August 2011
Breast Cancer Risk Biomarkers in Premenopausal Women

Condition: Breast Cancer
Intervention: Drug: Lovaza™
Sponsors: University of Kansas; Carol Fabian, MD
Recruiting - verified February 2012
Breast Cancer Risk Biomarkers in Postmenopausal Women

Condition: Breast Cancer
Intervention: Drug: Lovaza™
Sponsors: University of Kansas; Carol Fabian, MD; GlaxoSmithKline
Recruiting - verified February 2012
PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: BKM120; Drug: BEZ235; Drug: Letrozole; Drug: BKM120
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center
Recruiting - verified July 2011
MIBG Scintigraphy and Strain Echocardiography in the Detection of Subclinical Cardiovascular Effects One Year After (Neo)Adjuvant Breast Cancer Treatment With Docetaxel, Doxorubicin and Cyclophosphamide (TAC): a Pilot Study

Condition: Breast Cancer
Intervention:
Sponsors: Radboud University; Radboud University
Recruiting - verified September 2011
Partial Breast Proton Beam Irradiation

Condition: Breast Cancer
Intervention: Radiation: Accelerated Partial Breast Irradiation (APBI)
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012
MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast Cancer

Conditions: Breast Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: Akt inhibitor MK2206; Drug: lapatinib ditosylate; Genetic: mutation analysis; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); University of Wisconsin, Madison; National Cancer Institute (NCI)
Not yet recruiting - verified October 2011
Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction

Conditions: Bacterial Infection; Anti-infective Agents; Breast Implantation
Interventions: Drug: Cefadroxil discontinued early; Drug: Cefadroxil until drain removal
Sponsors: Stony Brook University; Stony Brook University; Plastic Surgery Educational Foundation
Recruiting - verified March 2012
Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer

Condition: Breast Cancer
Interventions: Procedure: palliative surgery; Procedure: therapeutic conventional surgery; Radiation: palliative radiation therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Eastern Cooperative Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Oral Vinorelbine in Combination With Trastuzumab for Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Trastuzumab; Drug: Vinorelbine
Sponsors: Vejle Hospital; Vejle Hospital
Recruiting - verified May 2012
Evaluation of Homeopathic Treatment for Hot Flashes in Non Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: BRN01; Drug: Placebo
Sponsors: Centre Leon Berard; Centre Leon Berard; BOIRON
Recruiting - verified November 2011
Digital Breast Tomosynthesis in Younger Symptomatic Women

Condition: Breast Cancer
Intervention:
Sponsors: NHS Tayside; Liz Coote; University of Dundee
Recruiting - verified October 2011
RO4929097, Paclitaxel, And Carboplatin Before Surgery in Treating Patients With Stage II or Stage III Triple-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: carboplatin; Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097; Drug: paclitaxel; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Arthur G. James Cancer Hospital & Richard J. Solove Research Institute; National Cancer Institute (NCI)
Recruiting - verified July 2011
Feasibility Study of Metronomic Chemotherapy for Locally Advanced HER2-Negative Breast Cancer

Condition: Locally Advanced HER2-negative Breast Cancer
Interventions: Drug: Paclitaxel/doxorubicin/cyclophosphamide; Drug: Paclitaxel/doxorubicin/cyclophosphamide
Sponsors: University of Sao Paulo; University of Sao Paulo; Fundação Faculdade de Medicina
Recruiting - verified September 2010
Olaparib in Combination With Carboplatin for Refractory or Recurrent Women's Cancers

Conditions: Mixed Muellerian Cancer; Cervical Cancer; Ovarian Cancer; Breast Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer; Endometrial Cancer; Carcinosarcoma
Interventions: Drug: Carboplatin; Drug: Olaparib; Drug: Treatment Effect
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified August 2011
Entinostat and Anastrozole or Tamoxifen in Treating Women With Triple-Negative Breast Cancer That Can Be Removed by Surgery

Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: entinostat; Drug: tamoxifen citrate; Genetic: reverse transcriptase-polymerase chain reaction; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); University of Chicago; National Cancer Institute (NCI)
Recruiting - verified January 2011
Study of IMC-18F1 or Ramucirumab DP in Combination With Capecitabine or Capecitabine on Previously Treated Breast Cancer Patients

Condition: Breast Cancer
Interventions: Biological: Ramucirumab DP; Biological: IMC-18F1; Drug: Capecitabine
Sponsors: ImClone LLC; ImClone LLC
Recruiting - verified May 2012
Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With Trastuzumab

Condition: Advanced HER2-positive Breast Cancer
Intervention: Drug: AUY922 + Trastuzumab
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
Blood Oxygen Level Dependent Magnetic Resonance Imaging (BOLD MRI) and Fluorothymidine Positron Emission Tomography (FLT PET) in Patients With Locally Advanced Breast Cancer Undergoing Neoadjuvant Chemotherapy

Condition: Locally Advanced Breast Cancer (LABC)
Intervention: Procedure: FLT PET and BOLD MRI scan
Sponsors: Ontario Clinical Oncology Group (OCOG); Ontario Clinical Oncology Group (OCOG)
Recruiting - verified March 2012
Cryotherapy in Preventing Peripheral Neuropathy and Nail Toxicity in Patients With Breast Cancer Who Are Receiving Paclitaxel

Conditions: Chemotherapeutic Agent Toxicity; Pain; Peripheral Neuropathy; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Therapy-related Toxicity
Interventions: Procedure: cryotherapy; Other: questionnaire administration; Procedure: quality-of-life assessment; Procedure: management of therapy complications; Procedure: assessment of therapy complications
Sponsors: Northwestern University; Northwestern University; National Cancer Institute (NCI)
Recruiting - verified May 2012
Comparison of the Cosmetic Outcome of Hypofractionated Versus Normofractionated IMRT in Treatment of Breast Cancer

Conditions: Tumors; Breast Cancer
Intervention: Radiation: intensity modulated radiotherapy (IMRT) for breast cancer
Sponsors: University Hospital Mannheim; University Hospital Mannheim
Recruiting - verified October 2010
Study of High-dose Chemotherapy (HDC) Combined With Adoptive Cellular Therapy With DC-CIK Cells in Triple Negative Breast Cancer Patients

Conditions: Breast Neoplasms; Neoplasm Metastasis
Intervention:
Sponsors: Beijing Cancer Hospital; Beijing Cancer Hospital
Recruiting - verified August 2010
Safety and Efficacy of RAD001 (Everolimus) in Combination With Letrozole in the Treatment of Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer

Conditions: Postmenopausal Women,; Locally Advanced or Metastatic Breast Cancer
Intervention: Drug: Everolimus + Letrozole
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
MIRNA Profiling of Breast Cancer in Patients Undergoing Neoadjuvant or Adjuvant Treatment for Locally Advanced & Inflammatory Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified January 2012
Prevention of Post-Mastectomy Breast Pain Using Ambulatory Continuous Paravertebral Blocks

Conditions: Paravertebral Catheter Insertion; Mastectomy; Breast Cancer
Interventions: Procedure: Placebo (normal saline) Continuous Infusion; Procedure: Ropivicaine 0.4% Continuous Infusion
Sponsors: University of California, San Diego; University of California, San Diego
Recruiting - verified March 2012
Study of Eniluracil + 5-Fluorouracil (5-FU) + Leucovorin Versus Capecitabine in Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Eniluracil; Drug: 5-Fluorouracil; Drug: Leucovorin; Drug: Capecitabine
Sponsors: Adherex Technologies, Inc.; Adherex Technologies, Inc.
Recruiting - verified August 2011
Standard or Hypofractionated Radiotherapy Versus Accelerated Partial Breast Irradiation (APBI)for Breast Cancer

Conditions: Breast Cancer; Lumpectomy
Interventions: Radiation: Whole Breast Irradiation + Boost; Radiation: Hypofractionated WBI; Radiation: Accelerated partial breast irradiation
Sponsors: UNICANCER; UNICANCER
Recruiting - verified August 2011
Correlation Between MRS (Magnetic Resonance Spectroscopy) and Tumor Response to Radiation Therapy in Breast Cancer

Condition: Breast Cancer
Intervention: Device: MRS
Sponsors: Alberta Health Services; Alberta Health Services
Recruiting - verified April 2012
Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Condition: Advanced Solid Malignancy, Safety and Tolerability, Pharmacokinetics, Pharmacodynamics, Tumour Response, Advanced or Metastatic Breast Cancer, PIK3CA
Interventions: Drug: AZD5363; Drug: AZD5363; Drug: AZD5363
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified February 2012
Vitamin D and Breast Cancer Biomarkers in Female Patients

Condition: Breast Cancer
Interventions: Dietary Supplement: vitamin D; Other: placebo
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI)
Recruiting - verified May 2012
Participation Restrictions in Breast Cancer Survivors

Condition: Breast Cancer
Intervention: Behavioral: Behavioral activation/problem-solving (BA/PS)
Sponsors: Dartmouth-Hitchcock Medical Center; Dartmouth-Hitchcock Medical Center; National Cancer Institute (NCI)
Recruiting - verified June 2011
Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase Inhibitors

Condition: Breast Cancer
Interventions: Drug: BMS-754807; Drug: letrozole
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb; Mayo Clinic
Recruiting - verified December 2011
Tissue Expander Breast Reconstruction Study on Breast Volume and Shape Change

Condition: Post-Mastectomy Breast Cancer Reconstruction
Interventions: Device: Contour Profile Tissue Expander; Device: Standard Round Tissue Expander
Sponsors: Northwestern University; Northwestern University; Mentor Worldwide, LLC
Recruiting - verified July 2011
Tesetaxel as First-line Therapy for Metastatic Breast Cancer

Condition: Breast Neoplasm
Intervention: Drug: Tesetaxel
Sponsors: Genta Incorporated; Genta Incorporated
Recruiting - verified November 2011
The Growth Factor Signature (GFS) as an Intermediate Biomarker of Response for Development of PI3K-Pathway Inhibitors in Patients With Breast Cancer (MK-8669-050)

Condition: Breast Cancer
Interventions: Drug: Ridaforolimus + Dalotuzumab; Drug: Ridaforolimus; Drug: Dalotuzumab
Sponsors: Merck; Merck
Recruiting - verified May 2012
Art Therapy Intervention for Breast Cancer Patients

Condition: Breast Cancer
Intervention: Other: art therapy
Sponsors: McGill University Health Center; McGill University Health Center; The Cedars Cancer Institute
Recruiting - verified August 2011
Lapatinib and WBRT for Patients With Brain Metastases From Lung or Breast Tumors

Conditions: Brain Metastases; Lung Tumors; Breast Tumors
Intervention: Drug: Lapatinib
Sponsors: Hellenic Cooperative Oncology Group; Hellenic Cooperative Oncology Group
Recruiting - verified December 2011
Soy Isoflavones Supplementation in Treating Women at High Risk For or With Breast Cancer

Conditions: BRCA1 Mutation Carrier; BRCA2 Mutation Carrier; Ductal Breast Carcinoma in Situ; Lobular Breast Carcinoma in Situ; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer
Interventions: Dietary Supplement: soy isoflavones; Other: placebo; Other: questionnaire administration; Procedure: magnetic resonance imaging; Procedure: biopsy; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: mammography
Sponsors: USC/Norris Comprehensive Cancer Center; USC/Norris Comprehensive Cancer Center; National Cancer Institute (NCI); California Breast Cancer Research Program
Recruiting - verified May 2012
Evaluation of an Anti-cancer Immunotherapy Combined With Standard Neoadjuvant Treatment in Patients With WT1-positive Primary Invasive Breast Cancer

Conditions: Neoplasms, Breast; WT1-positive Primary Invasive Breast Cancer
Interventions: Biological: GSK Biologicals' recombinant WT1 Antigen-Specific Cancer Immunotherapeutic (ASCI) GSK2302024A; Biological: Placebo
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified April 2012
Diffuse Optical Spectroscopy Imaging in Monitoring and Predicting Response in Patients With Locally Advanced Breast Cancer Undergoing Chemotherapy Before Surgery

Condition: Breast Cancer
Interventions: Drug: systemic chemotherapy; Other: laser spectroscopy; Procedure: breast imaging study; Procedure: magnetic resonance imaging; Procedure: mammography; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery; Procedure: ultrasound imaging
Sponsors: National Cancer Institute (NCI); American College of Radiology Imaging Network; National Cancer Institute (NCI)
Recruiting - verified January 2012
Ultrasound vs. Predetermined Distance Techniques for Paravertebral Nerve Block in Patients Having Breast Surgery

Conditions: Mastectomy; Breast Neoplasms
Interventions: Procedure: ultrasound; Procedure: predetermined distance
Sponsors: Ochsner Health System; Ochsner Health System
Recruiting - verified October 2011
Pre-Surgery Positron Emission Mammography in Patients With Newly Diagnosed Breast Cancer

Conditions: Breast Cancer; Breast Cancer Surgery
Intervention: Device: Positron Emission Mammography (PEM)
Sponsors: Swedish Medical Center; Swedish Medical Center
Recruiting - verified May 2012
Effect of Early vs Late Drainage Removal in Women After Radical Mastectomy With Axillary Clearance

Condition: Breast Cancer
Interventions: Procedure: Early drainage removal; Procedure: Late drainage removal
Sponsors: Medical University of Gdansk; Medical University of Gdansk
Recruiting - verified January 2012
A Pharmacokinetic and Randomized Trial of Neoadjuvant Treatment With Anastrozole Plus AZDO530 in Postmenopausal Patients With Hormone Receptor Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Anastrozole; Drug: ADZ0530; Drug: Placebo; Procedure: Pharmacokinetic studies; Procedure: Definitive Surgery; Procedure: Core Biopsy; Genetic: Tumor Tissue Collection for Genetic and Molecular Studies
Sponsors: University of Miami Sylvester Comprehensive Cancer Center; University of Miami Sylvester Comprehensive Cancer Center; Doris Duke Charitable Foundation
Recruiting - verified October 2011
Evaluation of the Cook Biodesign Plastic Surgery Matrix

Conditions: Breast Cancer; Breast Reconstruction; Nipple Reconstruction
Intervention: Device: Nipple reconstruction
Sponsors: Cook; Cook
Recruiting - verified March 2012
Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation

Condition: Breast Cancer
Intervention: Device: classic v high-frequency electrocoagulation
Sponsors: Medical University of Gdansk; Medical University of Gdansk
Recruiting - verified January 2012
Phase III Trial Comparing Capecitabine in Combination With Sorafenib or Placebo in the Treatment of Locally Advanced or Metastatic HER2-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Sorafenib(Nexavar, BAY43-9006) / Capecitabine; Drug: Placebo / Capecitabine
Sponsors: Bayer; Bayer; Onyx Therapeutics, Inc.
Recruiting - verified April 2012
An Open-Label, Multi-Center, Expanded Access Program With Eribulin for the Treatment of Advanced Breast Cancer Refractory

Condition: Metastatic Breast Cancer
Intervention: Drug: Eribulin Mesylate
Sponsors: Eisai Inc.; Eisai Inc.
Available - verified April 2012
Positron Emission Tomography (PET)-Computed Tomography (CT) PET/CT Evaluation of Treatment Response in Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: Radiopharmaceutical Administration [18F]-FDG; Radiation: Radiopharmaceutical: [18F]-FLT
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center
Recruiting - verified November 2011
An Observational Study of Avastin (Bevacizumab) in Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified March 2012
Ex Vivo-Expanded HER2-Specific T Cells and Cyclophosphamide After Vaccine Therapy in Treating Patients With HER2-Positive Stage IV Breast Cancer

Conditions: HER2-positive Breast Cancer; Male Breast Cancer; Stage IV Breast Cancer
Interventions: Biological: HER-2/neu peptide vaccine; Drug: cyclophosphamide; Biological: ex vivo-expanded HER2-specific T cells; Other: laboratory biomarker analysis; Other: flow cytometry; Other: immunoenzyme technique
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012
Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction

Conditions: Breast Cancer; Ductal Carcinoma
Interventions: Procedure: Nipple Area Complex-Sparing Mastectomy; Radiation: Nipple Area Complex Irradiation; Procedure: Breast Reconstruction; Procedure: Axillary Dissection or Sentinel Node Biopsy (SNB); Drug: Chemotherapy
Sponsors: University of Miami Sylvester Comprehensive Cancer Center; University of Miami Sylvester Comprehensive Cancer Center
Recruiting - verified October 2011
Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer

Conditions: Healthy, no Evidence of Disease; Hereditary Breast/Ovarian Cancer - BRCA1; Hereditary Breast/Ovarian Cancer - BRCA2
Interventions: Other: questionnaire administration; Other: survey administration; Other: counseling intervention; Other: educational intervention
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified May 2012
Comparative Study of Neoadjuvant Chemotherapy With and Without Zometa for Management of Locally Advanced Breast Cancers

Conditions: Locally Advanced Breast Cancer; Ductal Histologic Type; Without Her2 Overexpression.
Interventions: Drug: Zometa + Neoadjuvant therapy; Drug: Neoadjuvant therapy
Sponsors: Hospices Civils de Lyon; Hospices Civils de Lyon
Recruiting - verified December 2011
Partial Breast Irradiation (PBI) Using 40 Gy for Select Patients With Early Invasive or Noninvasive Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: multiple beams utilizing either intensity-modulated or 3D-conformal techniques
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified April 2012
Safety and Efficacy of AZD4547 in Combination With Exemestane Versus Exemestane Alone in ER+ Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: AZD4547; Drug: Exemestane; Drug: Placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified February 2012
Yoga for Women With Breast Cancer Undergoing Radiotherapy

Condition: Breast Cancer
Interventions: Other: Yoga Program; Other: Stretching + Relaxation Program; Behavioral: Questionnaires
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified December 2011
A Randomized Study to Determine the Efficacy of a Taxane and Bevacizumab With or Without Capecitabine as First Line Chemotherapy in Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Taxane, Avastin; Drug: Taxane, Avastin, Xeloda
Sponsors: German Breast Group; German Breast Group
Recruiting - verified August 2011
Study Of Abraxane® And Carboplatin As First-Line Treatment For Triple Negative Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Abraxane; Drug: Carboplatin
Sponsors: Duke University; Duke University; Celgene Corporation
Recruiting - verified September 2011
Adjuvant Chemotherapy for Elderly Non Frail Patients With an Increased Risk for Relapse of a Primary Carcinoma of the Breast

Condition: Breast Cancer
Interventions: Drug: Epirubicin, Cyclophosphamide; Drug: Cyclophosphamide, Methotrexate, 5 FU; Drug: Capecitabine, Nab-Paclitaxel
Sponsors: German Breast Group; German Breast Group
Recruiting - verified August 2011
Gene Expression Profiling of Metastatic Breast Cancer Predict the Therapeutic Response to Chemotherapy

Conditions: Breast Neoplasms; Neoplasm Metastasis
Intervention:
Sponsors: Beijing Cancer Hospital; Beijing Cancer Hospital
Recruiting - verified August 2010
Comparative Efficiency of Three Regimen, CEFci, CEF and EC as Neoadjuvant Chemotherapy for Primary Breast Cancer

Condition: Breast Cancer
Interventions: Drug: 5-FU（intravenous infusion）+epirubicin+cyclophosphamide; Drug: 5-FU（intravenous bolus）+epirubicin+cyclophosphamide; Drug: epirubicin+cyclophosphamide
Sponsors: Peking University; Tao OUYANG
Recruiting - verified April 2012
Postoperative Analgesia Impact of Narcotic Free Anesthesia

