- Conditions: Benign Prostatic Hyperplasia; Lower Urinary Track Symptoms
Interventions: Drug: onaBoNT-A + placebo; Drug: Tamsulosin + placebo
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Not yet recruiting - verified April 2012 - Condition: Pulmonary Hypertension
Interventions: Drug: Carvedilol; Drug: Carvedilol placebo
Sponsors: The Cleveland Clinic; The Cleveland Clinic; National Institutes of Health (NIH)
Not yet recruiting - verified April 2012 - Condition: Pulmonary Hypertension Inclusion Criteria 1. Must be Unaffected by a Neurologica
Interventions: Drug: Carvedilol; Drug: Imatinib
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2012 - Conditions: Nocturia; Benign Prostatic Hyperplasia; Incontinence
Interventions: Drug: onaBoNT-A + placebo; Drug: Tamsulosin + placebo
Sponsors: Baylor College of Medicine; Baylor College of Medicine; Department of Veterans Affairs
Not yet recruiting - verified May 2012 - Condition: Kidney Stones
Interventions: Drug: silodosin; Procedure: Extra-corporeal shock wave lithotripsy; Drug: Tamsulosin
Sponsors: Albert Einstein Healthcare Network; Albert Einstein Healthcare Network
Not yet recruiting - verified March 2012 - Condition: Postoperative Urinary Retention
Interventions: Drug: Tamsulosin hydrochloride; Other: Placebo
Sponsors: Mayo Clinic; Mayo Clinic
Recruiting - verified May 2012 - Condition: Posttraumatic Stress Disorder (PTSD)
Interventions: Biological: Prazosin as first-line agent; Behavioral: Cognitive Behavioral Therapy for PTSD
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Not yet recruiting - verified February 2012 - Conditions: Heroin Dependence; Opioid-Related Disorders
Intervention:
Sponsors: Wayne State University; Wayne State University; National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2012 - Condition: Drug Induced Constipation
Interventions: Drug: Nektar 118; Drug: Quinidine; Drug: Quinidine placebo; Drug: Morphine
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012 - Conditions: Alcohol Abuse; Posttraumatic Stress Disorder
Interventions: Drug: Prazosin; Drug: Placebo medication
Sponsors: Seattle Institute for Biomedical and Clinical Research; Seattle Institute for Biomedical and Clinical Research; National Institute on Alcohol Abuse and Alcoholism (NIAAA); VA Puget Sound Health Care System
Recruiting - verified December 2011 - Conditions: Hot Flashes; Breast Cancer
Interventions: Drug: solifenacin; Drug: Clonidine
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified February 2012 - Condition: Cardiovascular Effects
Interventions: Other: Diesel Exhaust; Other: Filtered Air; Drug: Terazosin; Drug: placebo
Sponsors: University of Washington; University of Washington; National Institute of Environmental Health Sciences (NIEHS); Environmental Protection Agency (EPA)
Recruiting - verified January 2012 - Condition: Glaucoma
Intervention: Drug: Brinzolamide/Timolol Maleate Fixed Combination (AZARGA)
Sponsors: Alcon Research; Alcon Research
Recruiting - verified January 2012 - Condition: Anorexia
Interventions: Drug: megestrol acetate; Drug: Arm B (megestrol plus mirtazapine)
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified April 2012 - Conditions: Overactive Bladder; Overactive Urinary Bladder
Interventions: Drug: MK-4618; Drug: Tolterodine ER; Drug: MK-1468 and Tolterodine ER; Other: Placebo (MK-4618); Other: Placebo (Tolterodine ER); Drug: Prophylactic Antibiotic
Sponsors: Merck; Merck
Recruiting - verified February 2012 - Conditions: Dental Anesthesia; Anesthesia, Local; Anesthesia, Reversal
Interventions: Drug: OraVerse; Other: Sham injection
Sponsors: Novocol Pharmaceutical of Canada, Inc.; Novocol Pharmaceutical of Canada, Inc.
Recruiting - verified May 2012 - Condition: Depressive Disorder, Major
Interventions: Drug: LY2216684; Drug: Quinidine
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012 - Condition: Lower Urinary Tract Symptoms
Intervention: Drug: Solifenacin (Vesicare) 5 mg orally at the same time.
Sponsors: The Methodist Hospital System; The Methodist Hospital System; Astellas Pharma US, Inc.
