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Study of MLN8237 in Combination With Irinotecan and Temozolomide

Condition: Neuroblastoma
Interventions: Drug: MLN8237; Drug: Irinotecan; Drug: Temozolomide
Sponsors: New Approaches to Neuroblastoma Therapy Consortium; New Approaches to Neuroblastoma Therapy Consortium
Active, not recruiting - verified May 2012
Influence of Alcohol and Peer Passengers on Risky Driving Behavior in Young Adults

Condition: Injury Prevention
Intervention: Behavioral: Passenger effect
Sponsors: Centre Hospitalier Universitaire de Sherbrooke; Centre Hospitalier Universitaire de Sherbrooke
Recruiting - verified May 2012
Self-management of Chronic Mobility Limitations in MUHC Seniors

Condition: Seniors With Mobility Limitations
Interventions: Other: Mobility self-management with Mentor; Other: Mobility self-management with guidebook
Sponsors: McGill University; McGill University; Richard and Edith Strauss Foundation of Canada
Not yet recruiting - verified May 2012
Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population

Conditions: Alcohol Abuse; Drug Abuse; Mood Disorder; Anxiety Disorder; Conduct Disorder
Interventions: Behavioral: Personality-targeted interventions; Behavioral: Personality-targeted interventions; Behavioral: Personality-targeted interventions; Behavioral: Personality-targeted interventions
Sponsors: Université de Montréal; Université de Montréal
Recruiting - verified May 2012
Neuroblastoma Biology Study

Condition: Neuroblastoma
Intervention:
Sponsors: New Approaches to Neuroblastoma Therapy Consortium; New Approaches to Neuroblastoma Therapy Consortium
Recruiting - verified April 2012
Repetitive Transcranial Magnetic Stimulation for Treating Resistant Bipolar Depression

Condition: Bipolar Depression
Interventions: Device: Magstim Rapid2 Stimulator; Device: Magstim Rapid2 Stimulator
Sponsors: Douglas Mental Health University Institute; Douglas Mental Health University Institute
Not yet recruiting - verified April 2012
Composite Arterial and Venous Grafting Strategy Versus Conventional Coronary Artery Bypass Grafting

Condition: Coronary Artery Disease
Interventions: Procedure: LIMA to SVG Bridge Technique; Procedure: Conventional CABG
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Not yet recruiting - verified April 2012
Anterior Shoulder Dislocation

Condition: Shoulder Dislocation
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified April 2012
Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression

Condition: Bipolar Disorder
Interventions: Drug: Bupropion; Device: Repetitive Transcranial Magnetic Stimulation; Other: Placebo
Sponsors: McGill University Health Center; McGill University Health Center
Not yet recruiting - verified April 2012
Pilot Study to Assess the Efficacy of an Experimental 12-week Cognitive-behavioral Couple Therapy in the Treatment of Provoked Vestibulodynia

Condition: Vestibulodynia
Intervention: Behavioral: Cognitive-behavioral couple therapy (CBCT)
Sponsors: Université de Montréal; Université de Montréal
Not yet recruiting - verified May 2012
ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery

Conditions: Postpartum Hemorrhage; Uterine Atony
Intervention: Drug: Carbetocin
Sponsors: Maisonneuve-Rosemont Hospital; Maisonneuve-Rosemont Hospital; Université de Montréal
Recruiting - verified April 2012
Bereaving, But Not Alone : the Development and Actualization of a Mutual Aid Group for Children Who Have Lost a Parent.

Conditions: Mourning,; Grief,; Bereavement.
Intervention: Behavioral: Group intervention based on mutual aid.
Sponsors: Université de Montréal; Université de Montréal
Not yet recruiting - verified May 2012
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.

Condition: Parkinson's Disease
Interventions: Other: Argentinean Tango classes; Other: Simple pamphlet about the exercise in PD
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified April 2012
Efficacy of a Nurse Telephone Follow-up on Pain Intensity After Removal of Tonsils in Children

Condition: Pain
Intervention: Other: Telephone follow-up
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Completed - verified March 2012
WHO-HPH Project: Effect of a Recognition Process - a Multi-Centre Randomized Control Trial

Conditions: Smoking; Excessive Drinking; Lack of Physical Activity; Malnutrition; Obesity
Intervention: Other: WHO-HPH Recognition Process
Sponsors: Bispebjerg Hospital; Bispebjerg Hospital; World Health Organization Regional Office for Europe; International Network of Health Promoting Hospitals & Health Services (HPH); National HPH Network of Austria; National HPH Network of the Czech Republic; National HPH Network of Slovenia; National HPH Network of Switzerland; Regional HPH Network of Taiwan; National HPH Network of the Republic of Korea; Regional HPH Network of Victoria, Australia; Regional HPH Network of Montreal, Canada; National HPH Network of Italy
Recruiting - verified March 2012
ET 50 for Post Caesarean Section Spinal Hypotension

Condition: Hypotension
Interventions: Drug: 2 ml bupivacaine; Drug: 1.5 ml bupivicaine.
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified March 2012
Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease

Condition: Chronic Obstructive Pulmonary Disease
Intervention: Other: exercise
Sponsors: Laval University; Laval University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified March 2012
The Effect of Insulin on Protein Metabolism After Cardiac Surgery

Condition: Cardiac Surgery
Intervention: Drug: Regular human insulin injection
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified May 2012
The Effect of a Virtual Navigator on Colorectal Cancer Patient Empowerment

Condition: Colorectal Cancer
Interventions: Other: Oncology Interactive Navigator; Other: Routine Care
Sponsors: McGill University; McGill University
Recruiting - verified May 2012
Pilot Study on the Use of Acitretin for the Treatment of Severe Chronic Hand Dermatitis

Condition: Chronic Hand Dermatitis
Intervention: Drug: Acitretin
Sponsors: Innovaderm Research Inc.; Innovaderm Research Inc.; Tribute Pharmaceuticals
Not yet recruiting - verified March 2012
Trial of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Nasopharyngeal Aspiration

Condition: Pain
Interventions: Drug: 88% sucrose po; Drug: placebo po
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Recruiting - verified February 2012
Trial of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Bladder Catheterization

Condition: Pain
Interventions: Drug: 88% sucrose po solution; Drug: placebo po
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Not yet recruiting - verified February 2012
Testing the Developmental Origins Hypothesis

Conditions: Diabetes; Stroke; Obesity
Intervention:
Sponsors: Children's & Women's Health Centre of British Columbia; Children's & Women's Health Centre of British Columbia
Recruiting - verified March 2012
Does Incorporation of EPA and DHA in Lipoproteins Differ According to Apolipoprotein E Genotype?

Condition: Healthy
Intervention: Dietary Supplement: omega-3 fatty acids
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified February 2012
Do Apolipoprotein E Polymorphisms Influence Risk of Cognitive Decline by Modulating Omega-3 Fatty Acid Metabolism?

Condition: Healthy
Intervention: Dietary Supplement: omega-3 fatty acid
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Completed - verified April 2012
Phase-I Study of Radiolabeled DFH-12 (PulmoBind) for Molecular Imaging of the Pulmonary Circulation

Conditions: Pulmonary Disease; Pulmonary Hypertension
Intervention: Radiation: 99mTC-PulmoBind
Sponsors: Montreal Heart Institute; Montreal Heart Institute
Recruiting - verified February 2012
A Phase II Multi-institutional Study Assessing Simultaneous In-field Boost Helical Tomotherapy for 1-3 Brain Metastases

Condition: Metastasis to Brain of Primary Cancer
Intervention: Radiation: Whole brain external beam radiation with simultaneous in-field boost
Sponsors: Lawson Health Research Institute; Lawson Health Research Institute; Ontario Institute for Cancer Research
Recruiting - verified February 2012
Pre-habilitation to Improve Outcomes in Patients Undergoing Liver Resection for Cancer

Conditions: Colorectal Neoplasm; Biliary Tract Neoplasm; Liver Neoplasm
Interventions: Dietary Supplement: Whey protein and dietary supplements; Other: prehab exercise
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified February 2012
Awakening to the Taste of Food Among Restrained Women

Condition: Other Eating Disorders
Intervention: Behavioral: Conscious food tasting intervention
Sponsors: Laval University; Laval University; Canadian Foundation for Dietetic Research (CFDR)
Active, not recruiting - verified March 2012
Effect of High Dose Insulin on Infectious Complications Following Major Surgery

Condition: Surgical Site Infection After Major Surgery
Interventions: Other: Hyperinsulinemic normoglycemic clamp; Other: Standard glucose management
Sponsors: McGill University Health Center; McGill University Health Center
Not yet recruiting - verified February 2012
Excess Skin and Physical Activity

Condition: Obesity
Intervention:
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified February 2012
Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension

Condition: Pulmonary Arterial Hypertension
Intervention: Other: Submaximal exercises
Sponsors: Laval University; Laval University
Recruiting - verified January 2012
The Effect of Prophylactic Antiemetic Dexamethasone on Plasma Cortisol Levels

Condition: Postoperative Nausea and Vomiting
Interventions: Drug: Saline; Drug: Dexamethasone; Drug: Dexamethasone
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified May 2012
Comparison of Closed-loop Operation After Morning Meal With and Without Carbohydrate Counting

Condition: Type-1 Diabetes
Intervention: Device: Dual Hormone closed-loop system
Sponsors: Institut de Recherches Cliniques de Montreal; Institut de Recherches Cliniques de Montreal; McGill University Center for Intelligent Machines; Montreal Children's Hospital
Recruiting - verified January 2012
Effectiveness of a Self-care Intervention for Depression in Primary Care Patients With Chronic Physical Illnesses

Conditions: Depression; Chronic Disease
Interventions: Behavioral: Supported self-care; Behavioral: Unsupported self-care
Sponsors: McGill University; McGill University; Fonds de la Recherche en Santé du Québec
Recruiting - verified March 2012
Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Fentanyl; Drug: Placebo comparator
Sponsors: Laval University; Laval University
Completed - verified January 2012
Clinical Trial Examining the Short and Long-term Effect of Myofascial Trigger Points Injection in Low Back Pain Patients

Condition: Low Back Pain
Interventions: Drug: Bupivacaine; Drug: Saline
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified January 2012
Effect of Mobilizations and Exercises Targeting the Opening of Intervertebral Foramens Following Cervical Radiculopathy

Condition: Radiculopathy
Interventions: Procedure: Program targeting the opening of intervertebral foramen; Procedure: Conventional Rehabilitation Program
Sponsors: Laval University; Laval University; Fonds de la Recherche en Santé du Québec
Not yet recruiting - verified December 2011
Endoscopic Ultrasonography (EUS) Guided Fine Needle Aspiration Using Free Stylet 22g and 25 g Needles

Condition: Solid Neoplasms
Intervention: Device: Endosonography guided fine needle aspiration cytology ( Cook Medical, Boston Scientific)
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified December 2011
The Oscillation for Acute Respiratory Distress Syndrome (ARDS) Treated Early (OSCILLATE) Trial

Condition: Acute Respiratory Distress Syndrome (ARDS)
Interventions: Device: SensorMedics 3100B High Frequency Oscillatory Ventilator; Procedure: Lung Protective Ventilation
Sponsors: Canadian Critical Care Trials Group; Canadian Critical Care Trials Group; Canadian Institutes of Health Research (CIHR); McMaster University; University of Toronto
Recruiting - verified January 2010
Holmium Laser Enucleation of Prostate(HOLEP) vs Greenlight(XPS) Laser Photoselective Vaporization of Prostate(PVP)

Condition: Benign Prostate Hyperplasia
Interventions: Procedure: HOLEP (Holmium Laser Enucleation of The Prostate); Procedure: PVP-XPS (Photoselective Vaporization of the Prostate)
Sponsors: Royal Victoria Hospital, Canada; Royal Victoria Hospital, Canada; McGill University
Recruiting - verified January 2012
Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

