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Nicotine

Nicotine

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  • The Effect of Smoking on Thermoregulation

    Condition:   Cigarette Smoking
    Interventions:   Drug: Nicotine;   Other: cigarette smoking
    Sponsors:   Sheba Medical Center;   Sheba Medical Center;   IDF
    Not yet recruiting - verified May 2012
  • Twitter-enabled Mobile Messaging for Smoking Relapse Prevention

    Condition:   Smoking
    Intervention:   Behavioral: quit smoking twitter group social support intervention
    Sponsors:   University of California, Irvine;   University of California, Irvine
    Not yet recruiting - verified May 2012
  • Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Volunteers

    Condition:   Systemic Inflammatory Response Syndrome
    Interventions:   Other: Endotoxin;   Other: Endotoxin + Nicotine
    Sponsors:   Rigshospitalet, Denmark;   Rigshospitalet, Denmark;   Bispebjerg Hospital
    Not yet recruiting - verified May 2012
  • Dose-response Effect of a Noni Juice Mixed Fruit Beverage

    Conditions:   Oxidative Stress;   Quality of Life;   Metabolic Syndrome
    Intervention:   Dietary Supplement: Noni juice mixed fruit beverage
    Sponsors:   Tahitian Noni International, Inc.;   Tahitian Noni International, Inc.;   Sprim Advanced Life Sciences;   University of Indonesia
    Recruiting - verified May 2012
  • Tailored Tobacco Quitline for Rural Veterans

    Condition:   Cigarette Smoking
    Interventions:   Drug: Nicotine replacement therapy - transdermal nicotine patch;   Behavioral: Tailored behavioral intervention;   Behavioral: Tobacco quitline referral;   Drug: Nicotine replacement therapy - nicotine gum;   Drug: Nicotine replacement therapy - nicotine lozenge;   Drug: Bupropion SR;   Drug: Varenicline;   Drug: Combination pharmacotherapy - transdermal nicotine patch + nicotine gum;   Drug: Combination pharmacotherapy - transdermal nicotine patch + nicotine lozenge;   Drug: Combination pharmacotherapy - transdermal nicotine patch + bupropion;   Behavioral: Alcohol use risk reduction;   Behavioral: Behavioral activation for the treatment of depression;   Behavioral: Behavioral management of post-cessation weight gain
    Sponsors:   University of Iowa;   University of Iowa;   Department of Veterans Affairs
    Not yet recruiting - verified May 2012
  • Intensified Secondary Prevention Intending a Reduction of Recurrent Events in TIA and Minor Stroke Patients

    Condition:   Mini-Stroke
    Intervention:   Behavioral: Patient centered structured support program
    Sponsors:   Charite University, Berlin, Germany;   Charite University, Berlin, Germany;   Technische Universität München;   University of Erlangen-Nürnberg Medical School;   Praxis für Neurologie und Psychiatrie am Prinzregentenplatz, München;   Berlin University of Technology
    Recruiting - verified April 2012
  • Sex/Gender and Nicotine Addiction: Hormones, Behavior and Neuroimaging

    Condition:   Nicotine Dependence
    Intervention:   Drug: Intravenous Nicotine
    Sponsors:   Mclean Hospital;   Mclean Hospital;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified May 2012
  • Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders.

    Condition:   Smoking Cessation
    Interventions:   Drug: placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
    Sponsors:   Pfizer;   Pfizer
    Not yet recruiting - verified May 2012
  • Pilot Pharmacokinetic Study of New Nicotine Lozenge Formulations

    Condition:   Healthy Smokers
    Interventions:   Drug: V0474 - A mg;   Drug: V0474 - B mg;   Drug: V0474 - C mg;   Drug: V0018 - B mg;   Drug: Niquitin® Fresh Mint 4 mg
    Sponsors:   Pierre Fabre Medicament;   Pierre Fabre Medicament
    Recruiting - verified April 2012
  • The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking

    Condition:   Nicotine Dependence
    Interventions:   Drug: Oxytocin;   Drug: placebo
    Sponsors:   Medical University of South Carolina;   Kevin Gray
    Not yet recruiting - verified April 2012
  • A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications

    Condition:   Asthma
    Interventions:   Drug: Fluticasone propionate DPI Dose 1;   Drug: Fluticasone propionate DPI Dose 2;   Drug: Fluticasone propionate DPI Dose 3;   Drug: Fluticasone propionate DPI Dose 4;   Other: Placebo DPI;   Drug: Flovent Diskus 250 mcg
    Sponsors:   Teva Pharmaceutical Industries;   Teva Pharmaceutical Industries
    Not yet recruiting - verified May 2012
  • P60 Program Project Grant-Outreach for Smoke-Free Homes

    Conditions:   Smoking Cessation;   Tobacco Cessation
    Interventions:   Behavioral: Brochure;   Behavioral: Counseling
    Sponsors:   Masonic Cancer Center, University of Minnesota;   Masonic Cancer Center, University of Minnesota
    Recruiting - verified April 2012
  • Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

    Conditions:   Cigarette Smoking;   Nicotine Dependence
    Interventions:   Drug: varenicline (Chantix);   Drug: bupropion (Zyban) & nicotine patches;   Drug: nicotine patches
    Sponsors:   Duke University;   Duke University;   Philip Morris USA, Inc.
    Recruiting - verified May 2012
  • Pexacerfont to Reduce Stress-induced Tobacco Craving

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified February 2012
  • Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation

    Conditions:   Cigarette Smoking;   Tobacco Use Disorder;   Nicotine Dependence;   Smoking Cessation
    Intervention:   Behavioral: Smoking Cessation Decision Aids
    Sponsors:   Seoul National University Hospital;   Seoul National University Hospital;   Pfizer
    Not yet recruiting - verified March 2012
  • Disease-modifying Potential of Transdermal NICotine in Early Parkinson's Disease

    Condition:   Parkinson's Disease
    Intervention:   Drug: nicotine transdermal patch
    Sponsors:   University of Vermont;   James BOYD MD;   Michael J. Fox Foundation for Parkinson's Research
    Not yet recruiting - verified March 2012
  • Improving Adherence to Web-Based Cessation Programs: A Social Network Approach