Recruiting - verified October 2011 - Conditions: Alcohol Dependence; Anxiety
Interventions: Drug: Doxazosin; Drug: Placebo
Sponsors: Brown University; Brown University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified September 2011 - Condition: Methamphetamine Dependence
Intervention: Drug: Doxazosin extended release
Sponsors: University of Arkansas; University of Arkansas; National Institute on Drug Abuse (NIDA); Baylor College of Medicine
Recruiting - verified November 2011 - Condition: Ejaculation
Interventions: Drug: Treatment sequence 2; Drug: Treatment sequence 1
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified May 2012 - Condition: Sialorrhoea
Interventions: Drug: OC oral solution treatment A; Drug: OC oral solution treatment B; Drug: OC oral solution treatment C; Drug: OC oral solution treatment D
Sponsors: Orient Pharma Co., Ltd.; Orient Pharma Co., Ltd.
Recruiting - verified May 2012 - Condition: Alzheimer's Disease
Interventions: Drug: Carvedilol; Drug: Placebo
Sponsors: Johns Hopkins University; Johns Hopkins University; Mount Sinai School of Medicine
Recruiting - verified March 2012 - Condition: Cancer Survivor
Interventions: Drug: carvedilol; Other: placebo; Other: pharmacogenomic studies; Other: laboratory biomarker analysis; Procedure: quality-of-life assessment; Genetic: polymorphism analysis; Genetic: microarray analysis; Genetic: polymerase chain reaction; Other: enzyme-linked immunosorbent assay; Other: questionnaire administration
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified May 2012 - Conditions: Brain Injuries; Craniocerebral Trauma; Trauma, Nervous System; Traumatic Brain Injury
Interventions: Drug: IV Propranolol and Per Tube Clonidine; Drug: Placebo
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified March 2012 - Condition: Urinary Bladder, Overactive
Interventions: Drug: MK-4618 low-dose; Drug: MK-4618 mid-low dose; Drug: MK-4618 mid-high dose; Drug: tolterodine ER; Drug: Placebo for MK-4618; Drug: Placebo for tolterodine ER; Drug: MK-4618 high dose
Sponsors: Merck; Merck
Recruiting - verified May 2012 - Condition: Overactive Bladder
Interventions: Drug: Tolterodine ER; Drug: Placebo
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012 - Condition: Floppy Iris Syndrome
Intervention:
Sponsors: University of Michigan; University of Michigan
Recruiting - verified July 2010 - Condition: Non-treatment Seeking Methamphetamine Users
Interventions: Drug: oral placebo and methamphetamine 20mg po; Drug: Prazosin 1mg po and oral methamphetamine placebo; Drug: Prazosin 1mg po and Methamphetamine 20mg po
Sponsors: University of Arkansas; University of Arkansas; National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2012 - Condition: Posttraumatic Stress Disorder
Interventions: Drug: Mirtazapine; Drug: Sertraline; Other: Sugar pill
Sponsors: Research Foundation for Mental Hygiene; Research Foundation for Mental Hygiene; National Institute of Mental Health (NIMH)
Recruiting - verified July 2010 - Conditions: Cocaine Dependence; Cocaine Withdrawal
Interventions: Drug: controlled release carvedilol; Drug: Placebo
Sponsors: University of Arkansas; University of Arkansas; National Institute on Drug Abuse (NIDA); Baylor College of Medicine
Recruiting - verified May 2012 - Condition: Alcohol Dependence
Interventions: Drug: Quetiapine XR plus mirtazapine; Drug: Quetiapine fumarate extended release (Quetiapine XR)
Sponsors: Dartmouth-Hitchcock Medical Center; Dartmouth-Hitchcock Medical Center
Recruiting - verified February 2012 - Conditions: Opioid Related Disorders; Opioid Dependence; Opioid Addiction
Interventions: Drug: Buprenorphine/naloxone; Drug: Clonidine; Drug: Tramadol ER
Sponsors: National Institute on Drug Abuse (NIDA); National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2012 - Condition: Treatment Refractory Depression
Interventions: Drug: Ketamine; Drug: Clonidine; Drug: placebo
Sponsors: Washington University School of Medicine; Washington University School of Medicine; University of Miami
Not yet recruiting - verified March 2012 - Condition: Neonatal Abstinence Syndrome
