- Condition: Obstructive Sleep Apnoea
Intervention:
Sponsors: Abertawe Bro Morgannwg University NHS Trust; National Institute for Health Research, United Kingdom; Hywel Dda NHS Trust; Swansea University
Recruiting - verified February 2012 - Condition: Stroke
Interventions: Drug: Alteplase; Drug: Placebo
Sponsor: Universitätsklinikum Hamburg-Eppendorf
Not yet recruiting - verified January 2012 - Conditions: Colorectal Cancer; Colorectal Liver Metastasis; Liver Surgery; Exercise Intervention
Intervention: Behavioral: Exercise Intervention
Sponsor: Aintree University Hospitals NHS Foundation Trust
Recruiting - verified January 2012 - Conditions: Anxiety; COPD
Intervention: Drug: escitalopram
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Not yet recruiting - verified January 2012 - Condition: Allergic Rhinitis
Intervention: Biological: Allergovit grass or birch
Sponsor: Royal Sussex County Hospital
Not yet recruiting - verified February 2012 - Conditions: Acute Leukaemia; Chronic Leukaemia; Myeloma; Lymphoma
Intervention: Radiation: Targeted radiotherapy
Sponsors: Southampton University Hospitals NHS Trust; Royal Free and University College Medical School
Recruiting - verified January 2012 - Condition: Acute ST Elevation Myocardial Infarction
Interventions: Drug: unfractionated heparin; Drug: Bivalirudin
Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust
Not yet recruiting - verified January 2012 - Condition: Total Knee Replacement
Intervention:
Sponsors: NHS Fife; De Puy International
Completed - verified January 2012 - Condition: Chronic Obstructive Pulmonary Disease
Intervention: Device: Telehealth monitoring system (Honni Med)
Sponsor: South Eastern Health and Social Care Trust
Completed - verified January 2012 - Condition: Tracheal Intubation
Intervention: Device: Laryngoscopy
Sponsor: NHS Tayside
Not yet recruiting - verified January 2012 - Condition: Obesity
Intervention: Device: FreeStyle Navigator
Sponsors: University of Leicester; University Hospitals, Leicester; Royal College of Surgeons
Not yet recruiting - verified January 2012 - Condition: Cough
Intervention:
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Not yet recruiting - verified January 2012 - Condition: Total Knee Replacement
Intervention:
Sponsors: NHS Fife; De Puy International
Completed - verified January 2012 - Condition: Mood
Interventions: Dietary Supplement: 5-Hydroxytryptophan; Dietary Supplement: Pharmaceutical grade silica
Sponsor: Northumbria University
Completed - verified January 2012 - Condition: Infantile Colic
Intervention: Procedure: Manual therapy
Sponsor: Professor Jennifer Bolton
Completed - verified January 2012 - Condition: In-plane Ultrasound Guided Needling Training
Intervention:
Sponsor: University of Aberdeen
Not yet recruiting - verified January 2012 - Conditions: Gastrointestinal Ulcer Haemorrhage; Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions: Drug: Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg; Drug: Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; University of Southampton; University of Durham; University of Birmingham; University of Oxford
Not yet recruiting - verified January 2012 - Conditions: Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Bronchitis, Chronic; Pulmonary Emphysema; Disease Progression
Intervention:
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council; The Hillingdon Hospitals NHS Foundation Trust; West Hertfordshire Hospitals NHS Trust
Recruiting - verified January 2012 - Conditions: Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive; Pulmonary Emphysema; Bronchitis, Chronic; Lung Diseases; Disease Progression
Intervention:
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council
Recruiting - verified January 2012 - Condition: HIV Related Neurocognitive Impairment
Intervention:
Sponsor: St Stephens Aids Trust
Recruiting - verified January 2012 - Condition: Type 2 Diabetes,
Intervention: Other: No intervention, observational study
Sponsors: Royal Devon and Exeter NHS Foundation Trust; National Institute for Health Research, United Kingdom; University of Exeter
Recruiting - verified December 2011 - Condition: Gastro-oesophageal Reflux Disease
Intervention:
Sponsor: Imperial College London
Not yet recruiting - verified January 2012 - Condition: Cerebral Vasculature
Intervention: Other: cocoa
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified January 2012 - Conditions: Obesity Related Glomerulopathy; Impaired Renal Function; Bariatric Surgery
Intervention:
Sponsor: Imperial College London
Recruiting - verified January 2012 - Condition: Paroxysmal Atrial Fibrillation
Interventions: Device: ILR insertion; Procedure: AF ablation
Sponsor: Neil Sulke
Not yet recruiting - verified January 2012 - Condition: Atrial Fibrillation
Interventions: Device: Implantation of implantable loop recorder; Procedure: Percutaneous ablation of atrial fibrillation; Procedure: Surgical ablation of atrial fibrillation
Sponsor: Eastbourne General Hospital
Not yet recruiting - verified December 2011 - Condition: Critical Illness
Interventions: Drug: Valaciclovir/Aciclovir; Drug: Valganciclovir/Ganciclovir
Sponsors: University Hospital Birmingham NHS Foundation Trust; National Institute for Health Research, United Kingdom
Not yet recruiting - verified January 2012 - Condition: Alcoholism
Interventions: Other: Training and support (T&S); Other: Financial incentive; Other: E-SBI (online screening and brief intervention)
Sponsors: Fundacion Clinic per a la Recerca Biomédica; European Commission; Stichting Katholieke Universiteit; University of Newcastle Upon-Tyne; King's College London; Goeteborgs Universitet; Linkoeping University; Departament de Salut de la Generalitat de Catalunya; Panstwowa Agencja Rozwiazywania Problemow Alkoholowych; University College, London; Maastricht University; Pomorski Uniwersytet Medyczny w Szczecinie
Enrolling by invitation - verified December 2011 - Condition: Obesity
Interventions: Drug: Y242; Drug: 0.9% saline
Sponsors: Imperial College London; Medical Research Council
Not yet recruiting - verified January 2012 - Conditions: Left Ventricular Function Systolic Dysfunction; Left Ventricular Function Diastolic Dysfunction; Ageing
Intervention: Drug: Ramipril
Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
Not yet recruiting - verified January 2012 - Condition: Respiratory Insufficiency
Interventions: Drug: Heliox21; Drug: Air O2
Sponsor: University College, London
Not yet recruiting - verified December 2011 - Condition: Age Related Macular Degeneration (ARMD)
Interventions: Behavioral: Supervised Reading; Behavioral: EVT at the PRL; Behavioral: EVT at the TRL
Sponsors: Moorfields Eye Hospital NHS Foundation Trust; British Eye Research Foundation, operating as Fight for Sight
Recruiting - verified December 2011 - Condition: Multiple Myeloma
Intervention: Drug: Bortezomib
Sponsor: University College, London
Recruiting - verified January 2012 - Condition: Tuberculosis
Interventions: Biological: Aerosol inhaled MVA85A; Biological: Intradermal MVA85A
Sponsor: University of Oxford
Recruiting - verified January 2012 - Conditions: Autism Spectrum Disorders; Specifically Classic or Core Autism
Intervention: Behavioral: Click-East app
Sponsors: University of Edinburgh; NHS Lothian; Newcastle University
Not yet recruiting - verified November 2011 - Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.Conditions: Cancer; Pain
Interventions: Other: analgesic ladder; Other: analgesic ladder
Sponsors: University of Edinburgh; NHS Lothian
Not yet recruiting - verified November 2011 - Condition: Hypercholesterolemia
Intervention: Dietary Supplement: beetroot juice
Sponsors: Queen Mary University of London; British Heart Foundation
Recruiting - verified December 2011 - Condition: Depression
Intervention: Behavioral: SilverCloud Platform
Sponsors: University of Cambridge; Cambridgeshire and Peterborough Foundation Trust, United Kingdom; National Institute for Health Research, United Kingdom
Not yet recruiting - verified December 2011 - Condition: CD19 Positive Non-Hodgkin Lymphoma
Intervention: Genetic: aCD19z cells, IL2, pre conditioning Cyclophosphamide & Fludarabine
Sponsor: Christie Hospital NHS Foundation Trust
Suspended - verified June 2009 - Conditions: Overweight; Obesity
Intervention: Behavioral: online lifestyle counseling and a fortified diet beverage
Sponsors: Baylor College of Medicine; The Beverage Institute.; Temple University; MRC Human Nutrition Research, Cambridge, UK.; National Development and Research Institutes, Inc.
Completed - verified December 2011 - Conditions: Varicose Veins; Pain
Interventions: Other: Dedicated Nurse; Other: Music; Device: Transcutaneous electrical nerve stimulation; Behavioral: Massage and interaction
Sponsor: University of Surrey
Not yet recruiting - verified January 2012 - Condition: Target Controlled Infusion of Propofol
Interventions: Drug: Propofol; Drug: Propofol
Sponsor: Golden Jubilee National Hospital
Recruiting - verified December 2011 - Condition: Osteoarthritis
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Active, not recruiting - verified December 2011 - Conditions: Colonic Cancer; Metastasis
Interventions: Drug: Oral complex C3 curcumin + chemotherapy; Drug: Chemotherapy only
Sponsor: University of Leicester
Not yet recruiting - verified December 2011 - Condition: Congenital Uterine Anomalies
Intervention:
Sponsor: University of Nottingham
Not yet recruiting - verified December 2011 - Condition: Preterm Birth
Intervention:
Sponsor: University of Oxford
Recruiting - verified December 2011 - Condition: Maltreated Infants.
Interventions: Behavioral: GIFT; Behavioral: FACS
Sponsor: University of Glasgow
Not yet recruiting - verified December 2011 - Condition: Obesity Hypoventilation Syndrome
Intervention: Behavioral: Rehabilitation
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Critically Ill
Intervention:
Sponsors: Cardiff and Vale University Health Board; Cardiff University
Not yet recruiting - verified November 2011 - Condition: Intermittent Claudication
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Hallam University; University Hospital, Angers; Imperial College London
Recruiting - verified November 2011 - Condition: Syncope
Interventions: Device: Pacemaker implantation (Medtronic); Device: Pacemaker implantation (Medtronic); Device: Implantable Loop Recorder (Medtronic)
Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
Not yet recruiting - verified November 2011 - Condition: Obstructive Sleep Apnea
Intervention:
Sponsor: Bangor University
Not yet recruiting - verified November 2011 - Conditions: Pain; Hyperalgesia; Chronic Illness; Neuropathic Pain
Interventions: Drug: Pregabalin; Drug: Ketamine infusion; Drug: Placebo capsules; Drug: Placebo infusion
Sponsor: Barts & The London NHS Trust
Recruiting - verified December 2011 - Condition: Dementia
Interventions: Behavioral: The Talking Sense manual; Behavioral: Treatment as usual - communication information and advice
Sponsors: University of Portsmouth; Solent NHS Primary Care Trust; The Sir Halley Stewart Trust
Not yet recruiting - verified November 2011 - Conditions: Absorption and Metabolism; Effect on Vascular Function; Effect on Cytokine Concentrations
Intervention: Dietary Supplement: Olive leaf extract capsules
Sponsors: University of Reading; Comvita UK
Completed - verified November 2011 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: SFA diet; Dietary Supplement: MUFA diet; Dietary Supplement: n-6 PUFA diet
Sponsor: University of Reading
Recruiting - verified November 2011 - Condition: Vitiligo
Intervention: Device: 311 nm NB-UVB light
Sponsor: University of Nottingham
Not yet recruiting - verified January 2012 - Condition: Acute Bronchiolitis
Intervention: Device: 3% hypertonic saline
Sponsors: Sheffield Children's NHS Foundation Trust; University of Sheffield
Recruiting - verified October 2011 - Conditions: Ovarian Cancer; Peritoneal Metastases
Intervention:
Sponsors: Institute of Cancer Research, United Kingdom; Cancer Research UK; Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Imperial College Healthcare NHS Trust; Northumbria Healthcare NHS Foundation Trust
Not yet recruiting - verified January 2012 - Condition: Healthy Schoolchildren
Intervention: Other: None - observational study
Sponsor: University of Manchester
Active, not recruiting - verified November 2011 - Condition: Gout
Interventions: Other: Nurse intervention; Other: Standard care
Sponsors: University of Nottingham; Arthritis Research UK (funder)
Not yet recruiting - verified November 2011 - Conditions: Type 2 Diabetes; Anxiety; Depression
Intervention: Behavioral: CBT-based Guided Self-Help
Sponsor: University of Edinburgh
Not yet recruiting - verified November 2011 - Condition: Stroke
Interventions: Drug: Tenecteplase; Drug: alteplase
Sponsors: NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified November 2011 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified December 2011 - Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk FactorsCondition: Obesity
Intervention: Behavioral: Web-based program
Sponsors: Queen's University, Belfast; AXA PPP Healthcare
Recruiting - verified November 2011 - Condition: Multiple Sclerosis, Relapsing-Remitting
Interventions: Biological: Hookworm larvae; Biological: Placebo
Sponsors: University of Nottingham; National Multiple Sclerosis Society
Not yet recruiting - verified November 2011 - Condition: Attention Deficit Hyperactivity Disorder (ADHD)
Intervention:
Sponsors: NHS Tayside; Zentralinstitut fuer Seelische Gesundheit; Universita degli Studi di Cagliari; Vadaskert Child and Adolescent Psychiatry Clinic
Not yet recruiting - verified November 2011 - Conditions: Mediastinal Lymphadenopathy; Hilar Lymphadenopathy; Carcinoma; Lymphoma; Sarcoidosis; Mycobacterial Disease
Intervention: Device: Endobronchial ultrasound guided lymph node sampling
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Chelsea and Westminster NHS Foundation Trust; University of Heidelberg
Recruiting - verified November 2011 - Condition: Depression
Interventions: Other: Google Adwords; Other: Local organisation websites
Sponsors: University of Plymouth; University of Glasgow
Recruiting - verified November 2011 - Conditions: Esophageal Atresia With Tracheo-esophageal Fistula; Congenital Diaphragmatic Hernia
Interventions: Procedure: Hypercapnia during thoracoscopy; Procedure: Open surgery
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified November 2011 - Condition: Hepatitis C
Intervention: Drug: Sildenafil and Boceprevir
Sponsor: Imperial College London
Not yet recruiting - verified December 2011 - Condition: HIV
Intervention:
Sponsor: St Stephens Aids Trust
Recruiting - verified January 2012 - Condition: HIV Infection
Interventions: Drug: 1 Solvazinc tablet, day 2 to day 15; Drug: 1 Solvazinc tablet, day 15 to day 28
Sponsor: St Stephens Aids Trust
Recruiting - verified January 2012 - Condition: Breast Cancer
Interventions: Procedure: Both Superficial Inferior Artery and Vein Clamped; Procedure: Superficial Inferior Epigastric Vessels both unclamped; Procedure: SIE Artery Unclamped, Vein Clamped; Procedure: SIE Artery clamped, Vein unclamped
Sponsors: NHS Greater Glasgow and Clyde; Canniesburn Research Trust
Not yet recruiting - verified November 2011 - Condition: Choroideremia
Intervention: Drug: rAAV2.REP1
Sponsors: University of Oxford; Oxford University Hospitals NHS Trust; Moorfields Eye Hospital NHS Foundation Trust; University College, London; Central Manchester University Hospitals NHS Foundation Trust; University of Manchester; Southampton University Hospitals NHS Trust; University of Southampton
Recruiting - verified October 2011 - Conditions: Pulmonary Arterial Hypertension; Heart Failure
Interventions: Drug: Apelin; Drug: Saline (Placebo); Drug: Saline (Placebo); Drug: Apelin
Sponsors: Golden Jubilee National Hospital; NHS Lothian; Imperial College Healthcare NHS Trust
Not yet recruiting - verified October 2011 - Conditions: Malaria; Plasmodium Falciparum
Interventions: Biological: Plasmodium falciparum sporozoites; Biological: Plasmodium falciparum sporozoites; Biological: Plasmodium falciparum sporozoites
Sponsors: University of Oxford; Sanaria Inc (IND Sponsor)
Active, not recruiting - verified December 2011 - Condition: Type 1 Diabetes
Interventions: Drug: Diazoxide; Drug: Placebo
Sponsors: University of Dundee; Juvenile Diabetes Research Foundation
Not yet recruiting - verified December 2011 - Condition: Hirsutism
Interventions: Device: Intense Pulsed Light (IPL); Device: Alexandrite Laser
Sponsor: NHS Greater Glasgow and Clyde
Not yet recruiting - verified October 2011 - Condition: Coronary Artery Disease
Interventions: Other: CT coronary angiography; Other: Standard of Care
Sponsors: AJAY YERRAMASU; Wellington Hospital, London, UK; Barnet Hospital, Wellhouse Lane, Barnet, EN5 3DJ, UK; Chase Farm Hospital, The Ridgeway, Enfield, EN2 8JL, UK; Royal Free Hospital, Pond Street, London, NW3 2QG, UK
Recruiting - verified October 2011 - Condition: Healthy
Interventions: Dietary Supplement: Glucose; Dietary Supplement: Fructose; Dietary Supplement: Fructan; Dietary Supplement: Fructose and glucose
Sponsor: University of Nottingham
Active, not recruiting - verified November 2011 - Condition: Influenza
Interventions: Biological: MVA-NP+M1 and seasonal Influenza vaccine; Biological: Saline placebo and seasonal influenza vaccine
Sponsor: University of Oxford
Recruiting - verified November 2011 - Condition: Antibody Persistance After Booster Dose of Men C Vaccine
Intervention: Other: Venepuncture and blood sample collection.
