- Conditions: Obesity; Overweight
Interventions: Drug: NB32; Drug: PBO; Behavioral: Weight Management Program
Sponsors: Orexigen Therapeutics, Inc; Orexigen Therapeutics, Inc
Not yet recruiting - verified May 2012 - Condition: Healthy
Interventions: Drug: Naloxone; Drug: Delta-9-THC; Drug: Placebo
Sponsors: Yale University; Yale University
Recruiting - verified May 2012 - Conditions: Regional Block for Pain Control; Supraclavicular Block; Ultrasound Guided Block; Block Additive
Intervention: Drug: Buprenorphine
Sponsors: University of Wisconsin, Madison; University of Wisconsin, Madison
Recruiting - verified April 2012 - Condition: Opioid Related Disorder
Interventions: Drug: RBP-6300; Drug: Placebo
Sponsors: Reckitt Benckiser Pharmaceuticals, Inc; Reckitt Benckiser Pharmaceuticals, Inc
Recruiting - verified February 2012 - Condition: Prescription Opiate/Medication Dependence
Intervention: Drug: Vivitrol
Sponsors: University of Pennsylvania; University of Pennsylvania
Recruiting - verified April 2012 - Condition: Chronic Pain
Interventions: Drug: ALO-02; Drug: Placebo
Sponsors: Pfizer; Pfizer
Not yet recruiting - verified May 2012 - Condition: Substance-Related Disorders
Intervention: Drug: naltrexone for extended release injectable suspension
Sponsors: Rhode Island Hospital; Rhode Island Hospital; National Institute on Drug Abuse (NIDA); Alkermes
Recruiting - verified March 2012 - Conditions: Opiate Dependent; Previous Illicit Drug Use
Intervention: Drug: Buprenorphine and Methadone Hydrochloride
Sponsors: University Hospital, Clermont-Ferrand; University Hospital, Clermont-Ferrand; CSAPA ANPAA 63
Recruiting - verified March 2012 - Condition: Maternal Opioid Dependency During Pregnancy
Intervention: Drug: Buprenorphine
Sponsors: Johns Hopkins University; Johns Hopkins University
Recruiting - verified March 2012 - Condition: Low Back Pain
Interventions: Drug: Methadone; Drug: Buprenorphine/naloxone
Sponsors: State University of New York at Buffalo; State University of New York at Buffalo
Recruiting - verified March 2012 - Condition: Management of Moderate to Severe Pain
Interventions: Drug: ALO-02; Drug: Naltrexone block; Drug: ALO-02; Drug: Naltrexone block; Drug: OxyContin; Drug: Naltrexone block
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012 - Condition: Opiate Dependence
Interventions: Drug: Vivitrol; Behavioral: Employment based opiate abstinence reinforcement; Other: Usual Care Control
Sponsors: Johns Hopkins University; Johns Hopkins University; National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified March 2012 - Condition: Opioid Dependence
Interventions: Behavioral: Distress Tolerance; Behavioral: Health Education
Sponsors: Butler Hospital; Butler Hospital
Not yet recruiting - verified March 2012 - Conditions: Acute Pain Management; Renal Colic
Interventions: Drug: Buprenorphine; Drug: Morphine
Sponsors: Tehran University of Medical Sciences; Tehran University of Medical Sciences
Recruiting - verified March 2012 - Condition: Healthy Controls
Intervention: Radiation: PET imaging
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2012 - Condition: Opioid-Related Disorders
Interventions: Drug: Pioglitazone; Drug: Placebo
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Drug Abuse (NIDA)
Recruiting - verified November 2011 - Condition: Alcohol Drinking
Interventions: Drug: Naltrexone and memantine; Drug: Naltrexone and Placebo
Sponsors: Yale University; Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified January 2012 - Conditions: Opioid-Related Disorders; Heroin Dependence
Intervention: Drug: Naltrexone
Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); ZonMw: The Netherlands Organisation for Health Research and Development; Alkermes
Not yet recruiting - verified November 2011 - Condition: Healthy
Interventions: Drug: Placebo; Drug: Vorikonazole
Sponsors: Turku University Hospital; Turku University Hospital
