Nationwide

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Drug Interaction Study of Colchicine and Theophylline

Condition: Healthy
Interventions: Drug: theophylline; Drug: colchicine
Sponsors: Mutual Pharmaceutical Company, Inc.; Mutual Pharmaceutical Company, Inc.
Not yet recruiting - verified May 2012
Phase 1 ID93 + GLA-SE Vaccine Trial in Healthy Adult Volunteers

Condition: Pulmonary Tuberculosis
Interventions: Biological: ID93 + GLA-SE; Biological: ID93 alone
Sponsors: Infectious Disease Research Institute; Infectious Disease Research Institute; Aeras Global TB Vaccine Foundation; Bill and Melinda Gates Foundation; Paul G. Allen Family Foundation
Not yet recruiting - verified May 2012
Safety Study of Ch-mAb7F9 for Methamphetamine Abuse

Condition: Methamphetamine Abuse
Interventions: Biological: normal saline; Biological: ch-mAb7f9
Sponsors: InterveXion Therapeutics, LLC; National Institute on Drug Abuse (NIDA); University of Arkansas
Recruiting - verified May 2012
Dexpramipexole and Warfarin Drug Drug Interaction (DDI) Study

Condition: Healthy Volunteers
Interventions: Drug: Warfarin; Drug: Dexpramipexole
Sponsors: Biogen Idec; Biogen Idec
Not yet recruiting - verified May 2012
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ACHN-975 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: ACHN-975; Drug: placebo
Sponsors: Achaogen, Inc.; Achaogen, Inc.
Recruiting - verified May 2012
Changing Chat: Diaper Tips to Improve Language Development

Condition: Healthy Infants
Intervention: Device: Changing chat
Sponsors: Seattle Children's Hospital; Seattle Children's Hospital
Recruiting - verified May 2012
Volunteer Screening for Vaccine and Antivirals Clinical Trials

Condition: Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); NIAID Laboratory of Infectious Diseases; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2012
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Repeat Dose Administration of Long-Acting GSK1265744 and Long-Acting TMC278 Intramuscular and Subcutaneous Injections in Healthy Adult Subjects

Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: GSK1265744 Oral; Drug: GSK1265744 LAP 800mg intramuscular injection; Drug: GSK1265744 LAP 200mg subcutaneous injection; Drug: GSK1265744 LAP 200mg intramuscular injection; Drug: GSK1265744 LAP 400mg intramuscular injection; Drug: TMC278 LA 1200mg intramuscular injection; Drug: TMC278 LA 600mg intramuscular injection; Drug: GSK1265744 LAP 800mg intramuscular injection
Sponsors: ViiV Healthcare; ViiV Healthcare; GlaxoSmithKline
Not yet recruiting - verified May 2012
A/H5N1 Virus-Like Particle Antigen Dose Ranging Study With Adjuvant 2

Condition: Influenza (Pandemic)
Interventions: Biological: Monovalent Avian Influenza VLP (H5N1); Biological: Monovalent Avian Influenza VLP (H5N1); Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Saline Placebo
Sponsors: Novavax; Novavax; Department of Health and Human Services
Recruiting - verified May 2012
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7537 in Healthy Adult Volunteers

Condition: Ebola Hemorrhagic Fever
Interventions: Drug: AVI-7537; Other: Normal Saline Solution (NSS)
Sponsors: AVI BioPharma, Inc.; AVI BioPharma, Inc.; Department of Defense
Not yet recruiting - verified May 2012
St. Jude Cancer Education for Children Program: The Feasibility of Teacher Delivery (Pilot Study)

Condition: Healthy
Intervention:
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital
Recruiting - verified May 2012
Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment

Condition: Hepatic Impairment
Intervention: Drug: LCQ908
Sponsors: Novartis; Novartis
Recruiting - verified May 2012
Safety Study of Human Anti-Cytomegalovirus Monoclonal Antibody

Condition: Cytomegalovirus Infections
Interventions: Biological: TCN-202; Biological: Placebo
Sponsors: Theraclone Sciences, Inc.; Theraclone Sciences, Inc.
Recruiting - verified May 2012
The Effects of ∆-9-THC and Naloxone in Humans

Condition: Healthy
Interventions: Drug: Naloxone; Drug: Delta-9-THC; Drug: Placebo
Sponsors: Yale University; Yale University
Recruiting - verified May 2012
A/H5N1 VLP Antigen Dose Ranging Study With Adjuvant 1

Condition: Influenza (Pandemic)
Interventions: Biological: Monovalent Avian Influenza VLP (H5N1); Biological: Monovalent Avian Influenza VLP (H5N1); Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Monovalent Avian Influenza VLP (H5N1); Adjuvant; Biological: Saline placebo
Sponsors: Novavax; Novavax; Department of Health and Human Services
Recruiting - verified May 2012
Effectiveness of a Well-being Web-based Intervention

Condition: Focus of Study: Healthy Individuals
Intervention: Behavioral: Daily Challenge
Sponsors: MeYou Health, LLC; MeYou Health, LLC; Healthways, Inc.
Recruiting - verified April 2012
Healthy Lifestyle in Pregnancy

Conditions: Hperglycemia; Diabetes Mellitus; Weight Gain
Intervention: Behavioral: Weight Control
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
Functional Neuroimaging of Alcoholism Vulnerability (PIT)

Condition: Healthy
Interventions: Drug: Memantine; Drug: Placebo
Sponsors: Yale University; Yale University
Recruiting - verified May 2012
A Pharmacodynamic and Pharmacokinetic Study of RO5508887 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: RO5508887; Drug: Placebo
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified May 2012
Drug Interaction Study of Isavuconazole and Methadone

Conditions: Pharmacokinetics of Isavuconazole; Pharmacokinetics of Methadone; Healthy Volunteers
Interventions: Drug: Isavuconazole; Drug: Methadone
Sponsors: Astellas Pharma Inc; Astellas Pharma Global Development, Inc.; Basilea Pharmaceutica International Ltd
Recruiting - verified April 2012
A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects

Condition: Healthy
Intervention: Drug: Liothyronine, Sodium
Sponsors: Ipe, LLC; Ipe, LLC
Recruiting - verified April 2012
Efavirenz Versus Rilpivirine on Vascular Function, Inflammation, and Oxidative Stress

Condition: Cardiovascular Disease
Interventions: Drug: Efavirenz; Drug: Rilpivirine
Sponsors: Indiana University; Indiana University; Janssen Services, LLC
Not yet recruiting - verified April 2012
Dynamic Plantar Microvascular Skin Response to Compressive Loads in At-risk Diabetic and Healthy Control: a Pilot Study

Condition: Foot Ulcer, Diabetic
Intervention:
Sponsors: Temple University; Temple University
Recruiting - verified June 2011
A Study of LY2784544 in Healthy Male Subjects

Condition: Healthy Male Volunteers
Intervention: Radiation: Drug
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012
Cognizin Citicoline Dosing in a Healthy Adolescent Male Population

Condition: Neurocognitive Improvement
Interventions: Drug: Citicoline; Other: Microcrystalline Cellulose
Sponsors: University of Utah; Deborah Yurgelun-Todd
Not yet recruiting - verified April 2012
Evaluating the Safety of and Immune Response to HIV-MAG DNA Vaccine With or Without Plasmid IL-12 Adjuvant Delivered Intramuscularly Via Electroporation Followed by VSV-gag HIV Vaccine Boost in Healthy, HIV-Uninfected Adults

Condition: HIV Infections
Interventions: Biological: HIV-MAG vaccine; Biological: IL-12 pDNA adjuvant; Biological: VSV HIV gag vaccine; Biological: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified May 2012
SPARK a Healthy and Fit Lifestyle

Condition: Obesity
Interventions: Behavioral: Face-to-Face; Behavioral: Web-based; Behavioral: Single session
Sponsors: The Miriam Hospital; The Miriam Hospital; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
A Phase 1 Crossover Study of Blood Pressure and Heart Rate Response

Condition: Healthy Subjects
Interventions: Drug: TR-701 FA with PSE; Other: TR-701 FA Placebo with PSE
Sponsors: Trius Therapeutics, Inc.; Trius Therapeutics, Inc.
Recruiting - verified April 2012
A 2-part Study to Assess Local Tolerability, Safety and Pharmacokinetics of Ceftaroline in Healthy Subjects

Condition: Healthy
Interventions: Drug: 600 mg ceftaroline fosamil in 50 ml infusion volume; Drug: Placebo in 50 ml infusion volume; Drug: 600 ceftaroline fosamil in 250 ml infusion volume; Drug: Placebo in 250 ml infusion volume; Drug: 600 mg ceftaroline in 100 ml infusion volume; Drug: Placebo in 100 ml infusion volume
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified May 2012
A Study To Compare Pharmacokinetics Of Dacomitinib Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment

Conditions: Healthy; Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction
Interventions: Drug: dacomitinib; Drug: dacomitinib; Drug: dacomitinib
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
Phase 1 Safety, Tolerability and PK Study of Ondansetron and Hylenex Recombinant in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Ondansetron; Drug: Ondansetron + Hylenex; Drug: Zofran ODT; Drug: Ondansetron solution
Sponsors: Halozyme Therapeutics; Halozyme Therapeutics
Recruiting - verified April 2012
Bisphenol A Controlled Exposure Study

Condition: Healthy
Intervention: Other: deuterated-Bisphenol A (d-BPA)
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified February 2011
Immune Responses to H5N1 Vaccine With and Without MF59 Adjuvant

Conditions: Influenza; Healthy
Interventions: Biological: H5N1 vaccine plus MF59 adjuvant; Biological: H5N1 vaccine without adjuvant
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI); Center for Human Immunology, Autoimmunity and Inflammation
Recruiting - verified February 2012
Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults

Condition: Tuberculosis
Intervention: Drug: Rifapentine (RPT)
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified May 2012
Spectroscopic Imaging at 4T: A Drug Challenge Study

Condition: AOD Effects and Consequences
Interventions: Drug: Alprazolam; Drug: Dextroamphetamine
Sponsors: Mclean Hospital; Mclean Hospital
Not yet recruiting - verified April 2012
Evaluating the Safety and Immune Response of a Prime-Boost HIV Vaccine Regimen in Healthy, HIV-Uninfected Vaccinia-Naive Adults

Condition: HIV Infections
Interventions: Biological: GEO-D03 DNA vaccine; Biological: MVA/HIV62B (MVA62B) vaccine; Biological: Placebo for GEO-D03 DNA; Biological: Placebo for MVA62B:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID); GeoVax, Inc.
Not yet recruiting - verified May 2012
Efficacy Of Tocotrienol a Natural Vitamin E In Biopsy Wound

Condition: Scar
Intervention:
Sponsors: Ohio State University; Chandan K Sen; Carotech Inc.
Recruiting - verified April 2012
Energy Expenditure Responses to Different Temperatures