Sponsor: University of Oxford
Not yet recruiting - verified October 2011 - Conditions: Respiratory Rate; Pulse Oximetry
Interventions: Other: Recording of 12 lead ECG; Other: Recording of lying and standing blood pressure; Other: Recording of chest wall movement; Other: Recording of heart rate variability; Other: Recording of ECG and Pulse oximeter waveform at rest; Other: Recording of ECG and Pulse oximeter waveform during exercise
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Engineering and physical sciences research council; University of Oxford
Not yet recruiting - verified November 2011 - Condition: Lymphoma, Hodgkin
Intervention:
Sponsor: University College, London
Recruiting - verified July 2011 - Condition: Melanoma
Intervention: Procedure: Surgical Excision Margin
Sponsors: Norfolk and Norwich University Hospitals NHS Foundation Trust; Australia & New Zealand Melanoma Trials Group
Not yet recruiting - verified October 2011 - Conditions: Hip Fractures; Anesthesia
Intervention:
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; Brighton and Sussex University Hospitals NHS Trust
Not yet recruiting - verified November 2011 - Conditions: Burns; Smoke Inhalation Injury
Interventions: Behavioral: Injury Prevention Briefing Plus facilitation; Behavioral: Injury Prevention Briefing
Sponsor: University of Nottingham
Recruiting - verified October 2011 - Condition: Chronic Lymphocytic Leukemia
Intervention: Drug: Lenalidomide & Dexamethasone
Sponsor: University College, London
Not yet recruiting - verified October 2011 - Condition: Polycystic Ovary Syndrome
Intervention: Behavioral: Structured Lifestyle Education
Sponsors: University of Leicester; Society for Endocrinology
Recruiting - verified October 2011 - Condition: Chronic Stable Angina
Interventions: Drug: Allopurinol; Drug: Allopurinol; Drug: Placebo
Sponsors: Stephen McSwiggan; British Heart Foundation
Not yet recruiting - verified November 2011 - Conditions: Optic Neuritis; Multiple Sclerosis
Interventions: Drug: Phenytoin; Drug: Placebo
Sponsors: University College, London; National Multiple Sclerosis Society; Multiple Sclerosis Society of Great Britain and Northern Ireland
Not yet recruiting - verified October 2011 - Condition: Metastatic Clear Cell Renal Cancer
Intervention:
Sponsor: Queen Mary University of London
Recruiting - verified January 2012 - Conditions: Alzheimer's Disease; Schizophrenia
Interventions: Drug: amisulpride; Drug: amisulpride; Drug: amisulpride
Sponsor: Institute of Psychiatry, London
Not yet recruiting - verified October 2011 - Conditions: Mental and Behavioral Disorders; Withdrawal State
Intervention: Drug: Nicotine
Sponsor: Queen Mary University of London
Not yet recruiting - verified January 2012 - Condition: Mosquito Bite
Interventions: Drug: NSAI treatment; Drug: Steroid treatment
Sponsor: London School of Hygiene and Tropical Medicine
Not yet recruiting - verified October 2011 - Condition: Lung Disease
Intervention: Other: The Hospital2Home Service
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified December 2011 - Conditions: Idiopathic Pulmonary Arterial Hypertension; Iron Deficiency
Interventions: Drug: Saline; Drug: Ferinject
Sponsor: Imperial College London
Not yet recruiting - verified October 2011 - Condition: Chronic Pancreatitis
Intervention: Drug: Secretin
Sponsor: University of Nottingham
Completed - verified October 2011 - Condition: Cluster Headache
Interventions: Other: Polysomnography; Other: Actigraphy
Sponsors: University of Surrey; University of California, San Francisco
Recruiting - verified October 2011 - Condition: Asthma
Interventions: Drug: Zithromax; Drug: Placebo
Sponsors: Imperial College London; National Institute for Health Research, United Kingdom
Not yet recruiting - verified September 2011 - Condition: Esophageal Motility Disorders
Interventions: Drug: Azithromycin; Drug: Placebo
Sponsor: JAFAR JAFARI
Not yet recruiting - verified October 2011 - Condition: Atrial Fibrillation
Interventions: Procedure: Pulmonary vein isolation (PVI); Procedure: Pulmonary vein isolation + linear lesions; Drug: Pharmacological Substrate modification
Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Type 1 Diabetes Mellitus
Interventions: Other: Closed-loop; Other: Conventional insulin pump delivery
Sponsors: University of Cambridge; Diabetes UK
Not yet recruiting - verified September 2011 - Condition: Depression
Interventions: Other: OxIGen; Other: OxIGen: control version
Sponsors: University of Oxford; Lupina Foundation
Not yet recruiting - verified September 2011 - Condition: Invasive Pneumococcal Disease
Interventions: Biological: 13-valent pneumococcal conjugate vaccine; Biological: 10-valent pneumococcal conjugate vaccine
Sponsor: University of Oxford
Not yet recruiting - verified September 2011 - Condition: Cholestasis of Pregnancy
Intervention:
Sponsor: Imperial College London
Recruiting - verified December 2011 - Condition: Postoperative Respiratory Complications
Intervention: Procedure: Ventilation PEEP at 12 cmH2O :
Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); European Society of Anaesthesiology
Recruiting - verified September 2011 - Condition: Stress Hyperglycaemia
Interventions: Other: Closed-loop insulin delivery; Other: Standard IV insulin infusion sliding scale
Sponsors: University of Cambridge; European Commission; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified September 2011 - Conditions: Hematologic Malignancies; Multiple Myeloma
Interventions: Drug: Bz (Bortezomib); Drug: Len (lenalidomide)
Sponsor: European Myeloma Network
Not yet recruiting - verified October 2011 - Condition: Acute Stroke
Interventions: Drug: Donepezil; Drug: Placebo
Sponsors: Imperial College London; International Stem Cell Forum
Not yet recruiting - verified September 2011 - Conditions: Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis; Developmental Dysplasia of the Hip
Intervention:
Sponsor: Hussain Kazi
Not yet recruiting - verified September 2011 - Conditions: Critical Illness; Intensive Care
Interventions: Other: Exercise Programme; Other: Standard Care
Sponsors: University of Ulster; Belfast Health and Social Care Trust
Recruiting - verified December 2011 - Condition: Stroke
Intervention: Other: Self-directed Upper Limb SaeboFlex Training
Sponsor: Colchester Hospital University NHS Foundation Trust
Recruiting - verified October 2011 - Condition: Pneumococcal Disease
Interventions: Biological: Prevenar 13; Biological: Pneumovax II
Sponsors: University of Oxford; Mason Medical Research Foundation
Not yet recruiting - verified August 2011 - Condition: Osteoporosis
Interventions: Device: Strain Gauge; Other: Vibration therapy
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit funding
Recruiting - verified September 2011 - Condition: Oral Allergy Syndrome
Interventions: Biological: Allergovit Birch pollen; Other: Placebo
Sponsor: Royal Sussex County Hospital
Active, not recruiting - verified February 2012 - Condition: Peanut Hypersensitivity
Intervention: Other: Food challenge
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Imperial College London
Not yet recruiting - verified September 2011 - Condition: Treatment Resistant Depression
Intervention: Procedure: Deep Brain Stimulation, implanted
Sponsors: North Bristol NHS Trust; University of Bristol
Active, not recruiting - verified September 2011 - Glucose Variability in Type 1 Diabetes and Its Effect on Factors That Influence New Vessel FormationCondition: Type 1 Diabetes
Intervention: Device: Continuous Glucose Monitor (CGM) and Telemedicine (Enlite Guardian real-time system Medtronic®)
Sponsor: University of Dundee
Not yet recruiting - verified September 2011 - Condition: Drug Safety
Intervention: Behavioral: DQIP Intervention
Sponsors: University of Dundee; NHS Tayside; NHS Fife
Recruiting - verified August 2011 - Conditions: Graft Failure; Ischemia-reperfusion Injury
Interventions: Drug: Heme arginate (Normosang); Drug: 0.9% sodium chloride
Sponsors: University of Edinburgh; NHS Lothian
Not yet recruiting - verified August 2011 - Condition: Paediatric Thyrotoxicosis
Interventions: Procedure: Block and Replace; Procedure: Dose Titration; Drug: carbimazole; Drug: propylthiouracil; Drug: thyroxine
Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - verified September 2011 - Condition: Inflammatory Bowel Disease
Intervention: Behavioral: Multi-Convergent Therapy
Sponsor: Cardiff and Vale University Health Board
Enrolling by invitation - verified August 2011 - Condition: Carcinoid Syndrome
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Recruiting - verified September 2011 - Condition: Streptococcus Pneumoniae
Intervention:
Sponsor: Dr. Elizabeth Miller
Recruiting - verified August 2011 - Condition: Endometriosis
Interventions: Procedure: Surgery for ovarian endometrioma; Procedure: Surgery for ovarian endometrioma
Sponsors: Saad Amer; Derby Hospitals NHS Foundation Trust
Recruiting - verified August 2011 - Condition: Heart Transplantation
Intervention:
Sponsor: Nigel E. Drury
Not yet recruiting - verified August 2011 - Conditions: Healthy Volunteers; Chuvash Polycythaemia
Intervention: Other: Commercial airline flight
Sponsor: University of Oxford
Completed - verified August 2011 - Conditions: Stillbirths; Sudden Infant Death
Intervention:
Sponsors: Thayyil, Sudhin; Great Ormond Street Hospital for Children NHS Trust; University College London Hospitals
Active, not recruiting - verified August 2011 - Condition: Hallux Valgus
Interventions: Procedure: Landmark guided ankle block.; Procedure: PNS guided block.
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Completed - verified September 2011 - Condition: Cancer
Interventions: Other: Multimodal intervention; Other: Standard care
Sponsors: Norwegian University of Science and Technology; University of Edinburgh; Oslo University Hospital; NHS Greater Glasgow and Clyde
Recruiting - verified November 2011 - Condition: HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL)
Intervention: Drug: CHOP-daclizumab
Sponsor: King's College Hospital NHS Trust
Completed - verified July 2011 - Condition: Stroke
Intervention:
Sponsor: University of Southampton
Completed - verified July 2009 - Conditions: Oral Cancer; Head and Neck Cancer; Free Flap; Hypotension
Interventions: Drug: Epinephrine; Drug: Norepinephrine; Drug: Dobutamine; Drug: Dopexamine
Sponsor: Oxford University Hospitals NHS Trust
Completed - verified August 2011 - Condition: Multiple Sclerosis
Interventions: Other: Standard Physiotherapy Exercises; Other: Core Stability Training; Other: Relaxation
Sponsor: University of Plymouth
Recruiting - verified August 2011 - Condition: Clinical Skills Training
Interventions: Other: Emergency Psychiatry Immersion Course; Other: Observed SKills in the Emergency Room
Sponsors: King's College London; Guy's and St Thomas' NHS Foundation Trust; South London and Maudsley Charitable Funds; South London and Maudsley NHS Foundation Trust
Active, not recruiting - verified August 2011 - Condition: Heart Failure
Intervention: Other: CMR Guidance in terms of guiding LV lead implantation
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified August 2011 - Condition: Sepsis
Intervention: Biological: Lipopolysaccharide infusion
Sponsor: University of Nottingham
Recruiting - verified October 2011 - Conditions: Radiation Enteritis; Radiation Proctitis
Interventions: Dietary Supplement: FructoOligoSaccharide; Dietary Supplement: Maltodextrin
Sponsor: University College London Hospitals
Recruiting - verified August 2010 - Conditions: Breast Cancer; Ovarian Cancer
Interventions: Drug: 6-Mercaptopurine; Drug: Methotrexate
Sponsor: University of Oxford
Recruiting - verified September 2011 - Condition: Life Experiences
Interventions: Other: Information Sheet; Other: Consent; Other: interview; Other: Debrief
Sponsor: University of East London
Recruiting - verified August 2009 - Condition: Nicotine Withdrawal
Interventions: Behavioral: Stress Ball vs Nicotine-free E-Cigarette; Behavioral: Nicotine-free E-Cigarette vs De-nicotinised Cigarette
Sponsor: Queen Mary University of London
Not yet recruiting - verified August 2011 - Condition: Hepatitis C Virus
Intervention: Drug: rimantadine
Sponsors: The Leeds Teaching Hospitals NHS Trust; Cancer Research UK
Not yet recruiting - verified July 2011 - Conditions: Stroke; Cerebral Infarction; Cerebrovascular Disorders; Brain Diseases
Interventions: Device: Anodal tDCS; Other: Motor Training
Sponsors: University of Oxford; NIHR Biomedical Research Centre Oxford; The Dunhill Medical Trust
Recruiting - verified August 2011 - Condition: Metastatic Colorectal Cancer
Intervention: Other: Perfusion CT scan
Sponsors: University of Oxford; Oxford Biomedical Research Centre; Oxfordshire Health Services Research Committee; University Hospitals, Leicester
Recruiting - verified August 2011 - Conditions: Wegener's Granulomatosis; Microscopic Polyangiitis
Interventions: Procedure: Plasma exchange; Drug: Intravenous methyl prednisolone; Drug: Methyl prednisolone
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University Hospital Birmingham; Imperial College London; North West London Hospitals NHS Trust; University Hospitals, Leicester; Lund University Hospital; University Medical Centre Groningen; Fundacio Clinic; Helsinki University
Terminated - verified July 2011 - Condition: Vascular Diseases
Intervention:
Sponsors: York Teaching Hospitals NHS Foundation Trust; National Institute of Academic Anaesthesia
Not yet recruiting - verified July 2011 - Condition: Postmenopausal Osteoporosis
Intervention: Other: Observation
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Recruiting - verified August 2011 - Conditions: Typhoid Fever; Enteric Fever; Typhoid
Interventions: Biological: Vaccine placebo (excipients only); Biological: Ty21a; Biological: M10ZH09 vaccine
Sponsors: University of Oxford; Wellcome Trust; Imperial College London; University of Maryland
Recruiting - verified December 2011 - Condition: Hypertension
Intervention: Dietary Supplement: beetroot juice
Sponsor: Queen Mary University of London
Recruiting - verified June 2011 - Conditions: Vasculitis; Microscopic Polyangiitis; Granulomatosis With Polyangiitis; Wegener's
Intervention: Drug: Alemtuzumab
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified July 2011 - Condition: Human Immunodeficiency Virus
Intervention: Drug: P2G12
Sponsors: University of Surrey; European Commission
Completed - verified December 2011 - Condition: Children
Intervention:
Sponsor: University of Bristol
Completed - verified July 2011 - Condition: Displaced Olecranon Fractures in Elderly Patients
Interventions: Other: Non-operative; Other: Operative
Sponsor: Royal Infirmary of Edinburgh
Recruiting - verified July 2011 - Condition: Sub-Acute Stroke
Intervention: Device: Robot therapy and transcranial direct current stimulation
Sponsors: University of Southampton; Sobell Department of Motor Neuroscience and Movement Disorders, UCL, London
Not yet recruiting - verified May 2011 - Condition: Lowback and Leg Pain
Intervention: Device: High frequency spinal cord stimulation
Sponsor: Ensemble Hospitalier de la Côte
Recruiting - verified June 2011 - Condition: Acne Vulgaris
Intervention: Drug: Isotretinoin
Sponsor: University of Aberdeen
Completed - verified July 2011 - Condition: Chronic Obstructive Pulmonary Disease (COPD).
Interventions: Drug: Moxifloxacin; Drug: Azithromycin; Drug: Doxycycline; Drug: Placebo
Sponsors: University College, London; Royal Free Hampstead NHS Trust; University of Cambridge; National Institute for Health Research, United Kingdom
Not yet recruiting - verified June 2011 - Condition: Lung Cancer
Interventions: Drug: nelfinavir; Radiation: Radical Radiotherapy
Sponsor: Oxford University Hospitals NHS Trust
Not yet recruiting - verified December 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: olaparib; Drug: temozolomide; Genetic: gene expression analysis; Genetic: protein expression analysis; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: therapeutic conventional surgery
Sponsor: Cancer Research UK
Recruiting - verified October 2011 - Condition: Thyroid Cancer
Intervention: Radiation: I131 1.1 GBq
Sponsors: University College, London; Cancer Research UK
Not yet recruiting - verified July 2011 - Conditions: Migraine; Cluster Headache; Control; Menstrual Migraine
Intervention:
Sponsor: University College London Hospitals
Not yet recruiting - verified May 2011 - Conditions: Renal Failure; Arteriovenous Fistula
Intervention: Procedure: Active ultrasound surveillance of fistula and proactive treatment of stenosis
Sponsor: University of Hull
Not yet recruiting - verified July 2011 - Condition: Displaced Olecranon Fractures
Interventions: Procedure: Tension Band Wiring; Procedure: Plate fixation
Sponsor: Royal Infirmary of Edinburgh
Recruiting - verified July 2011 - Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention:
Sponsors: Centre for Research in Environmental Epidemiology, Spain; Katholieke Universiteit Leuven; University of Edinburgh; Royal Brompton & Harefield NHS Foundation Trust; University Medical Centre Groningen; University of Athens
Recruiting - verified October 2011 - Condition: Acute ST Elevation Myocardial Infarction
Interventions: Drug: sodium nitrite; Other: Placebo
Sponsors: University of Aberdeen; NHS Grampian; Medical Research Council; St George's Healthcare NHS Trust; Brighton and Sussex University Hospitals NHS Trust; Imperial College London; University of Birmingham
Not yet recruiting - verified July 2011 - Condition: Pain Relief After Forefoot Surgery
Interventions: Procedure: Ultrasound guided ankle block; Procedure: Medial forefoot block
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Recruiting - verified September 2011 - Condition: Impact of Food Composition on Gastric Emptying
Intervention: Other: Food type
Sponsors: Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust
Completed - verified June 2011 - Condition: Persistent Atrial Fibrillation
Interventions: Procedure: Thoracoscopically Assisted Surgical Ablation; Procedure: Catheter Ablation
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Enrolling by invitation - verified June 2011 - Condition: Obesity (BMI>30)
Intervention:
Sponsor: University of Oxford
Recruiting - verified June 2011 - Condition: Depression
Interventions: Drug: Metyrapone; Drug: placebo
Sponsors: Northumberland, Tyne and Wear NHS Foundation Trust; National Institute for Health Research, Efficacy and Mechanism Evaluation Programme
Recruiting - verified April 2011 - Condition: Bronchial Asthma
Interventions: Drug: Keratinocyte Growth factor; Drug: Saline placebo
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified June 2010 - Conditions: Adenosine Deaminase Deficiency; Severe Combined Immunodeficiencies (SCID)
Intervention: Genetic: EF1αS-ADA lentiviral vector transduced patient Cd34+ cells
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Not yet recruiting - verified June 2011 - Condition: Granulomatous Disease, Chronic, X-linked, Variant
Intervention: Genetic: pCCLchimGp91s lentiviral vector transduced CD34+ cells infusion
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Not yet recruiting - verified June 2011 - Condition: Myocardial Infarction
Intervention:
Sponsor: London School of Hygiene and Tropical Medicine
Active, not recruiting - verified June 2011 - Condition: Proliferative Diabetic Retinopathy
Intervention: Procedure: Pan retinal Photocoagulation
Sponsors: Moorfields Eye Hospital NHS Foundation Trust; Insulin Dependant Diabetes Trust
Not yet recruiting - verified June 2011 - Conditions: Colon Cancer; Breast Cancer; Trauma; Inflammatory Bowel Disease; Hernia
Intervention:
Sponsor: Imperial College London
Not yet recruiting - verified July 2011 - Condition: Cardiovascular Diseases
Interventions: Dietary Supplement: Low fat diet; Dietary Supplement: Hgih saturated fat diet; Dietary Supplement: High saturated fat diet
Sponsors: University of Reading; Wellcome Trust
Completed - verified June 2011 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsor: Imperial College London
Not yet recruiting - verified June 2011 - Condition: Mental Illness
Interventions: Behavioral: Decision Aid Tool; Other: Treatment as Usual
Sponsor: Institute of Psychiatry, London
Recruiting - verified November 2011 - Conditions: Mood Modulation; Modulation of Cognition
Interventions: Dietary Supplement: Hops Extract; Other: Placebo (silica)
Sponsors: Northumbria University; The New Zealand Institute for Plant and Food Research
Recruiting - verified August 2011 - Conditions: Obesity; Obesity Hypoventilation Syndrome