    Condition:   Smoking Cessation
    Interventions:   Behavioral: WEB;   Behavioral: Social Network;   Behavioral: Nicotine Replacement Therapy (NRT)
    Sponsors:   American Legacy Foundation;   American Legacy Foundation;   National Cancer Institute (NCI)
    Recruiting - verified March 2012
  • MassCONECT 4 Kids: Promoting Smoke-free Homes

    Condition:   Second-hand Smoking
    Interventions:   Behavioral: Motivational Interview;   Behavioral: Usual best practices
    Sponsors:   Harvard School of Public Health;   Harvard School of Public Health;   National Center on Minority Health and Health Disparities (NCMHD)
    Recruiting - verified February 2012
  • Smoking Habits and Smoking Cessation in Young Adults

    Conditions:   Smoking Cessation;   Smoking;   Habits
    Interventions:   Drug: varenicline;   Drug: Nicotine cutaneous patch
    Sponsors:   University of Oulu;   Tuula Toljamo;   Helsinki University;   Helsinki University Central Hospital;   University of Oulu
    Not yet recruiting - verified February 2012
  • Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms

    Condition:   Tobacco Use Disorder
    Intervention:   Drug: Nicotine lozenge 4 mg
    Sponsors:   University of Minnesota - Clinical and Translational Science Institute;   University of Minnesota - Clinical and Translational Science Institute;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2012
  • Effects of rTMS on Cigarette Smoking and Cognition in Schizophrenia

    Conditions:   Schizophrenia;   Nicotine Addiction
    Interventions:   Device: Repetitive Transcranial Magnetic Stimulation (rTMS);   Device: Sham Repetitive Transcranial Stimulation (rTMS)
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health;   Canadian Institutes of Health Research (CIHR)
    Recruiting - verified April 2012
  • Nicotine Withdrawal Symptoms and Smoking Relapse

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified November 2011
  • Quit Smoking With Nicotine Patch and Exercise/Health Education (Females Only)

    Condition:   Cigarette Smoking
    Interventions:   Behavioral: Moderate intensity exercise;   Behavioral: Health education
    Sponsors:   Brown University;   Brown University;   National Cancer Institute (NCI)
    Recruiting - verified January 2012
  • Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis

    Condition:   Acute Pancreatitis
    Intervention:   Procedure: surgical intervention after percutaneous catheter drainage
    Sponsors:   Postgraduate Institute of Medical Education and Research;   Postgraduate Institute of Medical Education and Research
    Recruiting - verified February 2012
  • Palatability of Experimental Cigarettes

    Condition:   Smoking
    Interventions:   Other: Very low level nicotine containing cigarette;   Other: Low nicotine level cigarette;   Other: Moderate level nicotine cigarette
    Sponsors:   Masonic Cancer Center, University of Minnesota;   Masonic Cancer Center, University of Minnesota
    Recruiting - verified May 2012
  • Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified October 2011
  • Community Network Program

    Condition:   Psychosocial Problem
    Interventions:   Behavioral: Health Education;   Behavioral: Questionnaires;   Behavioral: Telephone Counseling Sessions;   Drug: Nicotine Patches
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Institutes of Health (NIH)
    Recruiting - verified January 2012
  • A Trial of Medicaid Beneficiaries Calling the California Smokers' Helpline

    Condition:   Smoking Cessation
    Interventions:   Behavioral: Telephone counseling;   Drug: Nicotine-replacement therapy (patches);   Behavioral: Monetary incentives
    Sponsors:   University of California, San Diego;   University of California, San Diego;   University of California, San Francisco;   Centers for Medicare and Medicaid Services;   California Department of Health Services
    Not yet recruiting - verified December 2011
  • Smoking Cessation Intervention for Diabetic Patients

    Conditions:   Smoking;   Type 2 Diabetes
    Interventions:   Behavioral: Acceptance and Commitment Therapy;   Behavioral: Standard smoking cessation intervention
    Sponsors:   Rhode Island Hospital;   Rhode Island Hospital
    Recruiting - verified December 2011
  • Intravenous (IV) Nicotine Self Administration: Dose Ranging and Sex Differences in Smokers

    Condition:   Nicotine Addiction
    Interventions:   Drug: Saline;   Drug: Nicotine
    Sponsors:   Yale University;   Yale University
    Recruiting - verified December 2011
  • A Smoking Cessation Trial in HIV-infected Patients in South Africa

    Conditions:   Smoking Cessation;   HIV
    Interventions:   Drug: Nicotine;   Behavioral: Intensive Counseling
    Sponsors:   Johns Hopkins University;   Johns Hopkins University;   National Institute on Drug Abuse (NIDA);   University of Witwatersrand, South Africa;   American Legacy Foundation
    Not yet recruiting - verified March 2012
  • Interactive Voice Response Technology to Mobilize Contingency Management for Smoking Cessation

    Condition:   Cigarette Smoking
    Interventions:   Behavioral: contingency management for smoking abstinence;   Drug: transdermal nicotine;   Behavioral: Telephone counseling
    Sponsors:   University of Connecticut Health Center;   University of Connecticut Health Center;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified March 2012
  • SPECT Imaging of DAT Genotype

    Condition:   Nicotine Withdrawal
    Intervention:   Radiation: TRODAT
    Sponsors:   University of Pennsylvania;   University of Pennsylvania
    Recruiting - verified December 2011
  • Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Severe Sepsis

    Condition:   Sepsis
    Interventions:   Other: Fluid Resuscitation;   Other: Standard of Care
    Sponsors:   Cheetah Medical Inc.;   Cheetah Medical Inc.
    Recruiting - verified February 2012
  • A Safety and Cognitive Function Study of EVP-6124 Versus Placebo in Subjects With Nicotine Dependence

    Conditions:   Nicotine Dependence;   Smoking Cessation
    Interventions:   Drug: EVP-6124;   Drug: Placebo Capsule;   Drug: NicoDerm CQ Patch (Active);   Drug: NRT Patch (Placebo);   Behavioral: Brief Supportive and Behavioral Treatment
    Sponsors:   Massachusetts General Hospital;   A. Eden Evins;   EnVivo Pharmaceuticals, Inc.;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified April 2012
  • Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers

    Condition:   Smoking Cessation
    Interventions:   Biological: SEL-068;   Biological: Placebo
    Sponsors:   Selecta Biosciences, Inc.;   Selecta Biosciences, Inc.
    Recruiting - verified November 2011
  • Novel Treatments to Enhance Smoking Cessation Before Cancer Surgery: Effects on Smoking and Surgical Outcomes

    Condition:   Smoking Cessation
    Interventions:   Other: standard care;   Other: standard care plus contingency management
    Sponsors:   Yale University;   Yale University
    Recruiting - verified April 2012
  • Sympathovagal Balance in Smoking Cessation

    Condition:   Smoking Cessation
    Interventions:   Drug: Varenicline;   Drug: Placebo;   Drug: Nicorette TX
    Sponsors:   Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH;   Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH;   University Medical Center Goettingen
    Recruiting - verified November 2011
  • Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With Schizophrenia

    Condition:   Schizophrenia
    Interventions:   Drug: Nicotine polacrilex;   Drug: Regular chewing gum; Dentyne Ice, Wrigely´s Mint Gum
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health
    Recruiting - verified January 2012
  • Tobacco's Impact on Postoperative Complications in Acute Surgery

    Condition:   Vascular Disease
    Intervention:   Behavioral: Smoking intervention.
    Sponsors:   Rigshospitalet, Denmark;   Rigshospitalet, Denmark
    Recruiting - verified November 2011
  • Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders

    Condition:   Smoking Cessation
    Interventions:   Drug: Placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
    Sponsors:   Pfizer;   Pfizer;   GlaxoSmithKline
    Recruiting - verified May 2012
  • Effect of the Electronic Cigarette on Withdrawal Symptoms

    Conditions:   Mental and Behavioral Disorders;   Withdrawal State
    Intervention:   Drug: Nicotine
    Sponsors:   Queen Mary University of London;   Queen Mary University of London
    Not yet recruiting - verified May 2012
  • Development of Positive Psychotherapy for Smoking Cessation

    Condition:   Smoking
    Intervention:   Behavioral: Behavior smoking cessation counseling with nicotine patch
    Sponsors:   Brown University;   Brown University;   National Cancer Institute (NCI)
    Recruiting - verified October 2011
  • Meclizine as a Potential Smoking Cessation Treatment

    Condition:   Smoking Cessation
    Interventions:   Drug: Meclizine;   Drug: Nicotine patches
    Sponsors:   Duke University;   Duke University;   Philip Morris USA, Inc.
    Recruiting - verified March 2012
  • Varenicline in Combination With Nicotine Replacement Therapy for Smoking Cessation

    Condition:   Tobacco Dependence
    Interventions:   Drug: Varenicline, Nicotine Patch;   Drug: Varenicline and Placebo Patch
    Sponsors:   University of Stellenbosch;   University of Stellenbosch;   QuitSupport
    Recruiting - verified November 2011
  • Evaluation of Transdermal Nicotine Replacement Therapy (NRT) Activity Through Metabolic Induction

    Conditions:   Smoking;   Addiction
    Intervention:   Drug: Nicabate 21mg Transdermal Nicotine Replacement Therapy (NRT)Patch
    Sponsors:   The Queen Elizabeth Hospital;   The Queen Elizabeth Hospital;   Basil Hetzel Institute for Translational Research;   University of Adelaide;   University of South Australia;   Clinical Practice Unit;   Therapeutics Research Centre
    Recruiting - verified September 2011
  • Studying a Smoking Cessation Intervention in Patients With Lung Cancer Who Are Receiving Treatment

    Conditions:   Lung Cancer;   Tobacco Use Disorder
    Interventions:   Drug: nicotine patch;   Procedure: standard follow-up care
    Sponsors:   National Cancer Institute (NCI);   Wake Forest University;   National Cancer Institute (NCI)
    Not yet recruiting - verified September 2011
  • Randomized Controlled Trial of Mailed Nicotine Replacement Therapy to Canadian Smokers

    Condition:   Smoking
    Interventions:   Drug: Nicotine replacement therapy;   Other: No intervention
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health;   Canadian Institutes of Health Research (CIHR)
    Not yet recruiting - verified April 2012
  • Brain Nicotine Receptor Density & Response to Nicotine Patch

    Condition:   Cigarette Smoking
    Interventions:   Drug: Transdermal Nicotine Patch;   Drug: Transdermal Placebo Patch
    Sponsors:   Brentwood Biomedical Research Institute;   Brentwood Biomedical Research Institute
    Not yet recruiting - verified February 2012
  • Sensorimotor Replacement With Electronic and De-nicotinised Cigarettes

    Condition:   Nicotine Withdrawal
    Interventions:   Behavioral: Stress Ball vs Nicotine-free E-Cigarette;   Behavioral: Nicotine-free E-Cigarette vs De-nicotinised Cigarette
    Sponsors:   Queen Mary University of London;   Queen Mary University of London
    Not yet recruiting - verified August 2011
  • The Impact of Real-time fMRI Feedback on Response to Nicotine Cues

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   Medical University of South Carolina;   Medical University of South Carolina
    Recruiting - verified July 2011
  • Electronic Decision Support Systems for Smokers With Severe Mental Illness

    Conditions:   Severe Mental Illness;   Nicotine Dependence
    Interventions:   Behavioral: Electronic decision support system with CO monitor feedback;   Behavioral: Electronic decision support system without CO monitor feedback
    Sponsors:   Dartmouth-Hitchcock Medical Center;   Dartmouth-Hitchcock Medical Center;   U.S. Department of Education;   Bristol-Myers Squibb
    Recruiting - verified March 2012
  • Pioglitazone for Heroin and for Nicotine Dependence

    Conditions:   Heroin Dependence;   Nicotine Dependence
    Interventions:   Drug: Pioglitazone;   Drug: Placebo
    Sponsors:   New York State Psychiatric Institute;   New York State Psychiatric Institute;   National Institute on Drug Abuse (NIDA);   Omeros Corporation
    Recruiting - verified July 2011
  • Efficacy of Exercise and Counseling Intervention on Relapse in Smoker With Depressive Disorders

    Conditions:   Smoking Cessation;   Depression
    Intervention:   Behavioral: Exercise and counseling (for smoking cessation and physical activity)
    Sponsors:   University Hospital, Montpellier;   University Hospital, Montpellier
    Recruiting - verified March 2012
  • Integrated Treatment for Smoking Cessation & Anxiety in People With HIV Phase 1