Conditions: Healthy; Obese
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
Potential Use Of Brain Network Activation Analysis to Diagnose Major Depression

Condition: Major Depressive Disorder
Intervention:
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; ElMindA Ltd
Recruiting - verified April 2012
A Study in Healthy Volunteers to Evaluate Effects of Pre-Medication or Slow Dose Titration on Flushing and Gastrointestinal Events

Condition: Healthy Volunteers
Interventions: Drug: Standard dose BG00012; Drug: Aspirin placebo; Drug: Aspirin; Drug: Escalating doses of BG00012; Drug: BG00012 placebo
Sponsors: Biogen Idec; Biogen Idec
Recruiting - verified April 2012
H5N1 Vaccination With and Without AS03: Systems Biology Analysis

Condition: Influenza
Interventions: Biological: H5N1 Vaccine; Drug: ASO3 Adjuvant
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified March 2012
Effects of Auricular Vagus Nerve Stimulation on the Pro-inflammatory Cytokine Response in Healthy Adults

Condition: Cytokine Response to Vagus Nerve Stimulation
Intervention: Device: Vagus Nerve Stimulator
Sponsors: North Shore Long Island Jewish Health System; North Shore Long Island Jewish Health System
Recruiting - verified March 2012
Brain Imaging and Computer Games in Children With Either Bipolar Disorder, ADHD, Anxiety or Healthy Controls

Conditions: Bipolar Disorder; Attention Deficit Disorder With Hyperactivity; Attention Deficit Disorder Without Hyperactivity; Generalized Anxiety Disorder; Healthy
Intervention:
Sponsors: Bradley Hospital; Bradley Hospital; National Institute of Mental Health (NIMH)
Recruiting - verified March 2012
Study of the Effect of Repeat Doses of Isavuconazole on Cardiac Repolarization

Conditions: Pharmacokinetics of Isavuconazole; Healthy Volunteers
Interventions: Drug: Isavuconazole; Drug: Placebo; Drug: Moxifloxacin
Sponsors: Astellas Pharma Inc; Astellas Pharma Global Development, Inc.; Basilea Pharmaceutica International Ltd
Recruiting - verified April 2012
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers

Condition: Marburg Hemorrhagic Fever
Interventions: Drug: AVI-7288; Other: Placebo
Sponsors: AVI BioPharma, Inc.; AVI BioPharma, Inc.; Department of Defense
Not yet recruiting - verified March 2012
Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Conditions: Hepatic Impairment; Healthy
Intervention: Drug: Bardoxolone Methyl
Sponsors: Reata Pharmaceuticals, Inc.; Reata Pharmaceuticals, Inc.
Recruiting - verified May 2012
Study in Healthy Volunteers to Assess the Pharmacokinetics (PK) of Digoxin Administered Alone and in Combination With Vandetanib

Condition: Healthy Volunteers
Interventions: Drug: Digoxin; Drug: Vandetanib
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
A Fixed−Sequence, Two−Period, Open−Label Drug−Drug Interaction Study to Assess the Effect of an Inhibitor of Cytochrome P450 Isoenzyme 3A4 and Permeability Glycoprotein 1 on the Pharmacokinetics of TD−1211

Condition: Healthy
Interventions: Drug: TD-1211; Drug: TD-1211+ itraconazole
Sponsors: Theravance; Theravance
Not yet recruiting - verified March 2012
A Drug-Drug Interaction Study to Evaluate the Effect of Rifampin on the Pharmacokinetics of Apremilast

Condition: Healthy
Interventions: Drug: Apremilast; Drug: Rifampin
Sponsors: Celgene Corporation; Celgene Corporation
Recruiting - verified March 2012
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)

Conditions: Immune Defect; Periodontal Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified March 2012
Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Conditions: Muscular Dystrophies; Muscle Myopathies; Hereditary Spastic Paraplegias; Inherited Neuropathies; Inherited Neuromuscular Conditions
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2012
Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.

Conditions: Pharmacokinetics of Isavuconazole; Healthy Volunteers; Renal Impaired
Intervention: Drug: isavuconazole
Sponsors: Astellas Pharma Inc; Astellas Pharma Global Development, Inc.; Basilea Pharmaceutica International Ltd
Recruiting - verified April 2012
Study to Assess the Safety and the Phosphate Binding Capacity of Renazorb

Conditions: Safety; Phosphate Binding Capacity
Interventions: Drug: Renazorb 1500 mg/day; Drug: Renazorb 3000 mg/day; Drug: Renazorb 4500 mg/day; Drug: Renazorb 6000 mg/day
Sponsors: Spectrum Pharmaceuticals, Inc; Spectrum Pharmaceuticals, Inc
Recruiting - verified April 2012
A Study to Evaluate Safety and Tolerability of BMN 111 Administered to Healthy Adult Volunteers

Condition: Achondroplasia
Interventions: Drug: BMN 111; Drug: Normal Saline
Sponsors: BioMarin Pharmaceutical; BioMarin Pharmaceutical
Recruiting - verified May 2012
Safety Evaluation of Bowel Cleansing Regimen for PillCam® COLON 2 Capsule Endoscopy

Condition: Healthy Volunteers
Intervention: Other: The preparation regimen
Sponsors: Given Imaging Ltd.; Given Imaging Ltd.
Recruiting - verified April 2012
Improving White Blood Cell Collection From Healthy Donors

Conditions: Blood Donor; Leukocyte Transfusion; Granulocyte Colony-Stimulation Factor; Blood Component Removal
Interventions: Drug: Filgrastim (G-CSF); Drug: Dexamethasone
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified February 2012
Healthy Eating and Active Living Taught at Home

Conditions: Diabetes; Obesity
Intervention: Behavioral: PAT Curriculum + Health Information
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified March 2012
Pharmacokinetics Study of ALO-02 and OxyContin

Condition: Management of Moderate to Severe Pain
Interventions: Drug: ALO-02; Drug: Naltrexone block; Drug: ALO-02; Drug: Naltrexone block; Drug: OxyContin; Drug: Naltrexone block
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
A Study To Characterize The Pharmacokinetics Of Oxycodone In Healthy Volunteers

Condition: Management of Moderate to Severe Pain
Interventions: Drug: Oxycodone; Drug: Oxycodone; Drug: Oxycodone; Drug: Oxycodone; Drug: Oxycodone
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
An Interactive Web-based Intervention to Achieve Healthy Weight in Young Children

Conditions: Child; Obesity; Overweight
Interventions: Behavioral: face-to-face meetings; Behavioral: Standard of care
Sponsors: University of Wisconsin, Madison; University of Wisconsin, Madison
Not yet recruiting - verified March 2012
Assessment and Referral Versus Exercise in Primary Prevention of Falls: PA Healthy Steps Program

Conditions: Lower Extremity Weakness; Balance Problems
Interventions: Behavioral: Assessment and education; Behavioral: Healthy Steps with Falls Case Management; Behavioral: Healthy Steps in Motion
Sponsors: University of Pittsburgh; University of Pittsburgh; Centers for Disease Control and Prevention
Recruiting - verified March 2012
A Phase I Study to Assess the Pharmacokinetics of Metformin When Administered Alone and in Combination With Vandetanib

Condition: Healthy
Interventions: Drug: Metformin 1000 mg; Drug: Vandetanib 800 mg
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
Translocator Protein and Inflammation After Traumatic Brain Injury

Conditions: Traumatic Brain Injury; Healthy
Intervention: Radiation: PET
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH); Suburban Hospital; United States Uniformed Health Service@@@Bethesda
Recruiting - verified December 2011
Phase I Trial of a Single Dose of CRS3123

Condition: Enteric Infections
Interventions: Drug: CRS3123; Other: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified April 2012
Safety Study of Mibefradil When Given Four Times a Day in Healthy Volunteers

Condition: No Condition. Assessment of Healthy Volunteers.
Interventions: Drug: mibefradil; Other: Placebo
Sponsors: Tau Therapeutics LLC; Tau Therapeutics LLC; Celerion, Inc.; Dana-Farber/Partners CancerCare, Inc.; LifeWatch, Inc.
Recruiting - verified May 2012
A Randomized Study to Investigate the Safety and Immunogenicity of Various Schedules of Tetravalent Chimeric Dengue Vaccine in Healthy Adult Volunteers Between the Ages of 18 - 45 Years

Condition: Healthy
Intervention: Biological: DENVax
Sponsors: Inviragen Inc.; Inviragen Inc.
Recruiting - verified March 2012
First-in-Human Study to Evaluate AMG 579 in Healthy Subjects and Patients With Stable Schizophrenia

Condition: Schizophrenia
Interventions: Drug: AMG 579; Drug: Placebo
Sponsors: Amgen; Amgen
Recruiting - verified March 2012
Study in Healthy Volunteers to Assess the Pharmacokinetics of Midazolam Administered Alone and in Combination With Vandetanib

Condition: Healthy Volunteers
Interventions: Drug: Midazolam; Drug: vandetanib
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012
Phase 3 Study of ATX-101 Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area

Condition: Healthy
Interventions: Drug: ATX-101; Drug: Placebo
Sponsors: Kythera Biopharmaceuticals; Kythera Biopharmaceuticals
Recruiting - verified February 2012
Phase 3 Study of ATX-101 Versus Placebo for the Reduction of Localized Subcutaneous Fat in the Submental Area

Condition: Healthy
Interventions: Drug: ATX-101; Drug: Placebo
Sponsors: Kythera Biopharmaceuticals; Kythera Biopharmaceuticals
Recruiting - verified March 2012
Anesthetic Effect Duration Assessment

Condition: Healthy Volunteers
Intervention: Drug: Lidocaine 7% + Tetracaine 7% cream
Sponsors: Galderma; Galderma
Recruiting - verified May 2012
A Brain Imaging Study of Opioid (Morphine) and Non-opioid (Ketorolac) Conditioning Effects

Condition: Healthy Controls
Interventions: Radiation: Integrated MR-PET scan; Drug: Ketorolac; Drug: Morphine
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2012
The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Condition: Healthy Controls
Intervention: Radiation: PET imaging
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2012
Mild Neurocognitive Disorder in HIV Infection of the Brain

Condition: HIV-Associated Cognitive Motor Complex
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
Efficacy of Tart Cherry Juice in Reducing Muscle Injury and Biomarkers of Muscle Damage Among Healthy Adults

Conditions: Inflammation; Pain
Interventions: Dietary Supplement: tart cultivar Montmorency cherry juice; Dietary Supplement: placebo cherry fruit drink
Sponsors: Oregon Health and Science University; Oregon Health and Science University; Cherry Research Committee
Not yet recruiting - verified March 2012
MRI Study Looking at Resting Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.