Conditions: Cough; Anesthesia
Interventions: Drug: Remifentanil; Drug: Remifentanil
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified April 2012
A-priori Versus Provisional Heparin on Radial Artery Occlusion After Transradial Coronary Angiography and Patent Hemostasis

Condition: Coronary Artery Disease
Intervention: Other: Patent hemostasis and heparin
Sponsors: Laval University; Olivier F. Bertrand; Community Medical Center, Scranton, PA; Sheth Vadilal Sarabhai General Hospital
Completed - verified December 2011
Muscle-Related Side Effects of Statins: Functional Impact, Mechanisms, and Potential Relief With Vitamin D Supplementation

Condition: HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Drug: Vitamin D; Drug: Placebo
Sponsors: Centre hospitalier universitaire de Québec; Centre hospitalier universitaire de Québec; Canadian Institutes of Health Research (CIHR); Laval University
Not yet recruiting - verified December 2011
Management of Hypotension In the Preterm

Conditions: Hypotension; Low Blood Pressure; Prematurity of Fetus
Interventions: Drug: Dopamine hydrochloride; Drug: Dextrose 5%
Sponsors: University College Cork; University College Cork; BrePco Biopharma Limited; Cork University Hospital; Katholieke Universiteit Leuven; Univerzita Karlova v Praze; Centre hospitalier universitaire Sainte-Justine; University College Dublin; Coombe Women and Infants University Hospital; University of Alberta; Royal College of Surgeons, Ireland; GABO:milliarium mbH & Co. KG; National de la Santé et de la Recherche Medicale; University College, London; Clininfo S.A.
Not yet recruiting - verified November 2011
Evaluation of Clinical Outcomes and Costs of a Lifestyle Intervention in Obese Infertile Women

Conditions: Female Infertility; Polycystic Ovary Syndrome; Obesity
Intervention: Behavioral: Interdisciplinary lifestyle intervention
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Fonds de la Recherche en Santé du Québec
Recruiting - verified November 2011
Step Monitoring to Improve ARTERial Health

Conditions: Type 2 Diabetes; Hypertension
Interventions: Behavioral: Step count prescription; Behavioral: Usual care
Sponsors: McGill University Health Center; McGill University Health Center; Canadian Institutes of Health Research (CIHR)
Recruiting - verified April 2012
Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program

Conditions: Colon Cancer; Inflammatory Bowel Diseases; Diverticulitis
Interventions: Drug: Spinal analgesia; Drug: Patient Control Analgesia (PCA) Morphine
Sponsors: McGill University Health Center; McGill University Health Center
Completed - verified November 2011
Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY): Pilot Study

Conditions: Infection; Bone Neoplasms
Intervention: Procedure: Prophylactic Cefazolin Antibiotic Regimen
Sponsors: McMaster University; Michelle Ghert
Not yet recruiting - verified April 2012
What Needle Diameter Should Physician Use When They Perform Lumbar Puncture ? A Randomized Controlled Trial

Conditions: Post-lumbar Puncture Headache; Backache
Interventions: Device: whitacre 24 gauge; Device: whitacre 22 gauge
Sponsors: McGill University; McGill University; funding: McGill Emergency Medicine 2010 Grant Competition
Recruiting - verified November 2011
Cardiac Sarcoidosis Multi-Center Prospective Cohort

Condition: Cardiac Sarcoidosis
Intervention:
Sponsors: University of Ottawa Heart Institute; University of Ottawa Heart Institute; Ontario Ministry of Health and Long Term Care
Not yet recruiting - verified December 2011
Quality of Life and Dysphagia Following Palliative Stenting in Esophageal Cancer

Condition: Esophageal Cancer
Intervention:
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified November 2011
Study of the Predictive Marker FLT in Patients Suffering From AML

Condition: Acute Myeloid Leukemia
Intervention:
Sponsors: Centre Hospitalier Universitaire de Sherbrooke; Centre Hospitalier Universitaire de Sherbrooke
Recruiting - verified May 2012
Comparing Robotics and Laparoscopy With Laparotomy/Open Surgery for Endometrial Cancer

Condition: Cancer of the Endometrium
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto
Not yet recruiting - verified November 2011
Histological Validation Of Carotid Plaque Composition In Preoperative Imaging

Condition: Carotid Plaque
Intervention: Other: Imaging
Sponsors: University of Western Ontario, Canada; University of Western Ontario, Canada; Canadian Institutes of Health Research (CIHR)
Recruiting - verified October 2011
Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia

Condition: Vestibulodynia
Interventions: Procedure: Multimodal physiotherapy; Drug: lidocaine
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Canadian Institutes of Health Research (CIHR); Fonds de la Recherche en Santé du Québec
Recruiting - verified October 2011
Efficacy of Alkalinized Lidocaine Compared to Remifentanil on the Incidence of Coughing During Emergence of Anesthesia

Conditions: Cough; Anesthesia
Interventions: Drug: Remifentanil; Drug: Alkalinized lidocaine
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified April 2012
Transcranial Direct Current Stimulation as an Augmenting Intervention for Major Depression

Condition: Major Depressive Disorder
Interventions: Device: Transcranial Direct Current Stimulation; Device: Transcranial Direct Current Stimulation
Sponsors: Douglas Mental Health University Institute; Douglas Mental Health University Institute
Not yet recruiting - verified April 2012
Prebariatric Surgery Physical Activity Program

Condition: Obesity
Intervention: Behavioral: Supervised physical activity
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified October 2011
Is a Two-Film Skull X-ray Series as Sensitive as a Four-Film Series in the Diagnosis of Skull Fractures in Paediatric Patients

Condition: Head Trauma
Interventions: Other: 4-views series; Other: 2-views serie
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Recruiting - verified October 2011
Neoviderm in the Prevention of Radiation Dermatitis

Conditions: Breast Cancer; Head and Neck Cancer
Interventions: Other: Aveeno cream and Flamazine cream; Other: Neoviderm cream; Other: Aveeno cream and Flamazine cream; Other: Neoviderm cream
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Sir Mortimer B. Davis - Jewish General Hospital; Avario Healthcare Inc.
Recruiting - verified April 2012
Hypofractionated, Dose Escalation Radiotherapy for High Risk Adenocarcinoma of the Prostate

Condition: Prostate Cancer
Interventions: Radiation: hypofractionation; Radiation: conventional
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Sir Mortimer B. Davis - Jewish General Hospital
Not yet recruiting - verified September 2011
Measuring the Impact of Cognitive and Psychosocial Interventions in Persons With Mild Cognitive Impairment

Condition: Mild Cognitive Impairment
Interventions: Other: Cognitive intervention; Other: Psychosocial intervention
Sponsors: Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Laval University
Not yet recruiting - verified October 2011
Abdominal Fat and Imaging Measurements of Heart Disease

Conditions: Visceral Obesity; Atherosclerosis; Metabolic Syndrome
Intervention:
Sponsors: Laval University; Laval University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified May 2012
Flavanols and Skin Photo Protection: a Clinical Trial

Condition: Solar Skin Damage
Interventions: Other: Flavanol-rich chocolate; Other: Flavanol-free chocolate
Sponsors: Laval University; Laval University
Active, not recruiting - verified May 2012
Assisted Nerve Blocks

Condition: Surgery
Intervention:
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified September 2011
Cervical Video Assisted Thoracoscopic Surgery (C-VATS)

Condition: Lung Cancer
Intervention: Procedure: Cervical mediastinoscopy
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified September 2011
Ascorbyl Peroxide Association With Bronchopulmonary Dysplasia

Condition: Bronchopulmonary Dysplasia
Intervention:
Sponsors: St. Justine's Hospital; St. Justine's Hospital; Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified September 2011
How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months?

Condition: Vitamin D Deficiency
Interventions: Dietary Supplement: Vitamin D; Dietary Supplement: Vitamin D; Dietary Supplement: placebo
Sponsors: McGill University; McGill University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified April 2012
Evaluation of Circulating Osteogenic Factors in Trauma Patients

Conditions: Healthy; High Velocity Fracture; Cranial Trauma; Spinal Trauma
Intervention:
Sponsors: Centre Hospitalier Universitaire de Sherbrooke; Centre Hospitalier Universitaire de Sherbrooke; Universitaire de Sherbrooke; Canadian Institutes of Health Research (CIHR)
Recruiting - verified September 2011
Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site Pain

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Lidocaine; Drug: Placebo
Sponsors: Jewish General Hospital; Jewish General Hospital
Terminated - verified April 2012
Steroids, Azithromycin, Montelukast, and Symbicort (SAMS) for Viral Respiratory Tract Infection Post Allotransplant

Conditions: Respiratory Tract Infections; Bronchiolitis Obliterans; Cryptogenic Organizing Pneumonia; Lung Diseases, Interstitial
Interventions: Drug: Prednisone; Drug: Azithromycin; Drug: Montelukast; Drug: Symbicort
Sponsors: Maisonneuve-Rosemont Hospital; Maisonneuve-Rosemont Hospital; The Canadian Blood and Marrow Transplant Group
Recruiting - verified January 2012
Palliative and End-of-life Care in Advanced Dementia: Evaluation of a Program of Organization of Care in Long-term Care

Condition: Dementia
Intervention:
Sponsors: Laval University; Laval University
Not yet recruiting - verified September 2011
Feasibility Trial to Maintain Normal Cerebral Oxygen Saturation in High-Risk Cardiac Surgery

Condition: Cerebral Hypoxia
Intervention: Procedure: strategies to reverse decrease in rSO2
Sponsors: Montreal Heart Institute; Montreal Heart Institute; Université de Montréal
Recruiting - verified September 2011
A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery

Condition: Valvular Cardiac Surgery
Interventions: Drug: Rosuvastatin; Drug: Placebo
Sponsors: McGill University Health Center; McGill University Health Center
Not yet recruiting - verified August 2011
Assessment of a Drama Workshop Program for Immigrant and Refugee Adolescents

Condition: Learning Disabilities
Interventions: Other: Group tutoring program; Other: Control groups with no intervention; Other: Theatre workshops
Sponsors: McGill University Health Center; McGill University Health Center
Active, not recruiting - verified March 2012
Magnetic Resonance Cholangiopancreatography Versus Endoscopic Retrograde Cholangiopancreatography in the Approach to Patients With Suspected Biliary Obstruction

Condition: Suspected Biliary Obstruction
Interventions: Procedure: ERCP; Procedure: MRCP
Sponsors: McGill University Health Center; McGill University Health Center; Alberta Heritage Foundation for Medical Research (AHFMR); American College of Gastroenterology; American Digestive Health Foundation; Canadian Institute for Health Research (CIHR)
Terminated - verified August 2011
Syncope: Pacing or Recording in the Later Years

Conditions: Syncope; Heart Block; Conduction Disorder of the Heart
Interventions: Procedure: pacemaker; Procedure: implantable loop recorder
Sponsors: University of Calgary; Canadian Institutes of Health Research (CIHR); Vanderbilt University
Recruiting - verified April 2012
Evaluation Of Enoxaparin Pharmacokinetic For Thromboprophylaxis In Burn Care Patients

Condition: Skin Burn Extensive
Intervention:
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified August 2011
The Effectiveness of Video-capsule Endoscopy in Gastrointestinal Bleeding of Obscure Origin

Condition: Gastrointestinal Bleeding
Interventions: Device: Capsule GIVEN IMAGING; Procedure: Push-Enteroscopy
Sponsors: McGill University Health Center; McGill University Health Center; American Society for Gastrointestinal Endoscopy; American College of Gastroenterology; Canadian Institutes of Health Research (CIHR)
Completed - verified August 2011
Rate Versus Catheter Ablation Rhythm Control in Patients With Heart Failure and High Burden Atrial Fibrillation