Conditions: Pain, Postoperative; Breast Cancer; Postoperative Nausea and Vomiting
Interventions: Drug: fentanyl; Drug: beta-blocker (esmolol, metropolol)
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified February 2012
Skin Sparing Mastectomy and Immediate Breast Reconstruction With Latissimus Dorsi Flap After Neoadjuvant Chemotherapy and Radiotherapy (M-RIC)

Condition: Breast Carcinoma
Intervention: Procedure: Mastectomy, preservation of the skin envelope,followed by immediate reconstruction with autologous latissimus dorsi flap.
Sponsors: Clinique Clementville; Clinique Clementville
Recruiting - verified June 2011
Predictors of Ovarian Insufficiency in Young Breast Cancer Patients

Conditions: Breast Cancer; Ovarian Insufficiency; Ovarian Failure
Intervention:
Sponsors: University of California, San Diego; University of California, San Diego; University of Pennsylvania; American Cancer Society; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified August 2011
Safety, Tolerability, and Efficacy Study in Subjects With Advanced or Metastatic Breast Cancer

Condition: Advanced or Metastatic Breast Cancer
Intervention: Drug: KW-2450 in combination with lapatinib and letrozole
Sponsors: Kyowa Hakko Kirin Pharma, Inc.; Kyowa Hakko Kirin Pharma, Inc.
Recruiting - verified February 2012
A Study of Avastin (Bevacizumab) in Combination With Gemcitabine and Carboplatin as First Line Treatment in Patients With Triple Negative Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: gemcitabine; Drug: carboplatin
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Low Dose Tamoxifen in Hodgkin Lymphoma Survivors for Breast Cancer Risk Reduction

Condition: Breast Cancer
Interventions: Drug: Tamoxifen Citrate; Drug: Placebo
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI); St. Jude Children's Research Hospital; University Health Network, Toronto; Emory University; University of Michigan
Recruiting - verified February 2012
A Phase I Study of MGAH22 in Patients With Refractory HER2 Positive Cancers

Conditions: Non-Small Cell Lung Neoplasms; Prostate Neoplasms; Bladder Neoplasms; Ovarian Neoplasms; Breast Neoplasms
Intervention: Drug: MGAH22
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified March 2012
Re-expression of ER in Triple Negative Breast Cancers

Conditions: Breast Cancer; Breast Tumors; Breast Neoplasms
Intervention: Drug: Decitabine, LHB589, Tamoxifen
Sponsors: Emory University; Emory University; Novartis; Eisai Inc.
Recruiting - verified May 2012
Treatment Decision Impact of OncotypeDX™ in HR+, N- Breast Cancer Patients

Condition: Breast Cancer
Intervention: Device: Oncotype DX breast cancer test
Sponsors: Genomic Health®, Inc.; Genomic Health®, Inc.; Registrat-Mapi
Recruiting - verified April 2011
Preoperative Clinical Trial of Sorafenib in Combination With Cisplatin Followed by Paclitaxel for Triple Negative (ER-, PR-, Her2-)Early Stage Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Sorafenib
Sponsors: Emory University; Emory University; Onyx Pharmaceuticals; Bayer
Recruiting - verified April 2012
Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal Symptoms

Conditions: Ductal Carcinoma in Situ; Estrogen Receptor-positive Breast Cancer; Progesterone Receptor-positive Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Drug: letrozole; Drug: zoledronic acid; Other: laboratory biomarker analysis; Other: enzyme-linked immunosorbent assay; Other: mass spectrometry; Procedure: bone scan; Procedure: quality-of-life assessment; Other: questionnaire administration; Other: pharmacogenomic studies; Other: high performance liquid chromatography
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified January 2012
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors

Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy; Drug: Chemotherapy (control)
Sponsors: Medifocus, Inc.; Medifocus, Inc.
Recruiting - verified August 2011
Pilot Study of Partial Breast Irradiation Utilizing Permanent Breast Seed Implant to Treat Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: Partial Breast Irradiation Utilizing Permanent Breast Seed Implant
Sponsors: British Columbia Cancer Agency; British Columbia Cancer Agency; BC Cancer Foundation
Not yet recruiting - verified August 2011
PET-MR for Prediction and Monitoring of Response to Neoadjuvant Chemotherapy in Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Seoul National University Hospital; Seoul National University Hospital
Recruiting - verified July 2011
Anti Cancer Stem Cell Activity of Pre-operative Bevacizumab and Chemotherapy in Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab; Drug: no bevacizumab
Sponsors: Institut Paoli-Calmettes; Institut Paoli-Calmettes
Recruiting - verified April 2012
Personalised Program for Women Treated for Hodgkin Disease

Conditions: Hodgkin Disease; Breast Cancer
Intervention: Procedure: intensive screening
Sponsors: Institut Paoli-Calmettes; Institut Paoli-Calmettes
Recruiting - verified April 2012
Optimal Type of Aerobic Training in Breast Cancer

Condition: Breast Cancer
Interventions: Behavioral: High-Intensity Aerobic Training; Behavioral: Moderate-Intensity Aerobic Training; Behavioral: Progressive Stretching
Sponsors: Duke University; Duke University
Recruiting - verified July 2011
Intensity Modulated Radiotherapy (IMRT) vs. 3D-conformal Accelerated Partial Breast Irradiation (APBI) for Early Stage Breast Cancer After Lumpectomy

Condition: Breast Cancer
Interventions: Radiation: accelerated partial breast irradiation - 3D-conformal planning; Radiation: accelerated partial breast irradiation - IMRT planning
Sponsors: Rocky Mountain Cancer Centers; Rocky Mountain Cancer Centers
Recruiting - verified March 2011
Rehabilitation of Cognitive Changes in Breast Cancer Survivors

Condition: Breast Cancer
Intervention: Behavioral: Cogmed Working Memory Training Program
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; MARTELL FOUNDATION
Recruiting - verified October 2011
Study Evaluating the Safety and Efficacy of Onartuzumab (Metmab) And/Or Bevacizumab in Combination With Paclitaxel in Patients With Metastatic, Triple Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab; Drug: MetMAb; Drug: paclitaxel; Drug: placebo
Sponsors: Genentech; Genentech; Hoffmann-La Roche
Recruiting - verified March 2012
Aromasin® Non-Interventional Study Of Early Invasive Breast Cancer Patients In China

Condition: Breast Neoplasms
Intervention: Drug: Aromasin (exemestane)
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
Megadyne Ace Incision/Dissection Study

Conditions: Abdominoplasty; Bilateral Breast Reduction; Bilateral Breast Lift; Bilateral Brachioplasty; Bilateral Lateral Thigh and Buttocks Lift
Intervention: Device: E-Z Clean ACE Blade
Sponsors: Megadyne Medical Products Inc.; Megadyne Medical Products Inc.
Recruiting - verified February 2012
A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Conditions: Estrogen Receptor Negative (ER-Negative) Breast Cancer; Progesterone Receptor Negative (PR-Negative) Breast Cancer; Human Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer; Brain Metastases
Intervention: Drug: INIPARIB + irinotecan
Sponsors: Sanofi-Aventis; Sanofi-Aventis; UNC Lineberger Comprehensive Cancer Center
Recruiting - verified October 2011
Study of Apatinib in Metastatic Triple-Negative Breast Cancer Patients

Condition: Metastatic Breast Cancer
Intervention: Drug: Apatinib
Sponsors: Fudan University; Fudan University; Jiangsu HengRui Medicine Co., Ltd.
Recruiting - verified February 2012
Impact of Breast Magnetic Resonance Imaging (MRI) on Mastectomy Rates

Condition: Early Stage Breast Cancer
Intervention:
Sponsors: Summa Health System; Summa Health System
Recruiting - verified April 2012
A Study to Look at the Combination of Chemotherapy, Trastuzumab and RAD001 in HER2 Positive Breast Cancer

Condition: Breast Cancer
Intervention: Drug: paclitaxel
Sponsors: University of Kansas; University of Kansas; Novartis
Recruiting - verified October 2011
Neoadjuvant Platinum-based Chemoradiation Therapy for Locally Advanced Triple Negative Breast Cancer

Condition: Breast Neoplasms
Intervention: Drug: Platinum based chemotherapy, radiation, surgery
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified October 2011
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity

Conditions: Pleural Metastases; Breast Cancer; Colon Cancer; Ovarian Cancer; Uterine Cancer; Renal Cell Cancer; Thymic Cancer
Intervention: Procedure: Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
Sponsors: St. Luke's-Roosevelt Hospital Center; St. Luke's-Roosevelt Hospital Center
Recruiting - verified September 2011
Acupuncture Study for the Prevention of Taxane Induced Myalgias and Neuropathy

Conditions: Taxane Induced Neuropathy; Breast Cancer
Interventions: Other: Electro-acupuncture; Other: Sham acupuncture
Sponsors: Columbia University; Columbia University; Breast Cancer Research Foundation
Recruiting - verified October 2011
Study Evaluating Pantoprazole With Doxorubicin for Advanced Cancer Patients With Extension Cohort of Metastatic Breast Cancer Patients

Conditions: Advanced Solid Tumours; Breast Cancer
Interventions: Drug: pantoprazole sodium for injection; Drug: doxorubicin hydrochloride injection
Sponsors: University Health Network, Toronto; University Health Network, Toronto; Princess Margaret Hospital, Canada
Recruiting - verified March 2012
Study of Pregnancy Hormone Concentrations in Urban and Nomadic Mongolian Women

Condition: Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified March 2012
Genetics of Mammographic Appearances and Patterns (The GenMap Study)

Conditions: High Mammographic Density; Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified February 2012
Role of Early Versus Late Switch to Lapatinib-Capecitabine (TYCO)

Conditions: Cancer; Breast Cancer
Intervention: Drug: Treatment
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified April 2012
Exercise Program of Breast Cancer Patients Undergoing Chemotherapy With or Without Radiation

Condition: Breast Cancer
Intervention: Other: standardized regimen of exercises, including a warm-up period, ROM arm exercises, and strength training exercises.
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified November 2011
Improved Breast DCE MRI With SWIFT

Condition: Breast Cancer
Intervention: Device: Magnetic resonance imaging
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota; National Cancer Institute (NCI)
Recruiting - verified May 2012
Acupuncture for Sleep Disruption in Cancer Survivors

Conditions: Sleep Initiation and Maintenance Disorders; Breast Cancer
Intervention: Procedure: acupuncture
Sponsors: Stanford University; Stanford University; National Institutes of Health (NIH); National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified January 2012
Breast Cancer Patients: A Breast Cancer Rehabilitation and Exercise Laboratory

Condition: Early Stage Breast Cancer (Stage 0-III)
Intervention: Other: Exercise Regimen
Sponsors: Nevada Cancer Institute; Nevada Cancer Institute; Vons
Recruiting - verified July 2011
A Study to Compare the Safety and Efficacy of an Aromatase Inhibitor in Combination With Lapatinib, Trastuzumab or Both for the Treatment of Hormone Receptor Positive, HER2+ Metastatic Breast Cancer

Condition: Neoplasms, Breast
Interventions: Drug: lapatinib; Drug: trastuzumab; Drug: Aromatase inhibitor; Drug: lapatinib
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified May 2012
Moderating the Negative Impact of Abnormal Screening Mammograms

Condition: Breast Cancer
Intervention: Behavioral: Comprehensive Health Enhancement Support System (CHESS.)
Sponsors: University of Wisconsin, Madison; University of Wisconsin, Madison; National Cancer Institute (NCI)
Recruiting - verified November 2011
Excision Followed by Radiofrequency Ablation for Breast Cancer

Condition: Breast Cancer
Intervention: Device: Radiofrequency Ablation
Sponsors: University of Arkansas; University of Arkansas; Angiodynamics, Inc.
Recruiting - verified February 2012
Trial of Exemestane +/- MM-121 in Postmenopausal Women With Locally Advanced or Metastatic Estrogen Receptor Positive and/or Progesterone Receptor Positive Her2 Negative Breast Cancer

Condition: Her2 Negative Breast Cancer Patients
Interventions: Drug: MM-121 (SAR256212) and Exemestane; Drug: Placebo and Exemestane
Sponsors: Merrimack Pharmaceuticals; Merrimack Pharmaceuticals
Recruiting - verified May 2012
A Treatment With Fulvestrant and Exemestane in Postmenopausal Patients With Advanced Hormone Receptor-Positive (HR) + Breast Cancer

Conditions: Postmenopause; Breast Cancer
Intervention:
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor Therapy

Conditions: Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: vorinostat; Other: laboratory biomarker analysis; Procedure: biopsy; Radiation: F-18 16 alpha-fluoroestradiol; Procedure: positron emission tomography; Drug: anastrozole; Drug: letrozole; Drug: exemestane; Genetic: gene expression analysis
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Recruiting - verified March 2012
RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: exemestane; Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097; Drug: goserelin acetate
Sponsors: National Cancer Institute (NCI); H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI)
Recruiting - verified June 2011
Intraoperative Radiotherapy for Early Stage Breast Cancer

Condition: Breast Cancer
Intervention: Device: Intraoperative Radiotherapy
Sponsors: Hoag Memorial Hospital Presbyterian; Hoag Memorial Hospital Presbyterian
Recruiting - verified April 2012
Laboratory-Treated T Cells After Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer Undergoing Surgery

Condition: Breast Cancer
Interventions: Biological: HER2Bi-armed activated T cells; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: paclitaxel; Other: laboratory biomarker analysis; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: Barbara Ann Karmanos Cancer Institute; Barbara Ann Karmanos Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified January 2012
Safety Study of MGAH22 in HER2-positive Carcinomas

Conditions: Breast Cancer; Gastric Cancer; Bladder Cancer; Ovarian Cancer; Non-small Cell Lung Cancer
Intervention: Biological: MGAH22
Sponsors: MacroGenics; MacroGenics; Green Cross Corporation; National Cancer Institute (NCI)
Recruiting - verified April 2012
Study of Anastrozole +/- AZD8931 in Postmenopausal Women With Endocrine Therapy Naive Breast Cancer

Conditions: Neoplasms; Breast Neoplasms; Breast Cancer
Interventions: Drug: AZD8931; Drug: anastrozole; Drug: Placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
Docetaxel Plus Carboplatin Versus Epirubicin Plus Cyclophosphamide Followed by Docetaxel as Adjuvant Treatment in Triple-negative Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified September 2011
A Study of Avastin (Bevacizumab) Added to Herceptin (Trastuzumab) Plus Docetaxel in the Neoadjuvant Setting in Patients With Early Stage HER2-Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: trastuzumab [Herceptin]; Drug: docetaxel
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Incidence of Cancer in Women at Increased Genetic Risk of Ovarian Cancer

Conditions: Breast Cancer; Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Other: questionnaire administration; Procedure: evaluation of cancer risk factors; Procedure: quality-of-life assessment; Procedure: study of high risk factors
Sponsors: National Cancer Institute (NCI); Gynecologic Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Biomarkers in Blood Samples From Older Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: laboratory biomarker analysis; Other: medical chart review; Other: questionnaire administration
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Foretinib; Drug: Lapatinib
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified April 2012
A Phase II, Randomized, Open-label Study of Lapatinib Plus Chemotherapy Versus Trastuzumab Plus Chemotherapy in HER2-positive and p95HER2-positive Metastatic Breast Cancer

Condition: Neoplasms, Breast
Interventions: Drug: Lapatinib; Biological: Trastuzumab; Drug: Docetaxel; Drug: Paclitaxel; Drug: Vinorelbine
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Not yet recruiting - verified August 2011
Regimens Comparison for Breast Cancers of Positive Lymph Nodes

Condition: Breast Cancer
Interventions: Drug: Epirubicin, CTX, Paclitaxel; Drug: Epirubicin, Paclitaxel
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified September 2011
Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life

Condition: Breast Cancer
Interventions: Behavioral: survey web-based or telephone interview; Behavioral: survey web-based or telephone interview
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; The City College of New York; New York City Health and Hospitals Corporation; Lincoln Medical and Mental Health Center; New York Hospital Queens; Ralph Lauren Center for Cancer Care and Prevention
Recruiting - verified May 2012
A Study of Foretinib in Patients With Recurrent/Metastatic Breast Cancer

Condition: Recurrent Breast Cancer
Intervention: Drug: Foretinib
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified May 2012
A Study Evaluating the Efficacy and Safety of Lapatinib + Vinorelbine in ErbB2 Positive Metastatic Breast Cancer Patients

Condition: Metastatic Breast Cancer
Intervention: Drug: Lapatinib, Vinorelbine
Sponsors: Central European Cooperative Oncology Group; Central European Cooperative Oncology Group
Recruiting - verified May 2012
Bevacizumab and Paclitaxel or Bevacizumab, Cyclophosphamide, and Capecitabine as First-Line Therapy in Treating Women With Locally Advanced, Recurrent, or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: bevacizumab, Paclitaxel; Biological: Bevacizumab, Cyclophosphamide, Capecitabine
Sponsors: Swiss Group for Clinical Cancer Research; Swiss Group for Clinical Cancer Research
Recruiting - verified April 2012
Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors

Conditions: Brain and Central Nervous System Tumors; Breast Cancer; Colorectal Cancer; Kidney Cancer; Lung Cancer; Melanoma (Skin); Ovarian Cancer; Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: cediranib maleate; Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Princess Margaret Hospital, Canada; National Cancer Institute (NCI)
Recruiting - verified June 2011
Combination Therapy of F16IL2 and Paclitaxel in Solid Tumour Patients

Conditions: Tumour; Breast Cancer
Intervention: Drug: F16IL2 in combination with paclitaxel
Sponsors: Philogen S.p.A.; Philogen S.p.A.
Recruiting - verified August 2011
Effectiveness of a Cancer Center Based Physical Activity Intervention

Conditions: Breast Cancer; Quality of Life; Physical Activity
Intervention: Behavioral: Physical activity counseling
Sponsors: East Carolina University; East Carolina University
Recruiting - verified June 2011
Patient Registry: Partial Breast Irradiation

Condition: Breast Cancer
Intervention:
Sponsors: Aurora Health Care; David Rohde
Recruiting - verified January 2012
Multi-Beam Intensity-Modulated Radiation Therapy for Node-Positive Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: Multi-Beam Intensity-Modulated Radiation Therapy
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified January 2012
RAD001 Plus Carboplatin in Breast Cancer Patients

Condition: Breast Cancer
Intervention: Drug: RAD001
Sponsors: New York University School of Medicine; New York University School of Medicine; Novartis Pharmaceuticals
Recruiting - verified December 2011
A Pilot Study of Docosahexaenoic Acid (DHA) in Obese Menopausal Women

Conditions: Breast Cancer; Rectal Cancer; Colon Cancer; Obesity
Intervention: Dietary Supplement: dietary intervention
Sponsors: Rockefeller University; Rockefeller University
Recruiting - verified April 2012
Pharmacology of Adjuvant Hormonotherapy in Breast Cancer

Condition: Hormono-depending Adjuvant Breast Cancer
Intervention: Drug: Tamoxifen, Letrozole, Anastrozole or Exemestane
Sponsors: Institut Claudius Regaud; Institut Claudius Regaud
Recruiting - verified November 2011
Tamoxifen Citrate in Treating Patients With Metastatic or Recurrent Breast Cancer