Recruiting - verified November 2011 - Condition: Pathological Gambling
Interventions: Drug: Naltrexone pharmacotherapy; Drug: Placebo
Sponsors: National Institute for Health and Welfare, Finland; National Institute for Health and Welfare, Finland
Recruiting - verified February 2012 - Condition: Hypoglycemia
Intervention: Drug: Naltrexone
Sponsors: Yale University; Yale University; National Institutes of Health (NIH)
Recruiting - verified October 2011 - Condition: Opioid Dependence
Intervention: Drug: VIVITROL 380mg
Sponsors: Alkermes; Alkermes
Recruiting - verified November 2011 - Condition: Neonatal Abstinence Syndrome
Interventions: Drug: sublingual buprenorphine; Drug: oral morphine
Sponsors: Thomas Jefferson University; Thomas Jefferson University; National Institute on Drug Abuse (NIDA)
Recruiting - verified November 2011 - Condition: Amphetamine-Related Disorders
Interventions: Drug: extended-release naltrexone; Drug: Placebo
Sponsors: National Institute on Drug Abuse (NIDA); National Institute on Drug Abuse (NIDA); Alkermes
Not yet recruiting - verified October 2011 - Condition: Parkinson's Disease With Severe Pain
Interventions: Drug: Oxycodone/Naloxone Prolonged Release tablets; Drug: Placebo
Sponsors: Mundipharma Research GmbH & Co KG; Mundipharma Research GmbH & Co KG
Recruiting - verified February 2012 - Condition: Low Back Pain
Interventions: Drug: Oxycodone/Naloxone controlled-release; Drug: Oxycodone HCl controlled-release; Drug: Placebo
Sponsors: Purdue Pharma LP; Purdue Pharma LP
Recruiting - verified May 2012 - Condition: Low Back Pain
Interventions: Drug: Oxycodone/Naloxone controlled-release; Drug: Oxycodone HCl controlled-release; Drug: Placebo
Sponsors: Purdue Pharma LP; Purdue Pharma LP
Recruiting - verified May 2012 - Condition: Opioid Dependence
Intervention:
Sponsors: Alkermes; Alkermes
Recruiting - verified April 2012 - Conditions: Pain; Constipation
Interventions: Drug: oxycodone/naloxone prolonged release (OXN PR) tablets; Drug: oxycodone prolonged release (OxyPR) tablets
Sponsors: Mundipharma Research GmbH & Co KG; Mundipharma Research GmbH & Co KG
Recruiting - verified May 2012 - Conditions: Depression; Depressive Disorder; Depressive Disorder, Major
Interventions: Drug: Buprenorphine; Drug: Placebo
Sponsors: University of Pittsburgh; University of Pittsburgh; National Alliance for Research on Schizophrenia and Depression
Recruiting - verified January 2012 - Condition: Cocaine Dependence
Interventions: Drug: Buprenorphine + Naltrexone; Drug: Placebo + Naltrexone
Sponsors: University of California, Los Angeles; Walter Ling; National Institute on Drug Abuse (NIDA); The EMMES Corporation
Recruiting - verified February 2012 - Condition: Opiate Dependence
Interventions: Drug: Vivitrol; Drug: Naltrexone (oral); Behavioral: BDRC; Behavioral: Medical Management
Sponsors: Yale University; Yale University; St. Petersburg State Pavlov Medical University; National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified July 2011 - Conditions: Pain, Postoperative; Postoperative Nausea and Vomiting; Scoliosis
Interventions: Drug: Naloxone; Drug: Naloxone
Sponsors: Children's Mercy Hospital Kansas City; Children's Mercy Hospital Kansas City
Recruiting - verified February 2012 - Conditions: Pain; Sickle Cell Disease
Interventions: Drug: Morphine; Drug: Nubain
Sponsors: Children's Healthcare of Atlanta; Children's Healthcare of Atlanta; Atlanta Clinical and Translational Science Institute
Recruiting - verified September 2009 - Conditions: Human Immunodeficiency Virus; Acquired Immunodeficiency Syndrome; Opiate Addiction; Drug Dependence
Intervention: Drug: Buprenorphine/naloxone
Sponsors: Yale University; Yale University; George Mason University; Howard University
Recruiting - verified April 2012 - Condition: Opioid Dependence
Interventions: Drug: Opioid detoxification using buprenorphine vs. oral naltrexone; Drug: Buprenorphine
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute
Recruiting - verified June 2011 - Conditions: HIV; Alcohol Use Disorder
Interventions: Drug: Extended release-naltrexone; Drug: Placebo injection
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; Yale University; Asociación Civil Impacta Salud y Educación, Peru
Not yet recruiting - verified June 2011 - Condition: Low Back Pain
Interventions: Drug: Oxycodone/Naloxone Controlled-release; Drug: Placebo
Sponsors: Purdue Pharma LP; Purdue Pharma LP
Recruiting - verified February 2012 - Condition: Methamphetamine Dependence
Interventions: Other: placebo; Drug: Naltrexone and Bupropion SR
Sponsors: National Institute on Drug Abuse (NIDA); National Institute on Drug Abuse (NIDA)
Recruiting - verified August 2011 - Condition: Alcohol Abuse
Interventions: Device: AGATE; Device: SASED
Sponsors: Talaria, Inc; Talaria, Inc; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified September 2011 - Condition: Alcohol Dependence
Interventions: Drug: Valproate; Drug: Naltrexone
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified March 2012 - Conditions: Temporomandibular Disorder; Facial Pain
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsors: University of Florida; University of Florida; American Pain Society
Recruiting - verified March 2011 - Condition: Pain
Intervention: Drug: Buprenorphine transdermal system
Sponsors: Purdue Pharma LP; Purdue Pharma LP
Recruiting - verified December 2011 - Condition: Cancer
Intervention: Drug: oxycodone and naloxone
Sponsors: Mundipharma; Mundipharma
Recruiting - verified April 2012 - Condition: Malignant Glioma
Interventions: Drug: Naltrexone; Other: Placebo
Sponsors: Duke University; Duke University; Brain Tumor Fund for the Carolinas
Recruiting - verified March 2012 - Conditions: Alcohol Dependence; Alcohol Abuse
Interventions: Drug: Naltrexone; Behavioral: Brenda Therapy Sessions
Sponsors: University of North Carolina, Chapel Hill; University of North Carolina, Chapel Hill; National Institute on Alcohol Abuse and Alcoholism (NIAAA); National Institutes of Health (NIH)
Recruiting - verified January 2012 - Condition: Osteoarthritis Pain of the Hip and or Knee
Intervention: Drug: Buprenorphine transdermal patch
Sponsors: Mundipharma AB; Mundipharma AB
Recruiting - verified October 2011 - Condition: Depression
Intervention: Drug: Buprenorphine
Sponsors: Shalvata Mental Health Center; Shalvata Mental Health Center
Recruiting - verified January 2012 - Conditions: HIV; AIDS; Opioid Dependence; Drug Dependence
Intervention: Drug: Depot Naltrexone
Sponsors: Yale University; Yale University; Baystate Medical Center
Recruiting - verified August 2011 - Conditions: HIV; Alcoholism
Intervention: Drug: Naltrexone
Sponsors: University of Florida; University of Florida; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified April 2012 - Condition: Reduction in Heavy Drinking in Patients With HIV
Interventions: Drug: Naltrexone; Other: Placebo + Medication Management/Medication Coaching
Sponsors: Yale University; Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified January 2012 - Condition: Alcoholism
Interventions: Drug: N-acetylcysteine + high-dose naltrexone (150 mg); Drug: High-dose naltrexone (150 mg) alone; Drug: Low-dose naltrexone (50 mg) alone
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified March 2012 - Conditions: Interstitial Cystitis; Painful Bladder Syndrome; Pain
Interventions: Drug: Oxycodone naloxone prolonged release tablets; Drug: Placebo tablets
Sponsors: Mundipharma Research GmbH & Co KG; Mundipharma Research GmbH & Co KG
Recruiting - verified February 2012 - Conditions: Opioid Related Disorders; Opioid Dependence; Opioid Addiction
Interventions: Drug: Buprenorphine/naloxone; Drug: Clonidine; Drug: Tramadol ER
Sponsors: National Institute on Drug Abuse (NIDA); National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2012 - Conditions: Cancer; Pain; Tolerance
Intervention: Drug: oral ketamine