Conditions: Movement Disorders (Incl Parkinsonism); Tremor Familial Essential, 1; REM Sleep Behavior Disorder
Intervention:
Sponsors: University of Alabama at Birmingham; University of Alabama at Birmingham
Recruiting - verified March 2012
A Phase 1 TR-701 FA Study of Blood Pressure Response Post Tyramine Challenge

Condition: Healthy Volunteers
Interventions: Drug: TR-701 FA with Tyramine; Drug: Placebo-controlled withTyramine
Sponsors: Trius Therapeutics, Inc.; Trius Therapeutics, Inc.
Recruiting - verified February 2012
A Study of LY2484595 on the Electrical Activity of the Heart

Condition: Healthy Volunteers
Interventions: Drug: LY2484595; Drug: Placebo; Drug: Moxifloxacin
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified March 2012
Effect of Probiotic Supplementation on Immune Function in Healthy Infants

Condition: Inflammation
Interventions: Dietary Supplement: Lactobacillus reuteri DSM 17938; Other: Placebo
Sponsors: Emory University; Emory University; The Gerber Foundation
Recruiting - verified March 2012
A Study of LY3009104 in Healthy Volunteers

Condition: Healthy Volunteers
Interventions: Drug: LY3009104; Drug: Placebo; Drug: moxifloxacin
Sponsors: Eli Lilly and Company; Eli Lilly and Company; Incyte Corporation
Recruiting - verified March 2012
A Study To Evaluate The Effects Of PF-05175157 In Healthy Volunteers

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: PF-05175157; Drug: PF-05175157; Drug: PF-05175157; Drug: Placebo
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
A Study of LY2886721 in Healthy Participants

Condition: Healthy Volunteers
Interventions: Drug: LY2886721; Drug: Placebo
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified February 2012
A Phase 1, Randomized, Placebo-controlled, Single-dose Study to Evaluate the Safety of MEDI7814 in Adult Volunteers

Condition: Healthy Subjects
Intervention: Drug: MEDI7814
Sponsors: MedImmune LLC; MedImmune LLC
Recruiting - verified May 2012
Safety and Immunogenicity of a Novel H5N1 Influenza Vaccine in Healthy Adults Age 18-49 Years

Condition: Influenza
Intervention: Biological: VAX161 [STF2.HA5 H5N1]
Sponsors: VaxInnate Corporation; VaxInnate Corporation
Not yet recruiting - verified March 2012
Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118

Condition: Drug Induced Constipation
Interventions: Drug: NKTR-118; Drug: Rifampin
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012
A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately

Condition: Healthy
Interventions: Drug: CAZ-AVI; Drug: metronidazole; Drug: CAZ-AVI + metronidazole
Sponsors: AstraZeneca; AstraZeneca; Cerexa, Inc.
Recruiting - verified March 2012
A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Steady State in Healthy Subjects

Condition: Healthy
Interventions: Drug: SEP-228432; Drug: SEP-228432
Sponsors: Sunovion; Sunovion
Recruiting - verified February 2012
Study in Healthy Volunteers to Assess Effect of Omeprazole and Ranitidine on the Pharmacokinetics of Vandetanib

Conditions: Pharmacokinetic; Cmax; Tmax; Plasma AUC; Plasma [AUC(0-t)]; Plasma [AUC(0-672)]; (t1/2,λz)
Interventions: Drug: vandetanib; Drug: omeprazole; Drug: ranitidine
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012
A Multicenter, Open-label Study to Determine the Effects of Lacosamide on Sleep in Healthy Subjects

Condition: Healthy Subjects
Intervention: Drug: Lacosamide
Sponsors: UCB, Inc.; UCB, Inc.
Recruiting - verified February 2012
Crossover Study of Neuropsychological Effects of Lacosamide and Carbamazepine Immediate Release in Healthy Subjects

Condition: Healthy
Interventions: Drug: Lacosamide (LCM); Drug: Carbamazepine Immediate Release (CBZ-IR)
Sponsors: UCB, Inc.; UCB, Inc.
Recruiting - verified May 2012
Antimicrobial Efficacy of ALT005 Ophthalmic Prep Solution in Healthy Volunteers

Condition: Infection Secondary to Surgical Procedure
Interventions: Drug: ALT005 Ophthalmic Prep Solution; Other: saline control
Sponsors: Altacor Ltd.; Altacor Ltd.
Recruiting - verified February 2012
Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive Adults

Condition: Malaria
Interventions: Biological: Group 1: 10 ug FMP012 with 2 ug GLA-SE; Biological: Group 2: 10 ug FMP012 with 5 ug GLA-SE; Biological: 50 ug FMP012 with 5 ug GLA-SE or 2 ug GLA-SE; Other: Control
Sponsors: U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command; United States Agency for International Development (USAID); Infectious Disease Research Institute
Recruiting - verified February 2012
Deacylated Ghrelin and Beta Cell Function

Condition: Healthy Non-obese Subjects Between 18 and 50 Years of Age
Interventions: Drug: unacylated ghrelin; Drug: acyl ghrelin; Drug: combined acyl and desacyl ghrelin; Drug: saline
Sponsors: University of Cincinnati; University of Cincinnati; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2012
Study in Healthy Volunteers to Investigate the Effects of Quinidine on the Pharmacokinetics of NKTR-118

Condition: Drug Induced Constipation
Interventions: Drug: Nektar 118; Drug: Quinidine; Drug: Quinidine placebo; Drug: Morphine
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012
Phase I Safety Trial of Streptococcus Pneumoniae Whole Cell Vaccine (SPWCV) + Alum in Healthy Adults

Condition: Pneumococcal Vaccines
Interventions: Other: normal saline injection; Biological: SPWCV + alum
Sponsors: Program for Appropriate Technology in Health; PATH Vaccine Solutions
Recruiting - verified February 2012
The Effects of Antihistamines on Pre-Pulse Inhibition

Condition: Healthy
Interventions: Drug: Placebo; Drug: Meclizine; Drug: Meclizine
Sponsors: Duke University; Duke University; Wallace Foundation
Recruiting - verified February 2012
Simons Variation in Individuals Project, Functional Common Acquisition Protocol

Condition: Healthy
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco; Children's Hospital of Philadelphia
Recruiting - verified February 2012
The Impact of Genetic Variation in CYP2D6 on the Pharmacokinetics and Pharmacodynamics of Methamphetamine

Condition: Methamphetamine Metabolism, CYP2D6 Genotype
Intervention: Drug: A single oral 5 mg of duterium labeled methamphetamine
Sponsors: California Pacific Medical Center Research Institute; California Pacific Medical Center Research Institute; The Children's Mercy Hospital
Not yet recruiting - verified October 2009
The Effects of Chronic Exposure to Low-Level Blasts

Condition: Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS); Walter Reed Institute of Research; Naval Medical Research Center
Recruiting - verified January 2012
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers

Condition: High Altitude Pulmonary Hypertension
Interventions: Drug: Aminophylline; Drug: Ambrisentan; Drug: Aminophylline plus ambrisentan
Sponsors: Duke University; Duke University
Recruiting - verified March 2012
Preventing Fucose-dependent Binding of Aspergillus and Pseudomonas to Lung Mucin

Condition: Cystic Fibrosis
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco
Not yet recruiting - verified February 2012
DART Electrical Impedance Myography (EIM) Trial in Duchenne Muscular Dystrophy (DMD) and Healthy Controls

Condition: Duchenne Muscular Dystrophy
Intervention:
Sponsors: Dart Therapeutics. LLC; Dart Therapeutics. LLC
Recruiting - verified May 2012
Remote Ischemic Preconditioning Mechanism Study

Condition: Pain
Intervention: Device: Remote Ischemic Preconditioning, Capsaicin, UV-B
Sponsors: Wake Forest University Baptist Medical Center; Wake Forest University Baptist Medical Center
Not yet recruiting - verified February 2012
Pharmacokinetics of BIA 9-1067 in Healthy Japanese and Caucasian Subjects

Condition: Parkinson Disease
Interventions: Drug: BIA 9-1067; Drug: Placebo
Sponsors: Bial - Portela C S.A.; Bial - Portela C S.A.
Recruiting - verified January 2012
Effect of Chronic Consumption of a Cranberry Beverage on Inflammation and Oxidative Stress

Condition: Inflammation
Interventions: Other: Cranberry; Other: Non-Cranberry beverage
Sponsors: Tufts University; Tufts University; Washington State University; Ocean Spray, Inc.
Not yet recruiting - verified February 2012
Ascending Multiple-Dose Study to Evaluate VIA-3196 in Healthy Subjects

Condition: Drug Safety
Interventions: Drug: Placebo; Drug: VIA-3196
Sponsors: Madrigal Pharmaceuticals, Inc.; Madrigal Pharmaceuticals, Inc.
Recruiting - verified January 2012
Safety Study of HPP593 in Subjects During and After Limb Immobilization

Conditions: Muscle Atrophy; Hypodynamia
Interventions: Drug: HPP593; Drug: Placebo
Sponsors: High Point Pharmaceuticals, LLC.; High Point Pharmaceuticals, LLC.
Recruiting - verified January 2012
Blood Vessel Study

Conditions: Cardiovascular; P450s; Flow-Mediated Dilation; Brachial Artery Ultrasound; Endothelial Cell Function
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified January 2012
Single Ascending Dose Study of Intravenous TRV130A in Healthy Adult Males

Condition: Healthy
Interventions: Drug: TRV130A; Drug: Dextrose in Water
Sponsors: Trevena Inc.; Trevena Inc.
Recruiting - verified January 2012
A Study to Assess the Effect of Timing of Food Intake on the Pharmacokinetics of Abiraterone Following Single-Dose Administration of Abiraterone Acetate Tablets in Healthy Caucasian and Japanese Men

Condition: Pharmacology
Interventions: Drug: Abiraterone: Treatment A; Drug: Abiraterone: Treatment B; Drug: Abiraterone: Treatment C; Drug: Abiraterone: Treatment D
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified May 2012
Promoting Healthy Lifestyles Using Mobile Phones

Condition: Health Behavior
Intervention: Behavioral: Mobile Intervention for Lifestyle Eating/Exercise @ Stanford
Sponsors: Stanford University; Stanford University
Recruiting - verified January 2012
Healthy Home Offerings Via the Mealtime Environment (HOME) Plus

Condition: Obesity
Intervention: Behavioral: HOME Plus intervention
Sponsors: University of Minnesota - Clinical and Translational Science Institute; University of Minnesota - Clinical and Translational Science Institute; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2012
Study to Evaluate the Effect of Ha44 Gel on the Electrocardiogram in Healthy Volunteers

Condition: Pediculosis
Interventions: Drug: Ha44; Drug: Ha44 Placebo; Drug: Moxifloxacin Placebo; Drug: Moxifloxacin
Sponsors: Hatchtech Pty Ltd; Hatchtech Pty Ltd
Not yet recruiting - verified January 2012
Evaluation of the Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of E2609 in Healthy Subjects

Condition: Healthy
Interventions: Drug: E2609; Drug: Placebo
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified May 2012
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

