- Conditions: Amyotrophic Lateral Sclerosis; Respiratory Insufficiency
Interventions: Device: phenique nerve stimulation NeurX™ (Synapse Biomedical); Device: sham phrenic nerve stimulation
Sponsors: Assistance Publique - Hôpitaux de Paris; Assistance Publique - Hôpitaux de Paris; ARSla (Association pour la recherche sur la SLA); Fondation Thierry Latran
Not yet recruiting - verified April 2012 - Conditions: Parkinson Disease; Amyotrophic Lateral Sclerosis
Interventions: Drug: Xeomin; Drug: placebo
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center; MERZ Pharmaceuticals
Recruiting - verified March 2012 - Conditions: Sialorrhea; Amyotrophic Lateral Sclerosis
Interventions: Drug: Botox injection; Drug: Placebo injection
Sponsors: Hospices Civils de Lyon; Hospices Civils de Lyon
Recruiting - verified March 2012 - Condition: Amyotrophic Lateral Sclerosis
Interventions: Other: transcranial direct current stimulation; Other: Sham stimulation
Sponsors: Università degli Studi 'G. d'Annunzio' Chieti e Pescara; Università degli Studi 'G. d'Annunzio' Chieti e Pescara; Catholic University, Italy; Federico II University; Ministero della salute
Not yet recruiting - verified May 2012 - Condition: Amyotrophic Lateral Sclerosis
Interventions: Other: Resistance Exercise; Other: Endurance Exercise; Other: Stretching/Range-of-Motion
Sponsors: Johns Hopkins University; Johns Hopkins University; ALS Association
Recruiting - verified January 2012 - Condition: Amyotrophic Lateral Sclerosis
Intervention:
Sponsors: University of Miami; University of Miami
Not yet recruiting - verified January 2012 - Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Dexpramipexole; Drug: Dexpramipexole; Drug: Dexpramipexole Placebo; Drug: Moxifloxacin
Sponsors: Biogen Idec; Biogen Idec
Recruiting - verified January 2012 - Conditions: Amyotrophic Lateral Sclerosis; Nervous System Diseases; Sclerosis; Motor Neuron Disease; Spinal Cord Diseases; Central Nervous System Diseases; Neurodegenerative Diseases; Neuromuscular Diseases; ALS
Intervention:
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; ALS Therapy Alliance
Recruiting - verified April 2012 - Condition: Amyotrophic Lateral Sclerosis (ALS)
Interventions: Drug: MCI-186; Drug: Placebo; Drug: MCI-186 in open label phase
Sponsors: Mitsubishi Tanabe Pharma Corporation; Mitsubishi Tanabe Pharma Corporation
Recruiting - verified December 2011 - Condition: Amyotrophic Lateral Sclerosis
Intervention: Procedure: stem cell transplantation
Sponsors: General Hospital of Chinese Armed Police Forces; General Hospital of Chinese Armed Police Forces
Not yet recruiting - verified December 2011 - Conditions: Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; PLS; Motor Neuron Disease; Lou Gehrigs Disease; Familial Disease; Amyotrophic Lateral Sclerosis, Sporadic
Intervention:
Sponsors: University of Massachusetts, Worcester; University of Massachusetts, Worcester; National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified May 2012 - Conditions: Amyotrophic Lateral Sclerosis; Alzheimer Disease; Parkinson's Disease
Intervention:
Sponsors: China Medical University Hospital; China Medical University Hospital
Not yet recruiting - verified June 2011 - Conditions: Alzheimer's Disease; Amyotrophic Lateral Sclerosis (ALS); Multiple Sclerosis (MS); Parkinson's Disease; Stroke; Traumatic Brain Injury
Intervention:
Sponsors: Avanir Pharmaceuticals; Avanir Pharmaceuticals
Recruiting - verified May 2011 - Conditions: Amyotrophic Lateral Sclerosis; ALS
Interventions: Biological: HYNR-CS inj; Biological: Control group
Sponsors: Corestem, Inc.; Corestem, Inc.; Hanyang University
Recruiting - verified May 2011 - Condition: Amyotrophic Lateral Sclerosis
Intervention: Other: MRI + 18FDG-PET + neuropsychological assessments ; 18FDG performed especially for the research
Sponsors: University Hospital, Caen; University Hospital, Caen
Recruiting - verified February 2012 - Condition: Amyotrophic Lateral Sclerosis
Interventions: Biological: MSC-NTF cells transplantation (i.m.); Biological: MSC-NTF cells transplantation (i.t.)