    Conditions:   Nicotine Dependence;   Symptoms of Anxiety;   HIV
    Intervention:   Behavioral: Integrated cognitive-behavioral therapy for smoking cessation and anxiety
    Sponsors:   Massachusetts General Hospital;   Massachusetts General Hospital;   Southern Methodist University;   University of Houston
    Recruiting - verified July 2011
  • Intensive Smoking-cessation Versus Basic Smoking-cessation Advice in Smear-positive Patients With Pulmonary Tuberculosis

    Condition:   Tuberculosis
    Intervention:   Drug: nicotine replacement therapy
    Sponsors:   All India Institute of Medical Sciences, New Delhi;   All India Institute of Medical Sciences, New Delhi;   University of Cape Town;   Sri Venkateswara Institute of Medical Sciences University
    Recruiting - verified January 2012
  • Developing a Smoking Cessation Intervention for Methadone Maintained Smokers

    Conditions:   Nicotine Dependence;   Opiate Dependence
    Interventions:   Behavioral: Intensive, tailored intervention;   Behavioral: NJ Quitline Referral
    Sponsors:   University of Medicine and Dentistry New Jersey;   University of Medicine and Dentistry New Jersey;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2012
  • Treating South African Pregnant Women for Methamphetamine

    Conditions:   HIV;   Drug Addiction
    Interventions:   Behavioral: Psycho-education;   Behavioral: Experimental
    Sponsors:   RTI International;   RTI International;   University of Cape Town
    Recruiting - verified December 2011
  • Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation

    Condition:   Nicotine Dependence
    Interventions:   Drug: Varenicline;   Drug: Bupropion;   Drug: Nicotine patches
    Sponsors:   Duke University;   Duke University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2012
  • Behavioral Intervention for Low Income Depressed Smokers in Drug Treatment

    Conditions:   Cigarette Smoking;   Drug Use
    Interventions:   Behavioral: Standard Treatment;   Behavioral: BAD-AS;   Drug: Transdermal Nicotine Patch
    Sponsors:   University of Maryland;   University of Maryland;   American Cancer Society
    Recruiting - verified July 2011
  • Evaluation of Learning-Theory-Based Smoking Cessation Strategies

    Condition:   Nicotine Dependence
    Interventions:   Behavioral: Standard treatment;   Behavioral: Standard treatment+practice quitting
    Sponsors:   Rutgers University;   Rutgers University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified June 2011
  • Motivation and Skills for Detained Teen Smokers

    Conditions:   Motivational Intervention;   Nicotine Anonymous;   Cognitive Behavior Therapy;   Relaxation Therapy
    Intervention:   Behavioral: Motivational Intervention
    Sponsors:   University of Rhode Island;   University of Rhode Island
    Recruiting - verified January 2012
  • Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking

    Condition:   Cigarette Smoking Behavior
    Intervention:   Drug: Nicotine polacrilex
    Sponsors:   University of California, Los Angeles;   University of California, Los Angeles;   Philip Morris Products S.A.
    Not yet recruiting - verified June 2011
  • Behavioral Activation Intervention, Reward Processing, and Youth Smoking Cessation

    Condition:   Smoking
    Intervention:   Drug: Transdermal Nicotine Patch
    Sponsors:   University of Maryland;   University of Maryland;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified June 2011
  • Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation

    Condition:   Smokeless Tobacco Cessation
    Interventions:   Drug: Commit® nicotine lozenges (4 mg).;   Behavioral: Phone Counseling;   Behavioral: Self-help materials
    Sponsors:   Oregon Research Institute;   Oregon Research Institute;   National Cancer Institute (NCI);   Mayo Clinic
    Recruiting - verified January 2012
  • Targeted Intervention for Bipolar Smokers

    Conditions:   Nicotine Dependence;   Bipolar Disorder
    Interventions:   Behavioral: Counseling/Healthy Lifestyle;   Behavioral: Counseling/Managing Mood
    Sponsors:   University of Cincinnati;   University of Cincinnati;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified March 2012
  • Treating Low-Income Smokers in the Hospital Emergency Department

    Conditions:   Tobacco Use Cessation;   Smoking Cessation;   Smoking;   Tobacco Use Disorder
    Intervention:   Other: Brief Intervention with NRT Initiation
    Sponsors:   Yale University;   Yale University;   National Cancer Institute (NCI);   National Institutes of Health (NIH)
    Recruiting - verified November 2011
  • Nicotine for Marijuana Withdrawal

    Condition:   Marijuana Dependence
    Interventions:   Drug: Nicotine;   Drug: Placebo Patch
    Sponsors:   Southern Illinois University Carbondale;   Southern Illinois University Carbondale;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified March 2012
  • Brief Computerized Feedback for Smokers in Recovery

    Condition:   Smoking
    Interventions:   Other: Brief computerized feedback;   Other: Resources only (control)
    Sponsors:   Virginia Commonwealth University;   Virginia Commonwealth University
    Recruiting - verified October 2011
  • Pharmacogenetics of Nicotine Addiction Treatment

    Condition:   Nicotine Addiction
    Interventions:   Drug: Varenicline;   Drug: Placebo;   Drug: Transdermal Nicotine
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2012
  • Computer-Based Program to Facilitate Readiness and Motivation for Smoking Cessation

    Condition:   Smoking
    Interventions:   Behavioral: Personalized Feedback;   Behavioral: Treatment as Usual
    Sponsors:   University of Oklahoma;   University of Oklahoma
    Not yet recruiting - verified February 2012
  • Concurrent Bupropion / Varenicline for Smoking Cessation

    Condition:   Nicotine Dependence
    Interventions:   Drug: Varenicline;   Drug: Bupropion;   Drug: Nicotine patches;   Drug: Nicotine Inhaler
    Sponsors:   Duke University;   Duke University;   National Institute on Drug Abuse (NIDA);   Philip Morris USA, Inc.
    Recruiting - verified March 2012
  • Effect of Varenicline on Tobacco Addiction and on Abstinence-induced Cognitive Impairment

    Condition:   Drug Addiction
    Intervention:   Drug: Varenicline
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Not yet recruiting - verified December 2011
  • Social Determinants and Smoking Cessation