Condition: Breast Cancer
Interventions: Drug: tamoxifen citrate; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Eastern Cooperative Oncology Group; National Cancer Institute (NCI)
Recruiting - verified February 2012
LUX-Breast 1: BIBW 2992 (Afatinib) in HER2-positive Metastatic Breast Cancer Patients After One Prior Herceptin Treatment

Condition: Breast Neoplasms
Interventions: Drug: BIBW 2992; Drug: trastuzumab; Drug: vinorelbine; Drug: vinorelbine
Sponsors: Boehringer Ingelheim Pharmaceuticals; Boehringer Ingelheim Pharmaceuticals
Recruiting - verified May 2012
Safety and Efficacy of BKM120 in Combination With Trastuzumab in Patients With Relapsing HER2 Overexpressing Breast Cancer Who Have Previously Failed Trastuzumab

Conditions: Metastatic Breast Cancer; Trastuzumab; BKM120; HER2+
Intervention: Drug: BKM120
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Paclitaxel Plus Bevacizumab for Older Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Bevacizumab; Drug: Paclitaxel
Sponsors: Hellenic Oncology Research Group; Hellenic Oncology Research Group; University Hospital of Crete
Recruiting - verified March 2012
Myocet Plus Endoxan for Older Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Cyclophosphamide; Drug: Liposomal-encapsulated doxorubicin
Sponsors: Hellenic Oncology Research Group; Hellenic Oncology Research Group; University Hospital of Crete
Recruiting - verified March 2012
Breast Cancer Rehabilitation Program in Improving Quality of Life in Breast Cancer Survivors

Conditions: Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Other: questionnaire administration; Behavioral: exercise intervention; Procedure: quality-of-life assessment; Other: survey administration; Procedure: management of therapy complications; Procedure: psychosocial assessment and care
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University
Recruiting - verified April 2012
A Study of Trastuzumab Emtansine (T-DM1) Plus Pertuzumab/Pertuzumab Placebo Versus Trastuzumab [Herceptin] Plus a Taxane in Patients With Metastatic Breast Cancer (MARIANNE)

Condition: Breast Cancer
Interventions: Drug: trastuzumab emtansine; Drug: pertuzumab; Drug: pertuzumab-placebo; Drug: trastuzumab [Herceptin]; Drug: docetaxel; Drug: paclitaxel
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche; Genentech
Recruiting - verified March 2012
Role of Beta-Endorphin in Cancer Therapy Fatigue

Conditions: Breast Cancer; Fatigue
Intervention:
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2012
Evaluation of the Diagnostic Performance of MRI±Biopsy to Optimize Resection of Ductal Carcinoma In Situ (DCIS) Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: MRI±biopsy
Sponsors: Institut Gustave Roussy; Institut Gustave Roussy; National Cancer Institute, France
Recruiting - verified October 2010
Reducing Breast Cancer Recurrence With Weight Loss

Conditions: Breast Cancer; Overweight; Obesity
Interventions: Behavioral: Intensive Group; Behavioral: Less Intensive Group
Sponsors: University of California, San Diego; University of California, San Diego; Washington University School of Medicine; University of Colorado, Denver; University of Alabama at Birmingham
Recruiting - verified March 2010
FNA Tumor Sampling for CD137 Modulation: A Pilot Study

Conditions: Head and Neck Cancer; Breast Cancer; Head and Neck Cancers
Intervention: Procedure: FNA Biopsy
Sponsors: Stanford University; Stanford University
Recruiting - verified May 2012
International Travel Patterns and Risk Behaviour of Breast Cancer, Lymphoma Patients and Bone Marrow Transplant Recipients

Conditions: Breast Cancer; Lymphoma
Intervention: Behavioral: questionnaires
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified November 2011
Fluorescence-guided Resection in Breast Cancer

Condition: Breast Tumour
Intervention: Drug: PD L 506
Sponsors: photonamic GmbH & Co. KG; photonamic GmbH & Co. KG
Recruiting - verified February 2012
Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Temsirolimus plus Neratinib
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; National Comprehensive Cancer Network; Wyeth Pharmaceuticals, Inc., a Pfizer Company
Recruiting - verified May 2012
Fast Spectral Imaging Device for Tumor Margin Mapping

Condition: Breast Cancer
Intervention:
Sponsors: Duke University; Duke University; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting - verified June 2011
Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: letrozole; Drug: panobinostat; Genetic: RNA analysis; Genetic: microarray analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: enzyme-linked immunosorbent assay; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); North Central Cancer Treatment Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Allogeneic Natural Killer (NK) Cells for Ovarian, Fallopian Tube, Peritoneal and Metastatic Breast Cancer

Conditions: Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Breast Cancer
Interventions: Drug: Fludarabine; Drug: Cyclophosphamide; Drug: Cyclosporine; Biological: Natural killer cells; Drug: IL-2; Drug: Methylprednisolone; Drug: Methylprednisolone; Drug: Interleukin-2
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2012
Progressive Resistance Training Versus Relaxation for Breast Cancer Patients During Chemotherapy: Biological Mechanisms and Effects on Fatigue and Quality of Life

Conditions: Breast Cancer; Cancer-related Fatigue
Interventions: Other: Supervised progressive resistance training; Other: Supervised progressive muscle relaxation training (Jacobsen method)
Sponsors: German Cancer Research Center; German Cancer Research Center; National Center for Tumor Diseases, Heidelberg; Heidelberg University Hospital; Central Institute of Mental Health, Mannheim
Recruiting - verified April 2012
Veliparib, Cisplatin, and Vinorelbine Ditartrate in Treating Patients With Recurrent and/or Metastatic Breast Cancer

Conditions: Estrogen Receptor-negative Breast Cancer; Hereditary Breast/Ovarian Cancer - BRCA1; Hereditary Breast/Ovarian Cancer - BRCA2; Male Breast Cancer; Progesterone Receptor-negative Breast Cancer; Recurrent Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer
Interventions: Other: immunohistochemistry staining method; Genetic: gene expression analysis; Drug: veliparib; Drug: cisplatin; Drug: vinorelbine tartrate; Other: pharmacological study; Other: laboratory biomarker analysis
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Trastuzumab or Lapatinib Ditosylate in Treating Women With Early Breast Cancer

Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: lapatinib ditosylate; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Institute of Cancer Research, United Kingdom
Recruiting - verified July 2011
A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer

Condition: Breast Cancer
Interventions: Drug: metformin hydrochloride; Other: placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
A Registry Study of Permanent Breast Seed Implant

Condition: Breast Neoplasms
Intervention: Radiation: Permanent breast seeds implant
Sponsors: Sunnybrook Health Sciences Centre; Sunnybrook Health Sciences Centre; West Penn Allegheny Health System; British Columbia Cancer Agency; CHUQ
Recruiting - verified February 2012
Study of a Novel Indibulin Dosing Schedule for the Treatment of Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Indibulin
Sponsors: ZIOPHARM; ZIOPHARM; Memorial Sloan-Kettering Cancer Center
Recruiting - verified January 2012
High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer

Conditions: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer
Interventions: Dietary Supplement: cholecalciferol; Other: placebo
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Multiple Oncological Serial Scans Study

Condition: Breast Cancer
Interventions: Procedure: CT SCAN; Procedure: MRI scan; Procedure: 3D Ultrasound scan
Sponsors: United Bristol Healthcare NHS Trust; United Bristol Healthcare NHS Trust; Bosum Buddies; Friends of the Bristol Haematology and Oncology Centre
Recruiting - verified October 2010
MM-111 in Combination With Herceptin in Patients With Advanced Her2 Amplified, Heregulin Positive Breast Cancer

Conditions: HER2 Amplified Breast Cancer; Metastatic or Advanced Breast Cancer
Intervention: Drug: MM-111 and Herceptin
Sponsors: Merrimack Pharmaceuticals; Merrimack Pharmaceuticals
Recruiting - verified March 2012
Neo-Adjuvant Study in Triple Negative Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: Cetuximab; Drug: Ixabepilone
Sponsors: The Methodist Hospital System; The Methodist Hospital System; Bristol-Myers Squibb
Recruiting - verified June 2011
Positron Emission Tomography in Women With Advanced HER2-Positive Breast Cancer

Conditions: Breast Cancer; Stage IV Breast Cancer
Interventions: Procedure: positron emission tomography; Radiation: copper Cu 64-DOTA-trastuzumab; Procedure: Biopsy; Other: Immunohistochemistry staining method; Other: laboratory biomarker analysis; Genetic: mutation analysis
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified May 2012
MLN8237 in Patients With Ovarian, Fallopian Tube or Peritoneal Cancer Preceded by Phase 1 Study of MLN8237 Plus Paclitaxel Treatment of Ovary or Breast Cancer

Conditions: Ovarian Carcinoma; Fallopian Tube Cancer; Peritoneal Cancer; Breast Carcinoma
Interventions: Drug: MLN8237 + Paclitaxel; Drug: MLN8237+Paclitaxel vs. Paclitaxel alone
Sponsors: Millennium Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.
Recruiting - verified December 2011
Reducing Pain and Disability After Breast Cancer Surgery

Conditions: Breast Cancer; Chronic Pain
Interventions: Procedure: Thoracic Paravertebral Block (TPVB); Procedure: Local Anesthetic
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Canadian Breast Cancer Foundation
Recruiting - verified July 2011
Study of Neoadjuvant Chemotherapy With Nanoparticle Albumin Bound Paclitaxel, Doxorubicin and Cyclophosphamide (NAC) in Patients With Stages II-III Breast Cancer

Condition: Stages II-III Breast Cancer
Interventions: Drug: Nanoparticle Albumin Bound Paclitaxel; Drug: doxorubicin; Drug: cyclophosphamide
Sponsors: University of South Alabama; University of South Alabama; Celgene Corporation
Recruiting - verified August 2011
Nurse Intervention Project

Condition: Breast Cancer Patients
Intervention: Device: distress thermometer
Sponsors: Radboud University; Radboud University
Recruiting - verified September 2011
Imaging of ER Density to Guide and Improve Tailored Therapy for Acquired Anti-hormonal Resistant Breast Cancer

Condition: Breast Cancer
Intervention: Other: Diagnostic intervention: Positron Emission Tomography with 16-alpha-[18-fluoro]-17betaestradiol
Sponsors: University Medical Centre Groningen; University Medical Centre Groningen; Dutch Cancer Society
Recruiting - verified May 2011
A Study of Avastin With Taxane Therapy in Patients With Triple Negative Breast Cancer

Condition: Breast Cancer
Intervention: Drug: bevacizumab [Avastin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
A Pilot Study of F-18 Paclitaxel (FPAC) PET for Evaluating Drug Delivery of Solid Tumors in Breast, Lung, Renal, and Adrenal Cancers

Conditions: Breast Cancer; Lung Cancer; Renal Cancer; Adrenal Cancer
Intervention: Drug: F-18 Paclitaxel (FPAC)
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Not yet recruiting - verified September 2011
Ixabepilone and Vorinostat in Treating Patients With Metastatic Breast Cancer

Conditions: Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: vorinostat; Drug: ixabepilone; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified March 2012
Female Cancer Patients' Preference For Sexual Health Interventions

Conditions: Breast Cancer; Gynecologic Cancer
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified December 2011
Estrogen for Triple Negative Breast Cancer

Condition: Female Breast Cancer
Intervention: Drug: Estradiol
Sponsors: University of Wisconsin, Madison; University of Wisconsin, Madison
Recruiting - verified February 2012
Radiation Therapy in Treating Women With Locally Recurrent Breast Cancer Previously Treated With Repeat Breast-Preserving Surgery

Condition: Breast Cancer
Interventions: Other: circulating tumor cell analysis; Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: adjuvant therapy; Radiation: 3-dimensional conformal accelerated partial breast irradiation
Sponsors: National Cancer Institute (NCI); Radiation Therapy Oncology Group; National Cancer Institute (NCI)
Recruiting - verified July 2011
Study of XL147 (SAR245408) or XL765 (SAR245409) in Combination With Letrozole in Subjects With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: XL147 (SAR245408); Drug: XL765 (SAR245409); Drug: letrozole (Femara)
Sponsors: Sanofi-Aventis; Sanofi-Aventis
Recruiting - verified April 2012
Letrozole in Treating Healthy Postmenopausal Women at High Risk for Breast Cancer

Condition: Breast Cancer
Intervention: Drug: letrozole
Sponsors: National Cancer Institute (NCI); National Cancer Institute (NCI); University of Arizona
Recruiting - verified October 2011
PARP Inhibition for Triple Negative Breast Cancer (ER-/PR-/HER2-)With BRCA1/2 Mutations

Condition: Breast Cancer
Interventions: Drug: Cisplatin; Drug: Rucaparib; Drug: Cisplatin
Sponsors: Hoosier Oncology Group; Hoosier Oncology Group; Clovis Oncology, Inc.
Recruiting - verified March 2012
Pilot Study Using Molecular Profiling to Find Potential Targets and Select Treatments for Patients With Metastatic Breast Cancer.

Condition: Metastatic Breast Cancer
Intervention: Drug: (will be assigned based on molecular profile and RPMA)
Sponsors: TGen Drug Development Services; TGen Drug Development Services; SideOut Foundation
Recruiting - verified January 2012
Low Level Laser Therapy for Hair Preservation With Chemotherapy for Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: Low-Level Laser Therapy
Sponsors: Northwestern University; Northwestern University; Robert H. Lurie Cancer Center
Not yet recruiting - verified October 2011
Stanford Accelerated Recovery Trial (START)

Conditions: Pain; Breast Cancer; Lung Cancer
Interventions: Drug: Gabapentin; Drug: Placebo
Sponsors: Stanford University; Stanford University
Recruiting - verified September 2011
Study of Denosumab as Adjuvant Treatment for Women With High Risk Early Breast Cancer Receiving Neoadjuvant or Adjuvant Therapy (D-CARE)

Condition: Breast Cancer
Interventions: Drug: Placebo; Drug: Denosumab
Sponsors: Amgen; Amgen; Daiichi Sankyo Inc.
Recruiting - verified April 2012
Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer

Conditions: Metastatic Non Small Cell Lung Cancer; Metastatic Breast Cancer
Interventions: Drug: Pazopanib; Drug: Vinorelbine
Sponsors: Northwestern University; Northwestern University; Robert H. Lurie Cancer Center
Recruiting - verified October 2011
Neo Adjuvant Chemotherapy in Triple Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Docetaxel, Capecitabine; Drug: Doxorubicin, cyclophosphamide; Drug: Doxorubicin, cyclophosphamide, carboplatin, thiotepa, cyclophosphamide
Sponsors: The Netherlands Cancer Institute; The Netherlands Cancer Institute
Recruiting - verified May 2012
To Evaluate the Characteristics of a Breast Cancer

Condition: Breast Cancer
Interventions: Drug: EF5; Procedure: Partial or Total Mastectomy
Sponsors: Duke University; Duke University; National Institutes of Health (NIH); National Cancer Institute (NCI)
Not yet recruiting - verified June 2011
Facilitating Physical Activity Behavior and Health Outcomes in Breast Cancer Patients Receiving Chemotherapy

Condition: Breast Cancer
Interventions: Behavioral: Physical Activity Resource Kit; Behavioral: Standard Materials
Sponsors: Athabasca University; Athabasca University; University of Alberta; University of Calgary; Alberta Health Services
Recruiting - verified January 2010
Rosuvastatin in Treating Women With Cardiovascular Complications Who Are Undergoing Chemotherapy For Breast Cancer

Conditions: Cardiovascular Complications; Recurrent Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Breast Cancer
Interventions: Drug: rosuvastatin; Other: placebo; Other: survey administration; Procedure: management of therapy complications
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified April 2012
Aromatase Inhibitor-Associated Musculoskeletal Symptoms in Non-Metastatic, Post Menopausal Breast Cancer Patients

Condition: Breast Cancer
Interventions: Other: History and Physical Exam; Other: Grip Strength Measurement; Behavioral: Surveys; Other: Blood Collection; Procedure: Ultrasound of Hand/Wrist
Sponsors: University of California, Los Angeles; University of California, Los Angeles
Recruiting - verified February 2012
Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III Breast Cancer Who Are Receiving Paclitaxel

Conditions: Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Procedure: acupuncture therapy; Drug: paclitaxel; Other: questionnaire administration; Procedure: management of therapy complications
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified March 2012
Omega-3 Fatty Acids and Chemotherapy-induced Neuropathy and Inflammation in Breast Cancer

Condition: Breast Cancer
Interventions: Dietary Supplement: oil fish; Other: corn oil pearls
Sponsors: Tehran University of Medical Sciences; Tehran University of Medical Sciences
Recruiting - verified April 2011
Characterization of Circulating Tumor Cells (CTCs) to Direct Pre-Operative and Systemic Therapy in Patients With Locally Advanced or Metastatic Stage IV Breast Cancer

Conditions: Locally Advanced Breast Cancer; Metastatic (Stage IV) Breast Cancer; Stage III-IV Breast Cancer or Inflammatory
Intervention:
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI); Palo Alto Research Center
Recruiting - verified March 2012
Use of PRO Onc Assay to Assess HER2 in Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Procedure: PRO Onc Assay; Drug: Trastuzumab; Drug: Pertuzumab
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Prometheus Therapeutics and Diagnostics; Genentech
Recruiting - verified April 2012
MLN8237 in Adults With Nonhematological Malignancies, Followed by MLN8237 in Lung, Breast, Head and Neck or Gastroesophageal Malignancies

Conditions: Advanced Nonhematological Malignancies; Non-Small Cell Lung Cancer; Small Cell Lung Cancer; Metastatic Breast Cancer; Head and Neck Squamous Cell Carcinoma; Gastroesophageal Adenocarcinoma
Intervention: Drug: MLN8237
Sponsors: Millennium Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.
Recruiting - verified April 2012
Lapatinib in Combination With Docetaxel in Patients With HER-2 Positive Advanced or Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: lapatinib; Drug: docetaxel
Sponsors: Centre Georges Francois Leclerc; Centre Georges Francois Leclerc; GlaxoSmithKline; Sanofi-Aventis
Recruiting - verified November 2011
Cone Beam Computed Tomography for Breast Imaging

Condition: Breast Cancer
Interventions: Device: Computed Tomography; Device: Computed Tomography
Sponsors: Koning Corporation; Koning Corporation; Elizabeth Wende Breast Care; National Cancer Institute (NCI)
Recruiting - verified January 2012
Study of Ad.p53 DC Vaccine and 1-MTin Metastatic Invasive Breast Cancer

Condition: Breast Cancer
Interventions: Biological: Ad.p53 DC vaccine; Drug: 1-methyl-D-tryptophan (1-MT)
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI)
Recruiting - verified February 2012
I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Conditions: Breast Neoplasms; Breast Cancer; Breast Tumors
Interventions: Drug: Neratinib; Drug: ABT-888; Drug: Standard Therapy; Drug: AMG 386; Drug: AMG 479 (Ganitumab) plus Metformin
Sponsors: Foundation for the National Institutes of Health; Foundation for the National Institutes of Health
Recruiting - verified December 2011
Breast Lymph Node Mapping