Intervention:
Sponsor: Oxford University Hospitals NHS Trust
Not yet recruiting - verified June 2011 - Conditions: Cognitive Function; Mood; Cerebral Haemodynamics; Caffeine Withdrawal
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Caffeine and Placebo; Dietary Supplement: Placebo and Caffeine; Dietary Supplement: Caffeine
Sponsor: Northumbria University
Recruiting - verified June 2011 - Condition: Adverse Reaction to Peripheral Nerve- and Plexus-blocking Anesthetics
Intervention: Other: Interscalene brachial plexus block
Sponsor: Royal Surrey County Hospital
Not yet recruiting - verified June 2011 - Conditions: Vitamin D Deficiency; Insulin Resistance
Intervention: Drug: Vitamin D3 cholecalciferol
Sponsor: University of Leicester
Not yet recruiting - verified June 2011 - Conditions: Chronic Hypercapnic Respiratory Failure; Obesity Hypoventilation Syndrome; Neuromuscular Disease; Chronic Obstructive Pulmonary Disease
Intervention: Other: Surface parasternal electromyelography (EMG) set up
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified January 2011 - Conditions: Chronic Obstructive Pulmonary Disease; Chronic Respiratory Hypercapnic Failure; Neuromuscular Disease; Obesity Hypoventilation Syndrome
Intervention: Device: non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Not yet recruiting - verified March 2011 - Condition: Coronary Heart Disease
Intervention: Radiation: Computed tomography scan
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - verified June 2006 - Condition: HIV Infections
Interventions: Biological: DNA.HIVA; Biological: MVA.HIVA; Biological: MVA.HIVA; Biological: MVA.HIVA
Sponsors: International AIDS Vaccine Initiative; Medical Research Council-Oxford; University of Nairobi
Completed - verified June 2011 - Conditions: Obstructive Jaundice; Disease as Reason for ERCP; Immune Dysfunction; Immune Tolerance
Intervention:
Sponsor: University of Nottingham
Recruiting - verified August 2011 - Condition: Malaria
Interventions: Biological: Vaccination Schedule One; Biological: Vaccination Schedule Two; Biological: Vaccination Schedule Three; Biological: Vaccination Schedule Four; Biological: Vaccination Schedule Five; Biological: Vaccination Schedule Six; Biological: Vaccination Schedule Seven
Sponsor: University of Oxford
Recruiting - verified July 2011 - Conditions: Infertility; Miscarriage
Intervention: Other: Creighton Model System in conjunction with Natural Procreative Technology (NPT)
Sponsors: University of Utah; International Institute for Restorative Reproductive Medicine
Enrolling by invitation - verified October 2011 - Condition: Neonatal Respiratory Failure
Intervention: Device: Treatment protocol designed to evaluate (SLE 5000 ventilator)
Sponsor: King's College London
Completed - verified June 2011 - Conditions: Attention Deficit Hyperactivity Disorder; ADHD; Bipolar Disorder
Intervention:
Sponsors: King's College London; South London and Maudsley NHS Trust (SLAM)
Not yet recruiting - verified May 2011 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2010 - Condition: Acute Myocardial Infarction
Intervention:
Sponsors: University College, London; NICOR/MINAP, the United Kingdom; NICOR: National Institute for Cardiac Outcomes Research; MINAP: Myocardial Ischaemia National Audit Project; SWEDEHEART/RIKS-HIA, Sweden; SWEDEHEART: Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies; RIKS-HIA: Register of Information and Knowledge about Swedish Heart Intensive care Admissions
Active, not recruiting - verified May 2011 - Condition: Exercise Fat Oxidation
Interventions: Dietary Supplement: High calcium milk; Dietary Supplement: Control
Sponsor: Northumbria University
Recruiting - verified May 2011 - Conditions: Bleeding; Thrombosis; Cardiac Events
Intervention:
Sponsors: European Society of Anaesthesiology; University of Leeds; Erasmus Medical Center
Recruiting - verified November 2011 - Condition: Aortic Stenosis
Intervention:
Sponsors: University of Edinburgh; NHS Lothian; British Heart Foundation
Recruiting - verified May 2011 - Condition: Dysglycaemia
Interventions: Procedure: closed-loop insulin delivery; Drug: Usual diabetes treatment regimen
Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified May 2011 - Condition: Parkinson's Disease
Interventions: Dietary Supplement: Ketone ester drink; Dietary Supplement: Placebo (carbohydrate containing) drink
Sponsor: University of Oxford
Recruiting - verified May 2011 - Condition: Lymphoma
Intervention: Drug: AZD1152
Sponsors: Oxford University Hospitals NHS Trust; Christie Hospital NHS Foundation Trust; University of Manchester; Oxford Biomedical Research Centre; Early Phase Cancer Research Hub, Oxford
Recruiting - verified December 2011 - Condition: Healthy Volunteers
Interventions: Dietary Supplement: Brocco-sprout homogenate; Dietary Supplement: Alfalfa sprout homogenate
Sponsor: Imperial College London
Recruiting - verified May 2011 - Conditions: Nonalcoholic Fatty Liver Disease; NAFLD; Nonalcoholic Steatohepatitis
Intervention: Drug: Rifaximin
Sponsors: Imperial College London; National Health Service, United Kingdom
Recruiting - verified October 2011 - Condition: Tracheostomy
Intervention:
Sponsor: University Hospital of South Manchester NHS Foundation Trust
Not yet recruiting - verified May 2011 - Condition: Type 2 Diabetes
Intervention: Biological: Glycaemic optimisation before surgery
Sponsor: Imperial College London
Recruiting - verified January 2012 - Condition: Motor Activity
Interventions: Other: cocoa-based food; Other: cocoa-based food
Sponsor: Nestle Research Center
Completed - verified January 2012 - Condition: Rheumatoid Arthritis
Interventions: Drug: TolDC; Drug: Arthroscopy & saline irrigation alone
Sponsors: Newcastle University; Arthritis Research UK (funder); Newcastle-upon-Tyne Hospitals NHS Trust
Not yet recruiting - verified May 2011 - Condition: Legally Induced Abortion, Complete, Without Mention of Complication
Intervention: Other: Alternative follow-up protocol
Sponsors: Gynuity Health Projects; British Pregnancy Advisory Service (UK) (bpas)
Recruiting - verified May 2011 - Condition: Diabetes
Interventions: Behavioral: Leaflet; Behavioral: Exercise Advice; Behavioral: Normal Care
Sponsor: Ship Street Surgery
Not yet recruiting - verified May 2011 - Condition: Knee Osteoarthritis
Interventions: Procedure: High Frequency TENS; Procedure: Low frequency TENS; Procedure: Placebo TENS
Sponsor: University of Iowa
Completed - verified May 2011 - Conditions: Arthroscopic Shoulder Surgery; Pain Threshold
Interventions: Device: Electrical pain threshold measurement; Device: Measurement of electrical pain threshold
Sponsor: NHS Fife
Completed - verified May 2011 - Conditions: Insulin Resistance; Obesity; Dyslipidemia
Intervention: Dietary Supplement: Citrus Flavonoids
Sponsors: University of Nottingham; Florida Department of Citrus
Recruiting - verified January 2012 - Condition: Stroke
Interventions: Behavioral: LifeCIT; Behavioral: Standard Care
Sponsors: University of Southampton; National Institute for Health Research, United Kingdom; Southampton University Hospitals NHS Trust; Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust
Not yet recruiting - verified April 2011 - Conditions: Respiratory Syncytial Virus Infections; Respiratory Viral Infections
Intervention: Biological: RSV A Memphis 37
Sponsor: Imperial College London
Recruiting - verified May 2011 - Conditions: Ischemic Heart Disease; Coronary Artery Stenosis
Intervention: Device: Angioplasty (PROMUS Element™, and Xience™ Prime stent)
Sponsor: European Cardiovascular Research Center
Recruiting - verified April 2011 - Condition: Wiskott-Aldrich Syndrome
Intervention: Biological: ex vivo gene therapy
Sponsors: Genethon; Great Ormond Street Hospital for Children NHS Trust; Institute of Child Health
Recruiting - verified May 2011 - Condition: Neural Degeneration
Intervention: Dietary Supplement: Cocoa Drink
Sponsor: University of Reading
Active, not recruiting - verified February 2011 - Condition: Clinical and Aesthetic Outcome of Adhesive Bridges
Interventions: Procedure: Zirconia-based adhesive bridge; Procedure: Metal-based adhesive bridge
Sponsor: Queen Mary University of London
Not yet recruiting - verified November 2011 - Condition: Knee Osteoarthritis
Interventions: Procedure: Unicompartmental Knee Replacement; Procedure: Total Knee Replacement
Sponsors: University of Oxford; University of Aberdeen
Recruiting - verified May 2011 - Conditions: Colonic Cancer; Rectal Cancer; Colonic Diverticulum; Ulcerative Colitis
Interventions: Procedure: Ultrasound guided Transversus Abdominis Plane (TAP) bock; Procedure: Local anaesthetic infiltration of laparoscopic port sites
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - verified October 2011 - Conditions: Haemorrhoids; Haemorrhoidectomy; Milligan-Morgan Haemorrhoidectomy; Open Haemorrhoidectomy
Interventions: Procedure: Laser Haemorrhoidectomy; Procedure: Laser Haemorrhoidectomy
Sponsor: Northern Lincolnshire and Goole Hospitals NHS Foundation Trust
Completed - verified November 2011 - Conditions: Mucosal Lentiginous Melanoma; Acral Lentiginous Malignant Melanoma
Intervention: Drug: nilotinib
Sponsors: Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust
Recruiting - verified April 2011 - Condition: Premature Birth
Intervention: Device: Arabin Cervical Pessary
Sponsor: Maternal-Infantil Vall d´Hebron Hospital
Not yet recruiting - verified July 2011 - Conditions: Myocardial Infarction; Chronic Obstructive Pulmonary Disease
Intervention:
Sponsors: London School of Hygiene and Tropical Medicine; British Medical Research Council; University College, London
Active, not recruiting - verified April 2011 - Conditions: Demineralisation; White Spot Lesions; Orthodontic Treatment
Intervention: Device: Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
Sponsors: University of Dundee; NHS Tayside
Recruiting - verified April 2011 - Condition: Cancer
Intervention:
Sponsor: Aintree University Hospitals NHS Foundation Trust
Recruiting - verified September 2010 - Conditions: Effects of Chemotherapy; Cancer
Intervention:
Sponsors: Aintree University Hospitals NHS Foundation Trust; Southampton University Hospitals NHS Trust
Completed - verified August 2007 - Condition: Alveolar Soft Part Sarcoma (ASPS)
Interventions: Drug: Cediranib; Drug: Placebo
Sponsors: Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust
Recruiting - verified May 2011 - Condition: Healthy Volunteers
Intervention: Other: cross-linking of an emulsion drink
Sponsors: Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust
Recruiting - verified April 2011 - Condition: Bladder Cancer
Interventions: Other: Blood sample collection; Other: urine collection
Sponsor: Christie Hospital NHS Foundation Trust
Not yet recruiting - verified April 2011 - Condition: Healthy
Interventions: Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)
Sponsor: Northumbria University
Completed - verified April 2011 - Condition: Necrotizing Enterocolitis
Interventions: Procedure: cooling blanket/mattress; Procedure: Standard treatment of care at normothermia
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified June 2011 - Condition: Liver Cancer
Interventions: Drug: doxorubicin-eluting beads; Drug: sorafenib tosylate; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study; Procedure: quality-of-life assessment
Sponsor: University College, London
Recruiting - verified May 2011 - Conditions: HIV; Lymphoma
Intervention:
Sponsor: St Stephens Aids Trust
Recruiting - verified October 2011 - Condition: Obstructive Sleep Apnea
Interventions: Device: Provent®; Device: Placebo-Provent®; Procedure: CPAP
Sponsor: University of Zurich
Recruiting - verified January 2012 - Condition: Sepsis
Intervention:
Sponsors: University of Aberdeen; UK Intensive Care Society
Recruiting - verified January 2012 - Conditions: Oxygen Consumption; Aortic Aneurysm; Peripheral Arterial Disease
Intervention:
Sponsor: NHS Lothian
Recruiting - verified March 2011 - Condition: Chronic Kidney Disease
Intervention: Dietary Supplement: Vitamin D Cholecalciferol
Sponsors: St George's, University of London; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified March 2011 - Condition: HIV
Intervention: Drug: Raltegravir
Sponsor: Imperial College London
Recruiting - verified November 2011 - Condition: Cardiovascular Disease
Interventions: Drug: Polypill: Red Heart Pill; Drug: Usual medication
Sponsors: Imperial College London; Imperial College Healthcare NHS Trust; Royal College of Surgeons, Ireland; UMC Utrecht; Dr Reddy's Laboratories Ltd.; Pulsecor Ltd
Recruiting - verified May 2011 - Condition: Tumor Colorectal
Intervention: Behavioral: Exercise programme
Sponsors: Aintree University Hospitals NHS Foundation Trust; Southampton University Hospitals NHS Trust
Recruiting - verified March 2011 - Condition: Tumor of Esophagus, Stomach and Duodenum
Intervention:
Sponsors: Aintree University Hospitals NHS Foundation Trust; Southampton University Hospitals NHS Trust
Recruiting - verified March 2011 - Condition: Myocardial Infarction
Intervention: Other: Ferumoxytol
Sponsor: University of Edinburgh
Recruiting - verified October 2010 - Condition: Orthodontic Treatment
Intervention: Device: Conventional orthodontic bracket, passive self-ligating brackets and active self-ligating bracket
Sponsors: Barts & The London NHS Trust; East Kent Hospitals University NHS Foundation Trust; Southend NHS Foundation Trust
Recruiting - verified March 2011 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: NG-nitro-L-arginine; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: computed tomography; Procedure: dynamic contrast-enhanced magnetic resonance imaging
Sponsor: Cancer Research UK
Recruiting - verified September 2011 - Condition: HIV
Intervention: Drug: Maraviroc
Sponsor: Imperial College London
Not yet recruiting - verified December 2011 - Conditions: Snoring; Upper Airway Resistance Syndrome; Obstructive Sleep Apnea
Intervention: Behavioral: Singing exercises
Sponsor: Royal Devon and Exeter NHS Foundation Trust
Completed - verified March 2011 - Condition: Cancer
Interventions: Drug: ketamine hydrochloride; Other: pharmacogenomic studies; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: quality-of-life assessment
Sponsor: University of Glasgow
Recruiting - verified March 2011 - Conditions: CMV Reactivation; Allogeneic Stem Cell Transplantation; Autologous CMV Specific CD8+ T Cells
Interventions: Procedure: Lymphopheresis; Procedure: CMV specific lymphocyte infusion; Procedure: Peripheral blood for CMV DNA PCR; Procedure: Haematology/Blood chemistry
Sponsor: Imperial College London
Recruiting - verified December 2011 - Conditions: Intensive Care Unit Acquired Paresis; Muscle Wasting
Intervention: Other: Active muscle stimulation
Sponsors: Imperial College London; Medical Research Council; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified August 2011 - Conditions: Haematological Malignancies; Allogeneic Stem Cell Transplant; CD56+CD3- NK Cells
Interventions: Procedure: Infusion of donor derived ex-vivo selected NK cells to patients after transplant; Procedure: Haematology / Blood chemistry sampling
Sponsor: Imperial College London
Recruiting - verified December 2011 - Condition: Pharmacokinetics of Ciprofloxacin in Neonates
Intervention: Procedure: Collection of biological samples
Sponsors: Liverpool Women's NHS Foundation Trust; University of Liverpool
Recruiting - verified March 2011 - Condition: Hypertension
Interventions: Other: Two portions of fruit and vegetables per day (excluding berries and dark chocolate); Other: Six portions of fruit and vegetables per day (one of which must be berries) and 50g dark chocolate.
Sponsors: Queen's University, Belfast; Belfast Health and Social Care Trust
Recruiting - verified January 2011 - Conditions: Adenocarcinoma Pancreas; Chronic Pancreatitis
Intervention:
Sponsors: University of Medicine and Pharmacy Craiova; Copenhagen University Hospital, Denmark; Caritas-Krankenhaus, Bad Mergentheim, Germany; Institut Paoli-Calmettes; University of Witten/Herdecke; Hospital Meiningen Germany; Odense University Hospital; University of Santiago de Compostela; Università Vita-Salute San Raffaele; SRH Wald Klinikum Gera Germany; University of Bergen; Fundeni Clinical Institute of Digestive Diseases and Liver Transplant; Glasgow Royal Infirmary; University College, London
Recruiting - verified March 2011 - Condition: Glioblastoma Multiforme
Intervention: Drug: Peritumoural carboplatin administration.
Sponsor: North Bristol NHS Trust
Not yet recruiting - verified February 2011 - Condition: Depression
Intervention: Behavioral: Intervention: Exercise and motivational interviewing
Sponsors: University of Nottingham; National Institute for Health Research, United Kingdom
Recruiting - verified November 2011 - Conditions: Squamous Cell Carcinoma of Mouth; Squamous Cell Carcinoma of Oropharynx; Laryngeal Squamous Cell Carcinoma; Squamous Cell Carcinoma of the Hypopharynx
Interventions: Dietary Supplement: IMPACT; Dietary Supplement: An iso-caloric, iso-nitrogenous control feed
Sponsors: Aintree University Hospitals NHS Foundation Trust; Nestlé Nutrition
Completed - verified March 2008 - Conditions: Mania; Hypomania; Bipolar Affective Disorder
Interventions: Other: Cognitive Interpersonal Therapy; Other: Normal Clinical Care
Sponsors: NHS Greater Glasgow and Clyde; Chief Scientist Office of the Scottish Government; University of Glasgow
Recruiting - verified December 2011 - Condition: Adverse Effect of Unspecified General Anesthetics
Intervention:
Sponsors: NHS Research and Development; The Leeds Teaching Hospitals NHS Trust
Recruiting - verified December 2010 - Condition: Exercise Anaphylaxis
Interventions: Behavioral: Sprint interval exercise; Behavioral: Maximal continuous exercise
Sponsor: University of Leeds
Not yet recruiting - verified March 2011 - Condition: Pelvic Organ Prolapse
Intervention:
Sponsor: Croydon University Hospital
Completed - verified February 2005 - Condition: Head and Neck Cancer
Interventions: Drug: docetaxel; Drug: everolimus; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsor: University College, London
Terminated - verified December 2011 - Condition: Osteoarthritis of the Knee
Intervention: Other: Questionnaires
Sponsors: University of Nottingham; Arthritis Research Campaign
Recruiting - verified January 2012 - Condition: Adrenal Failure
Intervention: Drug: depot tetracosactide
Sponsor: Newcastle University
Recruiting - verified June 2011 - Condition: Neurodegeneration
Intervention: Other: Fruit juice beverage
Sponsor: University of Reading
Completed - verified November 2011 - Condition: Nerve Degeneration
Interventions: Dietary Supplement: High flavanone orange juice; Dietary Supplement: Control orange juice
Sponsor: University of Reading
Completed - verified November 2011 - Condition: Cardiovascular Disease
Intervention: Dietary Supplement: Processed High-flavanol
Sponsor: University of Reading
Completed - verified November 2010 - Condition: Childbirth Related Levator Injuries
Intervention:
Sponsor: Croydon University Hospital
Recruiting - verified November 2010 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: aminolevulinic acid; Drug: polifeprosan 20 with carmustine implant; Drug: temozolomide; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsor: Cancer Research UK
Recruiting - verified May 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: cediranib maleate; Drug: gefitinib; Genetic: gene expression analysis; Other: laboratory biomarker analysis
Sponsor: Cancer Research UK
Recruiting - verified May 2011 - Conditions: Haemophilia; Cardiovascular Disease
Intervention:
Sponsor: UMC Utrecht
Enrolling by invitation - verified February 2011 - Condition: Pregnancy in Adolescence
Intervention: Behavioral: Teens and Toddlers
Sponsor: London School of Hygiene and Tropical Medicine
Recruiting - verified April 2011 - Condition: Rheumatoid Arthritis
Interventions: Drug: Infliximab; Drug: Methylprednisolone; Drug: Methotrexate; Dietary Supplement: Folic acid
Sponsor: University of Leeds
Completed - verified March 2010 - Condition: Neonatal Encephalopathy
Intervention:
Sponsor: Thayyil, Sudhin
Not yet recruiting - verified March 2011 - Condition: Colorectal Cancer
Interventions: Other: Placebo; Dietary Supplement: Experimental: Nutritional Supplementation with EPA
Sponsor: University of Nottingham
Not yet recruiting - verified March 2011 - Condition: Prostate Cancer
Interventions: Drug: TOOKAD® Soluble; Other: Active Surveillance
Sponsor: Steba Biotech S.A.