Conditions: Heart Failure; Atrial Fibrillation
Interventions: Procedure: Catheter ablation-based AF rhythm control; Drug: Medication Rate Control
Sponsors: University of Ottawa Heart Institute; University of Ottawa Heart Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified March 2012
TRANSforming InTerprofessional Cardiovascular Prevention in Primary Care

Conditions: Diabetes Mellitus, Type 2; Hypertension; Dyslipidemias; Cholesterol, LDL; Comorbitdity
Interventions: Other: Facilitation; Other: Passive diffusion (usual implementation strategy)
Sponsors: Fonds de la Recherche en Santé du Québec; Fonds de la Recherche en Santé du Québec; Université de Montréal
Recruiting - verified August 2011
ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia

Conditions: Obstetric Anesthesia; Spinal Anesthesia; Hypotension; Fluid Therapy; Cesarean Section
Intervention: Drug: Hydroxyethylstarch 130/0.4
Sponsors: Maisonneuve-Rosemont Hospital; Maisonneuve-Rosemont Hospital; Université de Montréal
Recruiting - verified April 2012
Patency-Coronary Trial

Conditions: Complications Due to Coronary Artery Bypass Graft; Graft Failure
Interventions: Procedure: On-pump CABG; Procedure: Off-pump CABG
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified August 2011
The Effect of Intravenous Nutrition in Patients Undergoing Abdominal Surgery

Condition: Postoperative Protein Catabolism
Interventions: Other: Intravenous nutrition with glucose and amino acids; Other: Intravenous nutrition with amino acids
Sponsors: McGill University Health Center; McGill University Health Center
Completed - verified August 2011
Alkagin Paste in the Prevention of Radiation Dermatitis

Conditions: Anus Neoplasms; Rectal Neoplasms; Urogenital Neoplasms
Interventions: Other: Aveeno cream; Other: Alkagin paste
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Dr. Te Vuong; Avario Healthcare
Recruiting - verified May 2012
Impact of Physiotherapy Intervention for Children With Ankle Sprains

Condition: Physical Therapy
Intervention: Other: Physiotherapy
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified June 2011
Vitamin D Replacement in Statin-Induced Myopathy

Condition: HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Drug: Vitamin D (Cholecalciferol ); Drug: Placebo
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified July 2011
Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes

Conditions: Nonalcoholic Fatty Liver Disease; Nonalcoholic Steatohepatitis; Type 2 Diabetes
Intervention: Drug: Liraglutide-metformin vs insulin-metformin
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Diabete Quebec; Radiological Society of North America Research and Education Foundation; Canadian Heads of Academic Radiology-GE Healthcare Development Award
Recruiting - verified July 2011
Treatments for Insomnia in Patients With Parkinson's Disease

Conditions: Parkinson's Disease; Insomnia
Interventions: Device: Light box (Litebook company); Behavioral: CBT and sleep hygiene; Drug: Doxepin and Zopiclone; Device: Light box ( Litebook company)
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified December 2011
Hypoalbuminemia in Burn Patients

Condition: Second or Third Degree Burns
Intervention: Drug: 5% human albumin solution (HAS)
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Not yet recruiting - verified September 2011
A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours

Condition: Advanced Rare Tumours
Interventions: Drug: Sunitinib; Drug: Temsirolimus
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified May 2012
Using a Closed-loop System for Oxygen Delivery (FreeO2) to Optimize Oxygentherapy in Patients With COPD Exacerbation

Condition: COPD Exacerbation
Interventions: Device: Automated settings on the oxygen delivery device; Device: Manual settings with FreeO2 system in collection mode
Sponsors: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Recruiting - verified May 2011
Use of a Telehomecare Program for Young Patients With New Onset Type 1 Diabetes

Condition: Diabetes Mellitus, Type 1
Interventions: Device: Telehomecare (Intelligent Distance Patient Monitoring); Other: Standard education and follow up at diabetes clinic
Sponsors: Huot, Celine, M.D.; Huot, Celine, M.D.
Completed - verified July 2011
Accelerated Titration of Oxytocin for Nulliparous Patients With Labour Dystocia: ACTION Pilot Study

Condition: Labour Dystocia
Intervention: Drug: Oxytocin
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; The Physicians' Services Incorporated Foundation; The Ottawa Hospital; Canadian Institutes of Health Research (CIHR); Sainte Justine Hospital Research Institute
Recruiting - verified March 2012
Responsiveness of Exercise Tests in Pulmonary Arterial Hypertension

Condition: Pulmonary Arterial Hypertension
Interventions: Drug: Sildenafil; Drug: Sugar Pill
Sponsors: Laval University; Laval University
Recruiting - verified January 2012
Evaluation of a Primary Prevention Program for Anxiety Disorders Using Story Books

Condition: Anxiety
Intervention: Behavioral: Dominique's Handy Tricks
Sponsors: Universite du Quebec en Outaouais; Universite du Quebec en Outaouais
Completed - verified July 2011
Minilaparoscopic Versus Conventional Laparoscopic Cholecystectomy

Conditions: Cholelithiasis; Cholecystectomy
Interventions: Procedure: Laparoscopic cholecystectomy; Procedure: Minilaparoscopic cholecystectomy
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified April 2012
MRD Testing Before and After Hematopoietic Cell Transplantation Transplantation for Pediatric Acute Myeloid Leukemia

Condition: Acute Myeloid Leukemia
Intervention:
Sponsors: Center for International Blood and Marrow Transplant Research; Center for International Blood and Marrow Transplant Research; Resource for Clinical Investigations in Blood and Marrow Transplantation (RCI-BMT); Pediatric Blood and Marrow Transplant Consortium
Recruiting - verified May 2012
Integrated Obesity Care Management System

Condition: Obesity
Intervention: Other: Preceptorship and virtual community
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Completed - verified October 2011
Meaning-based Group Counselling for Bereavement

Conditions: Grief; Bereavement
Interventions: Behavioral: Meaning-Based Bereavement Group; Behavioral: Conventional Bereavement Group
Sponsors: Jewish General Hospital; Jewish General Hospital; McGill University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified June 2011
Motivational Intervention for Asthma

Condition: Asthma
Interventions: Behavioral: Motivational Interviewing; Behavioral: Control
Sponsors: Hopital du Sacre-Coeur de Montreal; Hopital du Sacre-Coeur de Montreal; Jewish General Hospital
Recruiting - verified October 2011
Safety Evaluation of Dexmedetomidine for EBUS-TBNA

Condition: Lung Cancer
Interventions: Drug: Remifentanil; Drug: Dexmedetomidine
Sponsors: Maisonneuve-Rosemont Hospital; Maisonneuve-Rosemont Hospital
Recruiting - verified June 2011
Group Cognitive-behavioral Intervention for Social Anxiety in Schizophrenia

Conditions: Social Anxiety; Schizophrenia
Interventions: Behavioral: Cognitive-Behavioral Therapy based intervention immediately; Behavioral: Wait list
Sponsors: McGill University; McGill University; Canadian Institute of Health Research Grant operating under Dr Martin Lepage
Recruiting - verified June 2011
Comparison of 4 Influenza Vaccines in Seniors

Condition: Influenza Vaccine
Interventions: Biological: Agriflu; Biological: Fluad; Biological: Intanza; Biological: Vaxigrip
Sponsors: University of British Columbia; University of British Columbia; PHAC/CIHR Influenza Research Network
Active, not recruiting - verified March 2012
Optimal Management of Malignant Dysphagia

Conditions: Malignant Dysphagia; Esophageal Cancer
Interventions: Radiation: Brachytherapy; Procedure: Stent insertion
Sponsors: McGill University Health Center; McGill University Health Center
Not yet recruiting - verified June 2011
Videolaryngoscope vs Classic Laryngoscope in Teaching Neonatal Endotracheal Intubation: a Randomized Controlled Trial.

Condition: Intubation, Intratracheal
Interventions: Device: Miller laryngoscope; Device: Storz videolaryngoscope
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Recruiting - verified July 2011
Endoscopic Peroral Myotomy for Treatment of Achalasia

Condition: Achalasia
Intervention: Procedure: Endoscopic Peroral Myotomy
Sponsors: Universitätsklinikum Hamburg-Eppendorf; Universitätsklinikum Hamburg-Eppendorf
Recruiting - verified May 2012
"Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy

Condition: Stroke
Interventions: Biological: rfVIIa; Other: Standard saline solution
Sponsors: Sunnybrook Health Sciences Centre; Dr. David Gladstone; Canadian Institutes of Health Research (CIHR)
Recruiting - verified April 2012
Enhancing Coping Skills in Patients With Cancer

Condition: Cancer
Intervention: Other: Self administered coping intervention
Sponsors: McGill University Health Center; McGill University Health Center; Louise Granofsky-Psychosocial Oncology Program, Segal Cancer Centre, Montreal
Suspended - verified May 2012
Multimodal Prehabilitation for Colorectal Surgery

Conditions: Colorectal Cancer; Colorectal Cancer Stage III
Interventions: Behavioral: multimodal prehabilitation; Behavioral: multimodal prehabilitation
Sponsors: McGill University Health Center; McGill University Health Center; Society of American Gastrointestinal and Endoscopic Surgeons
Recruiting - verified April 2012
Intervention to Improve Adherence in Teen Kidney Transplant

Conditions: Kidney Transplantation; Medication Adherence
Interventions: Device: Medminder adherence monitoring; Behavioral: Action-focused problem-solving; Device: Medminder dosage reminders
Sponsors: McGill University Health Center; McGill University Health Center; Children's Hospital of Philadelphia; Children's Hospital Medical Center, Cincinnati; Seattle Children's Hospital; University of Florida; Children's & Women's Health Centre of British Columbia; The Hospital for Sick Children
Recruiting - verified March 2012
Studies of Blood DNA in Patients With Severe Infection DYNAMICS

Conditions: Sepsis; Shock; Trauma
Intervention:
Sponsors: Hamilton Health Sciences Corporation; Hamilton Health Sciences Corporation
Recruiting - verified August 2011
Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes

Condition: Atherosclerosis
Intervention:
Sponsors: Canadian Atherosclerosis Imaging Network; Canadian Atherosclerosis Imaging Network; Canadian Institutes of Health Research (CIHR)
Recruiting - verified July 2011
Quinolone Prophylaxis for the Prevention of BK Virus Infection in Kidney Transplantation: A Pilot Study

Conditions: Disease Due to BK Polyomavirus; Kidney Transplant Infection
Intervention: Drug: Levofloxacin
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR); St. Paul's Hospital, Canada; Vancouver General Hospital; University of Alberta; University of Manitoba; University Health Network, Toronto; St. Michael's Hospital, Toronto; St. Joseph's Healthcare Hamilton; London Health Sciences Centre; McGill University Health Center; Dalhousie University
Recruiting - verified March 2012
The Impact of Omega-3 Fatty Acid Supplements on Fibromyalgia Symptoms

Condition: Fibromyalgia
Interventions: Dietary Supplement: Omega-3 (oil); Dietary Supplement: Fatty Acids (placebo)
Sponsors: McGill University Health Center; McGill University Health Center; Alan Edwards Centre for Research on Pain
Recruiting - verified January 2012
Effect of Vitamin D Replacement in Patients With Urolithiasis

Condition: Urolithiasis
Intervention:
Sponsors: McGill University Health Center; McGill University Health Center
Active, not recruiting - verified April 2011
Flow Diversion in Intracranial Aneurysm Treatment

Condition: Intracranial Aneurysm
Interventions: Procedure: flow diversion; Other: conservative management; Procedure: endovascular coiling; Procedure: balloon parent vessel occlusion; Procedure: surgical clipping
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified December 2011
Consumption of Chocolate in Pregnant Women.