Condition: Breast Cancer
Interventions: Other: Isosulfan Blue (Patent Blue Dye V); Other: Isosulfan Blue (Patent Blue Dye V)
Sponsors: University of British Columbia; University of British Columbia
Not yet recruiting - verified April 2012
Magnetic Resonance Imaging of Breast Cancer

Conditions: Breast Cancer; Breast Cancer Non-invasive Breast Cancer
Intervention: Procedure: MRI
Sponsors: Stanford University; Stanford University; National Institutes of Health (NIH)
Recruiting - verified May 2012
Panitumumab, Nab-paclitaxel and Carboplatin for HER2 Negative Inflammatory Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Panitumumab; Drug: Nab-paclitaxel; Drug: Carboplatin; Drug: 5-Fluorouracil; Drug: Epirubicin; Drug: Cyclophosphamide
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Celgene Corporation; Amgen
Recruiting - verified April 2012
Trial of Amrubicin as Treatment for Patients With HER2-Negative Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Amrubicin
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Celgene Corporation
Recruiting - verified July 2011
Adipose Tissue Transfer for Moderate Breast Cancer Conservative Treatment Sequella

Condition: Breast Cancer
Intervention: Procedure: fatty tissue transfer
Sponsors: Institut Claudius Regaud; Institut Claudius Regaud
Recruiting - verified November 2011
PD 0332991 in Treating Patients With Refractory Solid Tumors

Conditions: Adult Solid Tumor; Adenocarcinoma of the Colon; Adenocarcinoma of the Rectum; Adult Central Nervous System Germ Cell Tumor; Adult Teratoma; Benign Teratoma; Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; Familial Testicular Germ Cell Tumor; HER2-negative Breast Cancer; HER2-positive Breast Cancer; Male Breast Cancer; Ovarian Immature Teratoma; Ovarian Mature Teratoma; Ovarian Monodermal and Highly Specialized Teratoma; Progesterone Receptor-negative Breast Cancer; Progesterone Receptor-positive Breast Cancer; Recurrent Breast Cancer; Recurrent Colon Cancer; Recurrent Extragonadal Germ Cell Tumor; Recurrent Extragonadal Non-seminomatous Germ Cell Tumor; Recurrent Extragonadal Seminoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Melanoma; Recurrent Ovarian Germ Cell Tumor; Recurrent Rectal Cancer; Stage III Extragonadal Non-seminomatous Germ Cell Tumor; Stage III Extragonadal Seminoma; Stage III Malignant Testicular Germ Cell Tumor; Stage III Ovarian Germ Cell Tumor; Stage IV Breast Cancer; Stage IV Colon Cancer; Stage IV Extragonadal Non-seminomatous Germ Cell Tumor; Stage IV Extragonadal Seminoma; Stage IV Melanoma; Stage IV Ovarian Germ Cell Tumor; Stage IV Rectal Cancer; Testicular Immature Teratoma; Testicular Mature Teratoma
Interventions: Drug: PD-0332991; Other: pharmacological study
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified February 2012
Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life

Condition: Breast Cancer
Intervention:
Sponsors: City of Hope Medical Center; City of Hope Medical Center
Recruiting - verified March 2012
Imaging Modality Effects on the Multi-dimensional InfraRed Analysis (MIRA) Technology

Condition: Breast Cancer
Intervention:
Sponsors: Real Imaging Ltd.; Real Imaging Ltd.
Not yet recruiting - verified December 2009
Assessment of Cardiotoxicity by Cardiac Magnetic Resonance (CMR) in Breast Cancer Patients Receiving Trastuzumab

Condition: Stage I-IV Breast Cancer (Neo-adjuvant, Adjuvant, Locally Advanced and Metastatic)
Interventions: Procedure: Cardiac MRI; Biological: Biomarker Testing
Sponsors: St. Michael's Hospital, Toronto; St. Michael's Hospital, Toronto; Hoffmann-La Roche
Recruiting - verified August 2011
A Study of a Combination of Trastuzumab and Capecitabine With or Without Pertuzumab in Patients With HER2-positive Metastatic Breast Cancer (PHEREXA)

Condition: Breast Cancer
Interventions: Drug: pertuzumab; Drug: capecitabine [Xeloda]; Drug: capecitabine [Xeloda]; Drug: trastuzumab [Herceptin]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Laboratory-Treated T Cells After Second-Line Chemotherapy in Treating Women With HER2/Neu-Negative Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: HER2Bi-armed activated T cells; Drug: Cyclophosphamide; Other: Laboratory biomarker analysis
Sponsors: Barbara Ann Karmanos Cancer Institute; Barbara Ann Karmanos Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified November 2011
Internal Radiation Therapy of the Breast in Treating Women With Early-Stage Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: accelerated partial breast irradiation; Radiation: intracavitary balloon brachytherapy
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; SenoRx, Inc.
Recruiting - verified December 2011
Alternative Non-cross-resistant Adjuvant Chemotherapy for Operable Breast Cancer Non-response to Primary Chemotherapy

Condition: Primary Breast Cancer
Intervention: Drug: paclitaxel/anthracycline
Sponsors: Peking University; Tao OUYANG; Beijing Municipal Science & Technology Commission; Peking Union Medical College Hospital; Chinese Academy of Medical Sciences; Peking University First Hospital; Peking University People's Hospital; Beijing Chao Yang Hospital; 307 Hospital of PLA
Recruiting - verified April 2012
Evaluating the Adequacy of Giro-Couch to Support Prone Breast Boost Irradiation Using IMRT Technique With IGRT.

Condition: Breast Cancer
Intervention: Device: Support Device for Prone radiation therapy (Giro-Couch)
Sponsors: Azimuth Therapy Ltd.; Azimuth Therapy Ltd.
Not yet recruiting - verified August 2011
Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research

Conditions: Breast Cancer; Heart Failure
Intervention: Drug: perindopril OR bisoprolol OR placebo
Sponsors: Alberta Health Services; University of Alberta
Recruiting - verified April 2012
Primary Operation in SYnchronous meTastasized InVasivE Breast Cancer

Conditions: Synchronous Metastasized Breast Cancer; Circulating Tumor Cells
Interventions: Procedure: Surgery; Procedure: Surgery on Demand
Sponsors: Austrian Breast & Colorectal Cancer Study Group; Austrian Breast & Colorectal Cancer Study Group; Bayer; Amgen; Hoffmann-La Roche; AstraZeneca; Sanofi Aventis GmbH, Austria; Wyeth Lederle Pharma GmbH, Austria; GlaxoSmithKline; Merck Sharp & Dohme GmbH, Austria; Fond of the Viennese Mayor
Recruiting - verified February 2012
Chemotherapy-Induced Peripheral Neuropathy Survey

Conditions: Breast Cancer; Colorectal Cancer; Myeloma; Chemotherapy-induced Peripheral Neuropathy
Interventions: Behavioral: Questionnaire; Behavioral: Sensory Tests; Behavioral: Interview
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified March 2012
Staging of Axillary Lymph Nodes Using the PEM Flex Solo II Pet Scanner in Patients With Breast Cancer

Condition: Breast Cancer
Intervention: Device: Positron Emission Mammography
Sponsors: University of Chicago; University of Chicago
Recruiting - verified June 2011
Paclitaxel, Carboplatin, and Panitumumab in Treating Patients With Metastatic Breast Cancer

Conditions: Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Biological: panitumumab; Drug: paclitaxel; Drug: carboplatin; Procedure: laboratory biomarker analysis; Procedure: immunohistochemistry staining method
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University
Recruiting - verified April 2012
Lisinopril or Carvedilol Phosphate in Reducing Side Effects in Women With HER2-Positive Breast Cancer Receiving Trastuzumab

Conditions: Breast Cancer; Cardiac Toxicity
Interventions: Drug: carvedilol phosphate extended-release capsule; Drug: lisinopril; Other: placebo
Sponsors: National Cancer Institute (NCI); University of South Florida; National Cancer Institute (NCI)
Recruiting - verified February 2012
Valproic Acid in Combination With FEC100 for Primary Therapy in Patients With Breast Cancer

Condition: Breast Cancer
Intervention: Drug: VPA FEC100
Sponsors: University of California, San Francisco; University of California, San Francisco; H. Lee Moffitt Cancer Center and Research Institute
Recruiting - verified March 2012
Evaluation of Trastuzumab Without Chemotherapy as a Postoperative Adjuvant Therapy in HER2 Positive Elderly Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: trastuzumab; Drug: chemotherapy
Sponsors: Comprehensive Support Project for Oncology Research; Comprehensive Support Project for Oncology Research
Recruiting - verified June 2011
Ritonavir and Its Effects on Biomarkers in Women Undergoing Surgery for Newly Diagnosed Breast Cancer

Condition: Breast Cancer
Interventions: Drug: ritonavir; Procedure: therapeutic conventional surgery
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota; Susan G. Komen Breast Cancer Foundation
Recruiting - verified January 2012
Prediction of Response to Neoadjuvant Chemotherapy in Women With Operable Breast Cancer

Condition: Breast Cancer
Intervention: Other: ChemoFX Assay
Sponsors: Precision Therapeutics; Precision Therapeutics; Department of Defense
Recruiting - verified December 2011
Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Trastuzumab; Drug: Neratinib; Drug: Trastuzumab (post surgery); Drug: Doxorubicin; Drug: Cyclophosphamide
Sponsors: National Surgical Adjuvant Breast and Bowel Project (NSABP); National Surgical Adjuvant Breast and Bowel Project (NSABP); Wyeth Pharmaceuticals, Inc., a Pfizer Company
Recruiting - verified February 2012
Daily Everolimus in Combination With Trastuzumab and Vinorelbine in HER2/Neu Positive Women With Locally Advanced or Metastatic Breast Cancer

Conditions: HER2/Neu Over-expressing Locally Advanced Breast Cancer; Metastatic Breast Cancer
Interventions: Drug: everolimus, vinorelbine, trastuzumab; Drug: Placebo + vinorelbine + trastuzumab
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
Molecular Signature of Valproic Acid in Breast Cancer With Functional Imaging Assessment - a Pilot

Condition: Cancer
Intervention: Drug: Valproic Acid
Sponsors: University of Utah; University of Utah
Recruiting - verified January 2012
Efficacy and Safety of DLBS1425 in Subjects With Advanced/Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: DLBS1425; Drug: DLBS1425
Sponsors: Dexa Medica Group; Dexa Medica Group
Recruiting - verified April 2012
Nipple Sparing Mastectomy - Cosmetic Outcomes

Conditions: Breast Cancer; Breast Reconstruction; Cosmesis
Intervention: Procedure: Nipple Sparing Mastectomy
Sponsors: Carolinas Healthcare System; Carolinas Healthcare System
Recruiting - verified June 2011
Tissue Repository for Correlation of Molecular Markers With Response to Neoadjuvant and Metastatic Chemotherapy

Condition: Breast Cancer
Interventions: Other: biologic sample preservation procedure; Other: laboratory biomarker analysis; Procedure: biopsy
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Bimatoprost Ophthalmic Solution in Increasing Eyebrow and Eyelash Growth in Patients Who Have Undergone Chemotherapy for Breast Cancer and in Healthy Participants

Conditions: Alopecia; Breast Cancer
Interventions: Drug: bimatoprost ophthalmic solution; Drug: placebo
Sponsors: University of California, Los Angeles; University of California, Los Angeles; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Extension Study of Lapatinib Plus Herceptin With or Without Endocrine Therapy

Condition: Breast Cancer
Interventions: Drug: Herceptin / Lapatinib; Drug: Letrozole
Sponsors: Baylor Breast Care Center; Baylor Breast Care Center; Translational Breast Cancer Reserach Consortium; GlaxoSmithKline
Recruiting - verified January 2012
Compassionate Use of the Becker Expander/Breast Implant

Condition: Breast Reconstruction
Interventions: Device: Becker 50 Expander/Breast implant; Device: Becker 25 Expander/Breast implant
Sponsors: Mentor Worldwide, LLC; Mentor Worldwide, LLC
Available - verified March 2012
Study Assessing Safety and Tolerability of AZD8931 Alone or in Combination With Paclitaxel in Japanese Patients

Conditions: Neoplasms; Metastatic Cancer; Breast Cancer
Interventions: Drug: AZD8931; Drug: Paclitaxel
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
Study Comparing Whole Breast Radiotherapy With a Daily Versus a Weekly Tumor

Condition: Breast Cancer
Intervention: Radiation: Radiation therapy
Sponsors: New York University School of Medicine; New York University School of Medicine; department of radiation oncology
Recruiting - verified November 2011
A Study in Cancer Patients to Evaluate the Bioequivalence of Alternative Formulations of Lapatinib

Conditions: ErbB2 Overexpressing; Solid Tumors; Metastatic Breast Cancer; Neoplasms, Breast
Intervention: Drug: lapatinib
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified December 2011
F511 Cream in Preventing Palmar-Plantar Erythrodysesthesia in Patients Receiving Doxorubicin Hydrochloride Liposome for Metastatic Breast Cancer

Conditions: Breast Cancer; Palmar-plantar Erythrodysesthesia
Interventions: Drug: antiperspirant cream F511; Drug: pegylated liposomal doxorubicin hydrochloride
Sponsors: National Cancer Institute (NCI); Swiss Group for Clinical Cancer Research
Recruiting - verified July 2010
High-dose Methotrexate and Liposomal Cytarabine in Treating Patients With CNS Metastases From Breast Cancer

Conditions: Central Nervous System Metastases; Leptomeningeal Metastases; Recurrent Breast Cancer; Stage IV Breast Cancer; Tumors Metastatic to Brain
Interventions: Drug: methotrexate; Drug: liposomal cytarabine; Other: quality-of-life assessment; Other: questionnaire administration
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Recruiting - verified March 2012
A Multi Modality Surveillance Program for Women At High Risk for Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: University of Chicago; University of Chicago
Recruiting - verified June 2011
MUC1 Vaccine for Triple-negative Breast Cancer

Conditions: Breast Cancer; Inflammatory Breast Cancer; Stage I Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Triple-negative Breast Cancer
Interventions: Biological: MUC-1 peptide vaccine; Biological: poly ICLC; Biological: MUC1 peptide-poly-ICLC adjuvant vaccine; Other: laboratory biomarker analysis; Other: enzyme-linked immunosorbent assay; Other: flow cytometry
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center
Recruiting - verified March 2012
Serum Estradiol Levels In Postmenopausal Women With Breast Cancer Receiving Adjuvant Aromatase Inhibitors and Vaginal Estrogen

Conditions: Atrophic Vaginitis; Breast Cancer
Intervention: Drug: Vagifem® (vaginal 17β-estradiol) questionnaire & menopause symptom checklist
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified April 2012
Geriatric Group Psychoeducational Intervention for Elderly Patients With Cancer

Conditions: Breast Cancer; Prostate Cancer; Lung Cancer; Lymphoma Cancer; Gynecological Cancers
Interventions: Behavioral: group intervention and questionnaires; Behavioral: individual phone intervention and questionnaires
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified December 2011
Study to Evaluate the Effect of Sulforaphane in Broccoli Sprout Extract on Breast Tissue

Condition: Breast Cancer
Interventions: Drug: Broccoli sprout extract (sulforaphane); Dietary Supplement: Mango juice without extract
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; Breast Cancer Research Foundation
Recruiting - verified January 2012
Cyclosporine A in Combination With Nab-Paclitaxel in Patients With Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Cyclosporins; Drug: nab-paclitaxel
Sponsors: Northwestern University; Northwestern University; Avon Foundation
Recruiting - verified May 2012
Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner and Stereo Navigator Biopsy Accessory for the Diagnosis of Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: PEM Breast Biopsy
Sponsors: University of Cincinnati; University of Cincinnati
Recruiting - verified March 2012
A Study of Combination of Temsirolimus (Torisel®) and Pegylated Liposomal Doxorubicin (PLD, Doxil®/Caelyx®) in Advanced or Recurrent Breast, Endometrial and Ovarian Cancer

Conditions: Advanced/Recurrent Breast Cancer; Endometrial Cancer; Ovarian Cancer
Intervention: Drug: Temsirolimus/PLD
Sponsors: Radboud University; Radboud University
Recruiting - verified April 2012
Transfected Dendritic Cell Based Therapy for Patients With Breast Cancer or Malignant Melanoma

Conditions: Breast Cancer; Malignant Melanoma
Intervention: Biological: DC vaccine
Sponsors: Herlev Hospital; Herlev Hospital
Recruiting - verified March 2010
Study of CoQ10 During One Cycle of Doxorubicin Treatment for Breast Cancer

Condition: Breast Cancer
Interventions: Dietary Supplement: Coenzyme Q10; Dietary Supplement: Coenzyme Q10 Placebo
Sponsors: Columbia University; Columbia University; National Institutes of Health (NIH)
Recruiting - verified October 2011
Regulatory Tykerb PMS

Conditions: Cancer; Breast Cancer
Intervention: Drug: tykerb
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified August 2011
Cyclophosphamide and Vaccine Therapy With or Without Trastuzumab in Treating Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: allogeneic GM-CSF-secreting breast cancer vaccine; Biological: trastuzumab; Drug: cyclophosphamide
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Cone Beam Computed Tomography for Breast Imaging

Condition: Breast Cancer
Interventions: Radiation: Computed Tomography; Radiation: Computed Tomography; Radiation: Computed Tomography
Sponsors: Koning Corporation; Koning Corporation
Recruiting - verified January 2012
Study of Biomarkers in Predicting Heart Dysfunction in Women With Breast Cancer Treated With Trastuzumab

Conditions: Breast Cancer; Cardiac Toxicity
Interventions: Biological: trastuzumab; Other: laboratory biomarker analysis; Procedure: assessment of therapy complications
Sponsors: National Cancer Institute (NCI); All Ireland Cooperative Oncology Research Group
Recruiting - verified August 2009
Continued HER2 Suppression With Lapatinib Plus Trastuzumab Versus Trastuzumab Alone

Conditions: Adenocarcinoma; Her2+; Advanced Metastatic Breast Cancer; Metastatic ErbB2; Invasive Breast Cancer; Advanced Breast Cancer; Cancer; ErbB2+
Interventions: Drug: Lapatinib; Biological: Trastuzumab
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified May 2012
Lapatinib Ditosylate and Capecitabine in Treating Patients With Stage IV Breast Cancer and Brain Metastases

Conditions: Breast Cancer; Metastatic Cancer
Interventions: Drug: capecitabine; Drug: lapatinib ditosylate; Other: circulating tumor cell analysis; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); UNICANCER; National Cancer Institute (NCI)
Recruiting - verified August 2011
Study Into the Use of Electrical Impedance Mammography in the Diagnosis and Characterisation of Breast Disease

Condition: Breast Cancer
Intervention: Procedure: Breast scan - Electrical Impedance Mammography
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Recruiting - verified August 2009
Correlation of Genomic Variation in Enzymes Responsible for Metabolism of Capecitabine With Drug Metabolism

Condition: Breast Cancer
Intervention: Drug: Capecitabine
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Not yet recruiting - verified May 2012
Early Detection and Intervention for Mild and Moderate Lymphedema in Patients Treated for Breast Cancer

Conditions: Lymphedema; Breast Cancer
Interventions: Device: Compression Sleeve; Device: Short-Stretch Compression Bandage
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified January 2012
A Study of PI3-Kinase Inhibitor GDC-0941 in Combination With Paclitaxel and Bevacizumab in Patients With Locally Recurrent or Metastatic Breast Cancer

