Acetylcholine Clinical Trials

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Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior

Condition: Cocaine Use Disorders
Interventions: Drug: High-dose donepezil; Drug: Low-dose donepezil; Drug: Selegiline; Drug: Placebo
Sponsors: Midwest Biomedical Research Foundation; Midwest Biomedical Research Foundation; National Institute on Drug Abuse (NIDA)
Recruiting - verified May 2012
A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence

Conditions: Nicotine Dependence; Smoking Cessation
Interventions: Drug: EVP-6124; Drug: Placebo Capsule; Drug: NicoDerm CQ Patch (Active); Drug: NRT Patch (Placebo); Behavioral: Brief Supportive and Behavioral Treatment
Sponsors: Massachusetts General Hospital; A. Eden Evins; EnVivo Pharmaceuticals, Inc.; National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2012
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics

Condition: Cocaine Dependence
Interventions: Drug: Oral tacrine; Drug: Oral placebo
Sponsors: Midwest Biomedical Research Foundation; Midwest Biomedical Research Foundation
Not yet recruiting - verified May 2012
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins

Condition: Hyperglycemia
Interventions: Drug: 5% dextrose; Drug: vitamin C; Drug: Simvastatin; Drug: L-NMMA
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified May 2012
Heart Disease of the Small Arteries in Women

Condition: Heart Disease
Intervention: Procedure: noninvasive tests
Sponsors: Cedars-Sinai Medical Center; Cedars-Sinai Medical Center
Recruiting - verified March 2012
Endothelial Hyperpolarization in Humans

Condition: Hyperlipidemia
Interventions: Drug: Tetraethylammonium (TEA); Drug: L-NMMA; Drug: Bradykinin; Drug: Nitroprusside; Drug: S-methyl-L-thiocitrulline (SMTC); Drug: Acetylcholine
Sponsors: Emory University; Emory University
Recruiting - verified May 2012