Sponsors: Tel-Aviv Sourasky Medical Center; Tel-Aviv Sourasky Medical Center
Recruiting - verified September 2010 - Condition: Opiate Dependence
Intervention: Drug: Methadone, naloxone
Sponsors: Kuopio University Hospital; Kuopio University Hospital
Not yet recruiting - verified March 2012 - Condition: Alcohol-dependence
Intervention: Drug: Naltrexone
Sponsors: Tel-Aviv Sourasky Medical Center; Tel-Aviv Sourasky Medical Center; Ministry of Health, Israel
Not yet recruiting - verified March 2012 - Conditions: Postoperative Pain; Opioid Induced Constipation
Interventions: Drug: naloxone; Drug: oxycodone
Sponsors: Oslo University Hospital; Ullevaal University Hospital; Mundipharma AB
Recruiting - verified April 2010 - Conditions: HIV; Substance Abuse; HIV Infections
Interventions: Drug: Oral Naltrexone (ON); Drug: Implantable Naltrexone (IN)
Sponsors: University of Pennsylvania; University of Pennsylvania; National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified January 2012 - Conditions: Alcohol Dependence; Problem Drinking; Hazardous Drinking; Human Immunodeficiency Virus; AIDS
Interventions: Drug: Vivitrol- Intramuscular naltrexone (depot-formulation); Drug: Placebo
Sponsors: Yale University; Yale University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified August 2011 - Condition: Pruritus
Interventions: Drug: Naloxone; Drug: Saline/Morphine
Sponsors: University of British Columbia; University of British Columbia
Recruiting - verified December 2011 - Condition: Drug Dependence
Intervention: Drug: 2-4 of the drugs listed below
Sponsors: University of Arkansas; University of Arkansas; National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2012 - Condition: Pathological Gambling
Interventions: Drug: Naltrexone; Other: Placebo
Sponsors: Yale University; Yale University; National Center for Responsible Gaming
Recruiting - verified February 2012 - Conditions: Type 1 Diabetes; Hypoglycemia Unawareness
Interventions: Drug: Naltrexone; Drug: Naltrexone
Sponsors: University of Minnesota - Clinical and Translational Science Institute; University of Minnesota - Clinical and Translational Science Institute; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); American Diabetes Association
Recruiting - verified August 2011 - Condition: Opioid Dependence
Interventions: Drug: Memantine; Drug: Memantine; Drug: Placebo
Sponsors: University of Massachusetts, Worcester; University of Massachusetts, Worcester; National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2012 - Condition: Impulse Control Disorders in Parkinson's Disease
Intervention: Drug: Naltrexone
Sponsors: University of Pennsylvania; University of Pennsylvania; Michael J. Fox Foundation for Parkinson's Research
Recruiting - verified November 2011 - Condition: Opioid Dependence
Interventions: Drug: injectable naltrexone plus dronabinol; Drug: Naltrexone plus placebo
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute; National Institute on Drug Abuse (NIDA)
Recruiting - verified May 2012 - Conditions: Cannabis Dependence; Marijuana Dependence
Interventions: Drug: Lofexidine and Dronabinol; Drug: Placebo
Sponsors: New York State Psychiatric Institute; New York State Psychiatric Institute; National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2012 - Conditions: Neoplasms; Constipation; Opioid-Related Disorders
Intervention: Drug: Methylnaltrexone bromide
Sponsors: University of Vermont; University of Vermont
Recruiting - verified March 2012 - Condition: Opiate Addiction
Interventions: Drug: Buprenorphine/naloxone; Drug: Naltrexone
Sponsors: State University of New York at Buffalo; State University of New York at Buffalo
Recruiting - verified February 2011 - Condition: Opiate Dependence
Intervention: Behavioral: Linkage
Sponsors: Butler Hospital; Butler Hospital; Boston Medical Center
Recruiting - verified March 2012 - Condition: Pain, Postoperative
Interventions: Drug: Buprenorphine; Drug: Oxycodone