Sponsors: Hadassah Medical Organization; Hadassah Medical Organization; Brainstorm Cell Therapeutics Ltd.
Recruiting - verified June 2011 - Condition: Familial Amyotrophic Lateral Sclerosis
Intervention: Drug: Pyrimethamine
Sponsors: Weill Medical College of Cornell University; Weill Medical College of Cornell University; Muscular Dystrophy Association
Recruiting - verified July 2011 - Condition: Amyotrophic Lateral Sclerosis
Interventions: Dietary Supplement: Oxepa; Dietary Supplement: Jevity 1.5; Dietary Supplement: Jevity 1.0
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Muscular Dystrophy Association
Recruiting - verified February 2012 - Conditions: Tetraplegia; Spinal Cord Injuries; Amyotrophic Lateral Sclerosis; Brain Stem Infarctions; Locked in Syndrome
Intervention: Device: Placement of the BrainGate2 sensor into the motor cortex
Sponsors: Massachusetts General Hospital; Leigh R. Hochberg, MD, PhD.; National Center for Medical Rehabilitation Research (NCMRR); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified January 2012 - Condition: Amyotrophic Lateral Sclerosis
Intervention: Device: PtcCO2
Sponsors: Association Nationale pour le Traitement à Domicile de l'Insuffisance Respiratoire; Association Nationale pour le Traitement à Domicile de l'Insuffisance Respiratoire
Recruiting - verified February 2012 - Conditions: Amyotrophic Lateral Sclerosis; Familial Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis With Frontotemporal Dementia; Lou Gehrig's Disease; Motor Neuron Disease; Primary Lateral Sclerosis
Intervention: Other: Genetic study of ALS families
Sponsors: Northwestern University; Northwestern University
Recruiting - verified July 2011 - Condition: ALS (Amyotrophic Lateral Sclerosis)
Intervention: Device: Brain Computer Interface (BCI)
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs; New York State Department of Health
Recruiting - verified March 2012 - Conditions: Amyotrophic Lateral Sclerosis 1; Acquired Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis
Intervention: Drug: Arimoclomol
Sponsors: University of Miami; University of Miami; ALS Association; FDA Office of Orphan Products Development; Massachusetts General Hospital
Recruiting - verified March 2012 - Conditions: Amyotrophic Lateral Sclerosis; Motor Neuron Disease
Interventions: Device: noninvasive positive pressure ventilation; Device: noninvasive positive pressure ventilation
Sponsors: Columbia University; Columbia University
Recruiting - verified October 2011 - Condition: Amyotrophic Lateral Sclerosis (ALS)
Intervention: Drug: E0302 (mecobalamin)
Sponsors: Eisai Inc.; Eisai Co., Ltd.
Recruiting - verified May 2012 - Condition: Motor Neuron Diseases
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2011 - Condition: Amyotrophic Lateral Sclerosis
Intervention:
Sponsors: University of Miami; Michael Benatar; Muscular Dystrophy Association
Recruiting - verified April 2012 - Condition: Amyotrophic Lateral Sclerosis
Intervention:
Sponsors: University of Miami; Michael Benatar; ALS Association
Recruiting - verified April 2012 - Conditions: Motor Nueron Disease; Nervous System Diseases; Muscle Spasticity; Diffusion Tensor Imaging; Disease Progression; Evoked Potentials, Motor/Physiology
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2011
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