Condition: Preeclampsia
Interventions: Other: Flavanol-rich chocolate; Other: Placebo Chocolate
Sponsors: Laval University; Laval University
Recruiting - verified February 2012
Stenting in the Treatment of Aneurysm Trial

Condition: Intracranial Aneurysm
Interventions: Device: endovascular coiling with any type of currently approved coil (first or second generation); Device: endovascular stenting with or without coiling. The stent may be any of the currently approved stents for intracranial aneurysms.
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified December 2011
The Effects of Iodized Salt on Cognitive Development in Ethiopia

Conditions: Iodine Deficiency; Goiter; Cretinism
Intervention: Other: Iodized salt
Sponsors: McGill University; McGill University; MicroNutrient Initiative; Ethiopian Health and Nutrition Research Institute (EHNRI)
Recruiting - verified February 2012
Effect of Qigong Therapy in Patients With Advanced Lung and Gastrointestinal Cancer Undergoing Chemotherapy

Conditions: Carcinoma, Non-Small-Cell Lung; Cancer of the Gastrointestinal Tract
Interventions: Behavioral: Standard Exercise; Behavioral: Qigong Exercise
Sponsors: McGill University; McGill University; Jewish General Hospital
Active, not recruiting - verified February 2011
Predicting Malignancy Using Endoluminal Ultrasound Characteristics in Mediastinal Lymph Nodes

Condition: Neoplasm of Mediastinal Lymph Nodes
Intervention:
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal; C.E.T.O.C. CHUM Endoscopic Tracheo-Bronchial and Oesophageal Center
Completed - verified November 2011
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia

Conditions: Pre-Eclampsia; Fetal Growth Retardation; Prematurity of Fetus; Placental Insufficiency
Interventions: Drug: Acetylsalicylic acid (ASA) 160; Drug: Acetylsalicylic acid (ASA) 80
Sponsors: Centre hospitalier universitaire de Québec; Centre hospitalier universitaire de Québec
Recruiting - verified January 2012
Outcomes of Pandemic Influenza in Pregnancy

Condition: Influenza
Intervention:
Sponsors: Dalhousie University; Dalhousie University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified June 2011
Prospective Study on EUS Celiac Bloc Efficacy in Chronic Pancreatitis

Condition: Pancreatitis, Chronic
Interventions: Drug: Bupivacaine & Triamcinolone Acetonide; Other: No intervention except EUS procedure
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Erasme University Hospital
Recruiting - verified December 2011
Assisted Intubation

Condition: Intubation Conditions
Intervention: Other: Intubation
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified June 2011
The New GlideRite DLT Stylet®: An Observational Study

Condition: Double Lumen Tube Intubation
Intervention:
Sponsors: Laval University; Laval University
Completed - verified February 2012
Role of Cyberknife Stereotactic Radiation Therapy (SBRT) Followed by Gemcitabine for Patients With Locally Advanced Pancreatic Cancer

Conditions: Pancreatic Cancer; Unresectable Pancreatic Cancer
Intervention: Radiation: stereotactic body radiotherapy
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified December 2011
Closed-loop Control of Glucose Levels in the Context of Exercise in Adults With Type-1 Diabetes

Condition: Type 1 Diabetes
Interventions: Device: Conventional continuous subcutaneous insulin infusion therapy; Device: Dual-hormone closed-loop
Sponsors: Institut de Recherches Cliniques de Montreal; Institut de Recherches Cliniques de Montreal; McGill University; Montreal Children's Hospital; Diabète Québec; Medtronic Minimed
Completed - verified January 2012
Intervention to Improve Continuity of Care in Lung Cancer Patients

Condition: Lung Cancer
Intervention: Other: Multi-faceted intervention to improve continuity of care
Sponsors: Laval University; Laval University; Canadian Cancer Society
Recruiting - verified January 2012
Youth Lifestyle Intervention With Food and Exercise

Conditions: Healthy; Obesity
Interventions: Behavioral: 2 servings of dairy/day and exercise counselling; Behavioral: 4 servings of dairy/day and exercise counselling
Sponsors: McGill University; McGill University; Dairy Farmers of Canada
Recruiting - verified March 2012
Function of High Density Lipoproteins in Acute Coronary Syndromes

Condition: Acute Coronary Syndrome
Intervention:
Sponsors: McGill University Health Center; McGill University Health Center; McGill University
Recruiting - verified September 2011
PROSPER: PostpaRtum PrOphylaxiS for PE Randomized Control Trial Pilot

Conditions: Venous Thromboembolism; Postpartum
Interventions: Drug: Dalteparin Sodium; Drug: 0.9% Bacteriostatic Sodium Chloride
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified March 2012
High Dose Insulin Therapy to Improve Liver Function

Condition: Hepatitis C Virus
Intervention: Drug: Insulin
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified August 2011
Does the Use of the GlideRite® Endotracheal Tube in Combination With the I-gel® Improve Intubation Success Rate?

Conditions: Intubation; General Anesthesia
Interventions: Procedure: Tracheal intubation through LMA-Fastrach®; Procedure: Tracheal intubation through I-gel®
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified April 2012
Osteopathic Evaluation on Patients With Non-specific Back Pain: An Inter-examiner Reliability Study

Conditions: Inter-examiner Reliability; Location and Nature of Restriction or Lesion; Non-specific Back Pain
Intervention: Other: General Osteopathic Evaluation
Sponsors: Kirnan, Jaime; Kirnan, Jaime
Completed - verified June 2011
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery

Conditions: Neurosurgery; Orthopedic Surgery; Red Blood Cell Transfusion
Interventions: Drug: Tranexamic Acid; Drug: Placebo
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified April 2012
Polymorphisms and Busulfan PK Study

Condition: Any Disease in Children Who Receive a Stem Cell Transplantation With Busulfan IV
Intervention:
Sponsors: Swiss Pediatric Oncology Group; Swiss Pediatric Oncology Group; European Group for Blood and Marrow Transplantation
Recruiting - verified February 2012
Effects of Cardioselective β-blockers on Dynamic Hyperinflation in COPD

Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Bisoprolol; Drug: Placebo
Sponsors: Laval University; Laval University
Completed - verified November 2010
Incisional Hernia After Midline Versus Transverse Extraction Incision in Laparoscopic Colectomy

Condition: Laparoscopic Colectomy
Intervention: Procedure: laparoscopic colectomy
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified April 2012
Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases

Condition: Bone Metastases
Interventions: Drug: Dexamethasone; Drug: Placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified March 2012
Lactated Ringer's Solution in Neonates With Feeding Intolerance

Conditions: Intestinal Disease; Feeding Disorder Neonatal
Intervention: Drug: Lactated Ringer's Solution
Sponsors: McGill University Health Center; McGill University Health Center
Active, not recruiting - verified August 2011
Adrenal Vein Sampling International Study (AVIS Study)

Condition: Hyperaldosteronism
Intervention:
Sponsors: University Hospital Padova; University Hospital Padova
Completed - verified December 2011
Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS)

Condition: Amyotrophic Lateral Sclerosis (ALS)
Intervention: Drug: rasagiline
Sponsors: University of Kansas; Yunxia Wang, MD; Western ALS Study Group
Active, not recruiting - verified March 2012
Multicentred, Randomized Control Trial Comparing Narrow Versus Wide Focal Zones for Shock Wave Lithotripsy of Renal Calculi

Condition: Renal Calculi (Kidney Stones)
Intervention: Procedure: ESWL: Extraporeal Shock Wave Lithotripsy Intervention
Sponsors: University of British Columbia; University of British Columbia
Recruiting - verified November 2011
Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients

Condition: Colon Cancer
Interventions: Dietary Supplement: Oral Nutrition with dextrose and pressurized whey protein; Dietary Supplement: Peripheral Parenteral Nutrition
Sponsors: McGill University Health Center; McGill University Health Center; Montreal General Hospital; McGill University
Completed - verified February 2012
Art Therapy Intervention for Breast Cancer Patients

Condition: Breast Cancer
Intervention: Other: art therapy
Sponsors: McGill University Health Center; McGill University Health Center; The Cedars Cancer Institute
Recruiting - verified August 2011
Gestational Diabetes: Insulin or Oral Hypoglycemic Agents?

Condition: Gestational Diabetes Mellitus
Interventions: Drug: Insulin; Drug: Metformin, glyburide and insulin
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Fonds de la Recherche en Santé du Québec
Recruiting - verified November 2011
Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study)

Condition: Cardiac Disease
Interventions: Drug: Atenolol; Drug: Telmisartan; Drug: Atenolol Placebo; Drug: Telmisartan Placebo
Sponsors: Hamilton Health Sciences Corporation; Hamilton Health Sciences Corporation; Population Health Research Institute
Recruiting - verified March 2012
Pre-Operative Assessment of Chest Wall Invasion in Non-Small Cell Lung Cancer Using Pre-Operative, Surgeon Performed Ultrasound

Condition: Non Small Cell Lung Cancer
Intervention: Procedure: Transthoracic Ultrasound
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified November 2011
Thoracoscopic Localization of Pulmonary Nodules Using Direct Intracavitary Thoracoscopic Ultrasound

Condition: Lung Cancer
Intervention: Procedure: intracavitary ultrasound
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified November 2011
Postoperative Analgesia Impact of Narcotic Free Anesthesia

Conditions: Pain, Postoperative; Breast Cancer; Postoperative Nausea and Vomiting
Interventions: Drug: fentanyl; Drug: beta-blocker (esmolol, metropolol)
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified February 2012
The CHIPS Trial (Control of Hypertension In Pregnancy Study)

Condition: Gestational Hypertension
Interventions: Procedure: Intervention is blood pressure management approach; Procedure: Intervention is blood pressure management approach.
Sponsors: University of British Columbia; University of British Columbia; Canadian Institutes of Health Research (CIHR); Sunnybrook Research Institute
Recruiting - verified December 2011
Caffeine for Motor Manifestations of Parkinson's Disease

Condition: Parkinson's Disease
Intervention: Drug: Caffeine alkaloid
Sponsors: McGill University Health Center; McGill University Health Center; Canadian Institutes of Health Research (CIHR)
Completed - verified July 2011
Study Comparing Two Isoforms of Vitamin D Supplements for Infants

Condition: Healthy
Intervention: Dietary Supplement: Cholecalciferol (D3) or ergocalciferol (D2)
Sponsors: McGill University; McGill University; Canadian Foundation for Dietetic Research (CFDR)
Completed - verified March 2012
A Phase I Study of SB939 in Pediatric Patients With Refractory Solid Tumours and Leukemia

Conditions: Leukemia; Solid Tumours
Intervention: Drug: SB939
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified April 2012
Using Novel Canadian Resources to Improve Medication Reconciliation at Discharge

Conditions: Medication Reconciliation; Adverse Drug Events
Intervention: Other: Electronic Medication Reconciliation
Sponsors: McGill University; McGill University; Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified April 2012
Development and Evaluation of Modified Yoga in Systemic Lupus Erythematosus (SLE)

Condition: Systemic Lupus Erythematosus
Intervention: Other: Standard care plus Yoga
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified July 2011
Multi_center Study to Evaluate the Effect of N-3 Fatty Acids (OMEGA-3) on Arrhythmia Recurrence in Atrial Fibrillation

Condition: Atrial Fibrillation
Interventions: Drug: OMEGA-3; Drug: Placebo soybean oil
Sponsors: Montreal Heart Institute; Montreal Heart Institute
Recruiting - verified July 2011
Prospective Evaluation of Long-term Outcomes After Pulmonary Embolism

Condition: Pulmonary Embolism
Intervention:
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Sir Mortimer B. Davis - Jewish General Hospital
Recruiting - verified July 2010
Effect of Preoperative Pregabalin on Propofol Induction Dose

Conditions: Anesthesia, General; Laparoscopic Surgery
Intervention: Drug: Pregabalin
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified December 2011
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine

Conditions: Colon Cancer; Inflammatory Bowel Diseases; Diverticulitis
Interventions: Drug: Lidocaine; Procedure: Thoracic epidural block
Sponsors: McGill University Health Center; McGill University Health Center
Completed - verified November 2011
TAP Block for Open Radical Prostatectomy.