Recruiting - verified February 2012 - Condition: Depression
Interventions: Drug: Ketamine; Drug: Propofol
Sponsors: University of Aberdeen; NHS Grampian; Chief Scientist Office of the Scottish Government
Not yet recruiting - verified March 2011 - Condition: Cystic Fibrosis
Intervention:
Sponsor: Imperial College London
Recruiting - verified March 2011 - Conditions: Rheumatoid Arthritis; Arthritis
Interventions: Drug: Etanercept (ETN); Drug: Placebo
Sponsor: University of Leeds
Active, not recruiting - verified February 2011 - Condition: Type 2 Diabetes Mellitus
Intervention: Behavioral: Educational workshop
Sponsors: Loughborough University; University Hospitals, Leicester
Recruiting - verified October 2010 - Condition: Cardiomyopathy
Interventions: Drug: granulocyte colony stimulating factor (GCSF); Procedure: bone marrow mononuclear cells
Sponsors: Barts & The London NHS Trust; Royal Brompton & Harefield NHS Foundation Trust; University College London Hospitals
Recruiting - verified February 2011 - Condition: Glucocorticoid Treatment
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: Barts & The London NHS Trust; Barts and the London School of Medicine and Dentistry
Recruiting - verified March 2011 - Condition: Atrial Fibrillation
Interventions: Procedure: NavX Fusion; Procedure: Cartomerge
Sponsor: Barts & The London NHS Trust
Completed - verified September 2011 - Condition: Heart Failure
Interventions: Drug: Preset increase in frusemide dose; Other: No intervention
Sponsor: Barts & The London NHS Trust
Recruiting - verified March 2011 - Conditions: To Validate the Integrated Diagnostic System in the International Collaborative Microarray (INTERCOM); Study; To Develop a Clinically Feasible and Useful Reporting System for Molecular, Histopathology and Integrated; Diagnosis; To Incorporate the Integrated Diagnostic System Into International Diagnostic Standards
Intervention:
Sponsor: University of Alberta
Recruiting - verified September 2011 - Conditions: Chronic Obstructive Airway Disease; Asthma; Chronic Cough
Interventions: Other: Cough Challenge Tests; Other: ambulatory cough recording; Other: Cough questionnaires
Sponsor: University Hospital of South Manchester NHS Foundation Trust
Completed - verified September 2011 - Conditions: Cardiovascular Disease; Heart Failure
Interventions: Drug: Urocortin 2; Drug: Urocortin 3
Sponsors: University of Edinburgh; NHS Lothian
Completed - verified August 2011 - Condition: Huntington's Disease
Intervention:
Sponsors: CHDI Foundation, Inc.; Monash University
Recruiting - verified February 2012 - Condition: Rheumatoid Arthritis
Interventions: Drug: Etanercept; Drug: Abatacept; Biological: Rituximab; Drug: Adalimumab; Drug: Certolizumab Pegol; Drug: Infliximab
Sponsor: University of Leeds
Not yet recruiting - verified December 2010 - Condition: Marfan Syndrome
Interventions: Drug: Atenolol; Drug: VERAPAMIL; Drug: Perindopril
Sponsor: Cardiff University
Completed - verified January 2006 - Condition: Keloid
Interventions: Drug: 5- fluorouracil; Radiation: radiotherapy; Drug: Triamcinolone
Sponsor: Queen Mary University of London
Active, not recruiting - verified February 2011 - Conditions: Hepatitis C; Evidence of Liver Transplantation
Intervention: Drug: ITX 5061
Sponsors: University of Birmingham; University Hospital Birmingham; iTherX Pharmaceuticals Inc.; National Institute of Health Research, United Kingdom
Recruiting - verified November 2010 - Condition: Postoperative Pain
Interventions: Drug: Levobupivicaine; Drug: 0.9% Saline
Sponsor: Ashford and St. Peter's Hospitals NHS Trust
Recruiting - verified February 2011 - Condition: Chronic Postoperative Pain
Intervention: Drug: Ketamine
Sponsors: Imperial College Healthcare NHS Trust; National Institute for Health Research, United Kingdom
Not yet recruiting - verified January 2011 - Condition: Malignant Pleural Mesothelioma
Intervention: Drug: ADI-PEG 20
Sponsors: Queen Mary University of London; Cancer Research UK; UK: Barts Center for Experimental Cancer Medicine (CECM) for Trial Coordination
Recruiting - verified January 2011 - Condition: HIV Infection
Intervention:
Sponsor: St Stephens Aids Trust
Recruiting - verified April 2011 - Condition: High Altitude Headache
Interventions: Drug: Acetazolamide; Drug: Lactose monohydrate
Sponsors: Bangor University; Research Center for Sport, Mountain and Health of Rovereto, University of Verona, Italy; North Wales Research Committee, UK
Completed - verified December 2011 - Condition: HIV Infections
Intervention: Biological: CN54gp140 glycoprotein-hsp70 conjugate vaccine
Sponsors: St George's, University of London; European Union
Active, not recruiting - verified October 2011 - Condition: Pain
Interventions: Other: Epidural; Other: Local anaesthetic wound catheter
Sponsor: Scarborough General Hospital
Recruiting - verified February 2011 - Condition: Suspected Arterial Hypertension
Intervention: Other: no intervention performed
Sponsors: Klinikum Wels-Grieskirchen; Austrian Society of Hypertension (Werner Klein Stipendium); Government of lower Austria and European Funds for Regional Development (WST3-T-81/015-2008); I.E.M. (Stolberg, Germany) - unrestricted grant
Recruiting - verified October 2011 - Condition: Adenosine Deaminase Deficiency
Intervention: Biological: Intravenous infusion of transduced cells
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified August 2011 - Conditions: Cancer; Peripheral Neuropathy
Interventions: Drug: Ethosuximide; Drug: Placebo
Sponsors: Royal Marsden NHS Foundation Trust; Imperial College London
Recruiting - verified December 2011 - Condition: Chronic Lymphocytic Leukaemia (CLL)
Intervention: Drug: metronidazole, clarithromycin, ciprofloxacin and lansoprazole
Sponsor: King's College Hospital NHS Trust
Recruiting - verified July 2011 - Conditions: Persistent Cough; Whooping Cough
Interventions: Drug: Montelukast; Drug: Placebo
Sponsor: University of Oxford
Recruiting - verified November 2011 - Condition: Pre-Eclampsia
Intervention: Drug: Atorvastatin
Sponsor: University of Oxford
Enrolling by invitation - verified November 2011 - Condition: Motor Development of Premature Infants
Interventions: Other: HOP-ON; Other: SMILES
Sponsors: University of Nottingham; Action Medical Research
Recruiting - verified March 2011 - Conditions: Pregnancy Complications; Obesity
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: Epsom and St Helier University Hospitals NHS Trust; Fetal Medicine Foundation; King's College Hospital NHS Trust
Recruiting - verified January 2012 - Condition: HIV Infection
Interventions: Drug: Efavirenz; Drug: Efavirenz
Sponsors: Kirby Institute; Imperial College London
Recruiting - verified October 2011 - Condition: HIV Infection
Interventions: Drug: Efavirenz; Drug: Efavirenz
Sponsors: Kirby Institute; Chelsea and Westminster NHS Foundation Trust
Recruiting - verified October 2011 - Condition: Breast Cancer
Intervention: Drug: Metformin
Sponsors: Oxford University Hospitals NHS Trust; Oxford Biomedical Research Centre; Cancer Research UK
Recruiting - verified December 2011 - Conditions: Constipation; Abdominal Pain; Nausea; Vomiting
Intervention: Drug: Lactulose
Sponsor: NHS Fife
Not yet recruiting - verified December 2010 - Conditions: Fabry Disease; Fabry´s Disease; Anderson-Fabry Disease
Intervention:
Sponsor: University of Rostock
Recruiting - verified November 2010 - Condition: Colorectal Cancer
Interventions: Biological: panitumumab; Drug: L-leucovorin; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery; Radiation: radiation therapy
Sponsor: Wales Cancer Trials Unit
Recruiting - verified April 2011 - Condition: Pigmented Villonodular Synovitis
Intervention: Drug: Tasigna
Sponsors: Centre Leon Berard; Ministry of Health, France
Recruiting - verified June 2011 - Condition: Peanut Allergy
Intervention: Dietary Supplement: Peanut oral immunotherapy
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Active, not recruiting - verified July 2010 - Conditions: Type 2 Diabetes Mellitus; Obesity; Bariatric Surgery
Intervention: Drug: Insulin
Sponsor: Imperial College London
Recruiting - verified January 2012 - Condition: Fecal Incontinence
Intervention: Device: Medtronic InterStim / InterStim II
Sponsors: University of Aarhus; North West London Hospitals NHS Trust - St. Marks Hospital
Completed - verified November 2011 - Conditions: Breast Cancer; Colorectal Cancer; Esophageal Cancer; Head and Neck Cancer; Lung Cancer
Interventions: Other: 18F-fluoromisonidazole; Other: fluorescence angiography; Other: laboratory biomarker analysis; Procedure: infrared thermography; Procedure: magnetic resonance imaging; Procedure: therapeutic conventional surgery; Radiation: [18F]-ML-10; Radiation: fludeoxyglucose F 18; Radiation: rubidium Rb-82
Sponsor: University College London (UCL) Cancer Institute
Recruiting - verified December 2010 - Condition: Chronic Total Occlusion of Artery of the Extremities
Interventions: Device: Balloon angioplasty; Device: Primary stenting
Sponsor: University of Patras
Recruiting - verified December 2010 - Condition: Coronary Heart Disease
Interventions: Procedure: Remote ischaemic preconditioning; Procedure: Control
Sponsor: University College, London
Recruiting - verified January 2012 - Condition: Schizophrenia
Interventions: Drug: Amisulpride; Drug: placebo
Sponsors: Imperial College London; University of Manchester; University College, London
Not yet recruiting - verified September 2011 - Condition: Chronic Cough
Interventions: Drug: 10 % Lidocaine; Drug: 10 % Lidocaine; Drug: 0.9% saline
Sponsor: University Hospital of South Manchester NHS Foundation Trust
Completed - verified September 2011 - Condition: Influenza
Intervention: Drug: Seasonal Flu vaccine
Sponsor: University of Oxford
Completed - verified March 2011 - Conditions: Bladder Carcinoma; Infiltrative Bladder Carcinoma; Cystectomy
Intervention: Drug: LAPATINIB
Sponsor: University Hospital, Bordeaux
Recruiting - verified November 2011 - Conditions: Adenocarcinoma of the Gastroesophageal Junction; Esophageal Cancer
Interventions: Drug: gefitinib; Procedure: quality-of-life assessment
Sponsor: Oncology Clinical Trials Office at University of Oxford
Recruiting - verified August 2011 - Condition: Melanoma
Interventions: Drug: Docetaxel and AZD6244; Drug: Docetaxel and placebo
Sponsor: University of Oxford
Recruiting - verified August 2011 - Condition: Diabetes
Intervention: Other: patient care pathway
Sponsors: Peninsula NIHR Clinical Research Facility; University of Exeter; University of Dundee; Wellcome Trust; Department of Health, United Kingdom
Recruiting - verified March 2011 - Condition: Type 2 Diabetes
Intervention: Dietary Supplement: Mirtoselect
Sponsor: University of Aberdeen
Recruiting - verified December 2011 - Condition: Tuberculosis
Interventions: Biological: C-Tb; Biological: 2 TU Tuberculin PPD RT 23 SSI
Sponsor: Statens Serum Institut
Recruiting - verified November 2010 - Condition: Breast Cancer
Intervention:
Sponsors: Liz Coote; University of Dundee
Recruiting - verified October 2011 - Conditions: Graft Versus Host Disease; Leukemia; Lymphoma
Interventions: Other: CD4 DLI; Other: No DLI
Sponsor: University College, London
Recruiting - verified December 2011 - Condition: Urinary Incontinence
Interventions: Behavioral: Constructivist interactive workshop on urinary incontinence; Behavioral: Evidence-based self-management tool; Behavioral: General health lecture
Sponsors: Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Brunel University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2011 - Condition: Hypertension
Interventions: Dietary Supplement: Beetroot juice; Dietary Supplement: Water
Sponsors: Queen Mary University of London; University College, London
Completed - verified July 2011 - Condition: Cardiovascular Disease
Intervention: Dietary Supplement: Placebo oil
Sponsor: University of Aberdeen
Recruiting - verified May 2011 - Condition: Chronic Periodontitis
Intervention:
Sponsors: NHS South Birmingham; University of Birmingham
Not yet recruiting - verified July 2010 - Condition: HIV Infection
Intervention: Drug: Hydroxychloroquine
Sponsor: St Stephens Aids Trust
Recruiting - verified December 2011 - Condition: Leukemia
Interventions: Drug: hydroxychloroquine; Drug: imatinib mesylate; Genetic: cytogenetic analysis; Genetic: polymerase chain reaction; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Lynn McMahon; Medical Research Council; CRUK Trials unit Glasgow
Recruiting - verified November 2011 - Condition: Periodontitis
Interventions: Dietary Supplement: Juice plus+; Dietary Supplement: Placebo non active capsules
Sponsors: NHS South Birmingham; University of Wuerzburg; Academic Centre for Dentistry in Amsterdam
Recruiting - verified October 2010 - Condition: Diabetes Mellitus, Type 1
Intervention: Procedure: two step hyperinsulinaemic glucose clamp study.
Sponsor: The Royal Bournemouth Hospital
Suspended - verified July 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Biological: glioblastoma multiforme multipeptide vaccine IMA950; Biological: sargramostim; Drug: temozolomide; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsor: Cancer Research UK
Recruiting - verified October 2010 - Condition: Bronchiectasis
Intervention: Drug: Atorvastatin
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - verified November 2011 - Condition: BRONCHIECTASIS
Intervention: Drug: ATORVASTATIN
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - verified November 2011 - Condition: Asthma
Intervention: Drug: Budesonide (directly observed)
Sponsors: Liam Heaney; Queen's University, Belfast; Asthma UK; Northern Ireland Chest Heart & Stroke
Completed - verified February 2012 - Condition: Colorectal Cancer
Interventions: Dietary Supplement: Maltodextrin and Amioca starch; Dietary Supplement: Hi-maize 260; Dietary Supplement: Polydextrose; Dietary Supplement: Hi-maize 260 and polydextrose
Sponsors: Newcastle University; Northumbria Healthcare NHS Foundation Trust
Active, not recruiting - verified October 2011 - Condition: Heart Failure
Intervention:
Sponsor: Imperial College London
Recruiting - verified June 2011 - Condition: Poisoning
Interventions: Drug: Chlorphenamine and Ranitidine; Drug: Paracetamol; Drug: Paracetamol
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - verified September 2010 - Condition: Lung Cancer
Interventions: Drug: pazopanib hydrochloride; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study; Procedure: quality-of-life assessment
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified July 2011 - Condition: Antibiotic Prescribing by GPs for URTI.
Interventions: Behavioral: Persuasive communication; Behavioral: To be developed; Behavioral: General intervention
Sponsors: University of Dundee; University of Aberdeen; Newcastle University; University of Southampton; Chief Scientist Office of the Scottish Government; Scottish Primary Care Research Network; Scottish School of Primary Care
Recruiting - verified September 2010 - Condition: Cystic Fibrosis
Intervention: Other: Tobramycin time of administration
Sponsor: University of Nottingham
Recruiting - verified December 2011 - Condition: Known Difficult Intubation
Intervention:
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - verified November 2010 - Condition: Irritable Bowel Syndrome With Diarrhoea
Interventions: Drug: Mesalazine; Drug: Placebo
Sponsors: University of Nottingham; National Institute for Health Research, United Kingdom
Recruiting - verified January 2012 - Conditions: Depression; Personality Disorder
Interventions: Other: MBT; Other: treatment as usual
Sponsor: North East London Foundation Trust
Recruiting - verified July 2011 - Condition: Haploidentical Stem Cell Transplantation
Intervention: Biological: HSVTK retrovirally-transduced donor T lymphocytes
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified June 2011 - Condition: Non-cardiac Surgery
Intervention:
Sponsors: Queen Mary University of London; European Society of Anaesthesiology; European Society of Intensive Care Medicine
Completed - verified June 2011 - Conditions: Tobacco Dependence; Smoking Cessation
Interventions: Drug: Varenicline; Drug: Placebo; Drug: Varenicline
Sponsor: Queen Mary University of London
Recruiting - verified July 2011 - Conditions: Insulin Resistance; Obesity
Intervention: Dietary Supplement: orange juice
Sponsors: University of Nottingham; Florida Department of Citrus
Active, not recruiting - verified January 2012 - Conditions: Quorum Sensing; Prebiotics; Probiotics; Sepsis
Interventions: Dietary Supplement: Bifidobacterium longum BB536; Dietary Supplement: Active hexose correlated compound (AHCC); Dietary Supplement: Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC); Dietary Supplement: Corn starch placebo capsule; Drug: Azithromycin
Sponsor: University of Nottingham
Completed - verified May 2011 - Condition: Bladder Cancer
Interventions: Other: questionnaire administration; Procedure: quality-of-life assessment; Procedure: robot-assisted laparoscopic surgery; Procedure: therapeutic conventional surgery; Procedure: therapeutic laparoscopic surgery
Sponsor: Wales Cancer Trials Unit
Recruiting - verified September 2010 - Condition: Gestational Hypertension
Interventions: Procedure: Intervention is blood pressure management approach; Procedure: Intervention is blood pressure management approach.
Sponsors: University of British Columbia; Canadian Institutes of Health Research (CIHR); Sunnybrook Research Institute
Recruiting - verified December 2011 - Condition: Varicose Veins
Intervention:
Sponsor: BTG Ltd.
Active, not recruiting - verified June 2011 - Condition: Acute Lymphoblastic Leukemia
Interventions: Genetic: donor-derived EBV-specific cytotoxic T-cells (EBV-CTL) transduced with the retroviral vector SFGalpha-CD19-CD3zeta; Biological: Irradiated donor-derived Lymphoblastoid Cell Line
Sponsors: University College, London; European Union; The Leukemia and Lymphoma Society; Children with Leukaemia; Department of Health, United Kingdom; JP Moulton Charitable Foundation
Not yet recruiting - verified December 2011 - Conditions: Male Erectile Disorder; Prostate Cancer; Therapy-related Toxicity; Urinary Incontinence
Interventions: Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: high-intensity focused ultrasound ablation; Procedure: multiparametric magnetic resonance imaging; Procedure: quality-of-life assessment; Procedure: transperineal prostate biopsy; Procedure: transrectal prostate biopsy
Sponsor: University College London Hospitals
Recruiting - verified November 2010 - Condition: Prostate Cancer
Interventions: Drug: dutasteride; Drug: gadolinium-chelate; Other: active surveillance; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: functional magnetic resonance imaging; Procedure: prostate biopsy; Procedure: ultrasound imaging
Sponsor: University College London Hospitals
Recruiting - verified August 2011 - Condition: Lung Cancer
Interventions: Behavioral: Physician Advice; Behavioral: Intensive quit smoking support
Sponsors: Hywel Dda Health Board; Cardiff and Vale University Health Board
Recruiting - verified August 2010 - Condition: Tuberculosis
Interventions: Biological: BCG: 100 microlitres ~ 2-8 x 105 pfu; Biological: MVA85A: 1 x 108 pfu BCG: 100 microlitres ~ 2-8 x 105 pfu
Sponsor: University of Oxford
Recruiting - verified October 2011 - Condition: Antiretroviral Therapy in HIV-1 Infected Children
Interventions: Drug: Kaletra dosed once daily; Drug: kaletra dosed twice daily
Sponsors: PENTA Foundation; Medical Research Council; Agence Nationale de Recherche sur le SIDA (ANRS), France
Recruiting - verified February 2012 - PK Switch Efavirenz to Maraviroc in Patients Initially Suppressed on an Efavirenz-containing RegimenCondition: HIV Infection
Intervention: Drug: Maraviroc
Sponsor: St Stephens Aids Trust
Recruiting - verified August 2010 - Condition: Coronary Artery Disease
Interventions: Device: Coronary Stent Cypher; Device: Coronary stent Xience
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Completed - verified July 2011 - Conditions: Tobacco Dependence; Smoking Cessation
Interventions: Drug: Nicotine Patch; Drug: Placebo; Drug: Varenicline
Sponsor: Queen Mary University of London
Completed - verified October 2011 - Conditions: HIV; AIDS; Indicator Diseases/Indicator Conditions
Interventions: Other: HIV test (serological or salivary); Other: Interview
Sponsors: Chelsea and Westminster NHS Foundation Trust; HIV in Europe (Co-Sponsor)
Recruiting - verified October 2009 - Condition: Type 2 Diabetes
Intervention: Dietary Supplement: Mirtoselect
Sponsor: University of Aberdeen
Recruiting - verified December 2011 - Condition: Tuberculosis
Intervention: Biological: MVA 85A
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Prostate Cancer
Interventions: Other: informational intervention; Other: questionnaire administration
Sponsor: University College London Hospitals
Recruiting - verified November 2010 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Erdosteine; Drug: Placebo
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Galen limited
Withdrawn - verified July 2010 - Condition: Smoking Cessation
Intervention: Other: Respiragene test
Sponsors: University of Surrey; Lab 21, Cambridge; NHS Research and Development
Recruiting - verified January 2012 - Condition: Parkinson's Disease
Intervention: Drug: Exenatide
Sponsor: University College, London
Recruiting - verified August 2010 - Conditions: Atherosclerosis; Systemic Lupus Erythematosus
Interventions: Drug: Rosuvastatin; Drug: Placebo
Sponsor: Imperial College London
Recruiting - verified August 2011 - Condition: X-linked Severe Combined Immunodeficiency
Intervention: Genetic: Single infusion of autologous CD34+ cells transduced with the self-inactivating (SIN) gammaretroviral vector pSRS11.EFS.IL2RG.pre
Sponsor: Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified June 2011 - Condition: Myositis
Intervention: Procedure: Venepuncture
Sponsor: Salford Royal NHS Foundation Trust
Recruiting - verified September 2011 - Conditions: Vitamin D; Long Bone Fracture
Intervention: Other: No intervention
Sponsors: Barts & The London NHS Trust; London Deanery
Recruiting - verified February 2011 - Condition: Palpitations
Intervention: Device: Implantable Loop Recorder
Sponsor: Barts & The London NHS Trust
Recruiting - verified March 2011 - Conditions: Atrial Fibrillation; Heart Failure
Interventions: Procedure: Catheter ablation of persistent atrial fibrillation; Drug: Medical treatment alone
Sponsors: Barts & The London NHS Trust; British Heart Foundation
Recruiting - verified May 2010 - Condition: Myocardial Infarction
Intervention:
Sponsors: London School of Hygiene and Tropical Medicine; British Medical Research Council; University College, London
Active, not recruiting - verified June 2011 - Conditions: Children; General Anesthesia; Intubation
Intervention: Device: Airtraq laryngoscopy
Sponsors: University Hospitals Bristol NHS Trust; Oxford University Hospitals NHS Trust
Completed - verified December 2011 - Conditions: Hearing Loss; Cytomegalovirus
Intervention: Other: Screening urine and saliva tests for congenital Cytomegalovirus
Sponsor: Janet Berrington
Recruiting - verified October 2011 - Conditions: Left Ventricular Systolic Dysfunction; Mitral Regurgitation
Intervention:
Sponsors: Imperial College London; Humboldt-Universität zu Berlin; British Heart Foundation
Recruiting - verified August 2011 - Condition: Mental Disorders
Intervention:
Sponsors: University of Bristol; North Bristol NHS Trust
Active, not recruiting - verified August 2011 - Conditions: Endothelial Dysfunction; Atherosclerosis; Inflammation; Myocardial Ischemia
Interventions: Drug: Acetylcholine; Drug: Adenosine
Sponsor: St George's Healthcare NHS Trust
Recruiting - verified February 2011 - Condition: Haemodialysis
Intervention: Other: Use of ultrasound guidance in cannulation
Sponsor: University of Hull
Not yet recruiting - verified July 2010 - Condition: Caesarean Section
Interventions: Drug: 0.5% levobupivacaine; Drug: 0.75% Ropivacaine
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Withdrawn - verified December 2011 - Condition: Nutritional Support
Intervention: Other: Hypocaloric feeding
Sponsor: Scarborough General Hospital
Recruiting - verified June 2010 - Condition: Asthma
Interventions: Drug: Citalopram; Drug: Placebo
Sponsors: Liam Heaney; Asthma UK
Recruiting - verified February 2012 - Condition: Asthma
Interventions: Drug: Ciclesonide; Drug: Placebo
Sponsors: University of Nottingham; Nottingham University Hospitals NHS Trust; University Hospitals, Leicester
Recruiting - verified January 2012 - Conditions: Gastric Cancer; Head and Neck Cancer; Lymphoma; Lymphoproliferative Disorder; Nonneoplastic Condition
Interventions: Biological: EBNA1 C-terminal/LMP2 chimeric protein-expressing recombinant modified vaccinia Ankara vaccine; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsor: Cancer Research UK
Active, not recruiting - verified July 2011 - Condition: Lentigo Maligna
Intervention: Drug: Imiquimod
Sponsors: University Hospital Birmingham NHS Foundation Trust; Department of Health, United Kingdom
Active, not recruiting - verified May 2010 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: angiogenesis inhibitor GSAO; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: dynamic contrast-enhanced magnetic resonance imaging
Sponsor: Cancer Research UK
Recruiting - verified September 2011 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Simvastatin; Drug: Lactose tablet
Sponsor: University of Nottingham
Recruiting - verified January 2012 - Condition: Lymphoma, T-Cell, Peripheral
Intervention:
Sponsors: Associazione Angela Serra per la ricerca sul cancro; Fondazione Italiana Linfomi ONLUS; International T-cell non-Hodgkin Lymphoma Study Group
Recruiting - verified June 2011 - Condition: Peripheral Arterial Disease
Interventions: Drug: Allopurinol; Drug: Placebo
Sponsors: University of Dundee; NHS Tayside; British Heart Foundation
Active, not recruiting - verified January 2012 - Conditions: Postoperative Morbidity; Trauma; Wound Healing
Intervention: Dietary Supplement: Juice plus
Sponsors: University of Birmingham; NSA, Inc
Recruiting - verified January 2012 - Condition: Malaria
Interventions: Biological: AdCh63 MSP1, MVA MSP1, challenge; Biological: AdCh63 AMA1, MVA AMA1, challenge; Biological: AdCh63 AMA1, AdCh63 MSP1, MVA AMA1, MVA MSP1, challenge; Biological: AdCh63 MSP1, AdCh63 ME-TRAP, MVA MSP1, MVA ME-TRAP, challenge; Biological: Sporozoite challenge
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: HIV
Interventions: Other: Questionnaire; Other: Focus Group Discussion; Other: HIV test (serum or salivary); Other: Semi-structured telephone interview
Sponsors: Chelsea and Westminster NHS Foundation Trust; Department of Health, Taiwan; Health Protection Agency, United Kingdom; Homerton University Hospital NHS Foundation Trust; King's College Hospital NHS Trust; Hammersmith and Fulham Primary Care Trust
Recruiting - verified May 2010 - Condition: Wheezing
Interventions: Drug: Mannitol; Drug: Montelukast
Sponsors: Queen Mary University of London; University of Aberdeen; University of Leicester
Recruiting - verified July 2011 - Condition: Parkinson Disease
Intervention:
Sponsors: Michael J. Fox Foundation for Parkinson's Research; Institute for Neurodegenerative Disorders
Recruiting - verified July 2011 - Condition: Renal Failure
Intervention:
Sponsor: University of Nottingham
Recruiting - verified October 2011 - Condition: Malnutrition
Intervention:
Sponsor: Ludwig-Maximilians - University of Munich
Active, not recruiting - verified September 2010 - Condition: Asthma
Intervention: Drug: Pioglitazone
Sponsor: University of Nottingham
Recruiting - verified November 2011 - Conditions: Skeletal Muscle Wasting; Insulin Resistance
Intervention: Procedure: Major abdominal surgery
Sponsor: University of Nottingham
Enrolling by invitation - verified January 2012 - Condition: Asthma
Intervention: Other: 50% step down reduction in inhaled corticosteroid dose
Sponsor: University of Nottingham
Recruiting - verified January 2012 - Condition: Prostate Cancer
Interventions: Dietary Supplement: C-11 choline; Radiation: 18F-fluoromethylcholine
Sponsor: Cancer Research UK
Recruiting - verified February 2011 - Condition: HIV-1 Infection
Interventions: Biological: GTU-MultiHIV B clade vaccine1mg; Drug: Interleukin-2; Drug: GM-CSF; Drug: Growth Hormone
Sponsors: Imperial College London; Medical Research Council
Active, not recruiting - verified May 2011 - Condition: Healthy
Intervention: Procedure: Venepuncture
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Bladder Cancer
Interventions: Procedure: diagnostic cystoscopy; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: implanted fiducial-based imaging; Procedure: quality-of-life assessment; Radiation: 3-dimensional conformal radiation therapy; Radiation: image-guided radiation therapy; Radiation: selective external radiation therapy
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - verified February 2011 - Evaluation of Effect of Angiotensin-converting Enzyme (ACE) Inhibitors on Small Aneurysm Growth RateCondition: Abdominal Aortic Aneurysm
Interventions: Drug: perindopril arginine; Drug: amlodipine 5mgs; Drug: placebo
Sponsors: Imperial College London; National Institute for Health Research, United Kingdom
Recruiting - verified October 2011 - Condition: HIV Infections
Interventions: Biological: Opal-HIV-Gag(c) Low Dose; Biological: Opal-HIV-Gag(c) Medium dose; Biological: Opal-HIV-Gag(c) High dose; Other: Dimethyl Sulfoxide
Sponsors: Medicines Development Limited; Phillip T. and Susan M. Ragon Foundation; Imperial College London
Terminated - verified November 2011 - Condition: Cardiac Ion Channelopathy
Intervention:
Sponsor: Thayyil, Sudhin
Recruiting - verified June 2011 - Condition: Coronary Artery Bypass
Intervention:
Sponsor: Imperial College London
Recruiting - verified July 2011 - Condition: Coronary Stenosis
Intervention:
Sponsors: Imperial College London; Hospital San Carlos, Madrid
Recruiting - verified September 2011 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Diet and Vascular Health; Dietary Supplement: Diet and Vascular Health; Dietary Supplement: Diet and Vascular Health Study
Sponsors: Institute of Food Research; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK); University of East Anglia
Active, not recruiting - verified June 2011 - Condition: Metabolism and Clearance of Cyanidin 3 Glucoside
Intervention: Dietary Supplement: Cyanidin 3 glucoside
Sponsors: University of East Anglia; Institute of Food Research
Completed - verified October 2011 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: Aurora B/C kinase inhibitor GSK1070916A; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: diffusion-weighted magnetic resonance imaging; Radiation: fludeoxyglucose F 18
Sponsor: Cancer Research UK
Recruiting - verified February 2011 - Condition: Acute Coronary Syndromes
Intervention:
Sponsors: University College, London; Barts & The London NHS Trust
Active, not recruiting - verified July 2010 - Condition: Acute Coronary Syndrome
Intervention:
Sponsors: University College, London; Barts & The London NHS Trust; Queen Mary University of London; University of Bristol; Yale University
Active, not recruiting - verified December 2011 - Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: lapatinib ditosylate; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - verified July 2011 - Condition: Kidney Cancer
Interventions: Drug: sunitinib malate; Genetic: gene expression analysis; Other: biologic sample preservation procedure; Other: laboratory biomarker analysis; Procedure: therapeutic conventional surgery
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified September 2011 - Condition: Pancreatic Cancer
Interventions: Drug: Notch signaling pathway inhibitor MK0752; Drug: gemcitabine hydrochloride; Other: imaging biomarker analysis; Other: laboratory biomarker analysis; Other: pharmacological study; Radiation: fludeoxyglucose F 18
Sponsor: Cancer Research UK
Recruiting - verified December 2011 - Conditions: Systemic Lupus Erythematosus; Atherosclerosis
Interventions: Drug: Mycophenolate mofetil; Drug: sugar pill
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Institute of Child Health, University College London, London, UK.