Condition: Metastatic Breast Cancer, Locally Recurrent Breast Cancer
Interventions: Drug: bevacizumab; Drug: GDC-0941; Drug: paclitaxel
Sponsors: Genentech; Genentech
Recruiting - verified October 2011
Docetaxel,Carboplatin,Trastuzumab and Bevacizumab for Breast Cancer and Bone Marrow Micrometastases

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Biological: trastuzumab; Drug: carboplatin; Drug: docetaxel; Other: laboratory biomarker analysis
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Spectra Breast Implant Study

Conditions: Augmentation; Augmentation Revision; General Breast Enlargement; Post-lactational Involution; Asymmetry
Intervention: Device: Mentor Spectra/Becker 80 Breast Implant
Sponsors: Mentor Worldwide, LLC; Mentor Worldwide, LLC
Not yet recruiting - verified March 2012
Community Volunteers Promoting Physical Activity Among Cancer Survivors

Condition: Breast Cancer
Intervention: Behavioral: Moving Forward Together 2
Sponsors: The Miriam Hospital; The Miriam Hospital; American Cancer Society
Recruiting - verified July 2011
Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome

Conditions: Breast Cancer; Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms; Neuroblastoma; Ovarian Cancer; Testicular Germ Cell Tumor
Intervention: Dietary Supplement: Lactobacillus rhamnosus GG
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; National Cancer Institute (NCI)
Recruiting - verified November 2011
Phase III Trial of High Dose vs. Standard Dose Vit D2 With Docetaxel in Met Breast ca

Condition: Breast Cancer
Interventions: Drug: Docetaxel + High dose Vitamin D2; Drug: Docetaxel + Standard dose Vitamin D2
Sponsors: King Faisal Specialist Hospital & Research Center; King Faisal Specialist Hospital & Research Center
Recruiting - verified December 2011
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; University of Chicago; Dana-Farber Cancer Institute; Georgetown University; Johns Hopkins University; M.D. Anderson Cancer Center; University of Alabama at Birmingham; University of California, San Francisco; University of North Carolina; Duke University; Vanderbilt-Ingram Cancer Center; Indiana University Melvin and Bren Simon Cancer Center; Mayo Clinic; University of Pittsburgh; University of Michigan Health System
Recruiting - verified March 2012
Evaluate Trastuzumab Plus Standard Chemotherapy Given Before Surgery in Breast Cancer Patients With Low HER 2 Expression

Condition: Breast Cancer
Interventions: Drug: nab-paclitaxel; Drug: trastuzumab; Drug: Doxorubicin; Drug: cyclophosphamide
Sponsors: University of Kansas; University of Kansas; Celgene Corporation
Recruiting - verified October 2011
Exemestane or Docetaxel-cytoxan in Low Recurrence Score Cancers

Condition: Breast Cancer
Interventions: Drug: Exemestane; Drug: Docetaxel, cytoxan
Sponsors: Emory University; Emory University; Pfizer
Recruiting - verified February 2012
Phase I/II Study of Weekly Abraxane and RAD001 in Women With Locally Adv. or Metastatic Breast Ca

Condition: Breast Cancer
Interventions: Drug: everolimus; Drug: abraxane
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; National Cancer Institute (NCI)
Recruiting - verified October 2011
A Study of Trastuzumab Emtansine (T-DM1) in Combination With Docetaxel, and Potentially Pertuzumab, in Patients With Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: trastuzumab emtansine; Drug: docetaxel; Drug: pertuzumab
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Cisplatin and Paclitaxel With or Without Everolimus in Treating Patients With Stage II or Stage III Breast Cancer

Condition: Breast Cancer
Interventions: Drug: cisplatin; Drug: everolimus; Drug: paclitaxel; Other: placebo
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Metformin Pre-Surgical Pilot Study

Condition: Breast Cancer
Intervention: Drug: Metformin
Sponsors: Columbia University; Columbia University; Breast Cancer Research Foundation
Recruiting - verified October 2011
Enhancing Physical Activity Adherence After Breast Cancer Diagnosis (BEAT Cancer II)

Condition: Breast Cancer
Interventions: Behavioral: Experimental 1: exercise with 2 counseling types; Other: Usual Care - written materials
Sponsors: Southern Illinois University; Southern Illinois University; National Cancer Institute (NCI); University of Illinois at Urbana-Champaign
Recruiting - verified March 2012
Role of Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography (PET) Scanner in Evaluating Neoadjuvant Chemotherapy Response in Patients With Breast Cancer

Condition: Breast Cancer
Intervention: Device: PEM Flex Solo II PET Scanner
Sponsors: University of Chicago; University of Chicago
Recruiting - verified June 2011
Aggressive Local Therapy for Limited Bone-only Metastasis

Condition: Breast Cancer
Interventions: Drug: Standard Therapy; Procedure: Local Therapy
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified February 2012
A Study, Comparing a Dose-Titration Regimen of Fulvestrant With the Approved Dosing Regimen in Postmenopausal Patients With Hormone-Responsive Advanced Breast Cancer (ABC)

Condition: Breast Cancer
Intervention: Drug: Fulvestrant
Sponsors: Regina Elena Cancer Institute; Regina Elena Cancer Institute; AstraZeneca
Recruiting - verified June 2009
Survivor Stories: Impact on Cancer Patients' Quality of Life and Follow-up

Condition: Breast Cancer
Intervention: Other: The Survivor Stories Tablet
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified March 2012
Trastuzumab and Trastuzumab-MCC-DM1 Administered Intravenously and GDC-0941 Administered Orally to Patients With HER2-Positive Metastatic Breast Cancer Who Have Progressed on Previous Trastuzumab-Based Therapy

Condition: Metastatic Breast Cancer
Interventions: Drug: GDC-0941; Drug: trastuzumab-MCC-DM1; Drug: Trastuzumab
Sponsors: Genentech; Genentech
Recruiting - verified August 2011
A Phase 1, Dose Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous Dimethane Sulfonate (DMS612) in Advanced Malignancies

Conditions: Renal Cell Carcinoma; Breast Cancer; Colon Cancer; Lung Cancer; Non-Hodgkin Lymphoma
Intervention: Drug: dimethane sulfonate (DMS612, NSC 281612)
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
The Natural History of Solid Organ Cancer Stem Cells (SOCSC)

Conditions: Hepatic Cancer; Pancreatic Ductal Cancer; Colorectal Cancer; Breast Cancer; Gastric Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin

Conditions: Breast Cancer; Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
Trial of Dasatinib Plus Ixabepilone in 2nd or 3rd Line Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Dasatinib; Drug: Ixabepilone
Sponsors: Accelerated Community Oncology Research Network; Accelerated Community Oncology Research Network; Bristol-Myers Squibb
Recruiting - verified February 2012
A Study of Avastin (Bevacizumab) + Xeloda (Capecitabine)as Maintenance Therapy in Patients With HER2-Negative Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: capecitabine [Xeloda]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified January 2012
Laser Spectroscopy in Diagnosing Breast Cancer in Women With Breast Lesions

Condition: Breast Cancer
Interventions: Genetic: fluorescence in situ hybridization; Other: immunohistochemistry staining method; Other: medical chart review; Procedure: fluorescence spectroscopy; Procedure: histopathologic examination; Procedure: light-scattering spectroscopy
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Study of Breast Tissue From Women Who Have Undergone Breast Biopsy or Surgery

Condition: Breast Cancer
Interventions: Other: biologic sample preservation procedure; Other: immunohistochemistry staining method; Other: light microscopy; Other: medical chart review; Procedure: histopathologic examination; Procedure: needle biopsy; Procedure: spectroscopy
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Study of Tumor Tissue Samples From Patients Who Have Undergone Surgery for Breast Cancer

Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Anti-Hormone Therapy (With Anastrazole and Fulvestrant) Before Surgery to Treat Postmenopausal Women With Breast Cancer.

Condition: Invasive Breast Cancer
Interventions: Drug: Fulvestrant; Drug: Anastrazole
Sponsors: University of Kansas; University of Kansas; AstraZeneca
Recruiting - verified October 2011
Green Tea and Reduction of Breast Cancer Risk

Condition: Breast Cancer
Interventions: Drug: Green tea extract supplement; Other: Placebo
Sponsors: University of Minnesota - Clinical and Translational Science Institute; University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified January 2012
Xeloda (Capecitabine) and External Beam Radiation

Condition: Breast Cancer
Interventions: Radiation: Radiation Therapy; Drug: Capecitabine
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified January 2012
Randomized Phase II Trial of Trastuzumab or EVEROLIMUS in Hormone-refractory Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Trastuzumab (Herceptin); Drug: Trastuzumab (Herceptin) plus Everolimus
Sponsors: Emory University; Emory University; Genentech; Novartis Pharmaceuticals
Recruiting - verified November 2011
Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus Docetaxel and Cyclophosphamide (TC) in Triple-Negative or Her2 Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Docetaxel, Anthracycline (Doxorubicin or Epirubicin), Cyclophosphamide; Drug: Docetaxel, cyclophosphamide
Sponsors: Shanghai Jiao Tong University School of Medicine; Shanghai Jiao Tong University School of Medicine
Recruiting - verified March 2012
Bevacizumab, Docetaxel, and Cyclophosphamide in Treating Patients With Early-Stage High-Risk Breast Cancer

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Drug: cyclophosphamide; Drug: docetaxel; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); All Ireland Cooperative Oncology Research Group
Recruiting - verified May 2009
Hypofractionated Versus Standard Fractionated Whole Breast Irradiation to Node-negative Breast Cancer Patients

Conditions: Breast Cancer; Carcinoma in Situ of the Breast
Interventions: Radiation: standard fractionated radiotherapy; Radiation: hypofractionated radiotherapy
Sponsors: Danish Breast Cancer Cooperative Group; Danish Breast Cancer Cooperative Group; Danish Cancer Society
Recruiting - verified May 2009
Radiation Therapy in Treating Women With Early Stage Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: External beam boost; Radiation: whole breast irradiation
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; National Cancer Institute (NCI)
Recruiting - verified October 2011
Trial of Endocrine Against Locoregional Therapy First in Postmenopausal Women With Early Breast Cancer

Condition: Operable Breast Neoplasms
Intervention: Drug: letrozole (Femara)
Sponsors: Danish Breast Cancer Cooperative Group; Danish Breast Cancer Cooperative Group; The Danish Medical Research Council; Danish Cancer Society; Novartis
Recruiting - verified March 2012
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer

Conditions: Breast Cancer; Invasive Breast Cancer
Intervention: Procedure: Sentinel Lymph Node Biopsy
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Fondation du cancer du sein du Québec
Recruiting - verified June 2011
A Clinical Trial Assessing Safety and Efficacy of BZL101 for Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: BZL101
Sponsors: Bionovo; Bionovo
Not yet recruiting - verified February 2012
Optical Tomography With Ultrasound Guidance

Condition: Breast Cancer
Intervention:
Sponsors: University of Connecticut Health Center; University of Connecticut Health Center; National Institute for Biomedical Imaging and Bioengineering (NIBIB); Donaghue Medical Research Foundation
Recruiting - verified June 2011
A Study of NK012 in Patients With Advanced, Metastatic Triple Negative Breast Cancer

Condition: Triple Negative Breast Cancer
Intervention: Drug: NK012
Sponsors: Nippon Kayaku Co.,Ltd.; Nippon Kayaku Co.,Ltd.
Recruiting - verified June 2011
Study of Radiation Exposure and Bilateral Breast Cancer

Condition: Breast Cancer
Intervention: Other: questionaire, blood or saliva sample
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Translational Genomics Research Institute, Phoenix, Arizona.; University of Southern California; University of Virginia; Lund University; Ontario Cancer Registry; Northern California Cancer Center; Fred Hutchinson Cancer Research Center; University of Iowa; Danish Cancer Society; Beckman Research Institute; City of Hope National Medical Center; M.D. Anderson Cancer Center; Vanderbilt University School of Medicine; New York University School of Medicine; University of Chicago; University of California, Irvine; Stanford University
Recruiting - verified January 2012
Identifying Circulating Breast Cancer Cells in Women With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Other: flow cytometry; Other: fluorescence activated cell sorting; Other: immunohistochemistry staining method; Other: immunologic technique; Other: biomarker analysis
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

Condition: Breast Cancer
Interventions: Other: laboratory biomarker analysis; Other: medical chart review
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
Gene Expression in Tumor Tissue From Women Undergoing Surgery for Breast Cancer or Core Biopsy of the Breast

Condition: Breast Cancer
Interventions: Genetic: microarray analysis; Procedure: breast biopsy
Sponsors: Georgetown University; Georgetown University; National Cancer Institute (NCI)
Recruiting - verified October 2011
Study of Breast Tissue in Women Not Previously Diagnosed With Breast Cancer Who Are Undergoing Fine Needle Aspiration

Conditions: Breast Cancer; Healthy, no Evidence of Disease
Interventions: Procedure: Random fine need aspiration (rFNA); Other: Mammogram
Sponsors: Northwestern University; Northwestern University; National Cancer Institute (NCI)
Recruiting - verified May 2012
Positron Emission Mammography and Standard Mammography in Women With Dense Breast Tissue or Who Are at High Risk of Breast Cancer

Condition: Breast Cancer
Interventions: Other: questionnaire administration; Procedure: digital mammography; Procedure: positron emission mammography
Sponsors: Boston Medical Center; Boston Medical Center; Department of Defense
Recruiting - verified February 2012
Collecting and Storing Tissue Samples From Women With or Without Breast Cancer

Condition: Breast Cancer
Intervention: Other: biologic sample preservation procedure
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
Gene Expression Profiling and Genetic Analysis of Tissues From Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: fluorescence in situ hybridization; Genetic: molecular genetic technique; Other: immunohistochemistry staining method
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI); Eastern Cooperative Oncology Group; North Central Cancer Treatment Group; Southwest Oncology Group
Recruiting - verified April 2012
Biomarkers in Predicting Outcome in Postmenopausal Women With Hormone Receptor-Positive, Node-Positive Breast Cancer Treated With Tamoxifen With or Without Cyclophosphamide, Doxorubicin, and Fluorouracil

Condition: Breast Cancer
Interventions: Genetic: comparative genomic hybridization; Genetic: microarray analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: diagnostic laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified January 2008
Biomarkers in Predicting Response to Tamoxifen and Letrozole in Postmenopausal Women With Primary Breast Cancer Treated on Clinical Trial CAN-NCIC-MA17

Condition: Breast Cancer
Interventions: Genetic: microarray analysis; Genetic: polymerase chain reaction; Genetic: protein expression analysis; Other: diagnostic laboratory biomarker analysis; Other: fluorescent antibody technique; Other: immunohistochemistry staining method; Other: immunologic technique
Sponsors: National Cancer Institute (NCI); Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified April 2008
Trial of Concurrent Versus Sequential Tamoxifen With Radiotherapy in Breast Cancer Patients

Conditions: Pulmonary Fibrosis; Breast Cancer
Interventions: Drug: Tamoxifen; Radiation: Radiotherapy
Sponsors: Tata Memorial Hospital; Tata Memorial Hospital; Indian Council of Medical Research
Recruiting - verified August 2011
Enalapril Maleate and Doxorubicin Hydrochloride in Treating Women With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: doxorubicin hydrochloride; Drug: enalapril maleate
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified May 2012
Intellectual Impairment in Women With Breast Cancer

Condition: Breast Cancer
Interventions: Behavioral: Cognitive Rehabilitation; Behavioral: Neurofeedback Training (randomized)
Sponsors: Stanford University; Stanford University
Recruiting - verified April 2012
Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium

Conditions: Breast Cancer; Hypercalcemia of Malignancy; Colon Cancer; Endocrine Cancer; Head and Neck Cancer; Kidney Cancer; Lung Cancer; Lymphoma; Metastatic Cancer; Multiple Myeloma; Parathyroid Neoplasms; Renal Cancer; Thyroid Cancer; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; Non-Small Cell Lung Cancer
Intervention: Drug: denosumab
Sponsors: Amgen; Amgen
Recruiting - verified April 2012
Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Panitumumab; Drug: Carboplatin; Drug: Gemcitabine
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Amgen; Eli Lilly and Company
Recruiting - verified October 2011
Study of Impact of Routine "Clinical Cancer Department/Supportive Care Department" Consultation on the Prescription of a 4th Line of Chemotherapy

Condition: Metastatic Breast Cancer
Interventions: Other: Action Group; Other: Standard care
Sponsors: Centre Leon Berard; Centre Leon Berard
Recruiting - verified February 2012
Topical Application of Sulforaphane-containing Broccoli Sprout Extracts on Radiation Dermatitis

Conditions: Breast Cancer; Dermatitis
Interventions: Other: Sulforaphane-containing broccoli sprout extracts (active agent); Device: Vehicle (inactive control)
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified April 2012
Partial Breast Versus Whole Breast Irradiation in Elderly Women Operated on for Early Breast Cancer

Condition: Breast Carcinoma
Interventions: Radiation: Partial breast irradiation; Radiation: Whole breast irradiation
Sponsors: Danish Breast Cancer Cooperative Group; Danish Breast Cancer Cooperative Group; Danish Center for Interventional Research in Radiation Oncology (CIRRO); Danish Cancer Society
Recruiting - verified May 2009
Evaluation of an Apoptotic Test for Predicting Late Toxicities After Radiotherapy in Breast and Prostate Cancer Patients

Conditions: Breast Cancer; Prostate Cancer
Intervention:
Sponsors: Centre Val d'Aurelle - Paul Lamarque; Centre Val d'Aurelle - Paul Lamarque
Recruiting - verified February 2012
Evaluating the T Cell Response to a Peptide-based Vaccine in Patients With Breast Cancer

Condition: Breast Neoplasms
Intervention: Biological: 9 Peptides from Her-2/neu, CEA, & CTA
Sponsors: University of Virginia; University of Virginia; National Institutes of Health (NIH)
Recruiting - verified April 2012
Dose-escalation Study of Oral CX-4945

Conditions: Advanced Solid Tumors; Breast Cancer; Inflammatory Breast Cancer; Castleman's Disease; Multiple Myeloma
Intervention: Drug: CX-4945 oral formulation
Sponsors: Cylene Pharmaceuticals; Cylene Pharmaceuticals
Recruiting - verified June 2011
Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis

Condition: Breast Carcinoma
Interventions: Behavioral: radiation in prone position; Behavioral: radiation in supine position
Sponsors: University Hospital, Ghent; University Hospital, Ghent; National Cancer Plan, France
Recruiting - verified December 2011
Neoadjuvant Sunitinib With Paclitaxel/Carboplatin in Patients With Triple-Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Carboplatin; Drug: Sunitinib; Drug: Paclitaxel; Drug: Carboplatin; Drug: Sunitinib
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Pfizer
Recruiting - verified March 2012
Adjuvant Acupuncture Care for Breast Cancer Patients Experiencing Side Effects From Chemotherapy

Condition: Breast Cancer
Intervention: Procedure: Acupuncture therapy
Sponsors: University Hospital of North Norway; University Hospital of North Norway; Norwegian Cancer Society
Recruiting - verified May 2012
Everolimus in Combination With Trastuzumab and Paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Everolimus; Drug: Placebo
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases

Conditions: Breast Cancer; Lung Cancer; Metastatic Cancer; Multiple Myeloma and Plasma Cell Neoplasm; Prostate Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Procedure: assessment of therapy complications
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Capecitabine and Bevacizumab ± Vinorelbine in Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: capecitabine; Drug: bevacizumab; Drug: capecitabine; Drug: bevacizumab; Drug: vinorelbine
Sponsors: iOMEDICO AG; iOMEDICO AG; Arbeitsgemeinschaft fur Internistische Onkologie; Arbeitskreis Klinische Studien; Roche Pharma AG
Recruiting - verified March 2012
A Study of Herceptin (Trastuzumab)and Biomarkers in Patients With HER2-Positive Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: trastuzumab [Herceptin]; Drug: Standard taxane therapy; Drug: capecitabine [Xeloda]
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified April 2012
Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed By Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: paclitaxel
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI)
Recruiting - verified May 2012
Faslodex Post Marketing Surveillance

Condition: Breast Cancer
Intervention:
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified July 2011
Two Dimensional (2D) Silicon Transducer-Compression Plates for Breast Ultrasound

Conditions: Breast Masses; Breast Cysts
Intervention: Procedure: Breast Ultrasound imaging
Sponsors: University of Michigan; University of Michigan; National Institutes of Health (NIH)
Recruiting - verified May 2012
Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer: Concordance Study

Condition: Breast Cancer
Intervention:
Sponsors: University of Michigan Cancer Center; University of Michigan Cancer Center
Recruiting - verified August 2011
Cardiotoxicity of Adjuvant Trastuzumab

Conditions: Breast Neoplasms; Heart Failure
Intervention:
Sponsors: Royal Prince Alfred Hospital, Sydney, Australia; Royal Prince Alfred Hospital, Sydney, Australia
Recruiting - verified July 2011
A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women

Condition: Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified July 2011
Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Doxorubicin, Cyclophosphamide, and Pegfilgrastim With or Without Bevacizumab in Treating Women With Inflammatory or Locally Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Biological: pegfilgrastim; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: paclitaxel albumin-stabilized nanoparticle formulation
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Exercise for Breast Cancer Patients (EXCAP)

Condition: Breast Cancer Related Fatigue
Interventions: Behavioral: Exercise; Behavioral: Progressive walking and resistance exercise treatment
Sponsors: University of Rochester; University of Rochester; National Cancer Institute (NCI)
Recruiting - verified November 2011
Cancer Screening and Prevention Program for High Risk Women

Conditions: Ovarian Cancer; Breast Cancer
Intervention: Other: screening
Sponsors: New York University School of Medicine; New York University School of Medicine; Lynne Cohen Foundation for Ovarian Cancer Research
Recruiting - verified November 2011
Trastuzumab, Cyclophosphamide, and Vaccine Therapy in Treating Patients With High-Risk or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: allogeneic GM-CSF-secreting breast cancer vaccine; Biological: trastuzumab; Drug: cyclophosphamide; Other: flow cytometry; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: biopsy
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Broccoli Sprout Extract in Treating Women Who Have Had a Mammogram and Breast Biopsy

Conditions: Breast Cancer; Precancerous Condition
Interventions: Dietary Supplement: broccoli sprout extract; Other: placebo
Sponsors: OHSU Knight Cancer Institute; OHSU Knight Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified February 2012
Breast Cancers: Risk Factors Among Mexican Women in Mexico, Mexican-American and African-American Women in the U.S.

Condition: Breast Cancer
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Cytokine Expression During Radiation for Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: radiation therapy
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified April 2012
An Observational Study of Pregnancy and Pregnancy Outcomes in Women With Breast Cancer Treated With Herceptin During Pregnancy or Within 6 Months Prior to Conception

Conditions: Breast Cancer; Pregnancy
Intervention:
Sponsors: Genentech; Genentech
Recruiting - verified November 2011
Trial Using Docetaxel Cytoxan in Breast Cancers With High Recurrence Scores

Conditions: Breast Neoplasms; Breast Cancer; Cancer of the Breast
Intervention: Drug: Docetaxel and Cytoxan
Sponsors: Emory University; Emory University; Sanofi-Aventis
Recruiting - verified February 2012
An Open-Label Study of Trastuzumab Emtansine (T-DM1) vs Capecitabine+Lapatinib in Patients With HER2-Positive Locally Advanced or Metastatic Breast Cancer (EMILIA)

Condition: Breast Cancer
Interventions: Drug: trastuzumab emtansine; Drug: lapatinib; Drug: capecitabine [Xeloda]
Sponsors: Genentech; Genentech
Recruiting - verified April 2012
Phase I/II Trial of Sorafenib Plus Ixabepilone in HER2-Negative Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Sorafenib and Ixabepilone; Drug: Sorafenib and Ixabepilone
Sponsors: Sarah Cannon Research Institute; Sarah Cannon Research Institute; Bayer; Bristol-Myers Squibb
Recruiting - verified October 2011
Agatolimod and Trastuzumab in Treating Patients With Locally Advanced or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: trastuzumab; Drug: agatolimod sodium; Other: Correlative Studies
Sponsors: Ohio State University Comprehensive Cancer Center; Ohio State University Comprehensive Cancer Center; Pfizer
Recruiting - verified November 2011
Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer

Condition: Breast Cancer
Intervention: Other: Blood draw and questionaires
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; New York Medical College; New York Presbyterian Hospital; Weill Medical College of Cornell University
Recruiting - verified January 2012
Topical Imiquimod and Abraxane in Treating Patients With Advanced Breast Cancer

Conditions: Male Breast Cancer; Recurrent Breast Cancer; Skin Metastases; Stage IV Breast Cancer
Interventions: Drug: imiquimod; Drug: Abraxane; Other: laboratory biomarker analysis; Genetic: RNA analysis; Other: immunoenzyme technique
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Bevacizumab, Combination Chemotherapy, and Radiation Therapy in Treating Patients Undergoing Surgery For Inflammatory Breast Cancer

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Drug: aromatase inhibition therapy; Drug: cyclophosphamide; Drug: docetaxel; Drug: epirubicin hydrochloride; Drug: fluorouracil; Drug: tamoxifen citrate; Other: circulating tumor cell analysis; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); UNICANCER
Recruiting - verified July 2009
Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: doxorubicin; Drug: cyclophosphamide; Drug: paclitaxel; Procedure: Surgery D30 after chemotherapy
Sponsors: Hospital de Cancer de Barretos - Fundacao Pio XII; Hospital de Cancer de Barretos - Fundacao Pio XII; University of Sao Paulo General Hospital
Recruiting - verified May 2010
Dasatinib In Combination With Weekly Paclitaxel For Patients With Metastatic Breast Carcinoma CA 180 194

Condition: Breast Cancer
Intervention: Drug: Dasatinib and Paclitaxel
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Bristol-Myers Squibb
Recruiting - verified February 2012
Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in ErbB2 (HER2) Positive Metastatic Breast Cancer.

Conditions: Metastatic Breast Cancer; Metastases, Brain
Interventions: Drug: capecitabine; Drug: lapatinib; Drug: trastuzumab
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified April 2012
A Phase 2 Study of Standard Chemotherapy Plus BSI-201 (a PARP Inhibitor) in the Neoadjuvant Treatment of Triple Negative Breast Cancer

Condition: Triple Negative Breast Cancer
Intervention: Drug: gemcitabine plus carboplatin plus BSI-201
Sponsors: Sanofi-Aventis; Sanofi-Aventis; Breast Cancer Research Foundation
Recruiting - verified December 2011
Biweekly Avastin and Docetaxel as the First Line Treatment for Patients With Metastatic Breast Cancer

Condition: Neoplasms
Intervention: Drug: bevacizumab plus docetaxel
Sponsors: Tampere University Hospital; Tampere University Hospital; Oulu University Hospital; Turku University Hospital
Recruiting - verified March 2012
Mentor Siltex® Contour Profile Gel Mammary Prosthesis Continued Access Clinical Trial

Conditions: Breast Augmentation; Breast Reconstruction; Breast Revision
Intervention: Device: Mentor Siltex® Contour Profile Gel Mammary Prosthesis
Sponsors: Mentor Worldwide, LLC; Mentor Worldwide, LLC
Available - verified April 2012
Exemestane in Treating Postmenopausal Women With Stage IV Breast Cancer

Condition: Breast Cancer
Interventions: Drug: exemestane; Other: laboratory biomarker analysis; Procedure: quality-of-life assessment
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Safety Study of AMG 386 to Treat HER2-positive Locally Recurrent or Metastatic Breast Cancer

Conditions: Breast Cancer; Breast Neoplasms; Breast Tumors; Cancer; Locally Recurrent and Metastatic Breast Cancer; Metastases; Metastatic Cancer; Oncology; Solid Tumors; Tumors
Interventions: Drug: AMG 386 15 mg/kg, Capecitabine and Lapatinib; Drug: AMG 386 15mg/kg, Paclitaxel and Trastuzumab; Drug: AMG 386 30 mg/kg, Paclitaxel and Trastuzumab; Drug: AMG 386 30 mg/kg, Capecitabine and Lapatinib; Drug: AMG 386 10 mgkg, Paclitaxel and Trastuzumab; Drug: AMG 386 10 mg/kg, Capecitabine and Lapatinib
Sponsors: Amgen; Amgen
Recruiting - verified March 2012
American Breast Laser Ablation Therapy Evaluation

Condition: Benign Breast Conditions; Breast Fibroadenomas
Intervention:
Sponsors: Novian Health Inc.; Novian Health Inc.
Recruiting - verified November 2011
3-Dimensional Conformal Radiation Therapy or Internal Radiation Therapy After Breast-Conserving Surgery in Treating Women With Stage I or Stage II Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: 3-dimensional conformal radiation therapy; Radiation: brachytherapy
Sponsors: National Cancer Institute (NCI); All Ireland Cooperative Oncology Research Group
Recruiting - verified January 2009
Trastuzumab in Treating Older Women With Early-Stage Breast Cancer

Condition: Breast Cancer
Interventions: Biological: trastuzumab; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: quality-of-life assessment
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Chemotherapeutic Agents in Brain/Breast

Conditions: Breast Cancer; Metastatic Cancer
Interventions: Drug: capecitabine; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: gemcitabine hydrochloride; Drug: lapatinib ditosylate; Drug: paclitaxel; Drug: vinorelbine ditartrate; Drug: Trastuzumab
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; Department of Defense; National Cancer Institute (NCI)
Recruiting - verified May 2012
Case-Control Study of Inflammatory Breast Cancer in North Africa

Condition: Inflammatory Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified December 2011
A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: hypofractionation radiotherapy; Radiation: conventional fractionation radiotherapy
Sponsors: Chinese Academy of Medical Sciences; Chinese Academy of Medical Sciences
Recruiting - verified November 2008
Vaccine Therapy in Treating Patients With Stage IV Breast Cancer

Conditions: HER2-positive Breast Cancer; Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Interventions: Biological: HER-2/neu peptide vaccine; Procedure: leukapheresis; Biological: ex vivo-expanded HER2-specific T cells; Drug: cyclophosphamide; Other: laboratory biomarker analysis; Biological: sargramostim; Other: flow cytometry; Other: immunoenzyme technique; Genetic: gene expression analysis; Genetic: polymerase chain reaction
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Continuation Study of Lapatinib Monotherapy or Lapatinib in Combination With Other Anti-cancer Agents

Conditions: Solid Tumors; Neoplasms, Breast; Cancer
Interventions: Drug: Lapatinib in combination with an anti-cancer agent; Drug: Lapatinib; Drug: Lapatinib in combination with an anti-cancer agent as specified by parent protocol
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified February 2012
Combination Study of BMS-754807 and Herceptin® in Patients With Advanced or Metastatic Her-2-positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: BMS-754807; Drug: trastuzumab (Herceptin®)
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb
Recruiting - verified November 2010
Pregabalin for Postoperative Pain in Women Undergoing Breast Cancer Surgery

Condition: Postoperative Pain
Interventions: Drug: Placebo; Drug: Pregabalin 150 mg
Sponsors: IWK Health Centre; IWK Health Centre
Recruiting - verified July 2011
Vaccine Therapy and Aldesleukin in Treating Women With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: allogeneic large multivalent immunogen breast cancer vaccine; Biological: aldesleukin
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified May 2012
TOBI to Monitor Response to Neoadjuvant Therapy in Breast Cancer

Condition: Breast Cancer
Intervention: Device: Near-Infrared Tomographic Optical Breast Imaging
Sponsors: Massachusetts General Hospital; Steven Isakoff, MD, PhD
Recruiting - verified April 2012
Personalized Treatment Selection for Dasatinib in Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Dasatinib
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Bristol-Myers Squibb
Recruiting - verified May 2012
Preoperative Chemotherapy in Triple Negative Invasive Breast Cancer That Can be Removed by Surgery.

Condition: Breast Cancer
Intervention: Drug: Bevacizumab, nab-paclitaxel, carboplatin, doxorubicin hydrochloride, cyclophosphamide, PEG-Filgrastim
Sponsors: University of Tennessee Cancer Institute; University of Tennessee Cancer Institute; National Comprehensive Cancer Network; Celgene Corporation; Genentech
Recruiting - verified February 2012
Tailored Neoadjuvant Chemotherapy for Stage II/III Breast Cancer With Tumor Size More Than 2 cm

Conditions: Breast Cancer; Chemotherapy
Interventions: Drug: Taxotere , Epirubine; Drug: E-HDFL,EP,TE,N-HDFL,NP,T-HDFL,TP
Sponsors: National Taiwan University Hospital; National Taiwan University Hospital
Recruiting - verified January 2012
PRIMADOS Study:A Study of Avastin (Bevacizumab) Plus Docetaxel for First Line Treatment of Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: docetaxel
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified January 2012
A Study of Avastin (Bevacizumab) in Combination With Neoadjuvant Treatment Regimens in Patients With Primary HER2 Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: bevacizumab [Avastin]; Drug: Placebo; Drug: Standard chemotherapy or endocrine therapy
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche; The Norwegian Radium Hospital
Recruiting - verified April 2012
Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy

Condition: Breast Cancer
Interventions: Biological: trastuzumab; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI)
Recruiting - verified April 2012
Lapatinib in Women With Metastatic Breast Cancer Who Have Failed Prior Antihormone Therapy

Condition: Metastatic Breast Cancer
Intervention: Drug: lapatinib
Sponsors: University of Kansas; University of Kansas
Recruiting - verified October 2011
A Study to Determine the Value of 18F-FAZA PET Imaging in Patients With Breast Cancer

Condition: Breast Neoplasm
Interventions: Drug: 18F-FAZA PET scan; Drug: FluGlucoScan Injection (18F-FDB) PET scan
Sponsors: Alberta Health Services; Alberta Health Services
Recruiting - verified March 2012
Abiraterone Acetate in Treating Postmenopausal Women With Advanced or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: abiraterone acetate; Other: laboratory biomarker analysis; Other: pharmacogenomic studies
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012
Using Bio Markers to Predict Disease Recurrence and Cognitive Function in High Risk Breast Ca

Conditions: Locally Advanced Breast Cancer; Breast Cancer
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto
Recruiting - verified September 2011
A Phase I/II Clinical Trial of Vidaza With Abraxane in the Treatment of Patients With Advanced or Metastatic Solid Tumors and Breast Cancer

Conditions: Advanced or Metastatic Solid Tumors; Advanced or Metastatic Breast Cancer
Interventions: Drug: Azacitidine (Vidaza); Drug: Nab-paclitaxel (Abraxane)
Sponsors: University of South Alabama; University of South Alabama; Celgene Corporation
Recruiting - verified August 2011
IDO Inhibitor Study for Relapsed or Refractory Solid Tumors

Conditions: Breast Cancer; Lung Cancer; Melanoma; Pancreatic Cancer; Solid Tumors
Intervention: Drug: 1-methyl-D-tryptophan
Sponsors: NewLink Genetics Corporation; NewLink Genetics Corporation
Recruiting - verified December 2011
Pre-operative Hormonal Treatment for Hormone Receptor Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Anastrozole; Drug: Anastrozole+Fulvestrant; Drug: Tamoxifen; Drug: Tamoxifen
Sponsors: The Netherlands Cancer Institute; The Netherlands Cancer Institute; AstraZeneca
Recruiting - verified May 2012
Optical Spectroscopy During Breast Cancer Surgery and Core Needle Biopsy

Condition: Breast Cancer
Intervention:
Sponsors: Duke University; Duke University
Recruiting - verified February 2012
Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab Followed By Bevacizumab and Erlotinib Hydrochloride in Treating Patients With Metastatic Breast Cancer

Conditions: Estrogen Receptor-negative Breast Cancer; HER2-negative Breast Cancer; Progesterone Receptor-negative Breast Cancer; Stage IV Breast Cancer; Triple-negative Breast Cancer
Interventions: Drug: paclitaxel albumin-stabilized nanoparticle formulation; Biological: bevacizumab; Drug: erlotinib hydrochloride; Other: immunohistochemistry staining method; Other: flow cytometry; Other: laboratory biomarker analysis
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Digital Mammography: Computer-Aided Breast Cancer Diagnosis

Conditions: Breast Cancer; Breast Abnormalities
Intervention: Procedure: digital mammography
Sponsors: University of Michigan; University of Michigan
Recruiting - verified August 2011
Cryoablation Therapy in Treating Patients With Invasive Ductal Breast Cancer

Condition: Breast Cancer
Interventions: Procedure: cryosurgery; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); American College of Surgeons; National Cancer Institute (NCI)
Recruiting - verified May 2012
Breast Lesion Analysis for Tomosynthesis Mammography

Conditions: Breast Cancer; Breast Abnormalities
Intervention: Procedure: Computer aided analysis of breast lesions
Sponsors: University of Michigan; University of Michigan; National Institutes of Health (NIH)
Recruiting - verified August 2011
A Phase I, Open-label, Study of Pazopanib in Combination With Epirubicin or Doxorubicin for Advanced Solid Tumors

Condition: Neoplasms, Breast
Interventions: Drug: Doxorubicin; Drug: Pazopanib (GW786034); Drug: Epirubicin
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified March 2012
Study Of Letrozole With Or Without PD 0332991 For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast Cancer

Condition: Breast Cancer
Interventions: Drug: PD 0332991; Drug: letrozole; Drug: letrozole
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Combined Digital X-ray and Ultrasound Technique for Improved Detection and Characterization of Breast Lesions

Conditions: Breast Abnormalities; Breast Masses
Intervention: Procedure: Tomosynthesis and ultrasound imaging
Sponsors: University of Michigan; University of Michigan; National Institutes of Health (NIH)
Recruiting - verified May 2012
Effect of Aromatase Inhibitor Therapy on Blood Vessel Function in Postmenopausal Women With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: exemestane; Drug: letrozole; Procedure: assessment of therapy complications
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified April 2012
Trastuzumab in Treating Women With HER2-Positive Early Breast Cancer

Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: parenteral chemotherapy
Sponsors: National Cancer Institute (NCI); Warwick Medical School
Recruiting - verified November 2008
Randomized Phase II Trial of Letrozole With or Without Dasatinib as First and Second-line Treatment for Hormone Receptor-positive, HER2-negative Post-menopausal Breast Cancer That is Unresectable, Locally Recurrent or Metastatic

