Carbidopa Clinical Trials

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PharmacoMRI of Parkinson Disease

Condition: Parkinson's Disease
Intervention: Drug: Carbidopa-Levodopa
Sponsors: Northwestern University; Northwestern University
Recruiting - verified February 2012
Study in Advanced Parkinson's Disease Patients With Predictable Motor Fluctuations

Conditions: Parkinson's Disease; Motor Fluctuations
Interventions: Drug: DM-1992; Drug: Sinemet IR
Sponsors: Depomed; Depomed
Recruiting - verified April 2012
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence

Condition: Cocaine Dependence
Interventions: Drug: levodopa carbidopa and entacapone (LCE); Drug: Placebo
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute
Not yet recruiting - verified December 2011
Carbidopa-Levodopa Extended-Release (CD-LD ER) Alone or in Combination With Carbidopa-Levodopa Immediate Release (IR) to IPX066 Followed by Extension Safety Study of IPX066 in Subjects With Advanced Parkinson's Disease

Condition: Parkinson's Disease
Intervention: Drug: IPX066
Sponsors: IMPAX Laboratories, Inc.; IMPAX Laboratories, Inc.; Michael J. Fox Foundation for Parkinson's Research
Recruiting - verified August 2011
Augmenting Language Therapy for Aphasia: Levodopa

Conditions: Nonfluent Aphasia; Stroke
Intervention: Drug: levodopa/carbidopa
Sponsors: Rehabilitation Institute of Chicago; Rehabilitation Institute of Chicago; U.S. Department of Education
Recruiting - verified September 2011
Cognitive Remediation for Cocaine Dependence

Condition: Cocaine Dependence
Interventions: Drug: levodopa/carbidopa; Drug: Ropinirole; Drug: Placebo
Sponsors: The University of Texas Health Science Center, Houston; The University of Texas Health Science Center, Houston
Recruiting - verified February 2012
A Trial of Levodopa in Angelman Syndrome

Condition: Angelman Syndrome
Intervention: Drug: Levodopa/carbidopa
Sponsors: Children's Hospital Boston; Wen-Hann Tan; Rady Children's Hospital, San Diego; University of California, San Francisco; Baylor College of Medicine; Vanderbilt University; Greenwood Genetic Center; Angelman Syndrome Foundation; FDA Office of Orphan Products Development
Recruiting - verified March 2012
Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE)

Condition: Cocaine Abuse
Intervention: Drug: L-dopa / carbidopa / entacapone (LCE)
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute; National Institute on Drug Abuse (NIDA); Columbia University
Recruiting - verified December 2011
Levodopa for the Treatment of Residual Amblyopia

Condition: Amblyopia
Interventions: Drug: Levodopa/Carbidopa; Drug: Placebo; Other: Patching
Sponsors: Jaeb Center for Health Research; Jaeb Center for Health Research; National Eye Institute (NEI)
Recruiting - verified January 2012
Neurobiological Principles Applied to the Rehabilitation of Stroke Patients

Condition: Stroke
Interventions: Drug: Sinemet, ritalin, amphetamine, and placebo; Device: Transcranial magnetic stimulation (TMS); Other: Combined drug treatment and TMS
Sponsors: Emory University; Emory University; National Institutes of Health (NIH); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2012
Peripheral Dopamine in Postural Tachycardia Syndrome

Conditions: Postural Tachycardia Syndrome; Orthostatic Intolerance
Interventions: Drug: Carbidopa; Drug: Placebo
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified June 2011
Treatment of Orthostatic Hypotension

Conditions: Autonomic Nervous System Diseases; Orthostatic Hypotension
Interventions: Drug: droxidopa; Drug: placebo; Drug: alpha-methyldopa; Drug: carbidopa; Drug: metyrosine; Drug: levodopa; Drug: atomoxetine; Drug: metoclopramide
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified March 2012
Positron Emission Tomography (PET) Imaging in People With Gaucher Mutations

Conditions: Glucocerebrosidase Mutations; Gaucher Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified June 2011
Treatment of Orthostatic Hypotension in Autonomic Failure

Conditions: Autonomic Failure; Orthostatic Hypotension
Interventions: Drug: Atomoxetine; Drug: Acarbose; Drug: Pyridostigmine Bromide; Drug: Yohimbine; Drug: Midodrine HCl; Drug: placebo; Drug: Modafinil; Drug: Octreotide; Other: water intake; Drug: Diphenhydramine Hydrochloride; Drug: Ranitidine HCL; Drug: Tranylcypromine; Drug: Ergotamine/ Caffeine; Drug: Celecoxib; Drug: Pseudoephedrine; Drug: Methylphenidate; Drug: Indomethacin; Drug: Ibuprofen; Drug: Oxymetazoline 0.05% nasal solution; Dietary Supplement: Bovril; Drug: Acetazolamide; Drug: Rivastigmine tartrate; Drug: Carbidopa/levodopa; Device: abdominal binder; Device: abdominal binder (sham)
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012
Treatment of Supine Hypertension in Autonomic Failure

Condition: Hypertension
Interventions: Drug: Clonidine; Drug: Nitroglycerin transdermal; Drug: Dipyridamole/ Aspirin (Aggrenox); Drug: Desmopressin (DDAVP); Drug: Sildenafil; Drug: Nifedipine; Drug: Hydralazine; Drug: Hydrochlorothiazide; Drug: Placebo; Drug: Bosentan; Drug: Diltiazem; Drug: Eplerenone; Drug: guanfacine; Dietary Supplement: L-arginine; Drug: captopril; Drug: carbidopa; Drug: losartan; Drug: metoprolol tartrate; Drug: nebivolol hydrochloride; Drug: prazosin hydrochloride; Drug: tamsulosin hydrochloride; Other: Head-up tilt.
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012
PET Scanning in Parkinson's Disease

Condition: Parkinson's Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011