Interventions: Drug: Clonidine; Drug: Phenobarbital
Sponsors: Baystate Medical Center; Baystate Medical Center
Recruiting - verified April 2012 - Condition: Alzheimer's Disease
Interventions: Drug: Prazosin; Drug: Placebo
Sponsors: Seattle Institute for Biomedical and Clinical Research; Seattle Institute for Biomedical and Clinical Research; National Institute on Aging (NIA); VA Puget Sound Health Care System
Recruiting - verified February 2012 - Condition: Drug Dependence
Intervention: Drug: 2-4 of the drugs listed below
Sponsors: University of Arkansas; University of Arkansas; National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2012 - Condition: Post-Traumatic Stress Disorder
Interventions: Drug: Yohimbine; Drug: Placebo
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified January 2012 - Conditions: Breast Cancer; Cardiac Toxicity
Interventions: Drug: carvedilol phosphate extended-release capsule; Drug: lisinopril; Other: placebo
Sponsors: National Cancer Institute (NCI); University of South Florida; National Cancer Institute (NCI)
Recruiting - verified February 2012 - Conditions: Cannabis Dependence; Marijuana Dependence
Interventions: Drug: Lofexidine and Dronabinol; Drug: Placebo
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute; National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2012 - Conditions: Stress Disorders, Post-Traumatic; Combat Disorders; Sleep Disorders
Interventions: Drug: prazosin hydrochloride; Drug: placebo
Sponsors: Seattle Institute for Biomedical and Clinical Research; Seattle Institute for Biomedical and Clinical Research; Department of Defense; VA Puget Sound Health Care System; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified March 2012 - Condition: Social Anxiety Disorder
Intervention: Behavioral: Group Cognitive Behavioral Therapy
Sponsors: Southern Methodist University; Southern Methodist University
Recruiting - verified July 2011 - Condition: Lower Urinary Tract Symptoms
Interventions: Drug: dutasteride 0.5 mg, used with tolterodine ER 4mg or placebo; Drug: dutasteride
Sponsors: Siami, Paul F., M.D.; Siami, Paul F., M.D.; GlaxoSmithKline; Pfizer
Recruiting - verified July 2011 - Conditions: Erectile Dysfunction; Lower Urinary Tract Symptoms
Interventions: Drug: Alfuzosin; Drug: Alfuzosin
Sponsors: Chesapeake Urology Research Associates; Chesapeake Urology Research Associates; Sanofi-Aventis
Recruiting - verified February 2012 - Condition: Nocturia
Interventions: Behavioral: Behavioral; Drug: tamsulosin (alpha-adrenergic antagonist medication); Drug: placebo; Behavioral: placebo
Sponsors: Atlanta VA Medical Center; Atlanta VA Medical Center; Emory University; University of Alabama at Birmingham
Recruiting - verified January 2012 - Condition: Alcoholism
Interventions: Drug: Prazosin medication; Drug: Placebo medication
Sponsors: Seattle Institute for Biomedical and Clinical Research; Seattle Institute for Biomedical and Clinical Research; National Institute on Alcohol Abuse and Alcoholism (NIAAA); VA Puget Sound Health Care System; University of Washington
Recruiting - verified April 2011 - Conditions: Alcohol Dependence; Stress Disorders, Post-Traumatic
Intervention: Drug: Prazosin
Sponsors: Yale University; Elizabeth Ralevski
Recruiting - verified January 2012 - Conditions: Intracerebral Hemorrhage; Stroke; Hypertension
Intervention: Other: Blood pressure management policies
Sponsors: The George Institute; The George Institute; National Health and Medical Research Council, Australia
Recruiting - verified February 2012 - Condition: Kidney Stones
Interventions: Drug: Alfuzosin; Drug: nifedipine; Drug: doxazosin; Drug: prazosin
Sponsors: United States Naval Medical Center, San Diego; United States Naval Medical Center, San Diego
Recruiting - verified April 2012 - Condition: Cocaine Addictions
Interventions: Drug: sugar pill; Drug: carvedilol; Drug: Methadone
Sponsors: Yale University; Yale University; National Institute on Drug Abuse (NIDA)
Recruiting - verified December 2011 - Condition: Ventricular Tachycardia