Condition: Metastatic Breast Cancer
Interventions: Drug: Dasatinib + Letrozole; Drug: Letrozole
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb; US Oncology Research
Recruiting - verified February 2012
The Effect of Docetaxel or Gemcitabine-based Chemotherapy in East Asian and Caucasian Patients

Conditions: Non Small Cell Lung Cancer; Breast Cancer
Interventions: Drug: Docetaxel; Drug: gemcitabine and carboplatin
Sponsors: National University Hospital, Singapore; National University Hospital, Singapore
Recruiting - verified March 2012
Lapatinib and Circulating Tumor Cells in Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: Lapatinib
Sponsors: University Hospital of Crete; University Hospital of Crete
Recruiting - verified July 2011
Monitoring of Breast Tissue Change Due to Hormone Replacement Therapy in Post-menopausal Women Using OBS

Condition: Breast Cancer
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto; St. Michael's Hospital, Toronto
Not yet recruiting - verified November 2008
Weekly Paclitaxel/Carboplatin/Bevacizumab as First Line Therapy for Triple Negative Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Carboplatin; Drug: Bevacizumab; Drug: Paclitaxel
Sponsors: Hellenic Oncology Research Group; Hellenic Oncology Research Group; University Hospital of Crete
Recruiting - verified March 2012
Epirubicin or Not in Patients With TOP2A (Topoisomerase (DNA) II Alpha (170kD)) Normal Early Breast Cancer

Condition: Breast Neoplasms
Interventions: Drug: Epirubicin, cyclophosphamide and docetaxel; Drug: docetaxel, cyclophosphamide
Sponsors: Danish Breast Cancer Cooperative Group; Danish Breast Cancer Cooperative Group; Fonden til fremme af klinisk eksperimentel cancerforskning vedrørende c. mammae; Sanofi-Aventis; Dako
Recruiting - verified March 2012
Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children

Conditions: Breast Cancer; Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Other: counseling intervention; Other: educational intervention; Other: survey administration; Behavioral: psychosocial assessment and care; Behavioral: supportive care
Sponsors: Georgetown University; Georgetown University; National Cancer Institute (NCI); National Human Genome Research Institute (NHGRI)
Recruiting - verified October 2011
Ultrasound Based Localization of Lumpectomy Bed in Anatomical Coordinate System

Conditions: Resected Breast Cancer; Breast Cancer
Intervention: Other: ultrasound scan
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified April 2012
Quantitative Analysis of Outcomes in Breast Reconstruction

Condition: Breast Cancer
Interventions: Behavioral: Questionnaire; Procedure: Digital Imaging
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012
Trial of 2nd Generation Anti-CEA Designer T Cells in Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: Gene Modified T Cells; Biological: Gene Modified T Cells and Interleukin 2
Sponsors: Roger Williams Medical Center; Roger Williams Medical Center; Department of Defense
Recruiting - verified January 2012
A Breast Cancer Information Registry for Participants With Breast Cancer or Characteristics of Hereditary Breast Cancer

Conditions: Breast Cancer; Precancerous Condition
Interventions: Other: medical chart review; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: Excess human biological tissue; Procedure: quality-of-life assessment
Sponsors: University of Nebraska; University of Nebraska; National Cancer Institute (NCI)
Recruiting - verified June 2011
Tamoxifen in Women With Breast Cancer and in Women at High-Risk of Breast Cancer Who Are Receiving Venlafaxine, Citalopram, Escitalopram, Gabapentin, or Sertraline

Conditions: Breast Cancer; Depression; Hot Flashes; Psychosocial Effects of Cancer and Its Treatment
Interventions: Drug: citalopram hydrobromide; Drug: escitalopram oxalate; Drug: gabapentin; Drug: sertraline hydrochloride; Drug: tamoxifen citrate; Drug: venlafaxine; Genetic: molecular genetic technique; Other: high performance liquid chromatography; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: adjuvant therapy
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified April 2012
Rucaparib(CO-338;Formally Called AG-014699 or PF-0136738) in Treating Patients With Locally Advanced or Metastatic Breast Cancer or Advanced Ovarian Cancer

Conditions: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer; Ovarian Cancer
Interventions: Drug: rucaparib (CO-338; formally AG-014699 or PF-01367338); Genetic: protein expression analysis; Genetic: western blotting; Other: immunohistochemistry staining method; Other: liquid chromatography; Other: mass spectrometry; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012
Carboplatin, Paclitaxel, and Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: bevacizumab; Drug: carboplatin; Drug: ABI-007l albumin-stabilized nanoparticle formulation
Sponsors: Loyola University; Loyola University; Genentech
Recruiting - verified September 2011
IRS Proteins and Trastuzumab Resistance

Condition: Breast Cancer
Intervention:
Sponsors: University of Massachusetts, Worcester; University of Massachusetts, Worcester
Recruiting - verified February 2012
Letrozole in Treating Postmenopausal Women With Stage I, II or III Breast Cancer That Can Be Removed by Surgery

Condition: Breast Cancer
Interventions: Drug: letrozole; Genetic: RNA analysis; Genetic: gene expression analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: biopsy; Procedure: therapeutic conventional surgery
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
Predictive Blood Tests for Severe Radiation Reactions in Breast Cancer Patients

Condition: Abnormalities, Radiation-Induced
Intervention:
Sponsors: State University of New York - Upstate Medical University; State University of New York - Upstate Medical University; Carol M. Baldwin Breast Cancer Research Fund, Inc.
Recruiting - verified July 2011
Use of Organic Germanium or Placebo for the Prevention of Radiation Induced Fatigue

Conditions: Localized Breast Cancer; Localized Prostate Cancer; Patients Receiving External Beam Radiotherapy
Interventions: Dietary Supplement: Organic Germanium; Dietary Supplement: Placebo
Sponsors: Arizona Oncology Services; Arizona Oncology Services
Recruiting - verified June 2011
Early Detection of Breast Cancer Using Tomosynthesis Imaging

Condition: Breast Neoplasms
Intervention: Radiation: Mammography and tomosynthesis imaging
Sponsors: Duke University; Duke University
Recruiting - verified June 2011
Tissue Expander/Implant Reconstruction: A Single-Blinded, Randomized, Controlled Trial

Condition: Breast Cancer
Interventions: Procedure: Alloderm, Questionnaires; Procedure: Without ALLODERM, Questionnaires
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; University of Michigan; University of North Carolina, Chapel Hill
Recruiting - verified December 2011
Coxsackie Virus A21 Administered Intravenously (IV) for Solid Tumour Cancers

Conditions: Melanoma; Breast Cancer; Prostate Cancer
Intervention: Drug: CVA21
Sponsors: Viralytics; Viralytics
Recruiting - verified October 2011
Phase I/II Trial of Letrozole and Sorafenib in Post-Menopausal Hormone-Receptor + Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Sorafenib; Drug: Letrozole
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; Cancer Institute of New Jersey
Recruiting - verified June 2011
Vibro-Acoustography Imaging in Finding Breast Microcalcifications and Lesions in Women

Condition: Breast Cancer
Intervention:
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified July 2011
Optical Spectroscopy in Evaluating Tumor Margins in Patients Who Have Undergone Surgery for Breast Tumors

Condition: Breast Cancer
Interventions: Procedure: breast biopsy; Procedure: histopathologic examination; Procedure: light-scattering spectroscopy; Procedure: therapeutic conventional surgery
Sponsors: Vanderbilt University; Vanderbilt University; National Cancer Institute (NCI)
Recruiting - verified January 2012
Vaccination of Patients With Breast Cancer With Dendritic Cell/Tumor Fusions and IL-12

Condition: Breast Cancer
Interventions: Biological: Dendritic Cell/Tumor Fusion Vaccine; Drug: Interleukin-12; Drug: Interleukin-12
Sponsors: Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard University; Department of Defense; National Cancer Institute (NCI)
Recruiting - verified October 2011
A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer

Conditions: Breast Cancer,; Advanced Solid Tumors,; Cowden Syndrome
Intervention: Drug: BEZ235
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified November 2011
Studying the Effect of Freeze-Dried Table Grape Powder on Blood Estrogen Levels in Postmenopausal Women

Condition: Breast Cancer
Interventions: Dietary Supplement: standardized freeze-dried table grape powder; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified May 2012
Neoadjuvant Carboplatin, Weekly Abraxane and Trastuzumab in HER2+ Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Carboplatin; Drug: nab-paclitaxel; Drug: trastuzumab
Sponsors: Brown University; Debora G. Isdale; Yale University
Recruiting - verified February 2012
Magnetic Resonance Imaging in Patients With Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: MRI
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012
Phase II Trial of Doxil, Carboplatin, Bevacizumab in Triple Negative Untreated Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Interventions: Drug: Doxil; Drug: Carboplatin; Drug: Bevacizumab
Sponsors: University of Medicine and Dentistry New Jersey; University of Medicine and Dentistry New Jersey; Cancer Institute of New Jersey
Recruiting - verified October 2011
Assessment of the Efficacy of a Neoadjuvant Combination: "Chemotherapy-targeted Therapy" in Breast Cancer.

Condition: Breast Cancer
Interventions: Drug: Cetuximab; Drug: Docetaxel
Sponsors: Centre Jean Perrin; Centre Jean Perrin; Merck; Sanofi-Aventis
Recruiting - verified January 2012
Combined MRI and Optical Imaging to Improved Breast Cancer Diagnosis

Condition: Breast Cancer
Intervention: Device: combined optical and MR imaging
Sponsors: University of California, Irvine; University of California, Irvine
Recruiting - verified August 2011
Measuring Patient Satisfaction and Quality of Life Following Body Image Altering Surgery

Conditions: Breast Cancer; Breast Surgery; Breast Reconstruction; Breast Reduction; Breast Augmentation
Interventions: Behavioral: questionnaires; Behavioral: questionnaires
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; McMaster University; University College, London; Dartmouth-Hitchcock Medical Center; University of British Columbia; Johns Hopkins University; University of Pittsburgh
Recruiting - verified January 2012
Intensity Modulated Radiotherapy for Breast Cancer

Condition: Breast Cancer
Intervention: Radiation: IMRT
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified September 2011
The Synergism Or Long Duration (SOLD) Study

Condition: Breast Neoplasms
Interventions: Drug: trastuzumab (9 weeks) + docetaxel; Drug: trastuzumab (9 weeks) + docetaxel + CEF + trastuzumab (up to 51 weeks)
Sponsors: Finnish Breast Cancer Group; Finnish Breast Cancer Group
Recruiting - verified October 2011
Collection of Tissue, Blood, and Cells to Be Used For Studying the Causes, Prevention, Diagnosis, and Treatment of Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Memorial University Medical Center
Recruiting - verified February 2012
Molecular Genetic Basis of Invasive Breast Cancer Risk Associated With Lobular Carcinoma in Situ

Conditions: Breast Cancer; Lobular Carcinoma; Invasive Breast Cancer
Intervention: Other: Tissue specimen
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified January 2012
Quantitative Dynamic Contrast Enhanced Breast MRI

Condition: Breast Cancer
Intervention: Other: perform dynamic contrast enhanced (DCE) MRI
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Oregon Health and Science University; DeltaPoint,Inc.
Recruiting - verified December 2011
Spectroscopy With Surface Coils and Decoupling

Conditions: Adrenal Cortical Cancer; Brain Cancer; Breast Cancer; CNS Cancer; Colon Cancer; HEENT Cancer; Hodgkin's Disease; Kaposi's Sarcoma; Liver Cancer; Lung Cancer; Non-Hodgkin's Lymphoma; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Rectal Cancer; Renal Cancer; Sarcoma; Squamous Cell Carcinoma; Thyroid Cancer
Interventions: Device: Proton-decoupled 31P MRS at 1.5T; Device: 1H Spectroscopy at 1.5T and 3T
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Columbia University; University of Pennsylvania; St.George's Hospital (England); Royal Marsden NHS Foundation Trust; University Medical Center Nijmegen; Weill Medical College of Cornell University
Recruiting - verified February 2012
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients

Conditions: Breast Cancer; Colon Cancer; Prostate Cancer
Intervention: Genetic: PCR/PCR/LDR Strategy
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Columbia University; Weill Medical College of Cornell University
Recruiting - verified November 2011
Clinical Outcomes in Hereditary Cancer

Conditions: Breast Cancer; Pancreatic Cancer
Intervention: Other: Genotyping
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified November 2011
Ascertainment of Peripheral Blood or Saliva Samples for Genetic Epidemiology Studies of Familial Cancers

Conditions: Breast Neoplasms; Ovarian Neoplasms; Colonic Neoplasms; Prostatic Neoplasms; Uterine Cervical Neoplasms; Leukemia; Lymphoma, Non-Hodgkin
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified February 2012
Clinical Significance of Germline BRCA Mutations

Condition: Breast Cancer
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified April 2012
Study of Breast Cancer Prevention by Letrozole in High Risk Women

Condition: Breast Cancer
Interventions: Drug: Letrozole; Drug: Placebo
Sponsors: University of Kansas; Carol Fabian, MD; Novartis; National Cancer Institute (NCI)
Recruiting - verified February 2012
Percutaneous Removal and Margin Ablation for Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: Percutaneous Removal and Margin Ablation
Sponsors: University of Arkansas; University of Arkansas; Department of Health and Human Services; Ethicon Endo-Surgery; RITA Medical Systems
Recruiting - verified January 2012
Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation

Condition: Breast Cancer
Intervention: Procedure: Sentinel Node Biopsy
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified January 2012
Analyzing the Composition of Tears to Identify Cancer

Conditions: Breast Cancer; Ovarian Cancer; Colon Cancer; Benign Disease
Intervention: Other: Tear collection
Sponsors: University of Arkansas; University of Arkansas; Tenenbaum Family Foundation
Recruiting - verified January 2012
Safety Study of Modified Vaccinia Virus to Cancer

Conditions: Melanoma; Breast Cancer; Head and Neck Squamous Cell Cancer; Liver Cancer; Colorectal Cancer; Pancreatic Adenocarcinoma
Interventions: Biological: Vaccinia virus (vvDD-CDSR); Biological: Vaccinia virus (vvDD-CDSR); Biological: Vaccinia virus (vvDD-CDSR)
Sponsors: University of Pittsburgh; University of Pittsburgh
Recruiting - verified April 2012
Safety and Efficacy Study of FLT Radiolabeled Imaging Agent With PET Scan in Invasive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: 3'-Deoxy-3'-18F Fluorothymidine; Drug: 3'-Deoxy-3'-18F Fluorothymidine
Sponsors: American College of Radiology Imaging Network; American College of Radiology Imaging Network; Virginia Commonwealth University
Recruiting - verified April 2012
Axillary Reverse Mapping

Condition: Cancer of the Breast
Intervention: Procedure: Axillary Reverse Mapping
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified January 2012
Study of Combined Fulvestrant and RAD001 in Advanced/Metastatic Breast Cancer After Aromatase Inhibitor Failure

Condition: Breast Cancer
Interventions: Drug: RAD001; Drug: Fulvestrant
Sponsors: University of Kentucky; University of Kentucky; Novartis
Recruiting - verified December 2011
Brain Mets - Capecitabine and WBRT

Condition: Breast Cancer
Interventions: Drug: sunitinib; Drug: capecitabine; Radiation: WBRT
Sponsors: Baylor Breast Care Center; Baylor Breast Care Center
Recruiting - verified January 2012
Arimidex With or Without Faslodex In Postmenopausal Women With HR Positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Arimidex with Faslodex; Drug: Arimidex without Faslodex
Sponsors: Baylor Breast Care Center; Baylor Breast Care Center; AstraZeneca
Recruiting - verified January 2012
Immunohistochemical & Immunoblot Analysis of NIS (Na+/I-Symporter) in Archival & Frozen Tissue Sample

Conditions: Breast Cancer; Stomach Neoplasms; Salivary Gland Neoplasms; Thyroid Cancer
Intervention:
Sponsors: Stanford University; Stanford University
Recruiting - verified April 2012
Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis

Conditions: Breast Cancer; Bone Metastases
Interventions: Drug: Dasatinib; Drug: Zoledronic Acid
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Bristol-Myers Squibb
Recruiting - verified March 2012
Local Surgery for Metastatic Breast Cancer

Condition: Breast Cancer
Intervention: Procedure: Primary surgery
Sponsors: Federation of Breast Diseases Societies; Federation of Breast Diseases Societies; Istanbul University; Abant Izzet Baysal University; Marmara University
Recruiting - verified June 2011
Study to Determine Treatment Effects of Denosumab in Patients With Breast Cancer Receiving Aromatase Inhibitor Therapy

Condition: Breast Cancer
Interventions: Drug: Placebo; Drug: Denosumab
Sponsors: Amgen; Amgen
Recruiting - verified March 2012
Lapatinib in Treating Women With Ductal Carcinoma In Situ of the Breast

Condition: Breast Cancer
Interventions: Drug: lapatinib ditosylate; Other: placebo
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI); Breast Cancer Research Foundation
Recruiting - verified November 2011
Letrozole in Preventing Cancer in Postmenopausal Women Who Have Received 4-6 Years of Hormone Therapy for Hormone Receptor-Positive, Lymph Node-Positive, Early-Stage Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Letrozole; Drug: Letrozole
Sponsors: International Breast Cancer Study Group; International Breast Cancer Study Group
Recruiting - verified March 2012
Cognitive Changes Associated With Breast Cancer Treatment

Conditions: Breast Cancer; Cognitive Side Effects of Cancer Treatments; Stage I, II and III A Breast Cancer
Interventions: Behavioral: Questionnaires, MRI, Comet assay and Cell senescence; Behavioral: Questionnaires, MRI, Comet assay and Cell senescence; Behavioral: Questionnaires, MRI, Comet assay and Cell senescence
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Weill Medical College of Cornell University; The City College of New York; Brigham and Women's Hospital
Recruiting - verified February 2012
Lapatinib in Treating Patients With Advanced or Metastatic Breast Cancer That Overexpresses HER2

Conditions: Breast Cancer; Metastatic Cancer
Interventions: Drug: lapatinib ditosylate; Genetic: gene expression analysis; Other: diagnostic laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); University of California, San Francisco; National Cancer Institute (NCI)
Recruiting - verified July 2009
Outcomes of a DIEP Flap Program

Condition: Breast Cancer
Intervention:
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center
Recruiting - verified February 2012
Genetics of Women With Lobular Carcinoma in Situ of the Breast

Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Genetic: molecular diagnostic method; Genetic: polymorphism analysis; Genetic: protein expression analysis; Other: medical chart review; Other: questionnaire administration
Sponsors: National Cancer Institute (NCI); National Cancer Research Network
Recruiting - verified September 2007
Prospective & Retrospective Data Collection of Breast Cancer Cases From 2000 to Present

Condition: Breast Cancer
Intervention: Other: Breast Cancer database
Sponsors: King Faisal Specialist Hospital & Research Center; King Faisal Specialist Hospital & Research Center
Recruiting - verified December 2011
Vaccine Therapy in Treating Patients With Breast Cancer

Condition: Breast Cancer
Interventions: Biological: GP2 peptide + GM-CSF vaccine; Biological: GM-CSF (sargramostim); Biological: AE37 + GM-CSF vaccine; Biological: GM-CSF (sargramostim)
Sponsors: San Antonio Military Medical Center; San Antonio Military Medical Center; Antigen Express, Inc.; Norwell, Inc.
Recruiting - verified March 2012
Doxorubicin or Epirubicin and Cyclophosphamide in Treating Older Women With Invasive Breast Cancer