    Condition:   Smoking Cessation
    Interventions:   Behavioral: Questionnaires;   Drug: Nicotine Patch Therapy;   Behavioral: Counseling Sessions
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   CPRIT - Cancer Prevention Research Institute of Texas
    Not yet recruiting - verified November 2011
  • Dissemination of Tobacco Tactics for Hospitalized Smokers

    Condition:   Smoking Cessation
    Interventions:   Behavioral: Tobacco Tactics Intervention;   Other: Usual Care
    Sponsors:   University of Michigan;   University of Michigan;   National Institutes of Health (NIH)
    Recruiting - verified January 2012
  • Smoking Cessation in Hospitalized Smokers

    Condition:   Smoking Cessation
    Interventions:   Drug: Nicotine Patches;   Behavioral: Telephone Counseling;   Behavioral: Brief Hospital Counseling
    Sponsors:   University of California, San Diego;   University of California, San Diego;   National Cancer Institute (NCI)
    Recruiting - verified January 2011
  • Connect to Quit for Smoking

    Conditions:   Smoking;   Smoking Cessation
    Interventions:   Other: Coordinated Care;   Other: Usual Care
    Sponsors:   University of Pittsburgh;   University of Pittsburgh;   National Institutes of Health (NIH);   National Cancer Institute (NCI)
    Recruiting - verified September 2011
  • Cognitive Training for Nicotine Dependence

    Conditions:   Tobacco Use Disorder;   Smoking Relapse;   Cognitive Training;   Nicotine Addiction
    Interventions:   Behavioral: Cognitive Remediation Training (CRT);   Behavioral: Standard Care (SC)
    Sponsors:   University of Pennsylvania;   University of Pennsylvania
    Recruiting - verified January 2012
  • Internet-Administered Smoking Cessation Treatment for Overweight and Obese Smokers

    Conditions:   Smoking Cessation;   Overweight;   Obesity
    Intervention:   Drug: Nicotine patch
    Sponsors:   Yale University;   Yale University;   American Heart Association
    Recruiting - verified February 2012
  • Nicotinic Modulation of the Default Network of Resting Brain Function

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified August 2011
  • Physiological Responses in Tobacco Chippers

    Conditions:   Smoking;   Stress
    Intervention:  
    Sponsors:   Oregon Health and Science University;   Oregon Health and Science University
    Recruiting - verified May 2012
  • Nicotine and Brain Imaging Research Study

    Condition:   Nicotine
    Intervention:  
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified December 2011
  • Baclofen for Smoking Cessation in a Non-Psychiatric Population

    Condition:   Nicotine Dependence
    Interventions:   Drug: Baclofen 30 mg/day;   Drug: placebo pill;   Drug: Baclofen 60 mg/day
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health;   Canadian Tobacco Control Research Initiative
    Recruiting - verified December 2011
  • Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving

    Condition:   Tobacco Use Disorder
    Interventions:   Behavioral: Cue Extinction Training;   Drug: Nicotine Replacement Therapy;   Behavioral: Cue Extinction Therapy;   Behavioral: Progressive Muscle Relaxation
    Sponsors:   New York State Psychiatric Institute;   New York State Psychiatric Institute
    Recruiting - verified April 2012
  • Nicotine Treatment of Impulsivity in Parkinson's Disease

    Condition:   Parkinson's Disease
    Interventions:   Drug: nicotine patch;   Drug: placebo
    Sponsors:   University of Vermont;   University of Vermont;   Parkinson's Disease Foundation;   The Parkinson Study Group
    Recruiting - verified October 2010
  • Treating Adults at Risk for Weight Gain With Interactive Technology

    Conditions:   Smoking;   Body Weight
    Interventions:   Behavioral: Smoking Cessation;   Behavioral: Smoking Cessation plus Weight Loss
    Sponsors:   University of Tennessee;   University of Tennessee
    Recruiting - verified November 2011
  • Integrated Behavioral Intervention for Cigarette Smoking and Binge Drinking in Young Adults

    Condition:   for Cigarette Smoking and Binge Drinking Cessation
    Interventions:   Drug: nicotine transdermal patch;   Behavioral: behavioral intervention
    Sponsors:   Mayo Clinic;   Mayo Clinic;   James and Esther King Biomedical Research Program
    Recruiting - verified April 2012
  • Brain Activity and Smoking Cessation

    Condition:   Nicotine Dependence
    Intervention:   Behavioral: Smoking Cessation Counseling
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   National Cancer Institute (NCI)
    Recruiting - verified January 2012
  • New Treatment for Alcohol and Nicotine Dependence

    Conditions:   Alcohol Dependence;   Nicotine Dependence
    Interventions:   Drug: Topiramate with brief behavioral enhancement therapy;   Drug: Placebo plus brief behavioral enhancement therapy
    Sponsors:   University of Virginia;   University of Virginia;   National Institute on Alcohol Abuse and Alcoholism (NIAAA);   M.D. Anderson Cancer Center;   University of California, San Diego
    Recruiting - verified March 2012
  • Internet-based Group Contingency Management to Promote Smoking Abstinence

    Condition:   Cigarette Smoking
    Interventions:   Behavioral: Full Group Contingency;   Behavioral: Mixed Group Contingency
    Sponsors:   National Development and Research Institutes, Inc.;   National Development and Research Institutes, Inc.;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified April 2012
  • Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers

    Condition:   Smoking Cessation
    Intervention:   Other: Respiragene test
    Sponsors:   University of Surrey;   University of Surrey;   Lab 21, Cambridge;   NHS Research and Development
    Recruiting - verified March 2012
  • Maintaining Nonsmoking

    Condition:   Nicotine Dependence
    Interventions:   Drug: Varenicline;   Behavioral: Individual counseling;   Behavioral: Check-ins with medical staff;   Behavioral: individual counseling
    Sponsors:   University of California, San Francisco;   University of California, San Francisco;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified February 2012
  • Assessing Top Down and Bottom Up Attention Mechanisms in Smokers Using Nicotine Nasal Spray

    Conditions:   Drug Addiction;   Nicotine Dependence
    Intervention:   Drug: Nicotrol
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified September 2011
  • Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse

    Condition:   Cocaine Dependence
    Interventions:   Drug: Zonisamide;   Drug: Placebo;   Drug: Cocaine Hydrochloride;   Behavioral: Neurocognitive and Performance Battery;   Behavioral: Smoking Assessments
    Sponsors:   Johns Hopkins University;   Johns Hopkins University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified June 2011
  • Offering Proactive Tobacco Treatment

    Condition:   Tobacco Use Cessation
    Interventions:   Other: proactive outreach (PRO);   Other: Free telephone counseling (TC);   Other: Nicotine replacement therapy (NRT);   Other: Usual care (UC)
    Sponsors:   Masonic Cancer Center, University of Minnesota;   Masonic Cancer Center, University of Minnesota;   National Cancer Institute (NCI)
    Recruiting - verified September 2011
  • Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)

    Conditions:   Smoking;   ADHD
    Intervention:  
    Sponsors:   Duke University;   Duke University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified February 2012
  • Identifying Treatments to Motivate Smokers to Quit

    Conditions:   Smoking;   Smoking Cessation;   Motivation;   Nicotine
    Interventions:   Drug: Nicotine Patch;   Drug: Nicotine Gum;   Behavioral: Motivational Interviewing;   Behavioral: Smoking Reduction
    Sponsors:   University of Wisconsin, Madison;   University of Wisconsin, Madison;   University of Illinois;   Dean Health System;   Mercy Health System;   Aurora Health Care;   National Cancer Institute (NCI)
    Recruiting - verified August 2011
  • Evaluation of Treatments to Improve Smoking Cessation Medication Adherence

    Conditions:   Smoking;   Smoking Cessation;   Adherence;   Nicotine;   Motivation
    Interventions:   Drug: Short Term Combination Nicotine Replacement Therapy (patch + gum);   Drug: Long Term Combination Nicotine Replacement Therapy (patch + gum);   Behavioral: Intensive Maintenance Counseling;   Behavioral: Cognitive Medication Adherence Counseling (C-MAC);   Behavioral: Electronic Medication Monitoring Device (the Helping Hand) + Feedback;   Behavioral: Automated Adherence Prompting Phone Calls
    Sponsors:   University of Wisconsin, Madison;   University of Wisconsin, Madison;   Dean Health System;   Mercy Health System;   Aurora Health Care;   National Cancer Institute (NCI)
    Recruiting - verified August 2011
  • Identifying Optimal Smoking Cessation Intervention Components (Cessation)

    Conditions:   Smoking;   Smoking Cessation;   Nicotine
    Interventions:   Behavioral: Counseling before quit attempt;   Behavioral: Minimal In-person counseling during quit attempt;   Behavioral: Intensive in-person counseling;   Behavioral: Minimal phone counseling after quit date;   Behavioral: Intensive phone counseling;   Drug: Short Term Nicotine Patch During Quit Attempt;   Drug: Long Term Nicotine Patch During Quit Attempt;   Drug: Short Term Post-Quit Nicotine Gum;   Drug: Long Term Nicotine Gum During Quit Attempt;   Drug: Pre-Quit Nicotine Gum;   Drug: Pre-Quit Nicotine Patch
    Sponsors:   University of Wisconsin, Madison;   University of Wisconsin, Madison;   Dean Health System;   Mercy Health System;   Aurora Health Care;   National Cancer Institute (NCI)
    Recruiting - verified August 2011
  • Tobacco Dependence Treatment for Asian Americans

    Condition:   Tobacco Dependence
    Intervention:   Drug: nicotine patch
    Sponsors:   University of Massachusetts, Worcester;   University of Massachusetts, Worcester
    Recruiting - verified April 2012
  • Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia

    Conditions:   Schizophrenia;   Schizoaffective Disorder
    Intervention:   Drug: Varenicline
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health;   Pfizer
    Recruiting - verified March 2012
  • Efficacy of Varenicline for Smokeless Tobacco Use in India

    Condition:   Tobacco Use Disorder
    Interventions:   Drug: Varenicline;   Behavioral: Counseling
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   All India Institute of Medical Sciences, New Delhi
    Recruiting - verified January 2011
  • Comparison of 3 Learning Methods to Improve Independent Activities of Daily Living (IADLs) in Alzheimer Disease

    Condition:   Alzheimer Disease
    Interventions:   Behavioral: Errorless Learning;   Behavioral: Modeling;   Behavioral: Trial and Error
    Sponsors:   Centre Hospitalier Universitaire de Nice;   Department of Clinical Research and Innovation;   Institut National de la Santé Et de la Recherche Médicale, France;   Fondation Mederic Alzheimer
    Recruiting - verified December 2011
  • Smoking Termination Enhancement Project (STEP)

    Condition:   Smoking
    Interventions:   Behavioral: Cognitive Behavioral Treatment;   Drug: Nicotine Patch;   Behavioral: Wellness Program;   Behavioral: Aerobic Exercise
    Sponsors:   Southern Methodist University;   Southern Methodist University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified July 2011
  • Comparison of Low Yield Cigarettes in African Americans vs. Whites

    Condition:   Cigarette Smoking
    Intervention:   Drug: Deuterated nicotine and cotinine
    Sponsors:   University of California, San Francisco;   University of California, San Francisco
    Recruiting - verified March 2012
  • Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers

    Condition:   Nicotine Dependence
    Interventions:   Drug: Bupropion SR;   Drug: Nicotine;   Drug: Placebo pill and Placebo Patch;   Other: Delayed-Quit Control
    Sponsors:   Southern Illinois University Carbondale;   Southern Illinois University Carbondale;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified September 2011
  • An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

    Condition:   Nicotine Dependence
    Intervention:   Drug: Transdermal nicotine patch
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified December 2011
  • The Effect of Exercise on Acute Nicotine Withdrawal

    Conditions:   Nicotine Dependence;   Smoking;   Sleep Disorders, Intrinsic
    Intervention:   Behavioral: Exercise
    Sponsors:   University of Pittsburgh;   University of Pittsburgh;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified May 2012
  • Telehealth Therapy for Chronic Pain

    Condition:   Chronic Pain
    Interventions:   Behavioral: In-Person Acceptance and Commitment Therapy;   Behavioral: Telehealth Acceptance and Commitment Therapy
    Sponsors:   Department of Veterans Affairs;   Department of Veterans Affairs
    Recruiting - verified January 2012
  • Effects of Nicotine on Areas of Impaired and Preserved Functioning in Schizophrenia