Conditions: Opioid Consumption; Incidence of Nausea and Vomiting; Postoperative Pain; Assessment of Recovery
Interventions: Procedure: Normal saline via TAP catheters; Procedure: Lidocaine via TAP catheters
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified February 2012
A Randomized Phase II Study of Interleukin-21 (rIL-21) Versus Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma

Condition: Melanoma
Interventions: Drug: rIL-21; Drug: Dacarbazine
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified May 2012
A Trial of Routine Aspiration Thrombectomy With Percutaneous Coronary Intervention (PCI) Versus PCI Alone in Patients With ST-Segment Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI

Conditions: Acute Coronary Syndrome; ST Elevation Myocardial Infarction; Percutaneous Coronary Intervention
Intervention: Procedure: Percutaneous Coronary Intervention with or without manual aspiration thrombectomy
Sponsors: Population Health Research Institute; Population Health Research Institute
Recruiting - verified March 2012
An Intervention Study to Reduce the Use and Impact of Potentially Inappropriate Medications Among Older Adults

Conditions: Polypharmacy; Incontinence; Insomnia; Anxiety
Intervention: Behavioral: knowledge transfer tool
Sponsors: Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2011
Evaluation of the Use of Multimedia to Enhance Patient and Family Understanding

Condition: The Role of Multimedia on Retention and Comprehension of Key Concepts for Surgical Options in Newly Diagnosed Breast Cancer Patients.
Interventions: Other: This group of patients will be exposed to multimedia; Other: No Media
Sponsors: McGill University Health Center; McGill University Health Center
Enrolling by invitation - verified April 2012
(Mis)Perceptions About Healthy Eating: Effects on Food Intake and Appetite in Men and Women

Conditions: Eating; Obesity
Interventions: Behavioral: Healthy; Behavioral: Diet; Behavioral: Unhealthy
Sponsors: Laval University; Laval University; Canadian Institutes of Health Research (CIHR); Fonds de la Recherche en Santé du Québec; Danone Institute International
Completed - verified February 2012
Pleural Ultrasonography in Lung Cancer

Condition: Lung Cancer
Interventions: Procedure: thoracic ultrasound; Procedure: pleural aspiration
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Fonds de la Recherche en Santé du Québec; Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Society of University Surgeons
Completed - verified June 2011
Study of Foretinib in Combination With Lapatinib in Patients With Metastatic Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Foretinib; Drug: Lapatinib
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified April 2012
A Study of Foretinib in Patients With Recurrent/Metastatic Breast Cancer

Condition: Recurrent Breast Cancer
Intervention: Drug: Foretinib
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified May 2012
Motivational Interviewing for Medication Adherence in Asthma

Condition: Asthma
Interventions: Behavioral: Motivational interviewing; Behavioral: Usual care
Sponsors: Hopital du Sacre-Coeur de Montreal; Hopital du Sacre-Coeur de Montreal
Active, not recruiting - verified June 2011
Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin

Condition: Drug Interaction Potentiation
Intervention: Drug: Rosuvastatin, Pantoprazole
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Completed - verified December 2011
Conservative Treatment Versus the Surgical Treatment of Diaphyseal Fractures of Humerus

Condition: Humeral Diaphysis Fracture
Interventions: Procedure: Plate and screws or nailing; Device: Hanging Support System (HSS) brace
Sponsors: Hopital de l'Enfant-Jesus; Hopital de l'Enfant-Jesus
Recruiting - verified November 2011
Does Treating Obstructive Sleep Apnea in Obese Canadian Youth Improve Blood Sugar Control?

Conditions: Obesity; Obstructive Sleep Apnea
Intervention:
Sponsors: Katz, Sherri Lynne, M.D.; Katz, Sherri Lynne, M.D.; Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2011
Effectiveness of Intensive Rehabilitation on Shoulder Function After Proximal Humerus Fracture

Condition: Fracture of Proximal Humerus
Interventions: Device: PHILOS™ locked plate system by Synthes Canada©; Other: Early and intensive exercise program; Other: Standard rehabilitation program
Sponsors: Hopital de l'Enfant-Jesus; Hopital de l'Enfant-Jesus
Recruiting - verified November 2011
Immobilization After an Anterior Glenohumeral Joint Dislocation With a Bankart Lesion

Condition: Glenohumeral Joint Dislocation
Interventions: Device: Donjoy ER brace; Device: Thoraco brachial brace
Sponsors: Hopital de l'Enfant-Jesus; Hopital de l'Enfant-Jesus
Recruiting - verified November 2011
Acromio-clavicular Dislocation Type III - Conservative Treatment Versus Surgical Hook Plate Treatment

Condition: Acromio-clavicular Joint Dislocation (Type III)
Interventions: Other: Conservative treatment - brace; Device: Hook plate by Synthes
Sponsors: Hopital de l'Enfant-Jesus; Hopital de l'Enfant-Jesus
Recruiting - verified November 2011
Effects of a Probiotic on Body Weight

Condition: Obesity
Interventions: Other: Probiotic; Other: Placebo
Sponsors: Laval University; Laval University; Nestle Research Center
Recruiting - verified September 2011
A Study of SB939 in Patients With Translocation-Associated Recurrent/Metastatic Sarcomas

Condition: Metastatic Sarcoma
Intervention: Drug: SB939
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified April 2012
Chronic Hepatitis C (CHC) - Genotype 3 Infection in Canada

Condition: Chronic Hepatitis C - Genotype 3
Intervention:
Sponsors: University Health Network, Toronto; University Health Network, Toronto
Recruiting - verified February 2010
Antidepressants to Promote Recovery of Cardiac Patients Suffering From Depression

Conditions: Acute Coronary Syndrome; Major Depressive Episode
Intervention: Drug: Citalopram
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Canadian Institutes of Health Research (CIHR); Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Montreal Heart Institute
Terminated - verified June 2011
Onset of Labor and Metabolomics (GEM-2)

Condition: Pregnancy
Intervention:
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified March 2012
Partial Thromboplastin Time During the First 24 Hours of Antithrombotic Prophylaxis Using Unfractionated Heparin (UFH)

Condition: Thrombosis
Interventions: Drug: Variation of heparin dose; Drug: Variation of heparin dose
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified April 2012
Use of Ribavirin and Low Dose Ara-C to Treat Acute Myeloid Leukemia

Condition: Acute Myeloid Leukemia
Interventions: Drug: Ribavirin; Drug: Cytarabine arabinoside
Sponsors: Jewish General Hospital; Jewish General Hospital; The Leukemia and Lymphoma Society
Recruiting - verified March 2010
The Effect of Soy Protein on Neuropathic Facial Pain

Condition: Neuralgic Facial Pain
Interventions: Dietary Supplement: Isolated soy protein; Dietary Supplement: Isolated milk protein
Sponsors: McGill University Health Center; McGill University Health Center; Louise & Alan Edwards Foundation; Alan Edwards Centre for Research on Pain
Recruiting - verified January 2012
Exercise and Phytoestrogens: Effect on Factors Predisposing to Cardiovascular Disease(CVD) in Postmenopausal Women

Conditions: Postmenopause; Overweight
Interventions: Behavioral: Placebo + exercise; Dietary Supplement: Phytoestrogens without exercise; Other: Phytoestrogens + exercise; Other: Placebo without exercise
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Canadian Institutes of Health Research (CIHR); Centre de recherche sur le vieillissement du CSSS-IUGS
Recruiting - verified June 2010
Trial of Chemotherapy Plus Intravenous Vitamin C in Patients With Advanced Cancer for Whom Chemotherapy Alone is Only Marginally Effective

Condition: Cancer
Intervention: Dietary Supplement: vitamin C (ascorbic acid)
Sponsors: Jewish General Hospital; Jewish General Hospital
Recruiting - verified January 2010
The International Nocturnal Oxygen (INOX) Trial

Conditions: Chronic Obstructive Pulmonary Disease; Nocturnal Desaturation
Interventions: Device: Concentrator; Device: Sham concentrator
Sponsors: Laval University; Laval University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified February 2012
Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL

Conditions: Oral Cancer; High-grade Precancer
Interventions: Procedure: Fluorescence visualization device; Procedure: Fluorescence visualization device
Sponsors: University of British Columbia; University of British Columbia; Terry Fox Research Institute; British Columbia Cancer Agency
Recruiting - verified December 2011
Endobronchial Ultrasound (EBUS) for Nodal Staging in Esophageal Cancer

Condition: Esophageal Cancer
Interventions: Procedure: Endoscopic Ultrasound (EUS); Procedure: Endobronchial Ultrasound (EBUS)
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); C.E.T.O.C. - CHUM Endoscopic Tracheobronchial and Oesophageal Center; Marcel and Rolande Gosselin Chair in Thoracic Surgical Oncology; Fonds de la Recherche en Santé du Québec; Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Completed - verified November 2011
IMPACT-CABG Trial: IMPlantation of Autologous CD133+ sTem Cells in Patients Undergoing CABG

Conditions: Myocardial Infarct; Heart Failure
Intervention: Procedure: Injection of stem cells at time of coronary artery bypass grafting
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Miltenyi Biotech inc.; Centre de Recherche du Centre Hospitalier de l'Université de Montréal; Maisonneuve-Rosemont Hospital
Recruiting - verified December 2011
Retina Microvascularisation and Cardiovascular Heart Disease Prediction

Condition: Cardiovascular Disease
Intervention:
Sponsors: Montreal Heart Institute; Montreal Heart Institute; Fonds de la Recherche en Santé du Québec
Active, not recruiting - verified July 2011
Evaluation and Validation of New Biomarkers by Mass Spectrometry

Condition: Diabetes Mellitus
Intervention:
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Active, not recruiting - verified November 2011
Early Screening for Gestational Diabetes Mellitus

Condition: Gestational Diabetes Mellitus
Intervention: Procedure: 50 g oral glucose challenge test - 75 g oral glucose tolerance test
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Canadian Diabetes Association
Recruiting - verified November 2011
Closed-loop Sedation of Propofol for Patients Undergoing Spinal Anesthesia

Condition: Conscious Sedation
Intervention: Drug: controlled administration of propofol
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified November 2009
Minimally Invasive, Diagnosis and Staging of Lung Cancer

Condition: Lung Cancer
Interventions: Procedure: Cervical Mediastinoscopy; Procedure: Endobronchial Ultrasound (EBUS); Procedure: Endoscopic Ultrasound (EUS)
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Fonds de la Recherche en Santé du Québec; Society of University Surgeons; Centre de Recherche du Centre Hospitalier de l'Université de Montréal
Recruiting - verified November 2011
Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer

Condition: Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Trastuzumab; Drug: Neratinib; Drug: Trastuzumab (post surgery); Drug: Doxorubicin; Drug: Cyclophosphamide
Sponsors: National Surgical Adjuvant Breast and Bowel Project (NSABP); National Surgical Adjuvant Breast and Bowel Project (NSABP); Wyeth Pharmaceuticals, Inc., a Pfizer Company
Recruiting - verified February 2012
Study of Cervix and Inflammation in Preterm Birth Prediction

Condition: Preterm Birth
Interventions: Procedure: Transvaginal ultrasound; Procedure: Vaginal secretion sampling
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Completed - verified March 2012
PF-00299804 in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Has Not Responded to Standard Therapy for Advanced or Metastatic Cancer

Condition: Lung Cancer
Interventions: Drug: PF-00299804; Drug: Placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified May 2012
Pilot Study: Mindfulness-Based Cognitive Therapy as a Tool for Prophylactic Mood Stabilizing Therapy in Bipolar Disorder

Condition: Bipolar Disorder
Intervention: Behavioral: Mindfulness-Based Cognitive Therapy
Sponsors: Douglas Mental Health University Institute; Douglas Mental Health University Institute
Active, not recruiting - verified January 2012
Impact of an Integrated Obesity Management System on Patient's Care

Condition: Obesity
Intervention: Behavioral: 2-day preceptorship on obesity management
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Canadian Institutes of Health Research (CIHR)
Recruiting - verified February 2012
Study to Identify Mechanisms of Resistance to Standard Therapy in Patients With Metastatic Colorectal Cancer

Condition: Colorectal Cancer
Intervention: Other: Needle core biopsies of liver metastasis
Sponsors: Jewish General Hospital; Jewish General Hospital; Quebec Clinical Research Organization in Cancer; Fonds de la Recherche en Santé du Québec
Recruiting - verified September 2011
Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study

Condition: Fibromyalgia
Interventions: Drug: quetiapine; Drug: placebo
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Université de Montréal
Completed - verified October 2011
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine

Conditions: Colon Cancer; Inflammatory Bowel Diseases; Diverticulitis
Interventions: Drug: Lidocaine; Procedure: Epidural Block; Drug: PCA Morphine
Sponsors: McGill University Health Center; McGill University Health Center
Completed - verified November 2011
Validation of the Rhinitis Control Scoring System (RCSS)

Conditions: Asthma; Rhinitis
Intervention: Drug: Mometasone furoate and desloratadine
Sponsors: Laval University; Laval University
Recruiting - verified February 2012
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.