Completed - verified May 2005 - Condition: Heart Failure
Interventions: Device: BiV ICD; Device: ICD
Sponsor: Barts & The London NHS Trust
Active, not recruiting - verified March 2011 - Conditions: Premature Intestinal Microbiota; Necrotizing Enterocolitis; Late Onset Bloodstream Infection
Intervention:
Sponsors: Imperial College London; The Winnicott Foundation; National Heart and Lung Institute; Chelsea and Westminster NHS Foundation Trust
Recruiting - verified February 2011 - Conditions: Critical Illness; Sepsis
Intervention:
Sponsors: Intensive Care National Audit & Research Centre; Wellcome Trust
Recruiting - verified July 2011 - Condition: Pneumococcal Disease
Intervention: Biological: PCV13
Sponsors: University of Oxford; University of Bristol; University of Southampton; University of London
Completed - verified March 2011 - Condition: Prostate Cancer
Interventions: Other: counseling intervention; Other: educational intervention; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery; Radiation: iodine I 125; Radiation: palladium Pd 103
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified March 2010 - Conditions: Wilms Tumor; Neuroblastoma; Soft Tissue Sarcoma; Acute Lymphoblastic Leukemia
Intervention: Drug: doxorubicin
Sponsor: University Hospital Muenster
Recruiting - verified March 2010 - Conditions: Chemotherapeutic Agent Toxicity; Fatigue; Lung Cancer; Musculoskeletal Complications
Interventions: Drug: carboplatin; Drug: vinorelbine tartrate; Other: neuromuscular electrical stimulation; Other: physiologic testing; Procedure: fatigue assessment and management; Procedure: quality-of-life assessment
Sponsor: Wales Cancer Trials Unit
Recruiting - verified September 2010 - Condition: Dysphoria
Interventions: Drug: Escitalopram; Drug: Placebo
Sponsors: University of Oxford; P1vital Limited; University of Manchester; Institute of Psychiatry, London
Completed - verified June 2011 - Condition: Kidney Transplantation
Interventions: Drug: Rituximab; Drug: Tacrolimus; Drug: Mycophenolate mofetil; Drug: Hydrocortisone; Drug: Prednisolone; Drug: Prednisolone
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Astellas Pharma Ltd
Recruiting - verified December 2011 - Conditions: Vascular Disease; Heart Disease
Interventions: Drug: Urocortin 2, Urocortin 3; Drug: Saline placebo
Sponsor: University of Edinburgh
Suspended - verified February 2011 - Conditions: Vascular Disease; Heart Disease
Interventions: Drug: NO clamp; Drug: Saline; Drug: Fluconazole; Drug: Aspirin; Drug: Combined
Sponsors: University of Edinburgh; NHS Lothian
Recruiting - verified August 2011 - Condition: Malaria
Interventions: Biological: AdCh63 AMA1; Biological: AdCh63 AMa1 and MVA AMA1
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Dark chocolate enriched in flavan-3-ols and procyanidins; Dietary Supplement: Standard dark chocolate; Dietary Supplement: White chocolate
Sponsors: University of Aberdeen; Rural and Environment Research and Analysis Directorate (RERAD, UK); Biotechnology and Biological Sciences Research Council (BBSRC, UK); Natraceutical Industrial S.L.U., Valencia, Spain
Completed - verified August 2011 - Condition: Attention Deficit Hyperactivity Disorder
Interventions: Other: CBT plus treatment as usual; Other: Treatment as usual
Sponsor: South London and Maudsley NHS Foundation Trust
Recruiting - verified December 2011 - Condition: Palatally Impacted Canines
Intervention: Procedure: Alveolar-decortication.
Sponsor: University of Birmingham
Recruiting - verified January 2012 - Conditions: Fluid Overload; Water Electrolyte Imbalance; Acid Base Imbalance
Interventions: Drug: Crystalloid; Drug: Colloid
Sponsor: University of Nottingham
Completed - verified May 2011 - Conditions: Bladder Cancer; Cervical Cancer; Colorectal Cancer; Endometrial Cancer; Gastrointestinal Complications; Long-term Effects Secondary to Cancer Therapy in Adults; Ovarian Cancer; Prostate Cancer; Radiation Toxicity; Sarcoma; Testicular Germ Cell Tumor; Vaginal Cancer
Interventions: Other: questionnaire administration; Procedure: gastrointestinal complications management/prevention; Procedure: quality-of-life assessment
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified March 2010 - Conditions: Leukemia; Mucositis; Oral Complications
Interventions: Biological: palifermin; Biological: rituximab; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: fludarabine phosphate; Drug: imatinib mesylate; Drug: melphalan; Drug: mercaptopurine; Drug: methotrexate; Drug: nelarabine; Drug: pegaspargase; Drug: vincristine sulfate; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: assessment of therapy complications; Radiation: total-body irradiation
Sponsor: University College London Hospitals
Recruiting - verified June 2011 - Condition: Cardiovascular Disease
Interventions: Drug: Active Clonidine; Drug: Placebo Clonidine; Drug: Active ASA; Drug: Placebo ASA
Sponsors: Hamilton Health Sciences Corporation; McMaster University
Recruiting - verified December 2011 - Condition: Pulmonary Hypertension (Idiopathic, Familial or Anorexigen-associated)
Interventions: Drug: Dichloroacetate Sodium; Drug: Dichloroacetate Sodium; Drug: Dichloroacetate Sodium
Sponsors: University of Alberta; Imperial College London
Enrolling by invitation - verified November 2011 - Condition: Breast Cancer Mortality
Intervention: Other: Invitation for breast screening
Sponsors: University of Oxford; Department of Health, United Kingdom
Enrolling by invitation - verified June 2011 - Condition: Colorectal Cancer
Intervention:
Sponsors: Newcastle University; Northumbria Healthcare NHS Foundation Trust
Active, not recruiting - verified October 2011 - Condition: Coronary Artery Disease
Intervention: Device: Radi pressure wire (pressure wire assessment)
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified July 2011 - Conditions: Attention; Memory; Mood; Mental Fatigue
Intervention:
Sponsor: Northumbria University
Completed - verified August 2011 - Condition: Ischaemia-reperfusion (IR) Injury
Interventions: Drug: C-type natriuretic peptide (CNP); Drug: Saline; Drug: Acetylcholine
Sponsors: Queen Mary University of London; University College, London
Not yet recruiting - verified February 2010 - Condition: Type 1 Diabetes
Interventions: Other: Closed-loop insulin delivery; Other: Standard insulin pump treatment
Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust
Completed - verified February 2010 - Conditions: Respiratory Tract Infections; Influenza
Interventions: Dietary Supplement: Cholecalciferol (Vitamin D/Vigantol oil); Dietary Supplement: Miglyol oil
Sponsors: Barts & The London NHS Trust; National Health Service, United Kingdom
Recruiting - verified February 2011 - Condition: Type 1 Diabetes Mellitus
Intervention: Other: DAFNE course (Timing of delivery of education)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; University Hospitals, Leicester; Cambridge University Hospitals NHS Foundation Trust; University College London Hospitals; Northumbria Healthcare NHS Foundation Trust; NHS Greater Glasgow and Clyde; Norfolk and Norwich University Hospitals NHS Foundation Trust; East Lancashire Hospitals NHS Trust
Active, not recruiting - verified July 2011 - Conditions: Wegener's Granulomatosis; Microscopic Polyangiitis; Churg Strauss Syndrome; Polyarteritis Nodosa; Giant Cell Arteritis; Takayasu Arteritis
Intervention:
Sponsors: University of Oxford; American College of Rheumatology; The European League Against Rheumatism (EULAR); The Vasculitis foundation
Recruiting - verified January 2012 - Condition: Asthma
Intervention: Drug: Hydrocortisone/ Placebo and Propranolol
Sponsors: University of Dundee; NHS Tayside
Completed - verified October 2010 - Condition: Colorectal Cancer
Interventions: Drug: Eicosapentaenoic acid free fatty acid; Drug: Placebo
Sponsor: University of Leeds
Completed - verified October 2011 - Condition: Influenza
Intervention: Dietary Supplement: Prebiotic and probiotic mix
Sponsor: University of Reading
Active, not recruiting - verified July 2011 - Condition: Recovery From Critical Illness
Interventions: Dietary Supplement: Amino acid supplement; Other: PEPSE; Other: Intensive Care Unit (ICU) Recovery Manual; Dietary Supplement: Placebo nutritional supplement
Sponsors: St Helens & Knowsley Teaching Hospitals NHS Trust; Central Manchester University Hospitals NHS Foundation Trust
Recruiting - verified April 2011 - Conditions: Stroke; TIA; Surgery; Anaesthesia; Carotid Stenosis
Intervention: Device: OxyMask
Sponsor: Brighton and Sussex University Hospitals NHS Trust
Recruiting - verified February 2012 - Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis
Intervention: Drug: anti-TNF therapy (etanercept or adalimumab)
Sponsor: Imperial College London
Recruiting - verified September 2011 - Condition: Hypothermia
Intervention: Other: Under patient warming mattress
Sponsor: Brighton and Sussex University Hospitals NHS Trust
Recruiting - verified June 2011 - Condition: Nonalcoholic Steatohepatitis
Intervention: Drug: Losartan
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle University; University of Newcastle Upon-Tyne
Recruiting - verified February 2011 - Condition: Chronic Kidney Disease
Interventions: Other: Post operative progressive handgrip exercise; Other: Treatment as usual
Sponsors: Bangor University; Betsi Cadwaladr University Health Board
Recruiting - verified November 2011 - Conditions: Hypothermia; Shivering; Anesthesia, Obstetrical; Anesthesia, Regional; Cesarean Section
Intervention: Device: Warming with warming mattress
Sponsor: Brighton and Sussex University Hospitals NHS Trust
Completed - verified December 2011 - Condition: HIV Infections
Interventions: Drug: Maraviroc; Drug: placebo
Sponsor: St Stephens Aids Trust
Terminated - verified October 2011 - Condition: Myopathy
Intervention:
Sponsors: University of Nottingham; The Dunhill Medical Trust
Recruiting - verified October 2011 - Condition: Metabolic Syndrome
Interventions: Behavioral: Group lifestyle education; Other: Routine care
Sponsors: University of Leicester; University Hospitals, Leicester
Completed - verified December 2011 - Conditions: Dental Caries; Oral Microbial Colonization
Interventions: Dietary Supplement: Xylitol consumption; Behavioral: Childsmile preventative programme
Sponsors: NHS Fife; University of Turku
Active, not recruiting - verified December 2009 - Condition: Pancreatic Cancer
Interventions: Drug: capecitabine; Drug: gemcitabine hydrochloride; Procedure: quality-of-life assessment; Radiation: 3-dimensional conformal radiation therapy
Sponsor: Wales Cancer Trials Unit
Recruiting - verified May 2011 - Condition: Atrial Fibrillation
Intervention: Procedure: Atrial fibrillation ablation
Sponsor: Barts & The London NHS Trust
Recruiting - verified March 2011 - Condition: Atrial Fibrillation
Interventions: Procedure: catheter ablation; Procedure: catheter ablation
Sponsor: Barts & The London NHS Trust
Recruiting - verified March 2011 - Condition: Tuberculosis
Intervention: Biological: rdESAT-6 + rCFP-10 (C-Tb)
Sponsor: Statens Serum Institut
Completed - verified August 2011 - Condition: Skin Cancer
Interventions: Dietary Supplement: Omega-3 PUFA; Dietary Supplement: Gelatine
Sponsor: University of Manchester
Completed - verified August 2011 - Condition: Skin Cancer
Interventions: Dietary Supplement: Green tea + vitamin C high dose; Dietary Supplement: Placebo capsule
Sponsors: University of Manchester; University of Leeds; University of Bradford
Recruiting - verified November 2011 - Conditions: Anaesthesia; Airway Management; Videolaryngoscopy
Interventions: Device: Macintosh Laryngoscope; Device: Pentax AWS Videolaryngoscope
Sponsors: NHS Grampian; Research and Development Department, NHS Grampian; University of Aberdeen
Not yet recruiting - verified December 2011 - Condition: Cardiac Failure
Intervention: Device: Biventricular pacing
Sponsor: Cardiff and Vale University Health Board
Recruiting - verified June 2011 - Condition: Out-of-hospital Cardiac Arrest
Interventions: Procedure: Target temperature 36°C; Procedure: Target Temperature 33°C
Sponsors: Niklas Nielsen; Scandinavian Critical Care Trials Group; Copenhagen Trial Unit, Center for Clinical Intervention Research; Lund University; The George Institute of Global Health, Sydney, Australia
Recruiting - verified December 2011 - Conditions: Intrapartum Fetal Monitoring; Pregnancy
Interventions: Drug: Dinoprostone; Device: Monica AN 24
Sponsors: Liverpool Women's NHS Foundation Trust; University of Liverpool
Completed - verified November 2011 - Condition: Renal Failure
Interventions: Procedure: Percutaneous Insertion catheter; Procedure: Open insertion Catheter
Sponsor: University of Hull
Not yet recruiting - verified May 2010 - Conditions: Infection; Inflammation; Allergy; Children
Intervention:
Sponsor: Imperial College London
Recruiting - verified November 2011 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Fosinopril; Other: lactose
Sponsors: Imperial College London; Medical Research Council
Recruiting - verified June 2011 - Condition: Factor X Deficiency
Intervention: Biological: FACTOR X
Sponsors: Bio Products Laboratory; Bio Products Laboratory Ltd
Recruiting - verified January 2012 - Condition: Macular Degeneration
Interventions: Device: Epimacular Brachytherapy; Drug: Ranibizumab
Sponsor: King's College Hospital NHS Trust
Recruiting - verified February 2011 - Condition: Food Allergy
Intervention:
Sponsors: Brighton & Sussex Medical School; Brighton and Sussex University Hospitals NHS Trust; Guy's and St Thomas' NHS Foundation Trust
Completed - verified October 2009 - Condition: Cognitive and Cerebral Blood Flow Effects of Resveratrol
Interventions: Dietary Supplement: Trans- resveratrol; Other: Placebo (silica)
Sponsor: Northumbria University
Completed - verified March 2011 - Condition: Hypertension, Pulmonary
Intervention: Drug: propofol and isoflurane
Sponsor: University Hospitals Bristol NHS Trust
Completed - verified December 2011 - Condition: Heart Failure
Interventions: Drug: Placebo; Drug: Forceval plus 50 micrograms Vitamin D3
Sponsor: Belfast Health and Social Care Trust
Active, not recruiting - verified June 2011 - Conditions: Haemodialysis; Surgery
Intervention: Procedure: Arterial and venous duplex ultrasound examination
Sponsor: University of Hull
Recruiting - verified May 2010 - Condition: Malaria
Interventions: Biological: AdCh63-MSP1 (lower dose) vaccine and MVA-MSP1 vaccine; Biological: AdCh63-MSP1 vaccine (higher dose) and MVA-MSP1 vaccine followed by challenge
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Chronic Kidney Disease
Interventions: Other: Progressive resistance training programme; Other: Sham exercise; Other: Progressive resistance training; Other: Sham exercise
Sponsors: Bangor University; Betsi Cadwaladr University Health Board
Completed - verified December 2011 - Condition: Influenza
Intervention: Biological: MVA-NP+M1
Sponsors: University of Oxford; Wellcome Trust
Completed - verified January 2011 - Conditions: Type 2 Diabetes; Obesity
Intervention: Behavioral: 8-month group lifestyle programme
Sponsor: The Royal Bournemouth Hospital
Recruiting - verified August 2011 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: multikinase inhibitor AT9283; Other: enzyme-linked immunosorbent assay; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsor: Cancer Research UK
Recruiting - verified January 2012 - Conditions: Myocardial Reperfusion Injury; Cardiac Output, Low; Hypertrophy, Left Ventricular
Interventions: Drug: Perhexiline; Drug: Placebo marked PEXSIG
Sponsors: University Hospital Birmingham; University of Birmingham; Brighton and Sussex University Hospitals NHS Trust; British Heart Foundation
Recruiting - verified April 2011 - Condition: Stroke
Interventions: Drug: Transdermal glyceryl trinitrate patch; Drug: Pre-stroke antihypertensives
Sponsor: University of Nottingham
Recruiting - verified October 2011 - Condition: Prostate Cancer
Interventions: Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: single photon emission computed tomography; Radiation: technetium Tc 99m demobesin-4
Sponsor: Cancer Research UK
Recruiting - verified April 2010 - Condition: Prostate Cancer
Interventions: Other: pharmacological study; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: high-intensity focused ultrasound ablation; Procedure: quality-of-life assessment
Sponsor: University College London Hospitals
Recruiting - verified March 2011 - Conditions: Prostate Cancer; Sexual Dysfunction and Infertility
Interventions: Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: high-intensity focused ultrasound ablation; Procedure: quality-of-life assessment
Sponsor: University College London Hospitals
Recruiting - verified May 2011 - Conditions: Graft Versus Host Disease; Nonneoplastic Condition
Interventions: Biological: adoptive immunotherapy; Biological: alemtuzumab; Biological: in vitro-treated peripheral blood lymphocyte therapy; Drug: foscarnet sodium; Drug: ganciclovir; Genetic: polymerase chain reaction; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: infection prophylaxis and management; Procedure: peripheral blood stem cell transplantation; Procedure: standard follow-up care; Radiation: radiation therapy
Sponsor: University Hospital Birmingham
Recruiting - verified April 2010 - Condition: Acquired Immunodeficiency Syndrome
Intervention: Drug: lopinavir/ritonavir
Sponsor: Kirby Institute
Completed - verified March 2011 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Dietary Supplement: Cholecalciferol; Dietary Supplement: Miglyol oil
Sponsors: Barts & The London NHS Trust; National Health Service, United Kingdom
Recruiting - verified February 2011 - Condition: Asthma
Interventions: Dietary Supplement: Cholecalciferol; Dietary Supplement: Miglyol oil
Sponsors: Barts & The London NHS Trust; National Health Service, United Kingdom
Recruiting - verified February 2011 - Condition: HIV Infections
Interventions: Drug: Ribavirin; Drug: Raltegravir
Sponsor: Imperial College London
Completed - verified November 2011 - Condition: HIV Infections
Interventions: Drug: Maraviroc; Drug: Maraviroc
Sponsors: Imperial College London; Mater Misericordiae University Hospital, Dublin, Ireland
Recruiting - verified May 2011 - Condition: Smoking
Interventions: Behavioral: EFT (Emotional Freedom Techniques); Behavioral: CBT (Cognitive Behavioral Therapy)
Sponsor: Soul Medicine Institute
Recruiting - verified March 2011 - Condition: Giant Cell Arteritis
Interventions: Procedure: Ultrasound of temporal and axillary arteries; Procedure: Temporal artery biopsy
Sponsors: University of Oxford; University of Sheffield; Southend University Hospital; Nuffield Orthopaedic Centre NHS Trust; John Radcliffe Hospital; The Leeds Teaching Hospitals NHS Trust; University of Bristol; London School of Hygiene and Tropical Medicine; Medical Center for Rheumatology Berlin-Buch
Recruiting - verified January 2012 - Condition: Prostate Cancer
Interventions: Drug: WST11; Drug: WST11
Sponsor: Steba Biotech S.A.