Condition: Breast Cancer
Interventions: Biological: pegfilgrastim; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Genetic: proteomic profiling; Other: diagnostic laboratory biomarker analysis; Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry; Other: pharmacological study; Other: surface-enhanced laser desorption/ionization-time of flight mass spectrometry; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); Charing Cross Hospital
Recruiting - verified September 2007
Sunitinib Malate, Paclitaxel, Doxorubicin Hydrochloride, and Cyclophosphamide Before Surgery in Treating Patients With Stage IIB-IIIC Breast Cancer

Conditions: Inflammatory Breast Cancer; Male Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Interventions: Drug: sunitinib malate; Drug: paclitaxel; Drug: doxorubicin hydrochloride; Drug: cyclophosphamide; Biological: filgrastim; Procedure: therapeutic conventional surgery; Other: laboratory biomarker analysis; Other: flow cytometry
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Recruiting - verified February 2012
Primary Breast Cancer Occurring Concomitant With Pregnancy

Conditions: Breast Cancer; Pregnancy
Interventions: Drug: 5-Fluorouracil; Drug: Cyclophosphamide; Drug: Doxorubicin
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012
Effects of Tibetan Yoga on Fatigue and Sleep in Cancer

Condition: Breast Cancer
Interventions: Behavioral: Tibetan Yoga; Behavioral: Stretching Program; Other: No Intervention; Behavioral: Questionnaire; Behavioral: Booster Program
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Breast Cancer Risk Assessment Using Optical Breast Spectroscopy (OBS)

Condition: Breast Cancer
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto; Mount Sinai Hospital, Canada; Hamilton Health Sciences Corporation
Recruiting - verified November 2008
Partial Breast Irradiation With Interstitial High Dose Rate Brachytherapy

Condition: Breast Cancer
Intervention: Radiation: interstitial high dose-rate brachytherapy, PBI
Sponsors: University Of Perugia; University Of Perugia
Recruiting - verified June 2010
Predictors for Response to Dose-dense Docetaxel and Epirubicin Breast Cancer

Condition: Primary Breast Cancer
Interventions: Other: Pretreatment surgical specimen. Epirubicin 60mg/m2/2 w/4 cycles; Other: docetaxel 2-weekly; Other: pegfilgrastim 6mg injections
Sponsors: University of Bergen; University of Bergen; Haukeland University Hospital
Recruiting - verified May 2012
Strength and Range of Motion in Women Undergoing Surgery for Breast Cancer

Condition: Breast Cancer
Intervention: Other: physiologic testing
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified November 2011
Phase II Study With Abraxane, Bevacizumab and Carboplatin in Triple Negative Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Abraxane; Drug: Bevacizumab; Drug: Carboplatin
Sponsors: Duke University; Duke University; Genentech
Recruiting - verified June 2011
Inflammatory Breast Cancer (IBC) Registry

Condition: Breast Cancer
Interventions: Other: Interview; Procedure: Blood and Tissue Collection
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified February 2012
Delayed-Immediate Breast Reconstruction

Condition: Breast Cancer
Intervention: Procedure: Delayed-Immediate Breast Reconstruction
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Susan G. Komen Breast Cancer Foundation
Recruiting - verified April 2012
Comparison of Two Schedules of Zoledronic Acid in Treating Patients With Breast Cancer That Has Spread to the Bone

Conditions: Breast Cancer; Hypercalcemia of Malignancy; Metastatic Cancer; Musculoskeletal Complications; Pain
Interventions: Drug: zoledronic acid; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); University of Leeds
Recruiting - verified November 2007
Dynamic Breast MRI in Assessing Locally Advanced Breast Cancer

Condition: Locally Advanced Breast Cancer
Intervention:
Sponsors: Sunnybrook Health Sciences Centre; Sunnybrook Health Sciences Centre
Recruiting - verified April 2012
Changes in Breast Density and Breast Cancer Risk in Women With Breast Cancer and in Healthy Women

Condition: Breast Cancer
Interventions: Other: physiologic testing; Other: screening questionnaire administration; Procedure: breast imaging study; Procedure: radiomammography; Procedure: study of high risk factors
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
A Study of Herceptin (Trastuzumab) in Combination With 2nd-Line Chemotherapy in Patients With HER2 Positive Metastatic Breast Cancer.

Condition: Breast Cancer
Interventions: Drug: trastuzumab [Herceptin]; Drug: Second line chemotherapy
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified March 2012
A Pilot Study To Evaluate the Effectiveness of Pulsed Time-Domain Optical Spectroscopy for Monitoring the Responses in Neoadjuvant Treatments of Locally-Advanced Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: Sunnybrook Health Sciences Centre; Sunnybrook Health Sciences Centre; ART Advanced Research Technologies Inc.
Recruiting - verified April 2012
Pilot Investigation of Ultrasound Imaging and Spectroscopy and Ultrasound Imaging of Vascular Blood Flow as Early Indicators of Locally-Advanced Breast Cancer Response to Neoadjuvant Treatment

Condition: Locally Advanced Breast Cancer
Intervention:
Sponsors: Sunnybrook Health Sciences Centre; Sunnybrook Health Sciences Centre
Recruiting - verified April 2012
Genetic Testing or Clinical Assessment in Determining the Need for Chemotherapy in Women With Breast Cancer That Involves No More Than 3 Lymph Nodes

Condition: Breast Cancer
Interventions: Drug: capecitabine; Drug: cyclophosphamide; Drug: docetaxel; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Drug: fluorouracil; Drug: letrozole; Drug: methotrexate; Drug: tamoxifen citrate; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified November 2011
Trastuzumab (Herceptin), Bevacizumab, and Docetaxel (Taxotere) Trial in Stage IV Metastatic Breast Cancer (MBC) Patients

Condition: Breast Cancer
Interventions: Drug: Trastuzumab; Drug: Bevacizumab; Drug: Docetaxel
Sponsors: Ohio State University Comprehensive Cancer Center; Ohio State University Comprehensive Cancer Center; Genentech; Case Comprehensive Cancer Center; University of Pittsburgh
Recruiting - verified April 2012
A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study.

Conditions: Metastatic Breast Cancer; Advanced Breast Cancer; Gastrointestinal Stromal Tumor; Hepatocellular Carcinoma; Metastasizing Breast Cancer (F); Metastatic Castration-Resistant Prostrate Cancer; Metastatic Renal Cell Cancer; Non Small Cell Lung Cancer; Pancreatic Islet Cell Carcinoma
Intervention: Drug: sunitinib
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
Goserelin in Preventing Early Menopause in Premenopausal Women Undergoing Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer

Conditions: Breast Cancer; Infertility; Menopausal Symptoms
Interventions: Drug: cyclophosphamide; Drug: goserelin acetate; Procedure: adjuvant therapy; Procedure: fertility assessment and management; Procedure: neoadjuvant therapy
Sponsors: National Cancer Institute (NCI); Anglo Celtic Cooperative Oncology Group
Recruiting - verified May 2007
Regional Anesthesia and Breast Cancer Recurrence

Condition: Breast Neoplasms
Interventions: Drug: Sevoflurane; Drug: Sevoflurane
Sponsors: Outcomes Research Consortium; Outcomes Research Consortium
Recruiting - verified May 2012
HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.

Condition: Breast Cancer
Interventions: Drug: tamoxifen; Drug: triptorelin; Drug: letrozole; Drug: zoledronic acid
Sponsors: National Cancer Institute, Naples; National Cancer Institute, Naples; Second University of Naples
Recruiting - verified October 2011
BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the Brain

Conditions: Brain and Central Nervous System Tumors; Breast Cancer; Cognitive/Functional Effects; Drug/Agent Toxicity by Tissue/Organ; Psychosocial Effects of Cancer and Its Treatment
Interventions: Biological: trastuzumab; Drug: carboplatin; Drug: methotrexate; Drug: sodium thiosulfate
Sponsors: OHSU Knight Cancer Institute; OHSU Knight Cancer Institute; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012
Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity

Condition: Breast Cancer
Intervention: Biological: MAB HER 2 (HERCEPTIN)
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified January 2012
Spousal Relationships and Pain in Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Behavioral: Questionnaire; Behavioral: Interview
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Department of Defense
Recruiting - verified May 2012
Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status

Conditions: Lymphedema; Breast Cancer
Intervention: Device: Flexitouch
Sponsors: Stanford University; Stanford University
Recruiting - verified October 2011
Treatment Decision Making Based on Blood Levels of Tumor Cells in Women With Metastatic Breast Cancer Receiving Chemotherapy

Condition: Breast Cancer
Intervention: Drug: chemotherapy
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI); Cancer and Leukemia Group B
Recruiting - verified September 2011
Naltrexone in Treating Women With Metastatic Breast Cancer That Did Not Respond to Hormone Therapy

Condition: Breast Cancer
Interventions: Drug: naltrexone hydrochloride; Procedure: Positron-emission tomography (PET) / computed tomography (CT)
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2012
Liposomal Doxorubicin, Trastuzumab, and Docetaxel in HER2 Positive Metastatic Breast Cancer

Conditions: Breast Cancer; Neoplasm Metastasis
Intervention: Drug: Non pegylated liposomal doxorubicin, trastuzumab, docetaxel
Sponsors: Catharina Ziekenhuis Eindhoven; Catharina Ziekenhuis Eindhoven; Cephalon; Sanofi-Aventis
Recruiting - verified August 2011
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection

Conditions: Breast Cancer; Lymphedema; Perioperative/Postoperative Complications
Interventions: Behavioral: exercise intervention; Other: educational intervention; Procedure: assessment of therapy complications; Procedure: complementary or alternative medicine procedure; Procedure: management of therapy complications; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI)
Recruiting - verified May 2012
Stereotactic Radiation Therapy With or Without Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases

Conditions: Breast Cancer; Cognitive/Functional Effects; Lung Cancer; Metastatic Cancer; Prostate Cancer
Interventions: Radiation: radiation therapy; Radiation: stereotactic radiosurgery
Sponsors: National Cancer Institute (NCI); North Central Cancer Treatment Group; National Cancer Institute (NCI); American College of Surgeons; Eastern Cooperative Oncology Group; Radiation Therapy Oncology Group
Recruiting - verified July 2011
Efficacy and Safety of Imatinib and Vinorelbine in Patients With Advanced Breast Cancer

Condition: Breast Cancer
Intervention: Drug: Imatinib and Vinorelbine
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Study to Determine the Utility of FES-PET and FDG-PET in the Prediction of Response to Hormone Therapy in Women With Estrogen Positive Metastatic Breast Cancer

Condition: Metastatic Breast Cancer
Intervention:
Sponsors: Alberta Health Services; Alberta Health Services
Recruiting - verified December 2011
A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients

Condition: Breast Neoplasms
Interventions: Other: Blood draw; Other: Blood draw
Sponsors: Washington University School of Medicine; Washington University School of Medicine; National Institutes of Health (NIH)
Recruiting - verified September 2011
Effect of Chemotherapy Administered Before Surgery on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells

Condition: Breast Neoplasms
Intervention: Procedure: Biopsies for tissue and blood collection
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified September 2011
Temperature-Sensitive Liposomal Doxorubicin and Hyperthermia in Treating Women With Locally Recurrent Breast Cancer

Condition: Breast Cancer
Interventions: Biological: filgrastim; Biological: pegfilgrastim; Drug: lyso-thermosensitive liposomal doxorubicin; Procedure: hyperthermia treatment
Sponsors: National Cancer Institute (NCI); Duke Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified October 2007
EAP (Expanded Access Protocol) Of Lapatinib Combined With Capecitabine In Metastatic Breast Cancer

Condition: Neoplasms, Breast
Intervention: Drug: lapatinib + capecitabine
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified April 2012
A Study of Epoetin Alfa Plus Standard Supportive Care Versus Standard Supportive Care Only in Anemic Patients With Metastatic Breast Cancer Receiving Standard Chemotherapy

Conditions: Breast Cancer; Neoplasm Metastasis
Interventions: Other: Standard supportive care (packed RBC transfusion); Drug: epoetin alfa + packed RBC transfusion
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified May 2012
Partial Breast Irradiation (PBI) for Selected Patients With Early Breast Cancer

Condition: Breast Neoplasms
Intervention: Procedure: Partial Breast Irradiation
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified September 2011
Risedronate in Improving Bone Mineral Density and Bone Health in Postmenopausal Women With Ductal Carcinoma In Situ Enrolled in Clinical Trial CRUK-IBIS-II-DCIS

Conditions: Breast Cancer; Osteoporosis
Interventions: Drug: risedronate sodium; Other: diagnostic laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); International Breast Cancer Study Group
Recruiting - verified May 2007
Expanded Breast Cancer Registry and Tissue Repository

Condition: Breast Cancer
Intervention:
Sponsors: New Mexico Cancer Care Alliance; New Mexico Cancer Care Alliance
Recruiting - verified April 2012
Efficacy and Safety of Zoledronic Acid ( Every 4 Weeks vs. Every 12 Weeks) in Patients With Documented Bone Metastases From Bone Cancer

Condition: Breast Cancer
Intervention: Drug: Zometa® (zoledronic acid)
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Hormone Therapy With or Without Combination Chemotherapy in Treating Women Who Have Undergone Surgery for Node-Negative Breast Cancer (The TAILORx Trial)

Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: chemotherapy; Drug: exemestane; Drug: letrozole; Drug: tamoxifen citrate
Sponsors: National Cancer Institute (NCI); Eastern Cooperative Oncology Group; National Cancer Institute (NCI); Southwest Oncology Group; Cancer and Leukemia Group B; American College of Surgeons; North Central Cancer Treatment Group; NCIC Clinical Trials Group; National Surgical Adjuvant Breast and Bowel Project (NSABP)
Recruiting - verified July 2011
Telephone-Based Genetic Counseling or Standard Genetic Counseling in Women at Risk of Carrying the BRCA1 or BRCA2 Mutation

Condition: Breast Cancer
Interventions: Genetic: mutation analysis; Other: counseling intervention
Sponsors: Georgetown University; Georgetown University; National Cancer Institute (NCI)
Recruiting - verified October 2011
Quality of Life in African-American or Caucasian Female Breast Cancer Survivors

Conditions: Breast Cancer; Cancer Survivor; Depression; Fatigue; Sexual Dysfunction; Sleep Disorders; Spiritual Concerns
Interventions: Other: study of socioeconomic and demographic variables; Procedure: fatigue assessment and management; Procedure: management of therapy complications; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Indiana University Melvin and Bren Simon Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2007
Vaccine Therapy, Trastuzumab, and Vinorelbine in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Biological: sargramostim; Biological: therapeutic autologous dendritic cells; Biological: trastuzumab; Drug: vinorelbine ditartrate
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2012
Taxotere and Adriamycin/Cytoxan (AC) Validation in Breast Cancer Patients

Condition: Breast Cancer
Interventions: Drug: Taxotere; Drug: Adriamycin/Cytoxan; Drug: docetaxol; Drug: doxorubicin
Sponsors: Baylor Breast Care Center; Baylor Breast Care Center; Baylor College of Medicine
Recruiting - verified November 2011
Serum Proteomics to Predict Gemcitabine Sensitivity in Breast Cancer

Condition: Metastatic Breast Cancer
Intervention: Drug: gemcitabine, carboplatin
Sponsors: National University Hospital, Singapore; National University Hospital, Singapore
Recruiting - verified April 2012
Yoga-Based Cancer Rehabilitation Program

Conditions: Breast Neoplasms; Colorectal Neoplasms; Lung Neoplasms
Intervention: Behavioral: Yoga
Sponsors: Albert Einstein College of Medicine of Yeshiva University; Albert Einstein College of Medicine of Yeshiva University; National Cancer Institute (NCI); The Jacob and Valeria Langeloth Foundation
Recruiting - verified February 2012
Magnetic Resonance (MR) Spectroscopy of Breast Cancer Tissue

Condition: Breast Neoplasms
Intervention:
Sponsors: Norwegian University of Science and Technology; Norwegian University of Science and Technology; The Research Council of Norway; The Norwegian Women´s Public Health Association
Recruiting - verified September 2011
Upstaging of ALH/LCIS Found on Core Biopsy Based on Subsequent Excisional Biopsy

Condition: Breast Neoplasms
Intervention:
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center; Brigham and Women's Hospital
Recruiting - verified July 2011
Doxorubicin, Cyclophosphamide, and/or Paclitaxel in Treating Women With Nonmetastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: AC regimen; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: paclitaxel
Sponsors: National Cancer Institute (NCI); Duke Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified April 2008
Radiation Therapy in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer

Condition: Breast Cancer
Interventions: Radiation: 3-dimensional conformal accelerated partial breast irradiation; Radiation: brachytherapy; Radiation: whole breast irradiation
Sponsors: National Cancer Institute (NCI); National Surgical Adjuvant Breast and Bowel Project (NSABP); National Cancer Institute (NCI); Radiation Therapy Oncology Group; Southwest Oncology Group
Recruiting - verified May 2012
Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant

Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Disseminated Neuroblastoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; High Risk Metastatic Gestational Trophoblastic Tumor; Juvenile Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Previously Treated Childhood Rhabdomyosarcoma; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage II Ovarian Epithelial Cancer; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Malignant Testicular Germ Cell Tumor; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Ovarian Epithelial Cancer; Stage III Small Lymphocytic Lymphoma; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Breast Cancer; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Ovarian Epithelial Cancer; Stage IV Small Lymphocytic Lymphoma
Interventions: Drug: pentostatin; Biological: therapeutic allogeneic lymphocytes; Drug: mycophenolate mofetil; Drug: cyclosporine
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified January 2012
Genetic Testing in Predicting Response to Paclitaxel in Women With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: paclitaxel; Genetic: microarray analysis; Procedure: biopsy; Procedure: neoadjuvant therapy; Drug: Paclitaxel
Sponsors: Georgetown University; Georgetown University; National Cancer Institute (NCI)
Recruiting - verified October 2011
Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer

Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005
Nipple Aspiration, Ductal Lavage, and Duct Endoscopy For Diagnostic Assessment in Women Undergoing Surgery for Breast Cancer

Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer

Conditions: Breast Neoplasms; Ovarian Neoplasms
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
Cell Lines From High-Risk Breast Tissue

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified July 2011
High-Risk Breast Duct Epithelium

Conditions: Breast Neoplasms; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified January 2012
Morbidity After Diagnosis and Treatment of Breast Cancer Patients

Condition: Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified March 2012
Combination Chemotherapy After Surgery in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer

Condition: Breast Cancer
Interventions: Drug: CAF regimen; Drug: CMF regimen; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Drug: fluorouracil; Drug: methotrexate; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); International Breast Cancer Study Group
Recruiting - verified September 2008
Herceptin Followed by Chemotherapy in Treating Women With Metastatic Breast Cancer That Overexpresses HER2

Condition: Breast Cancer
Interventions: Drug: Herceptin™ (Her); Drug: Herceptin™ (Her) + chemo
Sponsors: Swiss Group for Clinical Cancer Research; Swiss Group for Clinical Cancer Research
Recruiting - verified May 2012