Condition: Healthy
Intervention:
Sponsors: Wake Forest University Baptist Medical Center; Wake Forest University Baptist Medical Center; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified January 2012
Studying Motor Neuron Tests

Conditions: Magnetic Resonance Imaging; Central Nervous System; Volunteer; Neurological Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2012
Brain-Derived Neurotrophic Factor in Obesity and Brain Function

Conditions: Obesity; Genetic Disorder; Mental Retardation; Developmental Delay
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2011
Bioequivalence of Two Products (Norditropin® Versus Nutropin AQ®) in Healthy Adult Volunteers

Conditions: Growth Hormone Deficiency; Healthy
Interventions: Drug: somatropin; Drug: somatropin
Sponsors: Novo Nordisk; Novo Nordisk
Not yet recruiting - verified March 2012
Psychophysiological Indicators of Performance in Computer-Based Simulation

Condition: Healthy
Interventions: Other: Low Valence; Other: High Valence
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified May 2012
Healthy Eating for Reproductive Health (HERHealth)

Conditions: Polycystic Ovarian Syndrome; Infertility; Obesity; Overweight
Interventions: Behavioral: Low-fat, Low-Glycemic Index, Vegan diet; Behavioral: Low Calorie
Sponsors: University of South Carolina; University of South Carolina; American Dietetic Association
Recruiting - verified March 2012
A Study to Assess the Relative Bioavailability Three New Formulations of Telaprevir in Healthy Subjects

Condition: Chronic Hepatitis C
Interventions: Drug: telaprevir formulation A; Drug: telaprevir Formulation B; Drug: telaprevir Formulation C; Drug: telaprevir Formulation D
Sponsors: Vertex Pharmaceuticals Incorporated; Vertex Pharmaceuticals Incorporated
Recruiting - verified March 2012
Assessing Single and Multiple Doses of HCV NS5A Inhibitor IDX719 in Healthy and HCV-Infected Subjects

Condition: Hepatitis C, Chronic
Interventions: Drug: IDX719 or matching placebo (oral suspension); Drug: IDX719 or matching placebo (oral suspension)
Sponsors: Idenix Pharmaceuticals; Idenix Pharmaceuticals
Recruiting - verified January 2012
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)

Condition: Amyotrophic Lateral Sclerosis
Interventions: Drug: Dexpramipexole; Drug: Dexpramipexole; Drug: Dexpramipexole Placebo; Drug: Moxifloxacin
Sponsors: Biogen Idec; Biogen Idec
Recruiting - verified January 2012
A Study to Assess the Safety and Tolerability of Single Ascending Doses of REGN1033(SAR391786)

Condition: Healthy Volunteers
Interventions: Drug: REGN1033(SAR391786); Drug: REGN1033(SAR391786); Drug: Placebo
Sponsors: Regeneron Pharmaceuticals; Regeneron Pharmaceuticals; Sanofi-Aventis
Recruiting - verified January 2012
Immune Memory After Papillomavirus Vaccination

Condition: Healthy Volunteers
Intervention: Drug: quadrivalent HPV vaccine
Sponsors: Emory University; Emory University; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2012
Study to Assess Effect of Cyclosporine on the Blood Levels of Ticagrelor

Condition: Healthy
Interventions: Drug: cyclosporine; Drug: ticagrelor
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified January 2012
Safety Study of Inactivated Shigella Whole Cell Vaccine in Adults

Condition: Shigellosis
Interventions: Biological: Shigella flexneri 2a whole cell killed vaccine (Sf2aWC); Biological: Shigella flexneri 2a whole cell killed vaccine (Sf2aWC); Biological: Shigella flexneri 2a whole cell killed vaccine (Sf2aWC); Biological: Shigella flexneri 2a whole cell killed vaccine (Sf2aWC)
Sponsors: Program for Appropriate Technology in Health; Program for Appropriate Technology in Health
Recruiting - verified January 2012
Evaluating the Safety and Immune Response to Two Admixtures of a Tetravalent Dengue Virus Vaccine

Condition: Dengue
Interventions: Biological: TetraVax-DV Vaccine - Admixture TV003; Biological: TetraVax-DV Vaccine - Admixture TV005; Biological: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2012
A Study to Compare the Safety and Immunogenicity of Pneumococcal Conjugate Vaccines in Healthy Volunteers (V114-002)

Condition: Pneumococcal Infections
Interventions: Biological: Pneumococcal Conjugate Vaccine (V114); Biological: Pneumococcal Polysaccharide Vaccine; Biological: Pneumococcal 13-Valent Conjugate Vaccine
Sponsors: Merck; Merck
Recruiting - verified May 2012
A Study of RG7667 in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: RG7667; Drug: Placebo
Sponsors: Genentech; Genentech
Not yet recruiting - verified December 2011
Pharmacokinetics, Safety, and Tolerability of TR-701 Free Acid (FA) in Elderly Subjects

Condition: Healthy Subjects
Interventions: Drug: TR-701 FA 200 mg; Drug: TR-701 FA 200 mg
Sponsors: Trius Therapeutics, Inc.; Trius Therapeutics, Inc.
Recruiting - verified December 2011
A Clinical Comparison of Two Marketed Skin Barriers on Healthy Volunteers

Condition: Peristomal Skin Complication
Interventions: Device: Sur-Fit Natura; Device: FormaFlex
Sponsors: Independent Nurse Consultants LLC; Independent Nurse Consultants LLC; ConvaTec Inc.
Recruiting - verified February 2012
Growth and Safety of a Low Lactose Milk-Based Infant Formula

Conditions: Growth; Healthy Term Infants
Intervention: Other: Low Lactose Infant Formula
Sponsors: PBM Products; PBM Products
Recruiting - verified January 2012
Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines

Condition: Hemorrhagic Fever With Renal Syndrome
Intervention: Biological: Vaccine/device combination for prevention of HFRS
Sponsors: U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command; United States Army Medical Research Institute of Infectious Diseases; United States Army Medical Materiel Development Activity; Ichor Medical Systems Incorporated; Walter Reed Army Institute of Research (WRAIR)
Recruiting - verified March 2012
Family Genetics Health Education and Healthy Behaviors

Conditions: Diabetes; Cancer; Heart Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified October 2011
Exploratory Trial to Evaluate Premature Endothelial Dysfunction in Early Rheumatoid Arthritis(RA)Compared to Patients With Established RA, and Normal Subjects

Conditions: Premature Endothelial Dysfunction; Rheumatoid Arthritis; Healthy
Intervention:
Sponsors: Orrin M Troum, M.D. and Medical Associates; Orrin M Troum, M.D. and Medical Associates; Bristol-Myers Squibb
Recruiting - verified December 2011
Noninvasive Study of Brain Connectivity With EEG and NIRS

Condition: Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 2011
Metabolic Effects of Olanzapine in Healthy Males

Condition: Healthy
Interventions: Drug: Olanzapine; Drug: Placebo
Sponsors: State University of New York at Buffalo; State University of New York at Buffalo
Recruiting - verified December 2011
Se-Methyl-Seleno-L-Cysteine or Selenomethionine in Preventing Prostate Cancer in Healthy Participants

Condition: Prostate Cancer
Interventions: Dietary Supplement: Se-methyl-seleno-L-cysteine; Dietary Supplement: selenomethionine; Other: placebo
Sponsors: National Cancer Institute (NCI); Robert H. Lurie Cancer Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Assessing Fermentability of a Dietary Fiber

Condition: Nutritional Intervention
Interventions: Dietary Supplement: A dietary fiber (FCHO); Dietary Supplement: Placebo
Sponsors: Institute for Food Safety and Health, United States; Institute for Food Safety and Health, United States; National Starch LLC
Recruiting - verified January 2012
A Positron Emission Tomography Study of SLV354 in Healthy Subjects and Subjects With Schizophrenia

Condition: Schizophrenia
Intervention: Drug: SLV354
Sponsors: Abbott; Abbott
Recruiting - verified April 2012
Multiple-Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ONO-2952 in Healthy Adult Subjects

Condition: Healthy
Interventions: Drug: ONO-2952; Drug: ONO-2952 Matching Placebo
Sponsors: Ono Pharma; Ono Pharma
Recruiting - verified January 2012
Drug-Drug Interaction Study With Pravastatin and Cyclosporine

Condition: Healthy
Interventions: Drug: Pravastatin alone; Drug: Pravastatin and Cyclosporine
Sponsors: University of California, San Francisco; University of California, San Francisco; National Institute of General Medical Sciences (NIGMS)
Not yet recruiting - verified December 2011
Effects of Dietary Fiber on Gastrointestinal Function

Condition: Gastrointestinal Health
Intervention: Other: Dietary fiber
Sponsors: National Starch LLC; National Starch LLC
Recruiting - verified December 2011
Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest.

Conditions: Irritable Bowel Syndrome; Non Cardiac Chest Pain; Cyclical Vomiting Syndrome; Functional Dyspepsia; Gastroparesis; Ulcerative Colitis; Vulvodynia; Crohn's Disease
Intervention:
Sponsors: University of California, Los Angeles; University of California, Los Angeles; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2012
Chikungunya Virus Vaccine Trial in Healthy Adults

Conditions: Chikungunya Virus; Vaccines, Virus-like Particles; Viral Vaccines; Humoral Immunity; Chikungunya Fever
Intervention: Biological: VRC-CHKVLP059-00-VP
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Bioavailability of Fish Oils: Emulsified Versus Capsular Triglyceride

Condition: Healthy Adults
Interventions: Dietary Supplement: Coromega Omega-3 Squeeze; Dietary Supplement: Coromega Nectar; Dietary Supplement: Barlean Swirl; Dietary Supplement: Nordic Omega-3 Softgel
Sponsors: USDA Grand Forks Human Nutrition Research Center; USDA Grand Forks Human Nutrition Research Center; Brian G Dyson Foundation
Recruiting - verified December 2011
Imaging Biomarkers in Parkinson's Disease

Condition: Parkinson Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified November 2011
NEI Intramural Biorepository for Retinal Diseases

Conditions: Age-Related Macular Degeneration; Diabetic Retinopathy; Von Hippel-Lindau Syndrome; Retinal Disease; Retinal Vein Occlusion
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Eye Institute (NEI)
Recruiting - verified May 2012
Circadian Phase Assessments at Home

Conditions: Healthy Controls; Delayed Sleep Phase Disorder.
Intervention: Behavioral: At home saliva sampling
Sponsors: Rush University Medical Center; Rush University Medical Center; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified December 2011
Repeating Patterns of Sleep Restriction and Recovery

Condition: Healthy
Interventions: Behavioral: Repeated sleep restriction and recovery; Behavioral: Control sleep
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center
Recruiting - verified January 2012
Iron Absorption in Vegetarian Children

Condition: Iron Absorption
Intervention:
Sponsors: Baylor College of Medicine; Baylor College of Medicine
Recruiting - verified January 2012
A Human Proof of Concept Study for [11C]-RO5011232 as Radiotracer and Study of the Binding of RO4917523 to Human mGlu5 Brain Receptor at Steady-State in Healthy Volunteers