Active, not recruiting - verified January 2012 - Condition: Hemophilia B
Intervention: Genetic: Gene Transfer
Sponsors: St. Jude Children's Research Hospital; Stanford University; Katharine Dormandy Haemophilia Centre and Haemostasis Unit
Recruiting - verified November 2011 - Condition: Critical Illness Myopathy
Intervention: Other: Pulmonary Rehabilitation
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Vascular Disease
Intervention:
Sponsors: Barts & The London NHS Trust; National Institute for Health Research, United Kingdom
Not yet recruiting - verified February 2011 - Conditions: Irritable Bowel Syndrome; Post Infective Bowel Dysfunction
Interventions: Drug: Saccharomyces Cerevisiae CNCM I-3856; Drug: placebo
Sponsors: University of Nottingham; Lesaffre International, Marcq-en-Baroeul, France
Withdrawn - verified January 2012 - Condition: Dyspnea
Intervention: Device: handheld fan directed to cheeks
Sponsors: Cambridge University Hospitals NHS Foundation Trust; St Catherines Hospice; Scarborough acute hospitals Trust; University hospitals Morecambe Bay; St Johns Hospice
Recruiting - verified June 2011 - Condition: Idiopathic Inflammatory Myopathy
Intervention:
Sponsor: Salford Royal NHS Foundation Trust
Recruiting - verified October 2009 - Condition: Influenza
Intervention:
Sponsors: Imperial College London; Wellcome Trust; Medical Research Council
Completed - verified June 2011 - Conditions: Anesthesia; Child; Infant
Intervention:
Sponsors: University Hospitals Bristol NHS Trust; Royal United Hospital Bath NHS Trust
Terminated - verified December 2011 - Condition: Prostate Cancer
Interventions: Drug: antiandrogen therapy; Drug: releasing hormone agonist therapy; Genetic: DNA analysis; Genetic: RNA analysis; Genetic: comparative genomic hybridization; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: magnetic resonance spectroscopic imaging
Sponsor: Cancer Research UK at Cambridge Research Institute
Recruiting - verified August 2009 - Condition: Prostate Cancer
Interventions: Other: laboratory biomarker analysis; Other: medical chart review; Other: questionnaire administration
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - verified August 2009 - Condition: Hematopoietic/Lymphoid Cancer
Interventions: Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Other: laboratory biomarker analysis; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Procedure: umbilical cord blood transplantation; Radiation: total-body irradiation
Sponsor: Cancer Research UK
Recruiting - verified April 2010 - Condition: Cancer
Interventions: Behavioral: Distress Thermometer and Problems List; Behavioral: Usual psychosocial support
Sponsors: University Hospitals Bristol NHS Trust; Royal United Hospital Bath NHS Trust; University of Bristol
Active, not recruiting - verified July 2011 - Condition: Breast Cancer
Intervention: Procedure: Breast scan - Electrical Impedance Mammography
Sponsor: Oxford University Hospitals NHS Trust
Recruiting - verified August 2009 - Condition: Schizophrenia
Interventions: Drug: Citalopram; Drug: Placebo
Sponsors: Imperial College London; University of Manchester; University of Southampton; King's College London; University of Oxford; University College, London; University of Bristol
Recruiting - verified September 2011 - Conditions: Pelvic Floor Disorders; Sexual Function; Incontinence; Pelvic Organ Prolapse
Intervention:
Sponsor: International Urogynecological Society
Active, not recruiting - verified November 2011 - Conditions: Stroke; Hemispatial Neglect
Interventions: Drug: Guanfacine; Drug: Placebo
Sponsors: Imperial College London; Wellcome Trust
Recruiting - verified June 2011 - Conditions: Anxiety Disorder; Breast Cancer; Depression; Fatigue
Interventions: Procedure: acupuncture therapy; Procedure: standard follow-up care
Sponsor: University of Manchester
Recruiting - verified August 2009 - Condition: Prostate Cancer
Interventions: Radiation: hypofractionated radiation therapy; Radiation: intensity-modulated radiation therapy
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified July 2009 - Conditions: Intensive Care; Blood Transfusion; Anemia
Interventions: Biological: Restrictive RBC Transfusion; Biological: Liberal RBC Transfusion
Sponsors: University of Edinburgh; NHS Lothian; Chief Scientist Office of the Scottish Government; Transfusion Medicine Education and Research Foundation
Completed - verified March 2011 - Condition: Primary Mediastinal B-Cell Lymphoma
Intervention:
Sponsor: International Extranodal Lymphoma Study Group (IELSG)
Active, not recruiting - verified November 2011 - Condition: Influenza
Interventions: Biological: MVA-NP+M1; Biological: MVA-NP+M1; Biological: MVA-NP+M1
Sponsors: University of Oxford; Wellcome Trust
Recruiting - verified June 2011 - Condition: Decompression, Surgical
Interventions: Procedure: Plasma Disc Decompression/Nucleoplasty; Procedure: Conservative Care (physiotherapy)
Sponsor: ArthroCare Corporation
Active, not recruiting - verified March 2011 - Conditions: Deglutition Disorders; Esophageal Diseases; Eosinophilia
Intervention: Other: assessment of disease activity using the EEsAI
Sponsors: University Hospital Inselspital, Berne; Institute of Social and Preventive Medicine, University Bern; Dept. of Gastroenterology, Kantonsspital Olten, Olten; Luzerner Kantonsspital; Mayo Clinic Rochester, Minnesota, USA; University of Cincinnati; University of Colorado, Denver; Northwestern University of Chicago, Illinois, USA; Indiana University School of Medicine; Philadelphia University
Recruiting - verified September 2011 - Conditions: Isolated Mediastinal Lymphadenopathy; Sarcoidosis; Tuberculosis; Lung Cancer; Lymphoma
Intervention: Procedure: EBUS
Sponsor: University College London Hospitals
Active, not recruiting - verified October 2011 - Conditions: Chronic Obstructive Pulmonary Disease; Pulmonary Rehabilitation
Intervention: Behavioral: Pulmonary Intervention
Sponsor: University of East Anglia
Active, not recruiting - verified August 2011 - Condition: Factor X Deficiency
Intervention: Biological: Human Coagulation FACTOR X
Sponsor: Bio Products Laboratory
Recruiting - verified January 2012 - Condition: Compartment Syndrome
Intervention: Device: Monitoring of StO2
Sponsor: University Hospital Birmingham NHS Foundation Trust
Completed - verified September 2011 - Conditions: Obstructive Lung Disease; Chronic Obstructive Pulmonary Disease; Asthma
Intervention: Dietary Supplement: AKL1
Sponsor: University of East Anglia
Active, not recruiting - verified August 2011 - Conditions: Myelodysplastic Syndromes; Leukemia, Myeloid, Acute
Interventions: Drug: Fludarabine; Drug: Busulphan; Drug: Thymoglobuline (Anti-thymocyte globulin [rabbit]) - Genzyme; Procedure: Haematopoietic stem cell infusion
Sponsor: King's College Hospital NHS Trust
Terminated - verified June 2011 - Conditions: Appetite Regulation; Obesity
Interventions: Dietary Supplement: Oligofructose; Dietary Supplement: Placebo
Sponsor: Imperial College London
Completed - verified December 2011 - Conditions: Disorder Related to Renal Transplantation; Pain
Interventions: Procedure: TAP block; Procedure: TAP block with placebo
Sponsor: Royal Liverpool and Broadgreen University Hospitals NHS Trust
Completed - verified October 2010 - Condition: Ovarian Cancer
Interventions: Genetic: DNA methylation analysis; Genetic: microarray analysis; Genetic: polymerase chain reaction; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsor: Scottish Gynaecological Cancer Study Group
Recruiting - verified July 2009 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Genetic: molecular genetic technique; Other: mass spectrometry; Other: pharmacological study
Sponsor: Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: carboplatin; Drug: cyclophosphamide; Drug: etoposide phosphate; Genetic: gene expression analysis; Genetic: polymorphism analysis; Other: pharmacological study
Sponsor: Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Sarcoma
Interventions: Genetic: microarray analysis; Genetic: molecular diagnostic method; Other: biologic sample preservation procedure
Sponsor: Christie Hospital NHS Foundation Trust
Recruiting - verified April 2008 - Condition: Migraine
Intervention:
Sponsors: The City of London Migraine Clinic; Genomics Research Centre, Griffith University, Australia
Recruiting - verified July 2011 - Condition: Melanoma (Skin)
Interventions: Genetic: gene expression analysis; Genetic: mutation analysis; Other: diagnostic laboratory biomarker analysis; Other: immunohistochemistry staining method; Procedure: sentinel lymph node biopsy
Sponsor: Leeds Cancer Centre at St. James's University Hospital
Recruiting - verified April 2008 - Condition: Atrial Fibrillation
Intervention: Procedure: catheter ablation
Sponsor: Barts & The London NHS Trust
Completed - verified August 2011 - Condition: Diabetic Neuropathy
Intervention:
Sponsor: Tameside Hospital NHS Foundation Trust
Recruiting - verified May 2009 - Condition: Malaria
Interventions: Biological: AdCh63 ME-TRAP; Biological: AdCh63 ME-TRAP; MVA ME-TRAP
Sponsor: University of Oxford
Completed - verified October 2011 - Condition: Malaria
Interventions: Biological: AdCh63 ME-TRAP; Biological: MVA ME-TRAP; Other: Sporozoite challenge; Biological: Mixture of AdCh63 ME-TRAP and MVA ME-TRAP intramuscularly
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Phenylketonuria
Interventions: Dietary Supplement: high oleic sunflower oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil
Sponsors: Ludwig-Maximilians - University of Munich; European Union
Active, not recruiting - verified October 2011 - Condition: Carotid Stenosis
Intervention: Procedure: CEA, CAS
Sponsors: University of Oxford; NHS Health Technology Assessment Programme; BUPA Foundation
Recruiting - verified November 2011 - Conditions: Chronic Kidney Disease; Vitamin D Deficiency
Interventions: Drug: Ergocalciferol (Vitamin D); Drug: Placebo
Sponsor: Barts & The London NHS Trust
Completed - verified March 2011 - Condition: Dental Caries
Intervention: Other: Fluoride varnish
Sponsor: University of St Andrews
Recruiting - verified July 2011 - Condition: Sickle Cell Disease
Interventions: Drug: Ibuprofen; Drug: Placebo; Drug: Diamorphine or Morphine
Sponsor: North West London Hospitals NHS Trust
Recruiting - verified March 2011 - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: CD-ROM
Sponsor: Queen's University, Belfast
Completed - verified August 2011 - Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart FailureConditions: Atrial Fibrillation; Heart Failure
Interventions: Drug: Medication to control ventricular rate in AF; Procedure: Catheter Ablation for Persistent Atrial Fibrillation
Sponsor: Royal Brompton & Harefield NHS Foundation Trust
Active, not recruiting - verified December 2011 - Condition: Cardiovascular Disease
Intervention: Other: Fruit and vegetable intervention
Sponsor: Queen's University, Belfast
Completed - verified August 2011 - Condition: Sarcoidosis
Interventions: Procedure: EUS-FNA/EBUS-TBNA + BAL; Procedure: EBB + TBLB + BAL
Sponsor: Leiden University Medical Center
Active, not recruiting - verified January 2012 - Condition: Adenocarcinoma of the Stomach
Intervention: Drug: capecitabine
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified May 2010 - Conditions: Polycythemia Vera; Essential Thrombocythemia
Intervention: Drug: HDAC inhibitor (MK-0683)
Sponsor: Copenhagen University Hospital at Herlev
Active, not recruiting - verified December 2011 - Condition: Laparoscopic Cholecystectomy
Intervention: Other: Succinylated gelatine, 40g/L, (Gelofusine - B Braun)
Sponsors: University of Nottingham; Sherwood Forest Hospitals NHS Foundation Trust
Completed - verified November 2011 - Condition: Bladder Cancer
Interventions: Procedure: therapeutic conventional surgery; Radiation: radiation therapy
Sponsor: Institute of Cancer Research, United Kingdom
Active, not recruiting - verified March 2009 - Condition: Pancreatic Adenocarcinoma
Intervention: Drug: capecitabine
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified May 2010 - Condition: Asthma
Interventions: Drug: Azithromycin; Drug: Placebo
Sponsors: Euan J Cameron; University of Glasgow; NHS Greater Glasgow and Clyde
Completed - verified October 2011 - Condition: Bronchiectasis
Interventions: Procedure: Chest physiotherapy; Procedure: Chest Physiotherapy + Exercise Program
Sponsor: NHS Lothian
Completed - verified November 2011 - Condition: Type 2 Diabetes Mellitus
Intervention: Dietary Supplement: cinnamon 2g per day for 12 weeks
Sponsors: Thames Valley University; Wembley Health Care centre, NHS, UK.; Monks Park Primary care centre, NHS UK.; Willesden Health centre, NHS, UK.
Completed - verified February 2009 - Condition: Infertility
Intervention: Drug: Nafarelin acetate, Oestradiol Valerate, Progesterone
Sponsors: University of Oxford; Oxford Fertility Unit, UK
Enrolling by invitation - verified January 2012 - Condition: Subarachnoid Hemorrhage
Interventions: Device: Lumbar Drain (Medtronic lumbar drainage system); Other: No lumbar drain
Sponsor: The Leeds Teaching Hospitals NHS Trust
Completed - verified February 2009 - Condition: Chronic Heart Failure
Interventions: Drug: Perhexiline; Drug: Placebo
Sponsors: University Hospital Birmingham NHS Foundation Trust; British Heart Foundation
Completed - verified November 2011 - Condition: Polymyalgia Rheumatica
Interventions: Drug: Timed Release Tablet Prednisone; Drug: Prednisolone
Sponsor: University Hospitals Bristol NHS Trust
Active, not recruiting - verified August 2011 - Conditions: Asthma; Rhinitis
Intervention: Other: no intervention
Sponsor: University of Dundee
Completed - verified May 2009 - Conditions: Myotonia; Non-Dystrophic Myotonia
Interventions: Drug: Mexiletine; Drug: Placebo
Sponsor: University of Kansas
Active, not recruiting - verified June 2011 - Conditions: Post-operative Pain; Postoperative Nausea; Postoperative Complications
Intervention: Drug: Levobupivicaine 0.25%
Sponsor: University of Nottingham
Completed - verified January 2012 - Conditions: Breast Cancer; Head and Neck Cancer; Lymphedema
Interventions: Other: questionnaire administration; Procedure: acupuncture therapy; Procedure: assessment of therapy complications; Procedure: management of therapy complications; Procedure: naturopathy therapy; Procedure: quality-of-life assessment
Sponsor: Lynda Jackson Macmillan Centre at Mount Vernon Hospital
Recruiting - verified January 2009 - Conditions: Malignant Mesothelioma; Metastatic Cancer
Interventions: Other: talc; Procedure: therapeutic thoracoscopy; Procedure: therapeutic videothoracoscopy
Sponsor: Papworth Hospital NHS Foundation Trust
Active, not recruiting - verified January 2012 - Is Regular Chest Physiotherapy an Effective Treatment in Severe, Non Cystic Fibrosis Bronchiectasis?Condition: Bronchiectasis
Intervention: Device: Acapella Physiotherapy
Sponsor: NHS Lothian
Completed - verified July 2010 - Condition: Leukemia
Interventions: Biological: pegfilgrastim; Biological: rituximab; Drug: cyclophosphamide; Drug: fludarabine phosphate; Genetic: cytogenetic analysis; Genetic: fluorescence in situ hybridization; Genetic: gene expression analysis; Genetic: mutation analysis; Genetic: protein expression analysis; Other: flow cytometry; Other: laboratory biomarker analysis
Sponsor: All Ireland Cooperative Oncology Research Group
Recruiting - verified January 2009 - Condition: Adipose Tissue
Intervention: Other: GIP (glucose dependent insulinotropic peptide) infusion
Sponsor: Aintree University Hospitals NHS Foundation Trust
Recruiting - verified December 2011 - Conditions: End-stage Renal Failure; Graft Rejection
Interventions: Drug: Tacrolimus (Kidney transplant maintenance immunosuppression); Drug: Kidney transplant maintenance immunosuppression
Sponsor: Hammersmith Hospitals NHS Trust
Recruiting - verified June 2011 - Condition: Ulcerative Colitis
Intervention: Other: Synbiotic (Synergy1/B. longum)
Sponsors: University of Dundee; National Association for Colitis and Crohn's Disease
Completed - verified July 2011 - Condition: Meniere's Disease
Interventions: Drug: Methylprednisolone; Drug: Gentamicin
Sponsors: Imperial College London; Meniere's Society; Imperial College Healthcare NHS Trust; Medical Research Council
Recruiting - verified September 2011 - Condition: Trachoma
Interventions: Drug: Azithromycin; Drug: Azithromycin
Sponsors: Johns Hopkins University; Bill and Melinda Gates Foundation
Recruiting - verified November 2011 - Condition: Venous Thromboembolism
Intervention:
Sponsors: Ottawa Hospital Research Institute; Heart and Stroke Foundation of Ontario
Recruiting - verified June 2011 - Conditions: Type 1 Diabetes; Type 2 Diabetes
Intervention: Biological: Autologous CD34+ stem cells
Sponsor: Imperial College London
Recruiting - verified July 2011 - Condition: Asthma
Interventions: Device: Fenzian Device; Device: Sham Device
Sponsors: University of California, Los Angeles; Fenzian Ltd.