Condition: Neuropathic Pain
Interventions: Drug: Pregabalin; Drug: Placebo
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Completed - verified April 2012
Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy

Conditions: Male Infertility; Varicoceles
Intervention: Procedure: Varicocelectomy
Sponsors: Mount Sinai Hospital, Canada; Mount Sinai Hospital, Canada; McGill University; Dalhousie University; McMaster University
Not yet recruiting - verified August 2011
Impact of Aerobic Exercise on Asthma Morbidity

Condition: Asthma
Interventions: Behavioral: Aerobic exercise; Behavioral: Usual care
Sponsors: Hopital du Sacre-Coeur de Montreal; Hopital du Sacre-Coeur de Montreal; McGill University Health Center
Recruiting - verified October 2011
(EASY)-IMProving Adherence to Clopidogrel Trial (IMPACT))

Condition: Coronary Artery Disease
Intervention: Behavioral: Multi-disciplinary disease management approach
Sponsors: Laval University; Laval University; Fonds de la Recherche en Santé du Québec
Completed - verified February 2012
Pre-eclampsia and Metabolomics

Condition: Preeclampsia
Intervention:
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Fondation des étoiles
Recruiting - verified March 2012
Study of the Effect of Eicosanoids on Contractile Activity of Pregnant Human Myometrium in Pathological Situation

Conditions: Obstetric Labor Complications; Prolonged Pregnancy
Intervention:
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke; Fonds de la Recherche en Santé du Québec
Recruiting - verified December 2011
Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index

Conditions: Deglutition Disorders; Esophageal Diseases; Eosinophilia
Intervention: Other: assessment of disease activity using the EEsAI
Sponsors: University Hospital Inselspital, Berne; University Hospital Inselspital, Berne; Institute of Social and Preventive Medicine, University Bern; Dept. of Gastroenterology, Kantonsspital Olten, Olten; Luzerner Kantonsspital; Mayo Clinic Rochester, Minnesota, USA; University of Cincinnati; University of Colorado, Denver; Northwestern University of Chicago, Illinois, USA; Indiana University School of Medicine; Philadelphia University
Recruiting - verified March 2012
The Enhanced Angiogenic Cell Therapy - Acute Myocardial Infarction Trial

Condition: Anterior Wall Myocardial Infarction
Interventions: Biological: Plasma-Lyte A and 25% Autologous Plasma; Biological: Autologous EPCs; Biological: Autologous EPCs Transfected with human eNOS
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR)
Not yet recruiting - verified May 2012
The Effect of Locomotor Training on Children With Incomplete Spinal Cord Injuries

Condition: Spinal Cord Injuries
Intervention:
Sponsors: McGill University; McGill University; Rick Hansen Foundation; Shriners Hospitals for Children; Fondation pour la Recherche sur la Moelle Épinière (Spinal Cord Research Foundation)
Withdrawn - verified July 2011
Randomized Clinical Trial Comparing 4RIF vs. 9INH for LTBI Treatment-effectiveness

Condition: Latent Tuberculosis Infection
Interventions: Drug: Isoniazid; Drug: Rifampin
Sponsors: McGill University; McGill University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2011
Evaluation of the Influence of Statins and Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects

Condition: Coronary Artery Disease
Interventions: Drug: Rosuvastatin-omeprazole; Drug: Rosuvastatin-pantoprazole; Drug: Rosuvastatin-esomeprazole; Drug: Rosuvastatin-ranitidine; Drug: Atorvastatin-omeprazole; Drug: Atorvastatin-pantoprazole; Drug: Atorvastatin-esomeprazole; Drug: Atorvastatin-ranitidine
Sponsors: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec; Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Completed - verified February 2012
Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain

Conditions: Nausea and Vomiting; Pain; Sleep Disorders; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: methadone hydrochloride; Other: questionnaire administration; Procedure: management of therapy complications
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Terminated - verified July 2011
Experimental Control Investigation of the Impact of Assistive Technology on the User-caregiver Dyad: a Multi-site Trial

Condition: Mobility Limitations
Intervention: Device: Assistive technology updating and tune up intervention
Sponsors: Université de Montréal; Université de Montréal
Completed - verified November 2011
Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion

Condition: Actinic Keratosis
Interventions: Drug: Methylaminolevulinate (Metvix, Metvixia); Device: Photodynamic Therapy (Aktilite)
Sponsors: Innovaderm Research Inc.; Innovaderm Research Inc.; Galderma Canada
Completed - verified September 2011
Vitamin Deficiency and Blood Pressure in Hospitalized Jewish General Hospital (JGH) Patients

Conditions: Vitamin C Deficiency; Vitamin D Deficiency
Interventions: Dietary Supplement: Vitamin D; Dietary Supplement: Vitamin C
Sponsors: Jewish General Hospital; Jewish General Hospital
Completed - verified June 2011
Is it Possible to Screen for Type 2 Diabetes at Day 2 in Gestational Diabetes Mellitus Patients Postpartum?

Conditions: Gestational Diabetes Mellitus; Type 2 Diabetes
Intervention: Procedure: Oral glucose tolerance test
Sponsors: Universitaire de Sherbrooke; Universitaire de Sherbrooke
Recruiting - verified November 2011
TIPPS: Thrombophilia in Pregnancy Prophylaxis Study

Conditions: Pregnancy; Thrombophilia; Pregnancy Complications
Interventions: Drug: dalteparin sodium 5,000 IU prefilled syringes (antenatal); Drug: dalteparin sodium (after delivery - Control group)
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified July 2011
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer

Conditions: Breast Cancer; Invasive Breast Cancer
Intervention: Procedure: Sentinel Lymph Node Biopsy
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Fondation du cancer du sein du Québec
Recruiting - verified June 2011
The Effectiveness of Information and Relaxation on Pre-procedural Block Anxiety and Procedural Discomfort During Medial Branch Block

Condition: Chronic Pain
Intervention: Behavioral: Relaxation and information session
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified July 2011
Evaluating the Impact of a New Complement to Physiotherapy Intervention for Positional Torticollis in Infants

Condition: Torticollis
Intervention: Other: Booklet
Sponsors: McGill University Health Center; McGill University Health Center
Terminated - verified July 2011
High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG)

Condition: Coronary Artery Bypass Graft
Interventions: Procedure: Apnea; Procedure: High frequency ventilation
Sponsors: Montreal Heart Institute; Montreal Heart Institute
Recruiting - verified July 2011
Ursodiol for Treating Parenteral Nutrition Associated Cholestasis in Neonates

Condition: Cholestasis
Interventions: Drug: Ursodiol; Drug: placebo
Sponsors: St. Justine's Hospital; St. Justine's Hospital
Recruiting - verified July 2011
Study Comparing Two Vitamin D Supplements for Infants: Liquid Versus D-Strips

Condition: Healthy
Interventions: Dietary Supplement: Vitamin D, cholecalciferol; Dietary Supplement: Vitamin D, cholecalciferol
Sponsors: McGill University; McGill University
Completed - verified March 2012
A Comparison of Contrast Enhanced Ultrasound (CEUS) and Contrast Enhanced Computed Tomography (CT) or Magnetic Resonance Imaging (MRI) for Characterization of Focal Liver Masses

Condition: Liver Tumors
Intervention:
Sponsors: Foothills Medical Centre; Foothills Medical Centre; Vancouver General Hospital; London Health Sciences Centre; Centre Hospitalier de l'Université de Montréal
Recruiting - verified March 2012
Canadian Study of Prediction of Risk and Evolution to Dialysis, Death and Interim Cardiovascular Events Over Time

Condition: Chronic Kidney Disease
Intervention:
Sponsors: University of British Columbia; University of British Columbia
Active, not recruiting - verified November 2011
Radiation Therapy and Cisplatin or Panitumumab in Treating Patients With Locally Advanced Stage III or Stage IV Head and Neck Cancer

Condition: Head and Neck Cancer
Interventions: Biological: panitumumab; Drug: cisplatin; Radiation: 3-dimensional conformal radiation therapy; Radiation: accelerated radiation therapy; Radiation: intensity-modulated radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified November 2011
Reducing Injuries From Medication-Related Falls Using Computerized Alerts for High Risk Patients

Condition: Fall Related Injury Risk
Intervention: Device: CDS for psychotropic drug management
Sponsors: McGill University; McGill University; Canadian Patient Safety Institute
Recruiting - verified March 2012
Long-term Study, Comparing Vest Therapy to Positive Expiratory Pressure (PEP) Therapy in the Treatment of Cystic Fibrosis

Condition: Cystic Fibrosis
Interventions: Other: Positive Expiratory Pressure (PEP); Other: High Frequency Chest Wall Oscillation (HFCWO) using InCourage Vest System
Sponsors: University of British Columbia; University of British Columbia; Canadian Cystic Fibrosis Foundation
Active, not recruiting - verified April 2012
Drug Eluting Stent Registry of Thrombosis

Condition: Coronary Artery Disease
Intervention:
Sponsors: Medstar Research Institute; Medstar Research Institute
Active, not recruiting - verified April 2012
Parental Presence During Fracture Reduction in Children at the Emergency Department; A Randomized Controlled Trial

Conditions: Conscious Sedation; Anxiety
Interventions: Behavioral: Parental presence; Behavioral: Control
Sponsors: St. Justine's Hospital; St. Justine's Hospital; Association des Médecins d'Urgence du Quebec
Recruiting - verified August 2011
The Canadian Triage and Acuity Scale for Children; A Prospective Multi-Center Evaluation.