    Conditions:   Nicotine Dependence;   Schizophrenia
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified August 2011
  • Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction

    Condition:   Nicotine Dependence
    Intervention:   Device: Transcranial Magnetic Stimulation
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA);   University of Maryland
    Recruiting - verified December 2011
  • Assessment of Craving in Nicotine-Dependent Patients With Schizophrenia Using Virtual Reality

    Condition:   Nicotine Dependence
    Intervention:  
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2011
  • Trial of Nicotine Nasal Spray as an Aid for Smoking Cessation in Schizophrenia

    Conditions:   Smoking Cessation;   Schizophrenia
    Intervention:   Drug: Nicotine Nasal Spray
    Sponsors:   University of Medicine and Dentistry New Jersey;   University of Medicine and Dentistry New Jersey;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified August 2011
  • Neural Substrates in Nicotine Withdrawal

    Condition:   Tobacco Use Disorder
    Interventions:   Drug: Tolcapone;   Drug: Placebo
    Sponsors:   University of Pennsylvania;   University of Pennsylvania;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified January 2012
  • Reducing Tobacco Related Health Disparities

    Conditions:   Smoking Cessation;   Smoking
    Interventions:   Behavioral: Standard Treatment (ST);   Behavioral: Telephone Counseling;   Behavioral: Quitline;   Behavioral: Nicotine Replacement Therapy (NRT)
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
    Recruiting - verified December 2011
  • Sensitivity to Intravenous Nicotine: Genetic Moderators

    Condition:   Influence of OPRM1 A118G Status on Subjective Responses to IV Nicotine.
    Intervention:   Drug: Nicotine
    Sponsors:   Yale University;   Yale University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified December 2011
  • Evaluation of Tobacco Treatment Strategies for Inpatient Psychiatry

    Condition:   Tobacco Dependence
    Interventions:   Behavioral: Brief Intervention;   Behavioral: Extended Treatment;   Behavioral: Usual Care
    Sponsors:   University of California, San Francisco;   University of California, San Francisco;   National Institute of Mental Health (NIMH)
    Recruiting - verified January 2012
  • Smoking Cessation for Veterans With Severe and Persistent Mental Illness

    Conditions:   Schizoaffective Disorder;   Schizophrenia;   Mood Disorders With Psychotic Features
    Interventions:   Behavioral: BTSCS;   Behavioral: StSST
    Sponsors:   Department of Veterans Affairs;   Department of Veterans Affairs
    Recruiting - verified December 2011
  • Combining Varenicline and Bupropion for Smoking Cessation

    Condition:   Smoking Cessation
    Interventions:   Drug: Varenicline;   Drug: Bupropion;   Other: Placebo;   Behavioral: Counseling/Phone Calls
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Institutes of Health (NIH);   National Institute on Drug Abuse (NIDA)
    Recruiting - verified April 2012
  • Highdose Nicotine Patch Therapy for Smokeless Tobacco Use

    Condition:   Smokeless Tobacco Use
    Interventions:   Drug: nicotine replacement therapy (nicotine patches);   Drug: placebo NRT
    Sponsors:   Mayo Clinic;   Mayo Clinic
    Recruiting - verified January 2012
  • Deep High-Frequency Repetitive Transcranial Magnetic Stimulation for Smoking Cessation

    Conditions:   Chronic Obstructive Pulmonary Disease;   Smoking
    Interventions:   Device: deep TMS HADD coil;   Device: sham deep TMS HADD coil
    Sponsors:   BeerYaakov Mental Health Center;   BeerYaakov Mental Health Center
    Recruiting - verified October 2011
  • Smoking Cessation for Low-Income Adults

    Conditions:   Smoking Cessation;   Smoking
    Interventions:   Behavioral: Smoking cessation training, support, and telephone follow-up;   Behavioral: Smoking cessation intervention;   Behavioral: Weekly Telephone Coaching
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
    Recruiting - verified April 2012
  • College Students and Smoking Cessation

    Conditions:   Smoking Cessation;   Habits;   Smoking
    Interventions:   Behavioral: Survey;   Behavioral: Counseling;   Behavioral: Survey;   Behavioral: Counseling
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
    Recruiting - verified May 2012
  • Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease

    Condition:   Idiopathic Parkinson's Disease
    Interventions:   Drug: Transdermal nicotine;   Other: Usual drug treatment of Parkinson's disease
    Sponsors:   Assistance Publique - Hôpitaux de Paris;   Assistance Publique - Hôpitaux de Paris
    Recruiting - verified May 2011
  • Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

    Conditions:   Tobacco Use Cessation;   Alcohol-related Disorders
    Intervention:   Behavioral: behavioral counseling plus contingency management
    Sponsors:   Yale University;   Yale University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)
    Recruiting - verified January 2012
  • Efficacy of Tobacco Quitline for Cancer Survivors

    Condition:   Smoking Cessation
    Interventions:   Other: Counselor-Initiated Tobacco Quit Line;   Other: Self-Paced Tobacco Quit Line
    Sponsors:   St. Jude Children's Research Hospital;   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
    Recruiting - verified January 2012
  • Drug /Cue Interactions In Alcohol-Tobacco Comorbidity

    Condition:   Nicotine Dependence
    Intervention:   Behavioral: Tobacco Research and Intervention Program
    Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   H. Lee Moffitt Cancer Center and Research Institute;   National Institutes of Health (NIH)
    Recruiting - verified January 2012
  • Improving the Delivery of Smoking Cessation Guidelines in Hospitalized Veterans

    Condition:   Cigarette Smoking
    Intervention:   Behavioral: Smoking Cessation Guideline Implementation
    Sponsors:   Department of Veterans Affairs;   Department of Veterans Affairs;   National Jewish Hospital Quitline;   Iowa State University
    Recruiting - verified December 2011
  • Contingency Management for Smoking in Substance Abusers

    Condition:   Substance Abuse
    Interventions:   Drug: Nicotine Replacement Treatment (NRT);   Behavioral: Brief Advice
    Sponsors:   Brown University;   Brown University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified February 2009
  • Post-Approval Clinical Study of the Talent Thoracic Stent Graft to Treat Thoracic Aortic Aneurysms (THRIVE)