Active, not recruiting - verified March 2011 - Condition: Rheumatoid Arthritis
Intervention:
Sponsors: Imperial College London; Medical Research Council
Completed - verified September 2011 - Condition: Asthma
Intervention: Other: bronchoscopy
Sponsors: Imperial College London; Asthma UK; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified June 2011 - Conditions: Alcohol Abuse; Drug Abuse; Depression; Panic Disorder; Conduct Disorder
Intervention: Behavioral: Personality-targeted interventions
Sponsors: King's College London; Action on Addiction
Completed - verified December 2010 - Condition: Acute AMI
Interventions: Other: Bone marrow derived progenitor cells or placebo infusion; Other: Placebo infusion
Sponsors: Barts & The London NHS Trust; University College, London; Queen Mary University of London
Recruiting - verified February 2011 - Condition: Non-Alcoholic Fatty Liver Disease
Intervention: Drug: OMACOR
Sponsors: Southampton University Hospitals NHS Trust; Department of Health, National Institute for Health Research (NIHR)
Active, not recruiting - verified April 2011 - Condition: Breast Cancer
Interventions: Drug: letrozole; Other: placebo
Sponsors: NCIC Clinical Trials Group; Eastern Cooperative Oncology Group; North Central Cancer Treatment Group; Southwestern Oncology Group (SWOG); Cancer and Leukemia Group B
Active, not recruiting - verified December 2011 - Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: cyclophosphamide; Drug: melphalan; Procedure: autologous hematopoietic stem cell transplantation
Sponsor: Leeds Cancer Centre at St. James's University Hospital
Recruiting - verified June 2009 - Condition: Autoimmune Adrenocortical Failure
Intervention: Drug: Solu-medrone, Mabthera
Sponsors: Newcastle University; Newcastle-upon-Tyne Hospitals NHS Trust
Active, not recruiting - verified March 2011 - Condition: Abdominal Aortic Aneurysm
Interventions: Procedure: Open repair; Procedure: EVAR
Sponsors: Imperial College London; London School of Hygiene and Tropical Medicine; University of Cambridge; The Leeds Teaching Hospitals NHS Trust; St George's, University of London
Recruiting - verified January 2012 - Condition: Chronic Ischaemic Heart Failure
Interventions: Drug: Granulocyte-colony stimulating factor; Procedure: Percutaneous intracoronary injection; Procedure: Percutaneous intramyocardial injection
Sponsor: Barts & The London NHS Trust
Recruiting - verified February 2011 - Condition: Irritable Bowel Syndrome With Diarrhoea
Interventions: Drug: Ondansetron; Drug: Placebo
Sponsors: University of Nottingham; National Institute for Health Research, United Kingdom
Completed - verified January 2012 - Conditions: Angina Pectoris; Coronary Heart Disease
Intervention:
Sponsors: University of Edinburgh; Imperial College London
Active, not recruiting - verified November 2011 - Condition: Dizziness
Interventions: Behavioral: Self-treatment booklet; Behavioral: Remote telephone support
Sponsor: University of Southampton
Completed - verified January 2010 - Conditions: Type 2 Diabetes Mellitus; Coronary Artery Disease
Interventions: Drug: clopidogrel; Drug: placebo
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; British Heart Foundation; University of Newcastle Upon-Tyne
Active, not recruiting - verified November 2009 - Conditions: Type 2 Diabetes Mellitus; Acute Coronary Syndrome
Intervention:
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; British Heart Foundation; University of Newcastle Upon-Tyne
Active, not recruiting - verified October 2008 - Condition: Normal Pressure Hydrocephalus
Intervention: Procedure: Surgical treatment
Sponsor: University College London Hospitals
Terminated - verified July 2008 - Conditions: Deep Vein Thrombosis; Pulmonary Embolism
Interventions: Other: Discontinue anticoagulant therapy (Negative d-dimer); Other: Continue on anticoagulant therapy (positive d-dimer)
Sponsors: McMaster University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified October 2011 - Condition: Coronary Artery Disease
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: University of Glasgow; NHS Greater Glasgow and Clyde; Chief Scientist Office of the Scottish Government
Active, not recruiting - verified April 2011 - Condition: Subclinical Cushing's
Intervention: Drug: Mifepristone
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - verified July 2010 - Condition: Head and Neck Cancer
Interventions: Procedure: computed tomography; Procedure: positron emission tomography; Procedure: therapeutic conventional surgery
Sponsor: Warwick Medical School
Recruiting - verified December 2008 - Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: parenteral chemotherapy
Sponsor: Warwick Medical School
Recruiting - verified November 2008 - Conditions: Intracerebral Hemorrhage; Stroke; Hypertension
Intervention: Other: Blood pressure management policies
Sponsor: The George Institute
Recruiting - verified July 2011 - Conditions: Tuberculosis; Monitoring, Immunologic
Intervention:
Sponsor: Tuberculosis Network European Trialsgroup
Completed - verified May 2011 - Condition: Prostate Cancer
Intervention: Drug: WST11
Sponsor: Steba Biotech S.A.
Active, not recruiting - verified January 2012 - Conditions: COPD; Emphysema
Interventions: Drug: Simvastatin; Drug: Placebo
Sponsor: University of East Anglia
Active, not recruiting - verified August 2011 - Conditions: Cardiovascular Disease; Diabetes
Interventions: Dietary Supplement: Flavonoid enrichment (cocoa / soy compounds); Dietary Supplement: Flavonoid enrichment (cocoa / soy compounds)
Sponsors: University of East Anglia; Institute of Food Research; The Bertram Diabetes Centre & Radiology department (Norfolk & Norwich University Hospital, UK); Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK); Diabetes UK; Frutarom Netherlands B.V. - Soy producer; Barry Callebaut - chocolate manufacturer contracted to produce intervention foods
Completed - verified May 2011 - Condition: Asthma
Intervention: Other: Fiberoptic bronchoscopy; blood test
Sponsors: Imperial College London; Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council
Recruiting - verified June 2011 - Condition: Crohn's Disease
Interventions: Drug: Colecalciferol D3 (Vigantol Oil); Drug: Medium chain triglycerides
Sponsor: Imperial College London
Withdrawn - verified June 2011 - Conditions: Acute Liver Failure; Intracranial Hypertension
Intervention: Device: Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero
Sponsors: Rigshospitalet, Denmark; University Hospital Birmingham; King's College London; Feinberg School of Medicine, Northwestern University
Completed - verified July 2010 - Conditions: Lymphoma; Neurotoxicity
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: prednisolone; Drug: procarbazine hydrochloride; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsor: Cancer Research UK
Recruiting - verified January 2009 - Conditions: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer; Ovarian Cancer
Interventions: Drug: rucaparib (CO-338; formally AG-014699 or PF-01367338); Genetic: protein expression analysis; Genetic: western blotting; Other: immunohistochemistry staining method; Other: liquid chromatography; Other: mass spectrometry; Other: pharmacological study
Sponsor: Cancer Research UK
Recruiting - verified January 2012 - Conditions: Right Hemisphere Stroke; Hemispatial Neglect; Motor Deficit
Intervention: Drug: Rotigotine
Sponsors: University College, London; Medical Research Council
Completed - verified January 2010 - Condition: Diverticulosis, Colonic
Interventions: Device: Mesalazine; Drug: Placebo
Sponsor: University of Nottingham
Active, not recruiting - verified March 2011 - Condition: Asthma
Intervention: Drug: budesonide
Sponsors: Imperial College London; Royal Brompton & Harefield NHS Foundation Trust
Withdrawn - verified June 2011 - Condition: Asthma
Intervention: Drug: prednisolone
Sponsors: Imperial College London; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified June 2011 - Condition: Bronchogenic Carcinoma
Interventions: Procedure: Endobronchial or Endoscopic Ultrasound; Procedure: Bronchoscopy, CT-guided biopsy, PET scan, Mediastinoscopy
Sponsors: University College London Hospitals; North Middlesex University Hospital; Barnet and Chase Farm Hospitals NHS Trust; The Whittington Hospital NHS Trust
Active, not recruiting - verified October 2011 - Condition: Acute Lung Injury
Interventions: Drug: N-acetylcysteine; Drug: 0.9% saline
Sponsors: Imperial College London; Royal College of Physicians; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified December 2011 - Condition: Transient Hypothyroxinemia
Interventions: Drug: sodium iodide; Drug: sodium chloride
Sponsors: University of Oxford; University of Dundee; Medical Research Council
Recruiting - verified December 2011 - Conditions: Anxiety Disorder; Long-term Effects Secondary to Cancer Therapy in Adults; Prostate Cancer; Sexual Dysfunction and Infertility; Urinary Complications
Interventions: Drug: cyproterone acetate; Drug: releasing hormone agonist therapy; Other: active surveillance; Other: medical chart review; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery; Procedure: therapeutic lymphadenectomy; Radiation: 3-dimensional conformal radiation therapy
Sponsor: Oxford Radcliffe Hospital
Active, not recruiting - verified October 2011 - Conditions: HIV Infections; Acquired Immune Deficiency Syndrome
Interventions: Biological: HIV glycoprotein CN54gp140 (vaccine); Biological: Carbopol 974
Sponsors: St George's, University of London; Bill and Melinda Gates Foundation; York Hospitals
Terminated - verified February 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Genetic: DNA methylation analysis; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group; Radiation Therapy Oncology Group; Medical Research Council; Cooperative Trials Group for Neuro-Oncology
Recruiting - verified May 2011 - Condition: Tracheal Intubation
Interventions: Device: McGrath; Device: Tracheal intubation using Macintosh Laryngoscope
Sponsor: NHS Grampian
Completed - verified March 2008 - Conditions: Intracranial Aneurysm; Subarachnoid Hemorrhage
Intervention: Procedure: endovascular coil embolization
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified January 2012 - Condition: Multiple Sclerosis
Interventions: Biological: Live Hookworm Larvae; Other: Histamine
Sponsor: University of Nottingham
Not yet recruiting - verified November 2011 - Conditions: Breast Cancer; Cervical Cancer; Endometrial Cancer; Fallopian Tube Cancer; Ovarian Cancer; Prostate Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer
Interventions: Genetic: gene expression analysis; Genetic: gene rearrangement analysis; Genetic: polymorphism analysis; Other: laboratory biomarker analysis; Radiation: radiation therapy
Sponsor: Christie Hospital NHS Foundation Trust
Recruiting - verified April 2008 - Conditions: Pain; Bone Metastasis
Interventions: Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy
Sponsor: International Atomic Energy Agency
Recruiting - verified October 2011 - Condition: Cancer
Intervention: Behavioral: EPAT© Educational Package
Sponsors: University of Edinburgh; Cancer Research UK
Recruiting - verified September 2011 - Condition: Myelodysplastic Syndromes
Intervention:
Sponsor: Radboud University
Recruiting - verified July 2011 - Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the TesticleCondition: Testicular Germ Cell Tumor
Interventions: Other: questionnaire administration; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: quality-of-life assessment
Sponsor: Medical Research Council
Recruiting - verified July 2009 - Conditions: Overweight; Obesity; Metabolic Syndrome
Interventions: Other: control diet, supported by dietary supplement twice daily; Other: high cereal fiber diet, supported by dietary supplement twice daily; Other: high protein diet, supported by dietary supplement twice daily; Other: diet moderately high both in cereal fiber and protein, supported by dietary supplement twice daily
Sponsors: German Institute of Human Nutrition; German Federal Ministry of Education and Research; University of Warwick; University Hospitals Coventry and Warwickshire NHS Trust; Medical University of Vienna; Heinrich-Heine University, Duesseldorf; University Hospital Tuebingen; Charite University, Berlin, Germany; Klinikum Ernst von Bergmann Potsdam; Institute for Cereal Processing Potsdam-Rehbruecke
Completed - verified December 2011 - Condition: Head and Neck Cancer
Interventions: Other: questionnaire administration; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment; Procedure: regional lymph node dissection; Procedure: therapeutic conventional surgery
Sponsor: The Facial Surgery Research Foundation
Recruiting - verified July 2009 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Low PA apple puree; Dietary Supplement: High PA apple puree; Drug: Aspirin
Sponsor: Institute of Food Research
Completed - verified March 2011 - Condition: Colorectal Cancer
Interventions: Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Completed - verified August 2009 - Condition: Cutaneous Melanoma
Intervention: Drug: vatalanib
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Active, not recruiting - verified April 2008 - Condition: Colorectal Cancer
Interventions: Other: laboratory biomarker analysis; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: quality-of-life assessment
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified August 2009 - Conditions: Prostate Cancer; Sexual Dysfunction and Infertility; Urinary Incontinence
Interventions: Other: questionnaire administration; Procedure: biopsy; Procedure: high-intensity focused ultrasound ablation; Procedure: magnetic resonance imaging; Procedure: quality-of-life assessment
Sponsor: University College London Hospitals
Recruiting - verified July 2009 - Condition: Prostate Cancer
Interventions: Other: questionnaire administration; Procedure: high-intensity focused ultrasound ablation; Procedure: quality-of-life assessment
Sponsor: University College London Hospitals
Recruiting - verified June 2009 - Condition: Cellulitis/Erysipelas of the Leg
Interventions: Drug: Penicillin VK; Other: placebo
Sponsors: University of Nottingham; Action Medical Research; UK Dermatology Clinical Trials Network
Active, not recruiting - verified January 2012 - Condition: Breast Cancer
Intervention: Drug: letrozole
Sponsor: International Breast Cancer Study Group
Recruiting - verified September 2008 - Condition: Testicular Germ Cell Tumor
Interventions: Other: biomarker analysis; Procedure: computed tomography
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified October 2007 - Condition: Depression
Interventions: Behavioral: Psychosocial support exercise programme; Behavioral: Prescribed exercise
Sponsors: University of Nottingham; Burdett Trust for Nursing; Nottinghamshire Healthcare NHS Trust; Nottingham City Primary Care Trust; Nottinghamshire County Teaching Primary Care Trust
Completed - verified March 2011 - Conditions: Gastrointestinal Complications; Prostate Cancer; Sexual Dysfunction and Infertility; Urinary Complications
Interventions: Drug: bicalutamide; Drug: goserelin acetate; Drug: leuprolide acetate; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsor: Medical Research Council
Recruiting - verified July 2009 - Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Genetic: molecular diagnostic method; Genetic: polymorphism analysis; Genetic: protein expression analysis; Other: medical chart review; Other: questionnaire administration
Sponsor: National Cancer Research Network
Recruiting - verified September 2007 - Condition: Childhood Obesity
Intervention: Behavioral: Obesity management framework
Sponsor: University of Bristol
Completed - verified February 2009 - Condition: Acute Myocardial Infarction
Interventions: Other: CD133+ infusion; Other: placebo infusion
Sponsors: Onze Lieve Vrouw Hospital; King's College London
Recruiting - verified May 2011 - Condition: Dermatitis, Photocontact
Intervention: Drug: 19 organic sunscreen filters and 5 topical NSAIDs
Sponsor: NHS Tayside
Completed - verified July 2011 - Conditions: Lung Cancer; Thromboembolism
Interventions: Drug: dalteparin; Procedure: quality-of-life assessment
Sponsor: Velindre NHS Trust
Recruiting - verified March 2008 - Condition: Breast Cancer
Interventions: Biological: pegfilgrastim; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Genetic: proteomic profiling; Other: diagnostic laboratory biomarker analysis; Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry; Other: pharmacological study; Other: surface-enhanced laser desorption/ionization-time of flight mass spectrometry; Procedure: adjuvant therapy
Sponsor: Charing Cross Hospital
Recruiting - verified September 2007 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: motexafin gadolinium; Drug: temozolomide; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsor: Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With IfosfamideConditions: Chemotherapeutic Agent Toxicity; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Genetic: gene expression analysis; Genetic: polymorphism analysis; Procedure: management of therapy complications
Sponsor: Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Malignant Mesothelioma
Interventions: Drug: bortezomib; Procedure: quality-of-life assessment
Sponsor: All Ireland Cooperative Oncology Research Group
Recruiting - verified August 2007 - Condition: Depression
Interventions: Drug: Folic Acid; Drug: Placebo
Sponsors: Bangor University; NHS Health Technology Assessment Programme; Swansea University; Cardiff University; University of Liverpool; North West Wales NHS Trust; North East Wales NHS Trust; Swansea NHS Trust
Completed - verified February 2009 - Conditions: Lung Cancer; Precancerous Condition
Interventions: Other: cytology and cytometry specimen collection procedure; Other: Chest x ray; Procedure: Autofluorescence bronchoscopy; Procedure: CT scan
Sponsor: University College, London
Completed - verified December 2011 - Conditions: Health Status Unknown; Lung Cancer
Interventions: Genetic: DNA methylation analysis; Genetic: DNA stability analysis; Genetic: gene expression analysis; Other: epidemiologic study; Other: study of socioeconomic and demographic variables; Procedure: biopsy; Procedure: evaluation of cancer risk factors; Procedure: study of high risk factors
Sponsor: University of Liverpool Cancer Research Centre
Recruiting - verified November 2007 - Condition: Kidney Cancer
Interventions: Drug: sorafenib tosylate; Procedure: adjuvant therapy
Sponsor: Medical Research Council
Recruiting - verified April 2008 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Biological: bevacizumab; Drug: carboplatin; Drug: paclitaxel; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: quality-of-life assessment
Sponsor: Medical Research Council
Recruiting - verified January 2012 - Conditions: Colorectal Cancer; Metastatic Cancer
Interventions: Biological: cetuximab; Drug: capecitabine; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Other: study of socioeconomic and demographic variables; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: quality-of-life assessment
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified April 2008 - Condition: Gastroesophageal Reflux
Intervention:
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Completed - verified June 2011 - Conditions: Heartburn; Gastro-esophageal Reflux
Intervention:
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Completed - verified June 2011 - Condition: Pelvic Organ Prolapse
Intervention: Procedure: Pelvic Floor Muscle Training
Sponsors: Glasgow Caledonian University; Chief Scientist Office of the Scottish Government; South Glasgow University Hospitals NHS Trust; University of Aberdeen; University of Otago
Completed - verified February 2010 - Condition: Breast Cancer
Interventions: Other: Interview; Procedure: Blood and Tissue Collection
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified October 2011 - Conditions: Pancreatic Cancer; Thromboembolism
Interventions: Drug: dalteparin; Drug: gemcitabine hydrochloride; Other: diagnostic laboratory biomarker analysis
Sponsor: Hull and East Yorkshire Hospitals NHS Trust
Recruiting - verified April 2007 - Condition: the Efficacy and Safety of Off-pump CABG
Interventions: Procedure: Coronary Artery Bypass Graft with the use of CPB; Procedure: Coronary Artery Bypass Graft without the use of CPB
Sponsors: Population Health Research Institute; McMaster University; University of Oxford; Instituto Dante Pazzanese de Cardiologia; ECLA Clinical Research Organization,; Fu Wai Hospital, Beijing, China; Facultad de Medicina, Universidad de La Frontera, Temuco, Chile; Fundación Cardiovascular de Colombia; Charles University, Czech Republic; Hopital Jean Minjoz; Centre for Chronic Disease Control, India; S. C. di Cardiochirurgia, Ospedale Santa Croce a Carle, Cuneo, Italy; Medical University of Gdansk; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Ankara University; Hotel Dieu Hospital; Centre hospitalier de l'Université de Montréal (CHUM); SAL Hospital, Ahmedabad, India
Recruiting - verified July 2011 - Conditions: Graft Versus Host Disease; Infection; Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Interventions: Genetic: polymerase chain reaction; Other: bronchoalveolar lavage; Other: immunoenzyme technique; Other: laboratory biomarker analysis; Procedure: bronchoscopy; Procedure: management of therapy complications
Sponsor: St. Bartholomew's Hospital
Recruiting - verified September 2007 - Conditions: Breast Cancer; Hypercalcemia of Malignancy; Metastatic Cancer; Musculoskeletal Complications; Pain
Interventions: Drug: zoledronic acid; Procedure: quality-of-life assessment
Sponsor: University of Leeds
Recruiting - verified November 2007 - Conditions: Leukemia; Myelodysplastic Syndromes
Interventions: Biological: alemtuzumab; Drug: arsenic trioxide; Drug: azacitidine; Drug: busulfan; Drug: clofarabine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: fludarabine phosphate; Drug: gemtuzumab ozogamicin; Drug: melphalan; Drug: tipifarnib; Genetic: DNA methylation analysis; Genetic: cytogenetic analysis; Genetic: gene expression analysis; Genetic: mutation analysis; Other: diagnostic laboratory biomarker analysis; Other: immunologic technique; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Sponsor: The University of New South Wales
Recruiting - verified August 2008 - Condition: Oesophagogastric Cancer
Interventions: Biological: bevacizumab; Drug: capecitabine; Drug: cisplatin; Drug: epirubicin hydrochloride; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: Professor David Cunningham; Cancer Research UK
Recruiting - verified January 2012 - Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Drug: etoposide phosphate; Drug: pravastatin sodium
Sponsor: University College, London
Recruiting - verified December 2011 - Condition: Respiratory Insufficiency of Prematurity
Interventions: Device: nCPAP; Device: NIPPV
Sponsors: McMaster University; Canadian Institutes of Health Research (CIHR)
Completed - verified August 2011 - Condition: Lymphoma
Interventions: Biological: bleomycin sulfate; Drug: carmustine; Drug: cyclophosphamide; Drug: cytarabine; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: etoposide phosphate; Drug: ifosfamide; Drug: melphalan; Drug: prednisolone; Drug: prednisone; Drug: procarbazine hydrochloride; Drug: vinblastine sulfate; Drug: vincristine sulfate; Procedure: autologous hematopoietic stem cell transplantation; Radiation: fludeoxyglucose F 18; Radiation: radiation therapy
Sponsor: Martin-Luther-Universität Halle-Wittenberg
Recruiting - verified June 2007 - Condition: Pancreatic Cancer
Interventions: Biological: sargramostim; Biological: telomerase peptide vaccine GV1001; Drug: capecitabine; Drug: gemcitabine hydrochloride
Sponsor: Royal Liverpool University Hospital
Recruiting - verified May 2009 - Condition: Sarcoma
Interventions: Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsor: Cancer Research Campaign Clinical Trials Centre
Recruiting - verified December 2007 - Conditions: Multiple Myeloma and Plasma Cell Neoplasm; Renal Failure