Condition: Healthy Volunteer
Interventions: Drug: RO4917523; Drug: RO5011232
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Recruiting - verified May 2012
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients

Conditions: Dyslipidemia; Healthy Volunteers
Intervention: Drug: TAP311
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012
Phase 1 LEISH-F3 Vaccine Trial in Healthy Adult Volunteers

Condition: Leishmaniasis
Interventions: Biological: LEISH-F3 + GLA-SE; Biological: LEISH-F3 + GLA-SE; Biological: LEISH-F3 alone
Sponsors: Infectious Disease Research Institute; Infectious Disease Research Institute
Recruiting - verified January 2012
A Study to Determine the Immunogenicity and Oral Tolerance to Keyhole Limpet Hemocyanin (KLH)

Condition: Autoimmune Disorders
Interventions: Biological: Subcutaneous Immucothel; Biological: subcutaneous Immucothel plus Montanide; Biological: Oral KLH followed by immunization
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance Network (ITN)
Recruiting - verified December 2011
Effect of Body Composition and Metabolism on Oocyte Gene Expression

Condition: Healthy
Intervention:
Sponsors: Arkansas Children's Hospital Research Institute; Arkansas Children's Hospital Research Institute
Recruiting - verified November 2011
Evaluating the Immune Response to a rAd5 HIV Vaccine Administered in Three Different Ways in Healthy, HIV-Uninfected Adults

Condition: HIV Infections
Interventions: Biological: VRC rAd5 vaccine (rAd5 gag-pol/env A/B/C); Biological: rAd5 env A; Biological: rAd5 env B; Biological: rAd5 env C; Biological: rAd5 gag-pol; Biological: Placebo Vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2012
Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota

Condition: Healthy Volunteers
Interventions: Dietary Supplement: Saccharomyces boulardii; Drug: Amoxicillin Clavulanate; Drug: Saccharomyces boulardii AND Amoxicillin Clavulanate
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center; Biocodex
Not yet recruiting - verified March 2012
Safety Study of AV-101 to Treat Capsaicin-Induced Pain

Condition: Neuropathic Pain
Interventions: Drug: AV-101; Drug: Placebo
Sponsors: VistaGen Therapeutics, Inc.; VistaGen Therapeutics, Inc.; Cato Research; National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified November 2011
Bone Marrow Cell Engraftment of the Uterus

Conditions: Endometriosis; Stem Cell Transplant; Healthy; Infertility; Asherman's Syndrome; Reproductive Disorders; Recurrent Pregnancy Loss
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 2011
Peak Impact Forces and Metabolic Cost During Mid-Forefoot Striking in Shod Versus Barefoot Runners

Condition: Healthy
Intervention: Other: no interventions
Sponsors: University of Florida; University of Florida
Recruiting - verified February 2012
A Study to Determine the Safety, Tolerability, and Effects of GSK2374697 in Healthy Volunteers

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: GSK2376497; Drug: 0.9% sodium chloride
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified February 2012
Safety, Tolerability and Pharmacokinetic First in Human (FIH) Study of Intravenous (IV) TKM-100201 Infusion

Condition: Ebola Virus Infection
Interventions: Drug: TKM-100201; Drug: Placebo
Sponsors: Tekmira Pharmaceuticals Corporation; Tekmira Pharmaceuticals Corporation; Department of Defense
Recruiting - verified April 2012
Drug Interaction Study of Clopidogrel and Rosuvastatin

Condition: Healthy
Interventions: Drug: Rosuvastatin; Drug: Clopidogrel
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified April 2012
A Multi-Center, Open-Label Study

Conditions: Renal Disease; End Stage Renal Disease
Intervention: Drug: Droxidopa
Sponsors: Chelsea Therapeutics; Chelsea Therapeutics
Not yet recruiting - verified March 2012
GSK1349572 Exposure in Blood, Seminal Fluid, and Rectal Fluid and Tissue in Healthy Male Subjects

Condition: Healthy
Intervention: Drug: dolutegravir
Sponsors: University of North Carolina, Chapel Hill; University of North Carolina, Chapel Hill; GlaxoSmithKline
Recruiting - verified December 2011
A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006

Condition: Insomnia
Interventions: Drug: E2006 1.0 mg; Drug: E2006 2.5 mg; Drug: E2006 5.0 mg; Drug: E2006 10.0 mg; Drug: E2006 25.0 mg; Drug: E2006 50.0 mg; Drug: E2006 100 mg; Drug: E2006 200 mg; Drug: zolpidem 10 mg; Drug: zolpidem - matched placebo; Drug: E2006 - matched placebo
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified April 2012
A Study to Assess Pharmacokinetics of Preladenant in Participants With Chronic Hepatic Impairment (P06513)

Condition: Chronic Hepatic Impairment
Intervention: Drug: Preladenant
Sponsors: Schering-Plough; Schering-Plough
Recruiting - verified May 2012
Study to Assess the Effects of Daily Administration of Pioglitazone on Brain Hemodynamics in Healthy Elderly Participants

Condition: Healthy
Interventions: Drug: Pioglitazone; Drug: Pioglitazone; Drug: Pioglitazone; Drug: Placebo
Sponsors: Takeda Global Research & Development Center, Inc.; Takeda Global Research & Development Center, Inc.
Recruiting - verified May 2012
A Study to Evaluate the Effect of Genotype on LY2216684

Condition: Depressive Disorder, Major
Interventions: Drug: LY2216684; Drug: Quinidine
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study Of PF-04427429 In Healthy Women Volunteers

Conditions: Pain; Migraine Disorders
Interventions: Biological: PF-04427429; Other: Normal saline
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
A Study to Evaluate CDX-301 (rhuFlt3L) in Healthy Volunteers

Condition: Healthy
Intervention: Drug: CDX-301
Sponsors: Celldex Therapeutics; Celldex Therapeutics
Recruiting - verified April 2012
A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, and Pharmacokinetics Profiles of Single and Multiple Ascending Oral Doses of TG-2349, and Followed by a Dose-Ranging Study in Hepatitis C Genotype 1 Infected Patients

Condition: Healthy
Interventions: Drug: TG-2349; Drug: placebo
Sponsors: TaiGen Biotechnology Co., Ltd.; TaiGen Biotechnology Co., Ltd.
Recruiting - verified January 2012
Study to Assess the Pharmacokinetics of Cabozantinib (XL184) in Hepatic Impaired Adult Subjects

Conditions: Healthy; Hepatic Impairment
Intervention: Drug: cabozantinib
Sponsors: Exelixis; Exelixis
Recruiting - verified December 2011
Analysis of Diphenylcyclopropenone (DPCP) in Normals

Condition: Healthy Volunteers
Interventions: Drug: Diphenylcyclopropenone; Drug: Placebo
Sponsors: Rockefeller University; Rockefeller University
Recruiting - verified May 2012
Study to Evaluate Safety, Tolerability, PK and PD of ALXN1007 in Healthy Subjects

Condition: Healthy
Interventions: Drug: ALXN1007; Other: Placebo
Sponsors: Alexion Pharmaceuticals; Alexion Pharmaceuticals
Recruiting - verified February 2012
Vitamin E δ-Tocotrienol Multiple Dose in Healthy Subjects

Condition: Pancreatic Cancer
Intervention: Drug: Vitamin E δ-Tocotrienol
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI); BioGene Life Science
Recruiting - verified March 2012
Vitamin D Levels in the Skin of Healthy Subjects After Oral Supplementation

Conditions: Healthy, no Evidence of Disease; Non-melanomatous Skin Cancer
Interventions: Dietary Supplement: cholecalciferol; Genetic: gene expression analysis; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); University of Arizona; National Cancer Institute (NCI)
Recruiting - verified December 2011
A Phase 1 Study of PPI-668 in Healthy Volunteers and Patients With Hepatitis C Virus (HCV) Genotype 1

Condition: Hepatitis C, Chronic
Interventions: Drug: PPI-668; Drug: Placebo
Sponsors: Presidio Pharmaceuticals, Inc.; Presidio Pharmaceuticals, Inc.
Recruiting - verified March 2012
Ultra Low Dose Interleukin-2 in Healthy Volunteers

Condition: Hematologic Diseases
Interventions: Drug: Interleukin-2 (100,000 international units); Drug: Interleukin-2 (200,000 international units)
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2011
A Study of the Safety and Pharmacokinetics of JNJ-38518168 in Japanese and Caucasian Male Participants and the Effect of JNJ-38518168 on the Blood Levels of Midazolam

Condition: Healthy Male Volunteer
Interventions: Drug: JNJ-38518168 (30 mg); Drug: JNJ-38518168 (10 mg); Drug: JNJ-38518168 (3 mg); Drug: Placebo; Drug: Midazolam and JNJ-38518168
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified April 2012
Trenev Trio®/Healthy Trinity® for Recurrent Gastrointestinal Symptoms

Condition: Recurrent Gastrointestinal Symptoms
Interventions: Dietary Supplement: Trenev Trio®/Healthy Trinity®; Dietary Supplement: Placebo
Sponsors: Sprim Advanced Life Sciences; Sprim Advanced Life Sciences; The National Institute of Probiotics
Recruiting - verified December 2011
Vitamin E δ-Tocotrienol (VEDT) Single Dose in Healthy Subjects

Condition: Pancreatic Cancer
Intervention: Drug: Vitamin E δ-Tocotrienol
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI); BioGene Life Science
Recruiting - verified March 2012
Experimental AD4-H5-VTN Vaccine in Healthy Volunteers

Condition: H5N1 Influenza
Interventions: Biological: Ad4-H5-VTN vaccination-tonsillar route; Biological: Ad4-H5-vaccination-oral route
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2011
Research Involving Subjects With Parkinson's Disease, Alzheimer Disease and Healthy Controls

Conditions: Parkinson Disease; Alzheimer Disease
Intervention: Drug: [18F] CFPyPB
Sponsors: Institute for Neurodegenerative Disorders; Institute for Neurodegenerative Disorders
Recruiting - verified May 2012
Expressed Prostatic Secretion and Post Massage Urine Biomarkers in Predicting Biopsy Results in Patients Undergoing Prostate Biopsy

Conditions: Conditions Influencing Health Status; Healthy; Prostate Cancer
Interventions: Other: laboratory biomarker analysis; Procedure: transrectal prostate biopsy
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified April 2012
Single-dose Iloperidone Pharmacokinetics in Patients With Mild or Moderate Liver Disease, Compared to Healthy Volunteers

Condition: Hepatic Impairment
Intervention: Drug: Iloperidone
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified February 2012
A Clinical Trial to Study the Safety, Tolerance and Immunogenic Response to Gardasil and rLP2086 Vaccine When Given at the Same Time to Children Between the Ages of 11 and 17