Conditions: Triage; Pediatrics
Intervention:
Sponsors: St. Justine's Hospital; St. Justine's Hospital; SickKids Foundation; Canadian Institutes of Health Research (CIHR)
Completed - verified July 2011
Bridge or Continue Coumadin for Device Surgery Randomized Controlled Trial

Condition: Hematoma
Interventions: Drug: low molecular weight heparin or unfractionated heparin; Drug: Warfarin or coumadin
Sponsors: University of Ottawa Heart Institute; University of Ottawa Heart Institute; Canadian Institutes of Health Research (CIHR)
Recruiting - verified July 2011
Cediranib, Paclitaxel, and Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: cediranib maleate; Drug: paclitaxel; Other: placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified March 2012
Efficacy of Probaclac in Irritable Bowel Syndrome in Children Aged 8 to 18 Years

Condition: Irritable Bowel Syndrome
Interventions: Other: Probaclac; Other: Placebo
Sponsors: St. Justine's Hospital; St. Justine's Hospital; Nicar Inc.
Recruiting - verified October 2011
Predicting Bleeding Risk on Anticoagulant Therapy for Venous Thromboembolism

Condition: Venous Thromboembolism
Intervention:
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Heart and Stroke Foundation of Ontario
Recruiting - verified June 2011
Effect of Fructose on Colonic Microflora

Condition: Healthy
Intervention: Dietary Supplement: Fructose powder
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Sir Mortimer B. Davis - Jewish General Hospital
Completed - verified February 2009
Ridaforolimus in Treating Patients With Recurrent Metastatic and/or Locally Advanced Endometrial Cancer

Condition: Endometrial Cancer
Interventions: Drug: ridaforolimus; Genetic: gene expression analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified September 2011
Impact of Emergency Department Probiotic Treatment of Diarrheal Illness on Daycare Attendance

Condition: Gastroenteritis
Interventions: Drug: Lacidophil (experimental high dose); Drug: Lacidophil (experimental standard dose); Drug: Placebo
Sponsors: The Hospital for Sick Children; The Hospital for Sick Children
Recruiting - verified May 2012
Letrozole in Treating Women With Primary Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor Therapy

Condition: Breast Cancer
Interventions: Drug: letrozole; Other: placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; Eastern Cooperative Oncology Group; North Central Cancer Treatment Group; Southwestern Oncology Group (SWOG); Cancer and Leukemia Group B
Active, not recruiting - verified May 2012
Improving the Pregnancy Rate With Endometrial Sampling Before Intrauterine Insemination

Conditions: Infertility; Clinical Pregnancy Rate
Intervention: Procedure: Endometrial sampling
Sponsors: McGill University Health Center; McGill University Health Center
Terminated - verified October 2009
Green Tea Intake for the Maintenance of Complete Remission in Women With Advanced Ovarian Carcinoma

Condition: Ovarian Carcinoma
Intervention: Dietary Supplement: Double-Brewed Green Tea
Sponsors: Centre hospitalier universitaire de Québec; Centre hospitalier universitaire de Québec; The Cancer Research Society
Active, not recruiting - verified February 2012
Influenza Vaccine Dose-Response in Infants and Toddlers: Immunogenicity and Reactogenicity

Condition: Influenza
Intervention: Biological: Inactivated Influenza Vaccine Trivalent Types A and B (Split Virion)
Sponsors: British Columbia Centre for Disease Control; British Columbia Centre for Disease Control
Completed - verified July 2011
Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial

Conditions: Acute Coronary Syndrome; Myocardial Infarction; Smoking
Interventions: Drug: Bupropion HCl ER; Drug: Placebo
Sponsors: McGill University; Mark Eisenberg; Canadian Institutes of Health Research (CIHR); Heart and Stroke Foundation of Quebec
Completed - verified May 2008
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol

Condition: Critical Illness
Interventions: Procedure: Protocolized Sedation; Procedure: Protocolized sedation, with daily interruption
Sponsors: Mount Sinai Hospital, Canada; Mount Sinai Hospital, Canada; Canadian Institutes of Health Research (CIHR); Ottawa Hospital Research Institute
Active, not recruiting - verified September 2011
Self-help Treatment for Insomnia in Breast Cancer Patients

Condition: Insomnia
Interventions: Behavioral: professionally administered cognitive-behavioral therapy; Behavioral: self-administered form of cognitive-behavioral therapy; Behavioral: placebo
Sponsors: Centre hospitalier universitaire de Québec; Centre hospitalier universitaire de Québec; Canadian Breast Cancer Research Alliance
Recruiting - verified August 2010
Minocycline in Clinically Isolated Syndromes (CIS) and Early Single Relapse Multiple Sclerosis (MS)

Conditions: Clinically Isolated Syndromes; Early Single Relapse of Multiple Sclerosis
Interventions: Drug: Apo-Minocycline; Drug: Placebo Comparator
Sponsors: University of Calgary; Dr. Luanne Metz; Multiple Sclerosis Society of Canada
Recruiting - verified March 2012
Cetuximab With or Without Brivanib in Treating Patients With K-Ras Wild Type Tumours and Metastatic Colorectal Cancer

Condition: Colorectal Cancer
Interventions: Biological: cetuximab; Drug: brivanib alaninate
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified May 2012
Canadian Oxygen Trial (COT)

Condition: Respiratory Insufficiency of Prematurity
Intervention: Other: Titration of oxygen therapy
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified March 2012
The Treatment of Carpal Tunnel Syndrome Using Thumb Pressure Along the Median Nerve

Condition: Carpal Tunnel Syndrome
Intervention: Procedure: Active Comparator, ischemic compressions
Sponsors: Guy Hains Chiropractor; Guy Hains Chiropractor
Completed - verified June 2011
The Treatment of the Median Nerve for the Elimination of the Symptoms Associated With the Carpal Tunnel Syndrome

Condition: Compression Neuropathy, Carpal Tunnel
Intervention: Procedure: Ischemic Compression (thumb Pressure)
Sponsors: Guy Hains Chiropractor; Guy Hains Chiropractor
Completed - verified June 2010
PRET: Patients Prone to Recurrence After Endovascular Treatment

Conditions: Intracranial Aneurysm; Subarachnoid Hemorrhage
Intervention: Procedure: endovascular coil embolization
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified January 2012
Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection

Conditions: Hepatic Insufficiency; Liver Failure
Interventions: Other: Preoperative glucose infusion; Other: Preoperative normal saline infusion
Sponsors: McGill University Health Center; McGill University Health Center
Recruiting - verified February 2012
Effect of Dietary Conjugated Linoleic Acid (CLA) on Parathyroid Hormone in Men

Condition: Healthy
Intervention: Dietary Supplement: Clarinol CLA
Sponsors: McGill University; McGill University
Completed - verified March 2012
Randomized Comparison of 2 Fixation Techniques for Unstable Intertrochanteric Hip Fractures

Condition: Hip Fractures
Intervention: Device: Dynamic Hip Screw (DHS); Trochanteric Fixation Nail (TFN)
Sponsors: McGill University Health Center; McGill University Health Center; Orthopaedic Trauma Association
Active, not recruiting - verified August 2011
Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression

Conditions: Bipolar Type II Disorder; Depression, Bipolar
Interventions: Device: Northern Light Technology (SADelite lamp) bright light-therapy; Device: Northern Light Technology (SADelite lamp) Dim light-therapy
Sponsors: Douglas Mental Health University Institute; Douglas Mental Health University Institute; National Alliance for Research on Schizophrenia and Depression
Recruiting - verified January 2012
Impact of Weight Loss Following Bariatric Surgery on Pulmonary Function in Patients With Morbid Obesity

Conditions: Bariatric Surgery; Obesity; Respiratory Diseases
Intervention:
Sponsors: Laval University; Laval University
Completed - verified February 2012
Obesity and Asthma:a Specific Phenotype

Conditions: Obesity; Asthma
Intervention:
Sponsors: Laval University; Laval University
Completed - verified February 2012
Characterisation of Asthma in Obese Subjects

Conditions: Asthma; Obesity
Intervention:
Sponsors: Laval University; Laval University
Completed - verified February 2012
Comparison of Three Fixation Techniques for Displaced Distal Radius Fractures

Condition: Distal Radius Fractures
Interventions: Procedure: Open Reduction and Internal Fixation; Procedure: Non-Spanning External Fixation; Procedure: Closed Reduction with Percutaneous Fixation
Sponsors: McGill University Health Center; McGill University Health Center; Orthopaedic Trauma Association
Recruiting - verified August 2011
Sorafenib and Low Dose Cytarabine in Treating Older Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Conditions: Leukemia; Myelodysplastic Syndromes
Intervention: Drug: cytarabine
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified September 2011
Interleukin-21 in Treating Patients With Metastatic or Recurrent Malignant Melanoma

Condition: Melanoma (Skin)
Interventions: Biological: recombinant human interleukin-21; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified May 2012
Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Genetic: DNA methylation analysis; Procedure: quality-of-life assessment; Radiation: Radiation
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; European Organization for Research and Treatment of Cancer - EORTC; Trans-Tasman Radiation Oncology Group (TROG)
Recruiting - verified March 2012
Clinical and Pharmacogenetic Study of Attention Deficit With Hyperactivity Disorder (ADHD)

Condition: Attention Deficit Hyperactivity Disorder
Interventions: Drug: Ritalin; Drug: Placebo
Sponsors: McGill University; McGill University
Recruiting - verified February 2012
ALL Adult Consortium Trial: Adult ALL Trial

Condition: Acute Lymphoblastic Leukemia
Interventions: Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Vincristine; Drug: Cyclophosphamide; Drug: Methylprednisone; Drug: Hydrocortisone Sodium Succinate; Drug: Dexamethasone; Drug: 6-MP; Drug: PEG-Asparaginase; Drug: Imatinib; Drug: Etoposide; Procedure: Radiation Therapy; Drug: E. coli Asparaginase
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Massachusetts General Hospital; Children's Hospital Boston
Recruiting - verified August 2011
Inflammatory Breast Cancer (IBC) Registry

Condition: Breast Cancer
Interventions: Other: Interview; Procedure: Blood and Tissue Collection
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified February 2012
Coronary Artery Bypass Surgery (CABG) Off or On Pump Revascularization Study

Condition: the Efficacy and Safety of Off-pump CABG
Interventions: Procedure: Coronary Artery Bypass Graft with the use of CPB; Procedure: Coronary Artery Bypass Graft without the use of CPB
Sponsors: Population Health Research Institute; Population Health Research Institute; McMaster University; University of Oxford; Instituto Dante Pazzanese de Cardiologia; ECLA Clinical Research Organization,; Fu Wai Hospital, Beijing, China; Facultad de Medicina, Universidad de La Frontera, Temuco, Chile; Fundación Cardiovascular de Colombia; Charles University, Czech Republic; Hopital Jean Minjoz; Centre for Chronic Disease Control, India; S. C. di Cardiochirurgia, Ospedale Santa Croce a Carle, Cuneo, Italy; Medical University of Gdansk; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Ankara University; Hotel Dieu Hospital; Centre hospitalier de l'Université de Montréal (CHUM); SAL Hospital, Ahmedabad, India
Recruiting - verified July 2011
Caffeine for Excessive Daytime Somnolence in Parkinson's Disease

Conditions: Parkinson's Disease; Excessive Daytime Somnolence
Interventions: Drug: Caffeine 100-200 mg BID; Drug: placebo
Sponsors: McGill University Health Center; McGill University Health Center; Canadian Institutes of Health Research (CIHR); University of Toronto
Completed - verified July 2011
Effect of Azithromycin on Lung Function in 6-18 Year-olds With Cystic Fibrosis (CF) Who Are Not Infected With P. Aeruginosa

Condition: Cystic Fibrosis
Interventions: Drug: azithromycin 250 mg tablets; Drug: placebo tablets
Sponsors: CF Therapeutics Development Network Coordinating Center; CF Therapeutics Development Network Coordinating Center; Cystic Fibrosis Foundation
Completed - verified February 2012
Bortezomib, Combination Chemotherapy, and Rituximab as First-Line Therapy in Treating Patients With Stage III or Stage IV Follicular Non-Hodgkin's Lymphoma

Condition: Lymphoma
Interventions: Biological: rituximab; Drug: bortezomib; Drug: cyclophosphamide; Drug: prednisone; Drug: vincristine sulfate
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified January 2012
Multicenter Study of Antiarrhythmic Medications for Treatment of Infants With Supraventricular Tachycardia

Condition: Supraventricular Tachycardia in Infants
Intervention: Drug: digoxin and propranolol
Sponsors: University of British Columbia; University of British Columbia; The Hospital for Sick Children; University of Utah
Completed - verified October 2011
Temozolomide and Everolimus in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Malignant Glioblastoma Multiforme