Interventions: Drug: chemotherapy; Drug: dexamethasone; Procedure: plasmapheresis
Sponsor: University of Glasgow
Recruiting - verified June 2007 - Conditions: Angina Pectoris; Coronary Disease
Intervention: Behavioral: Cardiac rehabilitation
Sponsors: National Heart and Lung Institute; British Heart Foundation; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified April 2010 - Conditions: Asthma; Smoking; Steroid Resistance; Corticosteroid Insensitivity
Intervention: Drug: oral steroid-dexamethasone
Sponsors: University of Glasgow; Chief Scientist Office of the Scottish Government
Completed - verified September 2008 - Conditions: Lung Cancer; Metastatic Cancer
Interventions: Drug: dexamethasone; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsor: Medical Research Council
Recruiting - verified January 2007 - Condition: Coronary Heart Disease
Interventions: Procedure: Remote ischemic preconditioning; Procedure: Placebo
Sponsor: University College London Hospitals
Recruiting - verified June 2010 - Condition: Multiple Sclerosis
Intervention: Procedure: MSC Treatment
Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Medical Research Council
Completed - verified October 2011 - Condition: Prostate Cancer
Interventions: Drug: cyproterone acetate; Drug: releasing hormone agonist therapy; Radiation: hypofractionated radiation therapy; Radiation: intensity-modulated radiation therapy
Sponsor: Institute of Cancer Research, United Kingdom
Recruiting - verified July 2009 - Conditions: Tuberculosis; HIV Infections
Interventions: Biological: MVA85A (TB vaccine); Biological: MVA 85A
Sponsor: University of Oxford
Completed - verified March 2011 - Condition: Sarcoma
Interventions: Biological: dactinomycin; Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: topotecan hydrochloride; Drug: vincristine sulfate; Drug: vinorelbine tartrate; Procedure: conventional surgery; Radiation: radiation therapy
Sponsors: European Paediatric Soft Tissue Sarcoma Study Group; Italian Association for Pediatric Hematology Oncology; Children's Cancer and Leukaemia Group; Dutch Childhood Oncology Group
Recruiting - verified July 2009 - Condition: Hemorrhage
Interventions: Drug: Tranexamic acid; Drug: Sodium Chloride 0.9%
Sponsor: London School of Hygiene and Tropical Medicine
Completed - verified June 2011 - Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer
Interventions: Drug: capecitabine; Other: clinical observation; Procedure: adjuvant therapy
Sponsor: Southampton University Hospitals NHS Trust
Recruiting - verified October 2011 - Conditions: Esophageal Cancer; Precancerous Condition
Interventions: Drug: acetylsalicylic acid; Drug: esomeprazole magnesium; Genetic: cytogenetic analysis; Genetic: gene expression analysis; Genetic: loss of heterozygosity analysis; Genetic: mutation analysis; Other: diagnostic laboratory biomarker analysis; Other: flow cytometry; Other: immunohistochemistry staining method; Procedure: biopsy
Sponsor: University Hospitals, Leicester
Recruiting - verified July 2009 - Conditions: Glaucoma; Glaucoma, Open Angle; Ocular Hypertension; Keratoconus
Intervention:
Sponsor: Aston University
Completed - verified June 2011 - Condition: Leukemia
Interventions: Biological: rituximab; Drug: cyclophosphamide; Drug: fludarabine phosphate; Drug: mitoxantrone hydrochloride
Sponsor: Cancer Research UK
Active, not recruiting - verified May 2007 - Conditions: Alcohol Abuse; Drug Abuse; Depression; Panic Disorder; Conduct Disorder
Intervention: Behavioral: PRE-Venture: Personality Risk Education
Sponsors: King's College London; Action on Addiction
Completed - verified February 2006 - Condition: Prostate Cancer
Interventions: Drug: acetylsalicylic acid; Drug: dexamethasone; Drug: diethylstilbestrol
Sponsor: St. Bartholomew's Hospital
Completed - verified April 2007 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Malignant Tumor of Peritoneum
Interventions: Drug: tamoxifen citrate; Other: laboratory biomarker analysis
Sponsor: Mount Vernon Cancer Centre at Mount Vernon Hospital
Recruiting - verified June 2009 - Condition: Lung Cancer
Interventions: Drug: cisplatin; Drug: vinorelbine tartrate; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsor: University College London Hospitals
Recruiting - verified May 2007 - Conditions: Anemia; Cardiovascular Complications; Hot Flashes; Osteoporosis; Prostate Cancer
Interventions: Drug: releasing hormone agonist therapy; Drug: transdermal estrogen
Sponsor: Imperial College London
Recruiting - verified June 2008 - Conditions: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor
Interventions: Biological: bleomycin sulfate; Drug: carboplatin; Drug: cisplatin; Drug: etoposide phosphate; Drug: vincristine sulfate
Sponsor: Medical Research Council
Recruiting - verified May 2007 - Condition: Osteoarthritis
Intervention: Procedure: Total Hip Replacement
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - verified May 2011 - Conditions: Anovulation; Obesity
Intervention: Procedure: weight reduction minimal access surgery
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Completed - verified July 2011 - Condition: Lymphoma
Interventions: Biological: pegfilgrastim; Biological: rituximab; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: prednisone; Drug: vincristine sulfate; Other: pharmacological study; Radiation: radiation therapy
Sponsor: German High-Grade Non-Hodgkin's Lymphoma Study Group
Recruiting - verified March 2010 - Condition: Childhood Langerhans Cell Histiocytosis
Interventions: Drug: leucovorin calcium; Drug: methotrexate; Drug: prednisolone; Drug: vinblastine sulfate
Sponsor: Histiocyte Society
Recruiting - verified May 2007 - Conditions: Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer
Interventions: Biological: bleomycin sulfate; Drug: carboplatin; Drug: etoposide; Procedure: conventional surgery
Sponsor: Children's Cancer and Leukaemia Group
Active, not recruiting - verified February 2006 - Condition: Healthy
Intervention: Behavioral: Selenomethionine (supplement) and selenium enriched onions
Sponsors: Institute of Food Research; Food Standards Agency, United Kingdom
Completed - verified March 2011 - Condition: Prostate Cancer
Interventions: Drug: celecoxib; Drug: docetaxel; Drug: prednisolone; Drug: releasing hormone agonist therapy; Drug: zoledronic acid; Procedure: orchiectomy
Sponsor: Medical Research Council
Recruiting - verified March 2008 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Intervention: Drug: erlotinib hydrochloride
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified October 2007 - Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer
Interventions: Drug: cisplatin; Drug: gemcitabine hydrochloride
Sponsor: University College London (UCL) Cancer Institute
Recruiting - verified December 2008 - Condition: Lung Cancer
Interventions: Drug: cisplatin; Drug: vinorelbine tartrate; Radiation: radiation therapy
Sponsor: Medical Research Council
Active, not recruiting - verified July 2007 - Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: exemestane; Drug: fulvestrant
Sponsor: Institute of Cancer Research, United Kingdom
Active, not recruiting - verified May 2011 - Conditions: Diabetic Neuropathy; Painful
Intervention: Drug: Cannabis based medicine extract (CBME)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Diabetes UK
Completed - verified October 2005 - Condition: Malignant Mesothelioma
Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2006 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group
Active, not recruiting - verified July 2009 - Condition: Lymphoma, Mucosa-Associated Lymphoid Tissue
Interventions: Drug: chlorambucil (drug); Drug: rituximab+chlorambucil; Drug: rituximab
Sponsor: International Extranodal Lymphoma Study Group (IELSG)
Active, not recruiting - verified November 2011 - Condition: Acromegaly
Intervention: Drug: Somatuline Autogel
Sponsor: Plymouth Hospitals NHS Trust
Completed - verified September 2005 - Condition: Toxemia
Intervention: Behavioral: preeclampsia
Sponsor: University of British Columbia
Recruiting - verified September 2011 - Condition: Larynx Carcinoma
Interventions: Radiation: Accelerated radiotherapy; Radiation: ARCON
Sponsors: Radboud University; Dutch Cancer Society
Active, not recruiting - verified May 2008 - Conditions: Coronary Disease; Ventricular Dysfunction, Left
Intervention: Drug: Ivabradine
Sponsor: Institut De Recherche International Servier
Completed - verified June 2011 - Condition: Coronary Arteriosclerosis
Intervention: Procedure: Coronary artery bypass surgery
Sponsors: Imperial College London; The Royal College of Surgeons of England; Royal Brompton & Harefield NHS Foundation Trust; National Heart Foundation, Australia; Victor Phillip Dahdaleh Charitable Foundation
Completed - verified October 2011 - Conditions: Cerebellar Ataxias; Spastic Paraplegias
Intervention:
Sponsors: Institut National de la Santé Et de la Recherche Médicale, France; Institut des Maladies Rares; Agence Nationale de la Recherche
Recruiting - verified June 2011 - Condition: Cervix Cancer
Interventions: Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy/Cisplatin; Radiation: Radiotherapy/Cisplatin
Sponsor: International Atomic Energy Agency
Completed - verified October 2011 - Conditions: Metastatic Cancer; Pain; Prostate Cancer
Intervention: Drug: ibandronate sodium
Sponsor: Cancer Research UK
Completed - verified June 2009 - Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005 - Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsor: Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005 - Conditions: Head and Neck Cancer; Radiation Toxicity; Xerostomia
Interventions: Procedure: management of therapy complications; Radiation: radiation therapy
Sponsor: Royal Marsden NHS Foundation Trust
Active, not recruiting - verified March 2008 - Condition: Breast Cancer
Intervention: Drug: anastrozole
Sponsors: Queen Mary University of London; International Breast Cancer Study Group
Recruiting - verified April 2008 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: paclitaxel; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsor: Royal College of Obstetricians and Gynecologists
Recruiting - verified May 2007 - Condition: Malignant Mesothelioma
Interventions: Drug: cisplatin; Drug: mitomycin C; Drug: vincristine sulfate; Drug: vinorelbine tartrate; Procedure: pain therapy; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment
Sponsor: Medical Research Council
Active, not recruiting - verified June 2008 - Condition: Breast Cancer
Interventions: Drug: anastrozole; Drug: tamoxifen citrate; Procedure: adjuvant therapy
Sponsors: Cancer Research UK; International Breast Cancer Study Group
Recruiting - verified July 2007 - Condition: Colorectal Cancer
Interventions: Drug: FOLFOX regimen; Drug: capecitabine; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Procedure: quality-of-life assessment
Sponsors: University of Leeds; Medical Research Council
Active, not recruiting - verified June 2011 - Condition: Kidney Cancer
Interventions: Biological: aldesleukin; Biological: recombinant interferon alfa; Drug: fluorouracil; Procedure: adjuvant therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; University of Glasgow
Active, not recruiting - verified July 2011 - Condition: Endometrial Cancer
Interventions: Drug: cisplatin; Drug: doxorubicin hydrochloride; Drug: paclitaxel
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2006 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: lomustine; Drug: procarbazine hydrochloride; Drug: temozolomide; Drug: vincristine sulfate
Sponsor: Institute of Cancer Research, United Kingdom
Active, not recruiting - verified May 2007 - Condition: Breast Cancer
Interventions: Drug: capecitabine; Drug: vinorelbine tartrate
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified December 2004 - Condition: Kidney Cancer
Interventions: Biological: dactinomycin; Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: vincristine sulfate; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: University Hospitals, Leicester; Societe Francaise Oncologie Pediatrique; Children's Cancer and Leukaemia Group; Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Recruiting - verified June 2009 - Condition: Breast Cancer
Interventions: Biological: trastuzumab; Procedure: adjuvant therapy
Sponsors: Breast International Group; European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group; International Breast Cancer Study Group
Active, not recruiting - verified January 2007 - Condition: Prostate Cancer
Intervention: Procedure: quality-of-life assessment
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified December 2004 - Condition: Esophageal Cancer
Interventions: Drug: cisplatin; Drug: epirubicin hydrochloride; Drug: fluorouracil; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsor: Medical Research Council
Recruiting - verified March 2007 - Condition: Breast Cancer
Interventions: Drug: exemestane; Drug: tamoxifen citrate; Procedure: adjuvant therapy
Sponsor: Cancer Research Campaign Clinical Trials Centre
Active, not recruiting - verified March 2007 - Condition: Neuroblastoma
Interventions: Biological: filgrastim; Biological: monoclonal antibody Ch14.18; Drug: busulfan; Drug: carboplatin; Drug: cyclophosphamide; Drug: etoposide; Drug: isotretinoin; Drug: melphalan; Drug: vincristine sulfate; Procedure: bone marrow ablation with stem cell support; Procedure: conventional surgery; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy
Sponsor: University Hospitals, Leicester
Recruiting - verified August 2010 - Condition: Malignant Mesothelioma
Interventions: Drug: cisplatin; Drug: mitomycin C; Drug: vinblastine sulfate; Drug: vinorelbine tartrate
Sponsors: British Thoracic Society; Medical Research Council
Active, not recruiting - verified May 2003 - Condition: Pancreatic Cancer
Interventions: Drug: erlotinib hydrochloride; Drug: gemcitabine hydrochloride
Sponsor: NCIC Clinical Trials Group
Completed - verified September 2011 - Condition: Anal Cancer
Interventions: Drug: cisplatin; Drug: fluorouracil; Drug: mitomycin C; Radiation: radiation therapy
Sponsor: University College London (UCL) Cancer Institute
Recruiting - verified March 2007 - Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma.Condition: Neuroblastoma
Interventions: Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: vincristine sulfate; Procedure: conventional surgery
Sponsor: European Infant Neuroblastoma Study Group - 1999
Active, not recruiting - verified November 2001 - Condition: Endometrial Cancer
Intervention: Drug: paclitaxel
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified December 2002 - Condition: Prostate Cancer
Interventions: Drug: bicalutamide; Drug: goserelin acetate; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified April 2008 - Condition: Breast Cancer
Interventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: docetaxel; Drug: epirubicin hydrochloride; Drug: fluorouracil; Genetic: microarray analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: biopsy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; Swedish Breast Cancer Group; Swiss Group for Clinical Cancer Research; Anglo Celtic Cooperative Oncology Group
Active, not recruiting - verified January 2010 - Condition: Head and Neck Cancer
Interventions: Biological: epoetin alfa; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; Trans-Tasman Radiation Oncology Group (TROG); Charite University, Berlin, Germany; Groupe Oncologie Radiotherapie Tete et Cou; Radius Hungaricus Oncology Group; Grup per l'Estudi dels Limfomes de Catalunya i Balears
Active, not recruiting - verified June 2006 - Condition: Colorectal Cancer
Interventions: Drug: FOLFIRI regimen; Drug: FOLFOX regimen; Drug: fluorouracil; Drug: irinotecan hydrochloride; Drug: leucovorin calcium; Drug: oxaliplatin
Sponsor: Medical Research Council
Active, not recruiting - verified March 2002 - Conditions: Colorectal Cancer; Metastatic Cancer
Interventions: Drug: FOLFOX regimen; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; Australasian Gastro-Intestinal Trials Group; Arbeitsgruppe Lebermetastasen und Tumoren; Cancer Research UK; Fondation Francaise de Cancerologie Digestive
Active, not recruiting - verified December 2000 - Condition: Lymphoma
Interventions: Drug: cyclophosphamide; Drug: cytarabine; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: leucovorin calcium; Drug: methotrexate; Drug: therapeutic hydrocortisone; Drug: vinblastine sulfate
Sponsor: Institut Gustave Roussy
Active, not recruiting - verified August 2011 - Condition: Lymphoma
Interventions: Drug: chlorambucil; Drug: dexamethasone; Drug: fludarabine phosphate; Drug: mitoxantrone hydrochloride
Sponsor: Lymphoma Trials Office
Active, not recruiting - verified March 2007 - Condition: Melanoma (Skin)
Interventions: Biological: pegylated interferon alfa; Procedure: adjuvant therapy
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified October 2000 - Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: paclitaxel; Drug: rebimastat
Sponsor: NCIC Clinical Trials Group
Completed - verified August 2011 - Condition: Breast Cancer
Interventions: Drug: tamoxifen citrate; Procedure: conventional surgery; Radiation: radiation therapy
Sponsor: British Association of Surgical Oncology: Breast Group
Active, not recruiting - verified December 2006 - Conditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Interventions: Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: hydroxyurea; Drug: idarubicin; Drug: mitoxantrone hydrochloride; Drug: thioguanine; Drug: tretinoin; Drug: valspodar
Sponsor: Leukemia Research Fund
Active, not recruiting - verified September 2006 - Conditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Interventions: Biological: filgrastim; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: fludarabine phosphate; Drug: tretinoin
Sponsor: Medical Research Council
Active, not recruiting - verified January 2006 - Condition: Endometrial Cancer
Interventions: Drug: cisplatin; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Procedure: adjuvant therapy; Procedure: conventional surgery; Radiation: radiation therapy
Sponsors: Nordic Society for Gynaecologic Oncology; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2006 - Condition: Ovarian Cancer
Interventions: Drug: carboplatin; Drug: thalidomide
Sponsor: Cancer Research UK
Recruiting - verified November 2011 - Condition: Leukemia
Interventions: Drug: chlorambucil; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: fludarabine phosphate; Drug: prednisolone; Drug: vincristine sulfate
Sponsors: Leukemia Research Fund; Medical Research Council
Active, not recruiting - verified January 2006 - Condition: Breast Cancer
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Drug: mitoxantrone hydrochloride; Drug: vinorelbine tartrate; Procedure: conventional surgery; Radiation: radiation therapy
Sponsor: Royal Marsden NHS Foundation Trust
Active, not recruiting - verified May 2005 - Condition: Testicular Germ Cell Tumor
Interventions: Drug: carboplatin; Radiation: radiation therapy
Sponsors: Medical Research Council; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified March 2011 - Condition: Prostate Cancer
Interventions: Biological: gonadotrophin releasing hormone; Radiation: radiation therapy
Sponsor: Medical Research Council
Active, not recruiting - verified July 2001 - Condition: Breast Cancer
Interventions: Drug: cyclophosphamide; Drug: epirubicin hydrochloride; Drug: paclitaxel
Sponsor: Medical Research Council
Active, not recruiting - verified December 2005 - Condition: Neuroblastoma
Intervention: Procedure: surgical procedure
Sponsor: Societe Internationale d'Oncologie Pediatrique
Recruiting - verified July 2007 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2006 - Condition: Sarcoma
Interventions: Drug: doxorubicin hydrochloride; Drug: ifosfamide
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Completed - verified January 2012 - Condition: Metastatic Cancer
Interventions: Procedure: adjuvant therapy; Radiation: radiation therapy; Radiation: stereotactic radiosurgery
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified October 2007 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: lomustine; Drug: procarbazine hydrochloride; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; Medical Research Council
Active, not recruiting - verified November 2011 - Condition: Melanoma (Skin)
Intervention: Biological: recombinant interferon alfa
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2011 - Condition: Endometrial Cancer
Interventions: Procedure: adjuvant therapy; Procedure: conventional surgery; Radiation: brachytherapy; Radiation: radiation therapy
Sponsor: Medical Research Council
Active, not recruiting - verified April 1999 - Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Drug: docetaxel; Drug: gemcitabine hydrochloride; Drug: ifosfamide; Drug: mitomycin C; Drug: paclitaxel; Drug: vinblastine sulfate; Drug: vinorelbine tartrate; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: Medical Research Council; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified May 2005 - Condition: Leukemia
Interventions: Biological: recombinant interferon alfa; Drug: cytarabine; Drug: hydroxyurea
Sponsor: Medical Research Council
Active, not recruiting - verified February 2008 - Condition: Breast Cancer
Intervention: Drug: tamoxifen citrate
Sponsor: Institute of Cancer Research, United Kingdom
Active, not recruiting - verified July 2011 - Condition: Hodgkin Lymphoma
Interventions: Biological: bleomycin sulfate; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: vinblastine; Radiation: radiation therapy
Sponsors: NCIC Clinical Trials Group; Eastern Cooperative Oncology Group
Completed - verified January 2012 - Condition: Lung Cancer
Interventions: Drug: cisplatin; Drug: ifosfamide; Drug: mitomycin C; Drug: vinblastine sulfate; Drug: vindesine; Drug: vinorelbine tartrate; Procedure: conventional surgery; Radiation: radiation therapy
Sponsor: London Lung Cancer Group
Active, not recruiting - verified May 2007 - Condition: Leukemia
Interventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: prednisolone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsor: Medical Research Council
Active, not recruiting - verified February 2003 - Condition: Prostate Cancer
Interventions: Drug: flutamide; Drug: triptorelin; Radiation: radiation therapy
Sponsor: Saint Luke's Hospital
Active, not recruiting - verified December 2011 - Condition: Head and Neck Cancer
Interventions: Drug: cisplatin; Radiation: low-LET cobalt-60 gamma ray therapy; Radiation: low-LET electron therapy; Radiation: low-LET photon therapy
Sponsor: European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified May 2007 - Condition: Lymphoma
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: mitoxantrone hydrochloride; Drug: prednisolone; Drug: vincristine sulfate
Sponsor: Cancer Research Campaign Clinical Trials Centre
Active, not recruiting - verified May 2007 - Condition: Ovarian Cancer
Intervention: Drug: ISIS 5132
Sponsor: NCIC Clinical Trials Group
Completed - verified September 2011 - Conditions: Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Drug: paclitaxel
Sponsor: Medical Research Council
Active, not recruiting - verified February 2001 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Intervention: Drug: chemotherapy
Sponsors: Medical Research Council; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified September 2005 - Conditions: Childhood Malignant Fibrous Histiocytoma of Bone; Sarcoma
Interventions: Biological: dactinomycin; Drug: carboplatin; Drug: cyclophosphamide; Drug: epirubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: vincristine sulfate; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: brachytherapy; Radiation: radiation therapy
Sponsor: Societe Internationale d'Oncologie Pediatrique
Active, not recruiting - verified May 1999 - Conditions: Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: docetaxel; Drug: paclitaxel; Procedure: surgical procedure
Sponsor: University of Glasgow
Active, not recruiting - verified October 2007
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