Conditions: Vaccines; Meningococcal Vaccines
Interventions: Biological: rLP2086 and Gardasil; Biological: rLP2086; Biological: Gardasil
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
A Clinical Trial to Study the Safety, Tolerance and Immunogenic Response to MCV4, Tdap and rLP2086 Vaccine When Given at the Same Time to Children Between the Ages of 10 Through 12 Years of Age

Conditions: Vaccines; Meningococcal Vaccines
Interventions: Biological: rLP2086 + MCV4 + Tdap; Biological: MCV4 + Tdap + saline; Biological: rLP2086 + saline
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a

Condition: Parkinson Disease
Intervention: Drug: [18F]MPPF
Sponsors: Institute for Neurodegenerative Disorders; Institute for Neurodegenerative Disorders
Recruiting - verified May 2012
Evaluating the Safety of and Immune Response to the VSV-Indiana HIV Vaccine in Healthy, HIV-Uninfected Adults

Condition: HIV Infections
Interventions: Biological: VSV-Indiana HIV gag vaccine; Biological: Placebo injection (normal saline)
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2012
Respiratory Muscle Strength and Function in Healthy Kids

Condition: Respiratory Muscle Strength
Intervention:
Sponsors: University of Florida; University of Florida
Recruiting - verified March 2012
Experimental PfSPZ Vaccine in Adults Without Malaria

Conditions: Malaria; Prevention and Control; Acquired Immunity
Intervention: Biological: PfSPZ
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID); Sanaria Incorporated; U.S. Military Malaria Vaccine Program
Recruiting - verified August 2011
Randomized Trial of Healthy Eating Interventions

Condition: Nutrition Therapy
Interventions: Behavioral: Information provision intervention; Behavioral: information provision + flat incentive; Behavioral: Information provision + tiered incentive; Behavioral: Usual Care
Sponsors: University of Pennsylvania; University of Pennsylvania; National Institute on Aging (NIA)
Recruiting - verified September 2011
Safety and Pharmacokinetics of Single Oral Doses of MBX-400 in Healthy Volunteers

Condition: Healthy Adult Subjects
Interventions: Drug: MBX-400; Other: Placebo
Sponsors: Microbiotix, Inc.; Microbiotix, Inc.
Recruiting - verified March 2012
Weight Management Interactions in a Virtual Clinical Environment

Conditions: Healthy; Body Weight
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified August 2011
Muscle Biopsies in Healthy Volunteers

Conditions: Sarcopenia; Frailty; Aging
Intervention: Procedure: Muscle Biopsy
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Aging (NIA)
Recruiting - verified January 2011
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

Conditions: Adolescent Developement; Brain; Developmental Biology
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified August 2011
Study of ACE-536 in Healthy Postmenopausal Women

Condition: Anemia
Interventions: Biological: ACE-536; Other: Placebo
Sponsors: Acceleron Pharma, Inc.; Acceleron Pharma, Inc.
Recruiting - verified March 2012
Studying Childhood-Onset Hemidystonia

Conditions: Dystonia; Cerebral Palsy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified August 2011
A Study of LY3015014 in Healthy Subjects With Elevated Low Density Lipoprotein Cholesterol

Condition: Hyperlipidemia
Interventions: Drug: LY3015014 (intravenously); Drug: Placebo (intravenously); Drug: LY3015014 (subcutaneously); Drug: Placebo (subcutaneously)
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified May 2012
A Study to Evaluate the Pharmacokinetics of AFQ056 in Subjects With Hepatic Impairment Compared to Healthy Subjects

Condition: Hepatic Impairment
Intervention: Drug: afq056
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
Improving Care for Patients With High Blood Pressure

Conditions: Hypertension; Cardiovascular Disease Risk
Intervention: Behavioral: Complex quality improvement intervention
Sponsors: University of North Carolina, Chapel Hill; University of North Carolina, Chapel Hill; National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified May 2012
A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents

Condition: Meningococcal Meningitis
Interventions: Biological: placebo+ Combined Tetanus, Reduced Diphtheria Toxoid Acellular Pertussis Vaccine+Quadrivalent Human Papillomavirus Vaccine; Biological: MenACWY Conjugate Vaccine+Combined Tetanus, Reduced Diphtheria Toxoid,Acellular Pertussis Vaccine +Quadrivalent Human Papillomavirus Vaccine
Sponsors: Novartis; Novartis; Novartis Vaccines
Recruiting - verified April 2012
Study to Assess the Effects of Mipomersen on Lipid and Lipoprotein Metabolism in Healthy Subjects

Condition: Healthy Volunteer
Interventions: Drug: mipomersen; Drug: Placebo
Sponsors: Genzyme; Genzyme; Isis Pharmaceuticals
Recruiting - verified April 2012
Developing Therapies for Traumatic Brain Injury

Condition: Traumatic Brain Injury
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Nursing Research (NINR)
Recruiting - verified June 2011
Promoting a Healthier Lifestyle Among Breast Cancer Survivors

Condition: Breast Cancer
Interventions: Behavioral: Motivational Interviewing; Behavioral: Counseling
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Department of Defense
Recruiting - verified January 2012
Safety Study of Spray-Dried Solvent/Detergent-Treated Plasma for Infusion in Healthy Volunteers

Condition: Coagulation Defects
Interventions: Biological: Spray-dried S/D-treated Plasma; Drug: Spray-dried S/D-treated plasma
Sponsors: Entegrion, Inc.; Entegrion, Inc.
Not yet recruiting - verified April 2012
Social Connections and Healthy Aging (The Senior Connection)

Conditions: Suicidal Ideation; Depression
Interventions: Behavioral: The Senior Connection; Other: Care as Usual
Sponsors: University of Rochester; University of Rochester; Centers for Disease Control and Prevention
Recruiting - verified February 2012
Imaging of CB1 Receptors Using (11C)SD5024

Condition: Healthy
Interventions: Procedure: Brain Scan-PET; Procedure: Brain Scan-MRI; Procedure: Arterial Line; Procedure: Venous Line; Procedure: Blood Sampling
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
Efficacy of Bitter Blockers on Taste Perception in Children and Adults

Condition: Healthy
Intervention:
Sponsors: Monell Chemical Senses Center; Monell Chemical Senses Center; National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified March 2012
Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)

Condition: Type 2 Diabetes Mellitus (T2DM)
Intervention: Drug: LIK066 or a matching placebo
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified May 2012
The Effects of GLA on Human Volunteers

Condition: Healthy Volunteers
Interventions: Drug: GLA-AF; Drug: GLA-SE; Other: Squalene
Sponsors: Rockefeller University; Rockefeller University; IDRI Corporation; Immune Design
Recruiting - verified February 2012
New Heart Imaging Techniques to Evaluate Possible Heart Disease

Conditions: Arteriosclerosis; Acute Cardiovascular Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2012
Role of Flavanols In Cardiovascular Function in Healthy Aging

Condition: Aging
Interventions: Dietary Supplement: CocoaVia Dark Chocolate Flavored Drink; Dietary Supplement: Placebo Trial: CocoaVia Dark Chocolate Flavored Drink
Sponsors: University of Texas at Austin; University of Texas at Austin
Recruiting - verified March 2012
Efficacy of 24-hour Intraocular Pressure Fluctuation Recording With the SENSIMED Triggerfish Contact Lens Sensor

Conditions: Primary Open Angle Glaucoma; Healthy Subjects
Intervention: Device: SENSIMED Triggerfish
Sponsors: Sensimed AG; Sensimed AG
Recruiting - verified December 2011
Nitric Oxide and Sickle Cell Pain

Conditions: Sickle Cell Disease; Pain
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Nursing Research (NINR)
Recruiting - verified April 2012
Immune Responses to Two Experimental HIV Vaccines in Healthy Adults

Conditions: HIV Negative; Adaptive Immunity; Innate Immunity
Interventions: Biological: VRC-HIVDNA016-00-VP; Biological: VRC-HIVADV014-00-VP
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified June 2011
Dose Escalation Trial of a Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers

Condition: Plague
Interventions: Biological: Flagellin/F1/V; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified January 2012
Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant

Conditions: Hookworm Infection; Hookworm Disease
Interventions: Biological: 10 μg Na-GST-1/Alhydrogel; Biological: 30 μg Na-GST-1/Alhydrogel; Biological: 100 μg Na-GST-1/Alhydrogel; Biological: 10 μg Na-GST-1/Alhydrogel with 1 μg GLA-AF; Biological: 30 μg Na-GST-1/Alhydrogel with 1 μg GLA-AF; Biological: 100 μg Na-GST-1/Alhydrogel with 1 μg GLA-AF; Biological: 10 μg Na-GST-1/Alhydrogel with 5 μg GLA-AF; Biological: 30 μg Na-GST-1/Alhydrogel with 5 μg GLA-AF; Biological: 100 μg Na-GST-1/Alhydrogel with 5 μg GLA-AF
Sponsors: Albert B. Sabin Vaccine Institute; Albert B. Sabin Vaccine Institute; Children's Research Institute; George Washington University
Recruiting - verified May 2012
(18F)FCWAY and the Blood-Brain Barrier

Condition: Drug Resistance
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
Screening Volunteers for Influenza Challenge Studies

Condition: Influenza, Human
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2012
Brain Areas Involved in Sound and Spoken Word Memory

Conditions: Brain Mapping; Language Disorder; Adult; Healthy; Memory Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Phase I Dose Escalation SARS-CoV Recombinant S Protein, With and Without Adjuvant, Vaccine Study

Condition: SARS
Interventions: Drug: Aluminum hydroxide adjuvant (Alhydrogel®); Other: Phosphate buffered saline Placebo; Biological: Recombinant S protein SARS vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified April 2012
Evaluation of [18F]MK-9470 as a Brain Tracer of Cannabinoid-1 Receptor in Parkinson's Disease and Healthy Subjects

Condition: Parkinson Disease
Intervention: Drug: [18F] MK-9470
Sponsors: Institute for Neurodegenerative Disorders; Institute for Neurodegenerative Disorders
Recruiting - verified May 2012
Screening Volunteers for Clinical Trials

Condition: Human Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2012
Genetics of the Acute Response to Alcohol in Social Drinkers

Conditions: Alcoholism; Genetics
Intervention: Drug: Ethanol
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified April 2012
COMIDAS Comparing Original Mexican Diets and Standard US Diets

Condition: Healthy
Intervention: Other: Mexican or American foods
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified April 2012
Effect of Interleukin-1 Receptor Antagonist on Inhalation of 20,000 EU Clinical Ctr Reference Endotoxin in Normal Volunteers

Condition: Healthy Control Subjects
Interventions: Drug: Anakinra; Drug: Placebo
Sponsors: University of North Carolina, Chapel Hill; Michelle Hernandez, MD; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2012
Evaluation of a Single Vaccination With One of Three Ascending Dose Levels of a 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) in Healthy Adults Aged 18 to <65 Years