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: everolimus; Drug: temozolomide; Genetic: microarray analysis; Other: immunohistochemistry staining method
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified January 2012
Vitamin D Dose-Response Study to Establish Dietary Requirements in Infants

Condition: Vitamin D Deficiency
Interventions: Drug: Vitamin D; Drug: Vitamin D; Drug: Vitamin D
Sponsors: McGill University; McGill University
Completed - verified March 2012
Bortezomib and Gemcitabine in Treating Patients With Relapsed Mantle Cell Lymphoma

Condition: Lymphoma
Interventions: Drug: bortezomib; Drug: gemcitabine hydrochloride
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified June 2011
AEG35156 and Docetaxel in Treating Patients With Locally Advanced, Metastatic, or Recurrent Solid Tumors

Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: AEG35156; Drug: docetaxel; Genetic: protein expression analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: flow cytometry; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified January 2012
AEG35156 and Docetaxel in Treating Patients With Solid Tumors

Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: AEG35156; Drug: docetaxel
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
BCG With or Without Gefitinib in Treating Patients With High-Risk Bladder Cancer

Condition: Bladder Cancer
Interventions: Biological: BCG vaccine; Drug: gefitinib; Procedure: quality-of-life assessment
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified January 2012
Radiation Therapy in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

Condition: Lung Cancer
Intervention: Radiation: 3-dimensional conformal radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified September 2011
PROFIT - Prostate Fractionated Irradiation Trial

Condition: Prostate Cancer
Interventions: Procedure: 7800 cGy/39 fractions in 8 weeks; Procedure: 6000 cGy/20 fractions in 4 weeks
Sponsors: Ontario Clinical Oncology Group (OCOG); Ontario Clinical Oncology Group (OCOG); Canadian Institutes of Health Research (CIHR); Trans-Tasman Radiation Oncology Group (TROG)
Active, not recruiting - verified October 2011
Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia

Conditions: Leukemia; Lymphoma
Interventions: Biological: alemtuzumab; Biological: anti-thymocyte globulin; Biological: filgrastim; Biological: rituximab; Biological: therapeutic allogeneic lymphocytes; Drug: busulfan; Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: methotrexate; Drug: mycophenolate mofetil; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); German CLL Study Group
Active, not recruiting - verified April 2007
RAPID: Randomized Trial of Accelerated Partial Breast Irradiation

Condition: Breast Cancer
Interventions: Radiation: 3D-CRT APBI; Radiation: WBI
Sponsors: Ontario Clinical Oncology Group (OCOG); Ontario Clinical Oncology Group (OCOG); Canadian Institutes of Health Research (CIHR); Canadian Breast Cancer Research Alliance
Active, not recruiting - verified July 2011
Comparison of Tendon Transfer, Botox Injections and Ongoing Treatment in Hemiplegic Cerebral Palsy

Condition: Cerebral Palsy
Interventions: Procedure: Upper Extremity Tendon transfer; Procedure: Botulinum Toxin injections in Upper Extremity; Procedure: Regularly ongoing therapy
Sponsors: Shriners Hospitals for Children; Shriners Hospitals for Children
Recruiting - verified January 2012
Letrozole in Preventing Breast Cancer in Postmenopausal Women Who Are at Increased Risk for Breast Cancer Due to High Breast Density

Condition: Breast Cancer
Interventions: Drug: letrozole; Other: Placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients.

Condition: Hypertension
Interventions: Drug: Candesartan Thiazide; Drug: Atenolol Thiazide; Drug: Thiazide Candesartan
Sponsors: Institut de Recherches Cliniques de Montreal; Institut de Recherches Cliniques de Montreal; Ottawa Hospital Research Institute
Completed - verified September 2005
Radiation Therapy or Temozolomide in Treating Patients With Gliomas

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group; British Medical Research Council; Trans-Tasman Radiation Oncology Group (TROG)
Active, not recruiting - verified February 2012
Caffeine for Apnea of Prematurity (CAP)

Condition: Apnea of Prematurity
Intervention: Drug: Caffeine citrate injection
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR); National Health and Medical Research Council, Australia
Active, not recruiting - verified March 2012
Computer-Based Decision Support in Managing Asthma in Primary Care

Condition: Asthma
Intervention: Device: computer-based decision support for asthma management
Sponsors: McGill University; McGill University; Canadian Institutes of Health Research (CIHR)
Completed - verified July 2011
Efficacy and Safety of Ivabradine on Top of Atenolol in Stable Angina Pectoris

Condition: Angina Pectoris
Intervention: Drug: Ivabradine
Sponsors: Servier; Institut De Recherche International Servier
Completed - verified June 2011
Randomized Clinical Trial of 4RIF vs. 9INH for the Treatment of Latent TB - Safety

Condition: Latent Tuberculosis Infection
Intervention: Drug: Isoniazide (drug), Rifampin (drug)
Sponsors: McGill University; McGill University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified June 2011
Predicting Complications in Women With Toxaemia

Condition: Toxemia
Intervention: Behavioral: preeclampsia
Sponsors: University of British Columbia; University of British Columbia
Recruiting - verified March 2012
Multicentre Radial Artery Patency Study: 5 Year Results

Condition: Coronary Artery Disease
Intervention: Procedure: Radial Artery and Saphenous Vein Grafts Randomized to either right coronary or left circumflex coronary artery territories
Sponsors: Sunnybrook Health Sciences Centre; Sunnybrook Health Sciences Centre; Canadian Institutes of Health Research (CIHR)
Completed - verified November 2011
NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction

Condition: Opiate Addiction
Interventions: Drug: Methadone; Drug: Diamorphine hydrochloride
Sponsors: University of British Columbia; University of British Columbia; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified October 2011
Selective D-Dimer Testing Compared With Uniform D-Dimer Testing in the Diagnosis of Deep Vein Thrombosis (SELECT)

Condition: Deep Vein Thrombosis
Interventions: Procedure: D-dimer testing; Procedure: D-dimer testing
Sponsors: McMaster University; McMaster University; Heart and Stroke Foundation of Ontario
Completed - verified October 2011
MDA D-Dimer / Recurrent DVT Study

Condition: Deep Vein Thrombosis
Intervention: Procedure: various diagnostic measures for DVT (e.g., CUS)
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR)
Completed - verified October 2007
Oral Vitamin K for Warfarin Associated Coagulopathy

Conditions: Coagulation; Bleeding; Thrombosis
Intervention: Drug: Phytonadione (Vitamin K1)
Sponsors: St. Joseph's Healthcare Hamilton; St. Joseph's Healthcare Hamilton; McMaster University
Completed - verified July 2011
Clinical Trial for the Prevention of Vasovagal Syncope

Condition: Syncope, Vasovagal, Neurally-Mediated
Intervention: Drug: fludrocortisone acetate
Sponsors: University of Calgary; University of Calgary; Canadian Institutes of Health Research (CIHR)
Completed - verified April 2012
Combination Chemotherapy and Cyclosporine Followed By Cryotherapy and/or Laser Therapy in Treating Patients With Newly Diagnosed Retinoblastoma in Both Eyes

Condition: Retinoblastoma
Interventions: Biological: filgrastim; Drug: carboplatin; Drug: cyclosporine; Drug: etoposide; Drug: vincristine sulfate; Procedure: cryosurgery; Procedure: laser therapy; Procedure: neoadjuvant therapy
Sponsors: National Cancer Institute (NCI); The Hospital for Sick Children
Recruiting - verified April 2009
Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Condition: Breast Cancer
Intervention: Drug: exemestane
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; Grupo Espanol de Investigacion del Cancer de Mama; UNICANCER
Active, not recruiting - verified August 2011
Comparison of Two Salvage Chemotherapy Regimens Before Autologous Stem Cell Transplantation With or Without Maintenance Rituximab in Treating Patients With Relapsed or Refractory Aggressive Non-Hodgkin's Lymphoma

Condition: Lymphoma
Interventions: Biological: rituximab; Drug: cisplatin; Drug: cytarabine; Drug: dexamethasone; Drug: gemcitabine hydrochloride; Other: clinical observation
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Recruiting - verified May 2012
Exemestane in Reducing Breast Density in Postmenopausal Women at Risk for Breast Cancer

Condition: Breast Cancer
Interventions: Drug: exemestane; Drug: Placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Epirubicin, Docetaxel, and Pegfilgrastim in Treating Women With Locally Advanced or Inflammatory Breast Cancer

Condition: Breast Cancer
Interventions: Biological: pegfilgrastim; Drug: docetaxel; Drug: epirubicin hydrochloride
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified September 2011
Combination Chemotherapy With or Without Rituximab in Treating Patients With Non-Hodgkin's Lymphoma

Condition: Lymphoma
Interventions: Biological: rituximab; Drug: CHOP regimen
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified May 2012
Comparison of Combination Chemotherapy Regimens in Treating Newly Diagnosed Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

Conditions: Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Drug: paclitaxel; Drug: topotecan hydrochloride
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified August 2011
Gemcitabine With or Without Erlotinib in Treating Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer

Condition: Pancreatic Cancer
Interventions: Drug: erlotinib hydrochloride; Drug: gemcitabine hydrochloride
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Combination Chemotherapy With or Without Colony-stimulating Factors in Treating Women With Breast Cancer

Condition: Breast Cancer
Interventions: Biological: epoetin alfa; Biological: filgrastim; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Drug: fluorouracil; Drug: paclitaxel
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; North Central Cancer Treatment Group; Southwest Oncology Group
Active, not recruiting - verified May 2012
Thalidomide and Prednisone Following Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma

Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: prednisone; Drug: thalidomide
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Carboplatin With or Without Gemcitabine in Treating Patients With Advanced Ovarian Epithelial Cancer That Has Not Responded to Previous Chemotherapy

Condition: Ovarian Cancer
Interventions: Drug: carboplatin; Drug: gemcitabine hydrochloride
Sponsors: National Cancer Institute (NCI); AGO Study Group; European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group
Active, not recruiting - verified June 2011
Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group
Active, not recruiting - verified September 2011
Flavopiridol in Treating Patients With Recurrent, Locally Advanced, or Metastatic Soft Tissue Sarcoma

Condition: Sarcoma
Intervention: Drug: alvocidib
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Radiation Therapy or Observation Only in Treating Patients With Endometrial Cancer Who Have Undergone Surgery

Condition: Endometrial Cancer
Intervention: Radiation: radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified April 2012
Combination Chemotherapy in Treating Patients With Multiple Myeloma

Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: dexamethasone; Drug: melphalan; Drug: prednisone
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
ISIS 5132 in Treating Patients With Metastatic or Recurrent Ovarian Cancer

Condition: Ovarian Cancer
Intervention: Drug: ISIS 5132
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Tamoxifen With or Without Octreotide in Treating Postmenopausal Women With Stage I, Stage II, or Stage III Breast Cancer

Condition: Breast Cancer
Interventions: Drug: octreotide acetate; Drug: tamoxifen citrate
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
Chemotherapy Plus Surgery in Treating Patients With Stage III or Stage IV Ovarian, Peritoneal, or Fallopian Tube Cancer

Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified March 2012
Marimastat Following Chemotherapy in Treating Patients With Small Cell Lung Cancer

Condition: Lung Cancer
Interventions: Drug: marimastat; Drug: Placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified January 2012
Radiation Therapy and Chemotherapy in Treating Patients With Hodgkin's Disease

Condition: Hodgkin Lymphoma
Interventions: Biological: bleomycin sulfate; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: vinblastine; Radiation: radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; Eastern Cooperative Oncology Group
Completed - verified January 2012
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer

Condition: Colorectal Cancer
Interventions: Drug: FOLFOX regimen; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified August 2011