Interventions: Drug: clonidine; Drug: metoprolol
Sponsors: University of Iowa; University of Iowa; National Center for Research Resources (NCRR)
Recruiting - verified December 2007 - Conditions: Autonomic Nervous System Diseases; Orthostatic Hypotension
Interventions: Drug: droxidopa; Drug: placebo; Drug: alpha-methyldopa; Drug: carbidopa; Drug: metyrosine; Drug: levodopa; Drug: atomoxetine; Drug: metoclopramide
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified March 2012 - Conditions: Chronic Fatigue Syndrome; Orthostatic Intolerance; Postural Tachycardia Syndrome
Interventions: Other: Autonomic Function Testing; Other: Saline infusions; Drug: L-NMMA trimethaphan; Drug: methyldopa
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012 - Condition: Burns
Interventions: Procedure: Stable Isotope Infusion Study; Procedure: Collection of blood and tissues; Procedure: Radiology testing: DEXA, K+ counter, ultrasound, MRI; Drug: Humatrope; Drug: Ketoconazole; Drug: Oxandrolone; Drug: Propranolol; Drug: Oxandrolone and propranolol combined; Drug: Humatrope and propranolol combined; Drug: Placebo; Behavioral: Exercise--Hospital supervised intensive exercise program; Behavioral: Home exercise program
Sponsors: The University of Texas, Galveston; The University of Texas, Galveston; U.S. Department of Education; National Institutes of Health (NIH); Shriners Hospitals for Children
Recruiting - verified March 2012 - Conditions: PTSD; Sleep Disorders
Interventions: Drug: prazosin; Other: placebo
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified May 2012 - Condition: Opioid-Related Disorders
Interventions: Drug: Clonidine; Drug: Placebo
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2012 - Conditions: Tachycardia; Chronic Orthostatic Intolerance
Interventions: Drug: Acetazolamide; Drug: Atomoxetine; Other: Baseline (No Drug); Drug: Clonidine; Drug: Entacapone; Drug: Entacapone & Propranolol; Drug: Atomoxetine & Propranolol; Drug: Indomethacin; Drug: Mecamylamine; Drug: Isosorbide Dinitrate; Dietary Supplement: Melatonin; Drug: Midodrine; Drug: Modafinil; Drug: Octreotide; Radiation: Placebo; Drug: Propranolol; Drug: Modafinil & Propranolol; Drug: Sertraline; Procedure: IV Saline; Other: Drinking Water; Device: Breathing Device; Drug: memantine; Device: Abdominal binder
Sponsors: Vanderbilt University; Satish R. Raj; National Institutes of Health (NIH)
Recruiting - verified February 2012 - Conditions: Cocaine Dependence; Depression
Interventions: Drug: Mirtazapine; Drug: Placebo
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute; National Institute on Drug Abuse (NIDA)
Recruiting - verified October 2011 - Condition: Hypertension
Interventions: Drug: Clonidine; Drug: Nitroglycerin transdermal; Drug: Dipyridamole/ Aspirin (Aggrenox); Drug: Desmopressin (DDAVP); Drug: Sildenafil; Drug: Nifedipine; Drug: Hydralazine; Drug: Hydrochlorothiazide; Drug: Placebo; Drug: Bosentan; Drug: Diltiazem; Drug: Eplerenone; Drug: guanfacine; Dietary Supplement: L-arginine; Drug: captopril; Drug: carbidopa; Drug: losartan; Drug: metoprolol tartrate; Drug: nebivolol hydrochloride; Drug: prazosin hydrochloride; Drug: tamsulosin hydrochloride; Other: Head-up tilt.
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012 - Conditions: Autonomic Failure; Orthostatic Hypotension
Interventions: Drug: Atomoxetine; Drug: Acarbose; Drug: Pyridostigmine Bromide; Drug: Yohimbine; Drug: Midodrine HCl; Drug: placebo; Drug: Modafinil; Drug: Octreotide; Other: water intake; Drug: Diphenhydramine Hydrochloride; Drug: Ranitidine HCL; Drug: Tranylcypromine; Drug: Ergotamine/ Caffeine; Drug: Celecoxib; Drug: Pseudoephedrine; Drug: Methylphenidate; Drug: Indomethacin; Drug: Ibuprofen; Drug: Oxymetazoline 0.05% nasal solution; Dietary Supplement: Bovril; Drug: Acetazolamide; Drug: Rivastigmine tartrate; Drug: Carbidopa/levodopa; Device: abdominal binder; Device: abdominal binder (sham)
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012
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Adrenergic Alpha Antagonists Clinical Trials |
