Biotin Clinical Trials

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Mechanisms Accounting for Unexplained Anemia in the Elderly

Conditions: Normal Aging; Anemia
Intervention: Procedure: Biotin RBC survival
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Aging (NIA)
Recruiting - verified February 2011
Feasibility and Effectiveness of Micronutrients as Palliative Care Therapy in Patients With Congestive Heart Failure

Conditions: Congestive Heart Failure; Ischemic Cardiomyopathy
Intervention: Dietary Supplement: Micronutrients
Sponsors: Phoenix VA Health Care System; Phoenix VA Health Care System
Recruiting - verified November 2011
Donor Peripheral Blood Stem Cell Transplant and Pretargeted Radioimmunotherapy in Treating Patients With High-Risk Advanced Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

Conditions: Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Chronic Myelomonocytic Leukemia; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Ringed Sideroblasts; Refractory Cytopenia With Multilineage Dysplasia; Secondary Acute Myeloid Leukemia
Interventions: Biological: pretargeted radioimmunotherapy; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Drug: cyclosporine; Drug: mycophenolate mofetil; Radiation: total-body irradiation; Other: pharmacological study; Procedure: peripheral blood stem cell transplantation; Drug: fludarabine phosphate
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium; National Cancer Institute (NCI)
Recruiting - verified March 2012
Biotin Status in Pregnancy

Condition: Biotin Deficiency
Interventions: Dietary Supplement: biotin; Dietary Supplement: biotin
Sponsors: University of Arkansas; University of Arkansas; University of Nebraska
Recruiting - verified January 2012
Red Blood Cell (RBC) Survival Following Transfusion in Infants

Condition: Neonatal Anemia
Interventions: Biological: Transfused Biotin RBCs - Adults Phase I; Biological: Transfused Biotin RBCs - Infants Phase II; Biological: Transfused Biotin RBCs - Infants Phase III
Sponsors: University of Iowa; University of Iowa; National Institutes of Health (NIH); National Heart, Lung, and Blood Institute (NHLBI); Thrasher Research Fund
Recruiting - verified February 2012
Treating Oxidative Stress and the Metabolic Pathology of Autism

Condition: Autistic Disorder
Interventions: Dietary Supplement: B12; Dietary Supplement: Placebo; Dietary Supplement: folate; Dietary Supplement: B complex; Dietary Supplement: vitamin C; Dietary Supplement: cod liver oil; Dietary Supplement: Mineral complex; Dietary Supplement: carnitine
Sponsors: Arkansas Children's Hospital Research Institute; Arkansas Children's Hospital Research Institute
Recruiting - verified January 2012