Sponsors: Vejle Hospital; Vejle Hospital; Norpharma A/S
Recruiting - verified December 2011 - Condition: Healthy Volunteers
Intervention: Drug: buprenorphine
Sponsors: University of Zurich; University of Zurich
Recruiting - verified August 2011 - Conditions: Hazardous Drinking; Cigarette Smoking
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsors: Brown University; Brown University
Recruiting - verified October 2011 - Condition: Alcohol Dependence
Interventions: Drug: Drug; Drug: Placebo
Sponsors: Medical University of South Carolina; Medical University of South Carolina; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified April 2012 - Condition: Chronic Pain
Interventions: Drug: Morphine; Drug: Oxycodone; Drug: Fentanyl; Drug: Buprenorphine
Sponsors: IRCCS Policlinico S. Matteo; IRCCS Policlinico S. Matteo; University of Pavia
Recruiting - verified February 2012 - Condition: Opiate Addiction
Interventions: Other: Brief Intervention with Buprenorphine initiation; Behavioral: Brief Intervention
Sponsors: Yale University; Yale University; National Institute on Drug Abuse (NIDA)
Recruiting - verified December 2011 - Conditions: HIV; Substance Abuse; HIV Infections
Interventions: Behavioral: Intensive Case Management; Drug: Buprenorphine; Behavioral: Money Management
Sponsors: Yale University; Yale University
Recruiting - verified June 2011 - Condition: Alcohol Dependence
Interventions: Drug: naltrexone; Drug: Placebo
Sponsors: University of Pennsylvania; University of Pennsylvania; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified August 2011 - Condition: Trichotillomania
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsors: University of Minnesota - Clinical and Translational Science Institute; University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified March 2012 - Condition: Smoking
Interventions: Drug: naltrexone; Drug: varenicline; Drug: placebo
Sponsors: Yale University; Yale University
Recruiting - verified January 2012 - Conditions: Heroin Dependence; Opioid-Related Disorders; Cocaine Abuse or Dependence
Intervention:
Sponsors: Wayne State University; Wayne State University; National Institute on Drug Abuse (NIDA)
Recruiting - verified October 2011 - Conditions: Diabetes Mellitus; Hypoglycemia; Autonomic Failure
Interventions: Drug: naloxone; Dietary Supplement: fructose; Behavioral: exercise
Sponsors: Albert Einstein College of Medicine of Yeshiva University; Albert Einstein College of Medicine of Yeshiva University; National Institutes of Health (NIH)
Recruiting - verified February 2012 - Condition: Opioid-Induced Constipation
Interventions: Drug: Methylnaltrexone bromide; Drug: Placebo
Sponsors: Salix Pharmaceuticals; Salix Pharmaceuticals; Progenics Pharmaceuticals, Inc.
Recruiting - verified January 2012 - Condition: Opioid-Induced Constipation
Intervention: Drug: Methylnaltrexone bromide
Sponsors: Salix Pharmaceuticals; Salix Pharmaceuticals; Progenics Pharmaceuticals, Inc.
Recruiting - verified January 2012 - Conditions: Opiate Dependence; Chronic Pain
Interventions: Behavioral: CBT; Drug: Buprenorphine; Other: Educational Counseling; Other: Physician Management
Sponsors: Yale University; Yale University
Recruiting - verified May 2012 - Condition: Opiate Dependence
Interventions: Behavioral: Behavioral: Buprenorphine/naloxone maintenance (Mtn); Behavioral: Behavioral: Buprenorphine/naloxone detoxification (Dtx)
Sponsors: Yale University; Yale University; National Institute on Drug Abuse (NIDA)
Recruiting - verified November 2011 - Condition: Breast Cancer
Interventions: Drug: naltrexone hydrochloride; Procedure: Positron-emission tomography (PET) / computed tomography (CT)
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2012 - Condition: Opioid-Related Disorders
Interventions: Drug: Clonidine; Drug: Placebo
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2012
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