Antifibrinolytic Agents Clinical Trials

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The Efficacy and Cost Analysis of Reinfusion Drains Versus Tranexamic Acid in Total Joint Arthroplasty

Condition: Total Joint Arthroplasty
Interventions: Device: Hemovac drain; Device: OrthoPAT drain; Drug: Tranexamic acid
Sponsors: OrthoCarolina Research Institute, Inc.; OrthoCarolina Research Institute, Inc.
Recruiting - verified January 2012
Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffein, Midazolam, and Digoxin in Cancer Subjects

Condition: Solid Tumors
Interventions: Drug: tivantinib; Drug: omeprazole; Drug: s-warfarin; Drug: caffeine; Dietary Supplement: vitamin K; Drug: digoxin; Drug: midazolam
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.; Medpace, Inc.
Recruiting - verified January 2012
Use of Phytonadione to Reduce International Normalized Ratio (INR) Variability in Patients on Long-term Warfarin Therapy

Condition: Coagulation Delay
Interventions: Dietary Supplement: phytonadione; Drug: none-control group
Sponsors: James A. Haley Veterans Administration Hospital; James A. Haley Veterans Administration Hospital
Recruiting - verified December 2011
Crossover of Oral Tranexamic Acid and Combined Oral Contraceptives in Adolescent Menorrhagia

Condition: Menorrhagia
Interventions: Drug: Oral tranexamic acid; Drug: Oral Contraceptive Pills
Sponsors: Baylor College of Medicine; Baylor College of Medicine; Texas Children's Hospital
Recruiting - verified September 2011
North American Study of Epistaxis in HHT

Conditions: Telangiectasia, Hereditary Hemorrhagic; Epistaxis
Interventions: Drug: Sterile saline; Drug: Bevacizumab; Drug: Estriol; Drug: Tranexamic Acid
Sponsors: Georgia Health Sciences University; James Gossage; Hereditary Hemorrhagic Telangiectasia Foundation International
Recruiting - verified February 2012
Effects of Aminocaproic Acid (ACA) on Rosacea-specific Inflammation

Condition: Rosacea
Interventions: Drug: Topical aminocaproic acid (ACA) mixed with Vanicream; Drug: Vehicle cream
Sponsors: University of California, San Diego; University of California, San Diego
Recruiting - verified April 2011
Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab

Conditions: Dermatologic Complications; Malignant Neoplasm; Pain
Interventions: Drug: menadione topical lotion; Other: placebo; Other: questionnaire administration; Procedure: management of therapy complications
Sponsors: Mayo Clinic; Mayo Clinic
Recruiting - verified May 2012
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty

Conditions: Acute Blood Loss Anemia; Osteoarthritis, Knee
Interventions: Drug: Tranexamic Acid; Drug: Placebo
Sponsors: Henry Ford Health System; Henry Ford Health System
Recruiting - verified April 2011
Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass

Condition: Congenital Heart Disease
Intervention:
Sponsors: Children's Hospital Boston; Children's Hospital Boston
Recruiting - verified June 2011
An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure

Condition: Reversal of Coagulopathy
Interventions: Biological: Beriplex® P/N; Biological: Fresh frozen plasma
Sponsors: CSL Behring; CSL Behring
Recruiting - verified May 2012
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass- Specific Aim 3

Condition: Coronary Arteriosclerosis
Interventions: Drug: HOE 140; Drug: Aminocaproic Acid; Drug: Placebo
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified July 2011