Bosentan Clinical Trials

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Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral Bosentan

Condition: Pulmonary Arterial Hypertension
Interventions: Device: St Jude Medical C7 Dragonfly Optical Coherence Tomography (OCT); Device: Boston Scientific Intravascular Ultrasound
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Actelion
Recruiting - verified May 2012
Registry of Sarcoidosis Associated Pulmonary Hypertension (RESAPH)

Conditions: Sarcoidosis; Pulmonary Hypertension
Intervention: Other: Observation
Sponsors: University of Cincinnati; University of Cincinnati; The Cleveland Clinic
Recruiting - verified November 2011
Persistent Pulmonary Hypertension of the Newborn

Condition: Persistent Fetal Circulation Syndrome
Interventions: Drug: Bosentan; Drug: Matching placebo
Sponsors: Actelion; Actelion
Recruiting - verified April 2012
Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Patients

Condition: Pulmonary Arterial Hypertension
Intervention: Drug: Imatinib
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Study of Incidence of Respiratory Tract Adverse Events in Patients Treated With Tyvaso® Compared to Other FDA Approved Pulmonary Arterial Hypertension (PAH) Therapies

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: inhaled prostacyclin; Drug: inhaled prostacyclin; Drug: prostacyclin; Drug: subcutaneous and intravenous prostacyclin; Drug: oral ERA; Drug: oral PDE5 inhibitors
Sponsors: United Therapeutics; United Therapeutics
Recruiting - verified January 2012
Pulmonary Arterial Hypertension in Children

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: bosentan; Drug: bosentan
Sponsors: Actelion; Actelion
Recruiting - verified November 2011
Pharmacogenomics in Pulmonary Arterial Hypertension

Conditions: Pulmonary Arterial Hypertension; Pulmonary Hypertension; PAH WHO Group I
Interventions: Drug: Sitaxsentan; Drug: Bosentan, Ambrisentan
Sponsors: West Penn Allegheny Health System; West Penn Allegheny Health System; National Institutes of Health (NIH); Baylor College of Medicine; Emory University; University of Chicago; Johns Hopkins University; Tufts Medical Center; Sir Mortimer B. Davis - Jewish General Hospital; London Health Sciences Centre; University of Maryland; University of California, San Francisco; University of Calgary; Chest Medical Associates; Columbia University; Lung Diagnostics, Ltd.; Duke University; University of California, Los Angeles; Latter Day Saints Hospital; Louisiana State University Health Sciences Center in New Orleans; Massachusetts General Hospital; Mayo Clinic; Medical College of Wisconsin; Southeastern Lung Care; Suncoast Lung Center; Children's Hospital Colorad; University Hospitals of Cleveland; University of Colorado, Denver; University of Michigan; University of Pittsburgh; University of Southern California; The University of Texas, Galveston; Vanderbilt University; Wayne State University; Ohio State University; University of Alabama at Birmingham; Washington University School of Medicine; Sentara Norfolk General Hospital; University of Texas Southwestern Medical Center; Bay Area Chest Physicians
Recruiting - verified January 2012
Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Bosentan; Drug: Sildenafil Citrate
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)

Condition: Pulmonary Hypertension
Interventions: Drug: bosentan; Drug: placebo
Sponsors: Actelion; Actelion
Recruiting - verified February 2012
Treatment of Supine Hypertension in Autonomic Failure

Condition: Hypertension
Interventions: Drug: Clonidine; Drug: Nitroglycerin transdermal; Drug: Dipyridamole/ Aspirin (Aggrenox); Drug: Desmopressin (DDAVP); Drug: Sildenafil; Drug: Nifedipine; Drug: Hydralazine; Drug: Hydrochlorothiazide; Drug: Placebo; Drug: Bosentan; Drug: Diltiazem; Drug: Eplerenone; Drug: guanfacine; Dietary Supplement: L-arginine; Drug: captopril; Drug: carbidopa; Drug: losartan; Drug: metoprolol tartrate; Drug: nebivolol hydrochloride; Drug: prazosin hydrochloride; Drug: tamsulosin hydrochloride; Other: Head-up tilt.
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012