    Condition:   Thoracic Aortic Aneurysms
    Intervention:   Device: Talent Thoracic Stent Graft System
    Sponsors:   Medtronic Endovascular;   Medtronic Endovascular;   Medtronic
    Recruiting - verified January 2012
  • Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors

    Conditions:   Schizophrenia;   Cigarette Smoking
    Interventions:   Drug: Varenicline;   Drug: Placebo for varenicline
    Sponsors:   Nathan Kline Institute for Psychiatric Research;   Nathan Kline Institute for Psychiatric Research
    Recruiting - verified May 2012
  • Preemptive Use of the Nicotine Patch for Postoperative Pain Relief After Open Abdominal Surgery

    Condition:   Postoperative Pain
    Intervention:   Drug: transdermal nicotine patch
    Sponsors:   Stony Brook University;   Stony Brook University
    Recruiting - verified August 2011
  • Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

    Conditions:   Bladder Cancer;   Cervical Cancer;   Esophageal Cancer;   Gastric Cancer;   Head and Neck Cancer;   Kidney Cancer;   Leukemia;   Liver Cancer;   Lung Cancer;   Pancreatic Cancer;   Tobacco Use Disorder
    Interventions:   Drug: nicotine;   Drug: varenicline;   Other: placebo
    Sponsors:   Butler Hospital;   Butler Hospital;   National Cancer Institute (NCI)
    Recruiting - verified March 2012
  • Varenicline and Motivational Advice for Smokers With Substance Use Disorders

    Conditions:   Smoking Cessation;   Nicotine Dependence
    Interventions:   Drug: Nicotine Replacement Treatment (NRT);   Drug: varenicline;   Behavioral: Behavioral counseling for smoking cessation;   Drug: Placebo patch;   Drug: Placebo
    Sponsors:   Brown University;   Brown University;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified February 2009
  • ADHD Smoking Cessation Study

    Conditions:   Attention Deficit Hyperactivity Disorder;   Nicotine Dependence
    Interventions:   Drug: Lis-dexamphetamine (LDX; Vyvanse) and Transdermal Nicotine Patch;   Drug: Placebo and transdermal nicotine patch
    Sponsors:   Duke University;   Duke University;   Shire Development LLC
    Recruiting - verified June 2011
  • Smoking Cessation Using Motivational Therapy and Varenicline

    Conditions:   Smoking;   HIV Infections
    Interventions:   Drug: Varenicline tartrate;   Drug: Nicotine Replacement Therapy;   Other: Biological Control;   Behavioral: Motivational Interview
    Sponsors:   Ohio State University;   Ohio State University;   National Heart, Lung, and Blood Institute (NHLBI)
    Recruiting - verified August 2011
  • Menstrual Cycle Effects on Smoking Cessation and Cue Reactivity

    Condition:   Nicotine Dependence
    Interventions:   Drug: varenicline;   Device: transdermal nicotine patch
    Sponsors:   Medical University of South Carolina;   Medical University of South Carolina
    Recruiting - verified July 2010
  • Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal

    Condition:   Smoking
    Intervention:   Other: Functional Magnetic Resonance Imaging (fMRI)
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Institutes of Health (NIH)
    Recruiting - verified December 2011
  • Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)

    Conditions:   Smoking;   Smoking Cessation
    Interventions:   Drug: Nicotine Patch;   Behavioral: Tobacco Quit Line Program
    Sponsors:   University of Tennessee;   University of Tennessee;   National Heart, Lung, and Blood Institute (NHLBI)
    Recruiting - verified October 2011
  • Nicotine Patch Pretreatment for Smoking Cessation in PTSD

    Conditions:   Stress Disorders, Posttraumatic;   Tobacco Use Disorder
    Interventions:   Drug: Nicotine;   Behavioral: Cognitive Behavioral Therapy for Smoking Cessation;   Drug: Bupropion SR
    Sponsors:   Department of Veterans Affairs;   Department of Veterans Affairs
    Recruiting - verified March 2012
  • Effects of Smoking on Opioid Receptor Binding: A PET Study

    Condition:   Substance-related Discorder
    Interventions:   Drug: Nicotine;   Drug: Carfentanil
    Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute on Drug Abuse (NIDA);   Johns Hopkins University
    Recruiting - verified June 2011
  • A Randomized Trial of Internet Access to Nicotine Patches

    Conditions:   Smoking Cessation;   Tobacco Use Disorder
    Interventions:   Drug: Nicotine patches;   Behavioral: Telephone counseling;   Behavioral: iQuit Smoking website
    Sponsors:   University of Michigan;   University of Michigan;   National Heart, Lung, and Blood Institute (NHLBI)
    Recruiting - verified January 2012
  • Study of Nicotine Patch in Pregnancy (SNIPP)

    Condition:   Smoking
    Intervention:   Drug: nicotine versus placebo
    Sponsors:   Assistance Publique - Hôpitaux de Paris;   Assistance Publique - Hôpitaux de Paris
    Recruiting - verified July 2007
  • Smoking Cessation for Depressed Smokers

    Conditions:   Smoking;   Depression
    Interventions:   Behavioral: Smoking Cessation Treatment;   Behavioral: Nicotine Replacement Therapy;   Behavioral: CBASP
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Institute of Mental Health (NIMH)
    Recruiting - verified May 2012
  • A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.

    Condition:   Tobacco Use Disorder
    Interventions:   Drug: Bupropion;   Drug: Bupropion
    Sponsors:   Hadassah Medical Organization;   Hadassah Medical Organization
    Recruiting - verified March 2012
  • Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP)

    Condition:   Smoking
    Interventions:   Drug: Nicotine Replacement Therapy;   Behavioral: behavioural intervention
    Sponsors:   Centre for Addiction and Mental Health;   Centre for Addiction and Mental Health;   Pfizer;   Ontario Ministry of Health and Long Term Care
    Recruiting - verified February 2012
  • Group Therapy for Nicotine Dependence: Mindfulness and Smoking

    Conditions:   Smoking;   Tobacco Use Cessation
    Interventions:   Behavioral: MBAT Group Therapy;   Drug: Nicotine;   Behavioral: Group Therapy;   Behavioral: Individual Therapy
    Sponsors:   M.D. Anderson Cancer Center;   M.D. Anderson Cancer Center;   National Institute on Drug Abuse (NIDA)
    Recruiting - verified May 2012

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