Conditions: Staphylococcal Infections; Staphylococcal Vaccines; Bacterial Infections; Staphylococcal Skin Infections
Interventions: Biological: SA4Ag vaccine low dose; Procedure: Blood draw; Procedure: Colonization swab sample; Biological: SA4Ag vaccine mid dose; Procedure: Blood sample; Procedure: Colonization swab sample; Biological: SA4Ag vaccine high dose; Procedure: Blood draw; Procedure: Colonization swab sample; Biological: Placebo; Procedure: Blood draw; Procedure: Colonization swab sample
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Robotic Assessment of Lower Extremity Motor Learning

Condition: Healthy Subjects
Intervention: Other: Lokomat
Sponsors: Spaulding Rehabilitation Hospital; Spaulding Rehabilitation Hospital
Recruiting - verified December 2011
An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females

Condition: Folliculogenesis
Interventions: Drug: Elagolix; Drug: Elagolix; Drug: Elagolix; Drug: Elagolix; Drug: Elagolix Dose Regimen 5; Drug: Elagolix Dose Regimen 6; Drug: elagolix dose regimen 7
Sponsors: Abbott; Abbott; Neurocrine Biosciences
Recruiting - verified February 2012
Biodistribution and Safety of the PET Probes [18F]FPRGD2 and [18F]FPPRGD2

Conditions: Breast Cancer; Non-Small-Cell Lung Cancer; Glioblastoma; Other Cancers
Intervention: Drug: FPPRGD2
Sponsors: Stanford University; Stanford University
Recruiting - verified February 2012
The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity

Conditions: Drug-Drug Interaction; Healthy Volunteers
Intervention: Drug: Fluoxetine
Sponsors: University of Washington; University of Washington; National Institute of General Medical Sciences (NIGMS)
Recruiting - verified April 2012
Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or Obesity

Conditions: Bone Diseases; Obesity; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2012
A Study To Assess Effects Of PF-04958242 On Bold Functional Magnetic Resonance Imaging During Working Memory Activation And Arterial Spin Labeling At Rest In Healthy Subjects

Condition: Schizophrenia
Interventions: Drug: Placebo; Drug: PF-04958242; Drug: PF-04958242
Sponsors: Pfizer; Pfizer; Yale University
Recruiting - verified April 2012
Detecting Dopaminergic Deficits in Individuals At-risk for Parkinsonism

Conditions: Parkinson Disease; Gaucher Disease; Idiopathic Rapid Eye Movement Sleep Disorder
Intervention:
Sponsors: University of Minnesota - Clinical and Translational Science Institute; University of Minnesota - Clinical and Translational Science Institute; GE Healthcare
Recruiting - verified April 2012
Collection of Blood for Multiple Collaborative Studies

Condition: HIV
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified April 2012
Biodistribution and Dosimetry Evaluation of [124I]FIAU

Condition: Prosthesis Related Infections
Intervention: Radiation: [124I]FIAU
Sponsors: BioMed Valley Discoveries, Inc; BioMed Valley Discoveries, Inc
Recruiting - verified March 2012
One Week Comparison Study of PTH and PTHrP Infusions

Conditions: Osteoporosis; Hypercalcemia of Malignancy; Hyperparathyroidism; Bone Diseases, Endocrine
Interventions: Drug: Parathyroid Hormone-related Protein (1-36); Drug: parathyroid hormone (1-34); Drug: PTH (1-34) and PTHrP (1-36)
Sponsors: University of Pittsburgh; University of Pittsburgh
Not yet recruiting - verified January 2012
TMC207 +/- Rifabutin/Rifampin

Condition: Tuberculosis
Interventions: Drug: TMC207; Drug: Rifampin; Drug: Rifabutin
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2012
Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis

Conditions: Multiple Sclerosis; Optic Neuritis
Intervention: Drug: Mangafodipir (Teslascan)
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting - verified January 2012
Phase 1 Study of Dimethandrolone Undecanoate in Healthy Men

Conditions: Healthy Men; Male Contraception
Interventions: Drug: Dimethandrolone Undecanoate; Drug: Placebo
Sponsors: Los Angeles Biomedical Research Institute; Los Angeles Biomedical Research Institute; National Institutes of Health (NIH); University of Washington
Recruiting - verified March 2012
The Relationship Between Uric Acid and Inflammatory Markers

Condition: Healthy Volunteers
Interventions: Drug: IV Uric Acid; Drug: IV Rasburicase
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Aging (NIA)
Recruiting - verified August 2010
A Study of the Association Between Autism and Immune Changes in the Brain

Conditions: Autism Spectrum Disorders; Brain Disease; Autism; Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
Oxytocin and Arginine Vasopressin in Pain Relief

Condition: Placebo Analgesia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified November 2011
Role of the Endogenous Opioid System Underlying Modulation of Experimental Pain

Conditions: Temporomandibular Disorder; Facial Pain
Interventions: Drug: Naltrexone; Drug: Placebo
Sponsors: University of Florida; University of Florida; American Pain Society
Recruiting - verified March 2011
Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls

Condition: Cystic Fibrosis
Interventions: Device: Peripheral quantitative computed tomography (pQCT); Device: Dual X-ray absorptiometry (DXA)
Sponsors: University of Arkansas; University of Arkansas
Recruiting - verified May 2012
Smoking Cessation Study In Healthy Adolescent Smokers

Condition: Smoking Cessation
Interventions: Drug: Varenicline 1mg BID; Drug: Varenicline 0.5mg BID; Drug: Placebo
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
Adrenal Hyperplasia Among Young People With PCOS

Conditions: Adrenal Hyperplasia; Polycystic Ovarian Syndrome; Oligomenorrhea; Obesity; Hyperandrogenism
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2012
Viral Infections in Healthy and Immunocompromised Hosts

Conditions: Virus Infections; Respiratory Viruses; Norovirus; Suspected Viral Infections
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Polyinosinic-Polycytidylic Acid-poly-L-lysine Carboxymethylcellulose (Poly-ICLC) in Healthy Volunteers

Condition: Healthy Volunteers
Intervention: Drug: Poly ICLC
Sponsors: Rockefeller University; Rockefeller University
Recruiting - verified January 2012
A Trial of 18F-AV-133 Positron Emission Tomography (PET)

Conditions: Type 1 Diabetes; Type 2 Diabetes
Intervention: Drug: 18F-AV-133
Sponsors: Avid Radiopharmaceuticals; Avid Radiopharmaceuticals
Recruiting - verified April 2012
A Study on the Effects of Soulera Herbal Blend Intake on Chronic Stress in Healthy Adults

Condition: Chronic Stress
Interventions: Dietary Supplement: Soulera Herbal Blend; Dietary Supplement: Placebo
Sponsors: NEMA Research, Inc.; Joseph Pergolizzi, MD; LeraPharm Inc.
Recruiting - verified April 2012
Edible Hepatitis B Vaccine Therapy in Healthy Participants Who Have Undergone Previous Vaccination

Condition: Healthy, no Evidence of Disease
Interventions: Biological: hepatitis B antigen peptide; Other: placebo; Other: immunoenzyme technique
Sponsors: Roswell Park Cancer Institute; Roswell Park Cancer Institute; National Cancer Institute (NCI)
Not yet recruiting - verified January 2012
Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.

Conditions: Osteopenia; Osteoporosis; Bone Disease
Intervention: Biological: RN564
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
Evaluation of Cortisol Resistance in Young Endurance-trained and Elderly Men

Conditions: Cortisol Resistance; Negative Feedback; ACTH; Mineralcorticoid; Glucocorticoid
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2011
Effects of Systemically Administered Hydrocortisone on the Immune System in Healthy Volunteers

Conditions: Immunosuppression; Healthy; Healthy Subjects
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2011
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.

Conditions: Ulcerative Colitis; Crohn's Disease
Interventions: Drug: AMG 181; Other: Placebo for AMG 181
Sponsors: Amgen; Amgen
Recruiting - verified May 2012
A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias

Conditions: Leukemia; Lymphoma; Neuroblastoma; Sarcoma; Desmoplastic Small Round Cell Tumor
Interventions: Drug: Melphalan; Drug: Fludarabine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Prednisone; Drug: Vincristine; Drug: Doxorubicin; Drug: Etoposide; Drug: Filgrastim; Biological: NK-DLI Infusions
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified March 2012
Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic

Condition: Healthy Infant With Colic Behavior and Fecal Characteristics
Interventions: Dietary Supplement: Nutramigen with Enflora; Dietary Supplement: Nutramigen A+
Sponsors: The University of Texas Health Science Center, Houston; The University of Texas Health Science Center, Houston; Mead Johnson Nutrition
Recruiting - verified May 2012
Safety and Adherence of a Non-medicated Intravaginal Ring (IVR)

Condition: Healthy
Intervention: Drug: Non-medicated Intravaginal Ring
Sponsors: Population Council; Population Council; National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Mental Health (NIMH); Microbicide Trials Network
Recruiting - verified May 2012
Development of Magnetic Resonance Spectroscopy Techniques for Imaging Metabolites and Neurotransmitters in Human Brain

Conditions: Brain Mapping; Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
New Onset Type 1 Diabetes: Role of Exenatide

Conditions: Type 1 Diabetes; New Onset Type 1 Diabetes
Interventions: Drug: Exenatide; Drug: Rapid and long acting insulin; Drug: long acting insulin + rapid acting + 1.25 mcg Exenatide
Sponsors: Albert Einstein College of Medicine of Yeshiva University; Albert Einstein College of Medicine of Yeshiva University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified May 2012
The Effect of Transcranial Magnetic Stimulation on Learning With Reward in Healthy Humans

Conditions: Traumatic Brain Injury; fMRI
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2011
Effect of Weight Loss on Breast Density Using Digital Mammography and MRI in Women Who Are At Increased Risk For Breast Cancer

Condition: Healthy, no Evidence of Disease
Interventions: Procedure: magnetic resonance imaging; Procedure: digital mammography; Procedure: conventional surgery
Sponsors: Northwestern University; Northwestern University; Robert H. Lurie Cancer Center
Recruiting - verified May 2012
Multiple Ascending Doses of AMG 139 in Healthy and Crohn's Disease Subjects

Condition: Crohn's Disease
Intervention: Drug: AMG 139
Sponsors: Amgen; Amgen
Recruiting - verified May 2012
Evaluating the Safety of and Immune Response to an HIV Vaccine Followed by Booster, Administered by Two Devices, in HIV-Uninfected Adults

Condition: HIV Infections
Interventions: Biological: PENNVAX-G DNA Vaccine; Biological: MVA-CMDR Vaccine; Biological: Placebo PENNVAX-G Vaccine; Biological: Placebo MVA-CMDR Vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2012
Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition

Conditions: Weight Gain; Healthy Subjects; Obesity; Women
Interventions: Dietary Supplement: Linoleic Acid; Dietary Supplement: Docosahexaenoic Acid; Dietary Supplement: Eicosapentaenoic Acid
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified July 2011
Effects Of PF-02545920 On Ketamine-Induced Abnormal Prefrontal Brain Response To Associative Learning In Healthy Subjects

Condition: Healthy
Interventions: Other: Saline; Drug: PF-02545920; Other: Ketamine; Drug: PF-02545920; Other: Saline; Other: Placebo; Other: Ketamine; Other: Placebo
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Developing Biomarkers of Dietary Intake

Conditions: Diet Therapy; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
Nicotinic Modulation of the Default Network of Resting Brain Function

Condition: Nicotine Dependence
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Drug Abuse (NIDA)
Recruiting - verified August 2011
Bosutinib In Subjects With Renal Impairment

Conditions: Renal Disease, End-Stage; Renal Insufficiency, Chronic; Renal Insufficiency, Acute
Interventions: Drug: Bosutinib; Drug: Bosutinib; Drug: Bosutinib; Drug: Bosutinib
Sponsors: Pfizer; Pfizer
Recruiting - verified May 2012
A Non-drug Study Profiling Asthma

Conditions: Asthma; Health
Intervention: Other: All patients
Sponsors: Centocor, Inc.; Centocor, Inc.
Recruiting - verified May 2012
TGF-(Beta) and Susceptibility to RSV

Conditions: Respiratory Syncytial Virus; Asthma
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified August 2011
Healthy Mood Internet Intervention Research Project

Condition: Major Depression
Interventions: Behavioral: Online self-help course plus live follow-up if needed; Behavioral: Online + incentives Follow-up Group
Sponsors: University of California, San Francisco; University of California, San Francisco; National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
Effect of Dexlansoprazole on Bone Homeostasis

Conditions: Homeostasis; Bone and Bones
Interventions: Drug: Dexlansoprazole; Drug: Esomeprazole; Drug: Placebo
Sponsors: Takeda Global Research & Development Center, Inc.; Takeda Global Research & Development Center, Inc.
Recruiting - verified February 2012
Metabolomics of Aging: Sub-study of the Healthy Elderly Active Longevity (HEAL) Study

Condition: Healthy
Intervention:
Sponsors: Scripps Translational Science Institute; Scripps Translational Science Institute
Recruiting - verified January 2012
Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer

Conditions: Healthy, no Evidence of Disease; Hereditary Breast/Ovarian Cancer - BRCA1; Hereditary Breast/Ovarian Cancer - BRCA2
Interventions: Other: questionnaire administration; Other: survey administration; Other: counseling intervention; Other: educational intervention
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Recruiting - verified May 2012
Testing and Calibration of Non-Invasive Optical Imaging Technology for Functional Brain Imaging

Conditions: Neurovascular Coupling; Hemoglobin; Functional Brain Imaging
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Center for Neuroscience and Regenerative Medicine (CNRM); Department of Defense; National Institutes of Health Clinical Center (CC)
Recruiting - verified May 2011
Evaluation of [18F] PBR111 and PET as a Marker of Inflammation in Subjects With Neurological Conditions

Condition: Alzheimer Disease
Intervention: Drug: Drug: [18F] PBR111
Sponsors: Institute for Neurodegenerative Disorders; Institute for Neurodegenerative Disorders
Recruiting - verified January 2012
Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol

Condition: Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2012
Metabolic Effects of Non-Nutritive Sweeteners

Condition: Healthy Volunteers
Intervention: Other: Sucralose
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2012
Impact of Physical Activity on Left Ventricular Mass and Lipid Metabolism

Condition: Left Ventricular Hypertrophy
Intervention: Other: Exercise training, women, marathon
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified March 2012
PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A

Conditions: Pain; Anxiety; Depression
Intervention: Drug: NOP-1A
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified May 2012
Neural Dynamics and Connectivity in Response Inhibition and Traumatic Brain Injury

Conditions: Traumatic Brain Injury; Stroke; Headache; PTSD
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS); Department of Defense; Center for Neuroscience and Regenerative Medicine (CNRM); National Institutes of Health Clinical Center (CC)
Recruiting - verified June 2011
Safety Evaluation of the GSK-580299 Vaccine in Women From the Control Group in the Primary NCT00294047 Study

Conditions: Human Papillomavirus (HPV) Type 16/18 Infections; Cervical Neoplasia
Intervention: Biological: GSK580299 (Cervarix™)
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified February 2012
Pharmacokinetics of Tenofovir, Emtricitabine, Maraviroc, and Raltegravir in Cervical, Vaginal, and Rectal Tissues and Secretions

Condition: Healthy Adult Females
Intervention: Other: Pharmacokinetic Sampling
Sponsors: University of North Carolina, Chapel Hill; University of North Carolina, Chapel Hill
Recruiting - verified March 2012
Role of Endogenous Estrogen in Growth-Hormone Regulation in Postmenopausal Women

Condition: Healthy
Intervention: Drug: Fulvestrant
Sponsors: Mayo Clinic; Mayo Clinic; National Institutes of Health (NIH); AstraZeneca
Recruiting - verified April 2012
Vitamin D Deficiency in Adolescent Girls

Conditions: Healthy; Vitamin D Deficiency
Interventions: Dietary Supplement: ergocalciferol; Other: placebo pill
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified April 2012
Influenza Antiviral DAS181-F03

Condition: Influenza
Interventions: Drug: DAS181; Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2012
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) Study

Conditions: Infant; Obesity
Interventions: Behavioral: Child Safety Insights; Behavioral: Parenting Insights
Sponsors: Penn State University; Ian M. Paul, M.D., M.Sc.; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2012
Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant

Condition: Septicemia
Interventions: Biological: CPG 7909; Drug: Placebo; Biological: J5-OMP Vaccine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative Colitis

Condition: Ulcerative Colitis
Intervention: Drug: Amg 181
Sponsors: Amgen; Amgen
Recruiting - verified May 2012
Evaluation of SAMe for Hot Flashes

Conditions: Healthy, no Evidence of Disease; Hot Flashes
Interventions: Drug: S-adenosyl-L-methionine disulfate p-toluene-sulfonate; Other: questionnaire administration; Procedure: quality-of-life assessment
Sponsors: Mayo Clinic; Mayo Clinic
Recruiting - verified April 2012
Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage

Conditions: Inflammation; Cancer; Cardiomyopathy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified March 2012
Study of the Effect of Innate on the Inflammatory Response to Endotoxin

Conditions: Asthma; Atherosclerosis; Metabolic Syndrome; Insulin Resistance; Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified March 2012
Fetal Programming of Obesity

Conditions: Healthy; Pregnancy
Intervention: Device: Observational study only
Sponsors: Arkansas Children's Hospital Research Institute; Arkansas Children's Hospital Research Institute; United States Department of Agriculture; University of Arkansas
Recruiting - verified April 2012
Defining the Brain Phenotype of Children With Williams Syndrome

Condition: Williams Syndrome
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified February 2012
VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

Conditions: Immunity, Mucosal; Immune System Processes; Blood Specimen Collection
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified December 2011
Imaging Techniques in MRI

Condition: Magnetic Resonance Imaging
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2011
A Study of the Kinetics of Lymphoid Cells in Patients With Monoclonal B-cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers

Condition: Monoclonal B-Cell Lymphocytosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI); North Shore Long Island Jewish Health System
Recruiting - verified January 2012
Collection of Peripheral Blood Stem Cells Using G-CSF and Plerixafor in Normal Volunteers

Condition: Normal Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Protocol to Obtain Blood and Bone Marrow Samples for Myeloma Research

Condition: Multiple Myeloma
Intervention:
Sponsors: Dartmouth-Hitchcock Medical Center; Dartmouth-Hitchcock Medical Center
Recruiting - verified June 2011
A Phase I Trial of Safety and Immunogenicity of Gardasil(Registered Trademark) Vaccination Post Stem Cell Transplantation in Patients With and Without Immunosuppression

Conditions: Gardasil Vaccine; Stem Cell Transplant; Immunogenicity; Quadrivalent HPC Vaccine; Healthy Volunteers
Intervention: Biological: Gardasil
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 2011
Brain Imaging Study of Adults With Autism Spectrum Disorders

Condition: Autism Spectrum Disorders
Interventions: Drug: Oxytocin; Drug: Vasopressin
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Studies of Autistic Patients: Gene Networks and Clinical Subtypes

Conditions: Autism; Tuberous Sclerosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 2011
Healthy Homes/Healthy Kids_5-9

Conditions: Obesity; Injury
Interventions: Behavioral: Healthy Eating/Physical Activity; Behavioral: Safety/Injury Prevention
Sponsors: HealthPartners Research Foundation; HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University of Washington; University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified April 2012
Top-Down Attentional Control of Visual-Processing

Conditions: Focal Brain Lesion; Focal Lesions; fMRI
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products

Conditions: Bone Marrow; Bone Marrow Stromal Cells; Mesenchymal Stem Cells; Blood Donors
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2011
The Impact of a Topical Vasodilating Cream on Female Sexual Experience

Condition: Female Sexual Dysfunction
Intervention:
Sponsors: East Suburban Ob Gyn; Michael Pelekanos MD; West Penn Allegheny Health System
Recruiting - verified March 2012
The Molecular Anatomy of Oral Wound Healing

Conditions: Wounds and Injuries; Wound Healing; Ulcer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified August 2011
Imaging Cannabinoid CB1 Receptors in Schizophrenia

Condition: Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Effects of a CRF1 Receptor Antagonist on Human Startle in Normal Female Volunteers

Condition: Anxiety Disorders
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Healthy Lifestyles for Mentally Ill People Who Have Experienced Weight Gain From Their Antipsychotic Medications - 2

Conditions: Diabetes; Obesity; Weight Gain
Intervention: Behavioral: Behavioral Weight Loss Program
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs
Recruiting - verified December 2011
Stress, Adjustment And Growth In Children With Cancer And Their Parents

Conditions: Posttraumatic Growth; Posttraumatic Stress Disorder
Intervention:
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital; National Cancer Institute (NCI)
Recruiting - verified March 2012
Aspirin in Reducing Events in the Elderly

Conditions: Functional Disability; Dementia; Heart Disease; Stroke; Cancer; Bleeding
Interventions: Drug: 100 mg enteric-coated aspirin; Drug: Placebo
Sponsors: Minneapolis Medical Research Foundation; Minneapolis Medical Research Foundation; National Health and Medical Research Council, Australia; Bayer; Monash University; Berman Center for Outcomes and Clinical Research
Recruiting - verified July 2011
Measuring Distress Tolerance With Functional MRI

Condition: Cocaine Dependence
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Drug Abuse (NIDA); University of Maryland
Recruiting - verified July 2011
Time to Conceive: A Study of Fertility

Condition: Healthy
Intervention: Other: No intervention
Sponsors: University of North Carolina, Chapel Hill; University of North Carolina, Chapel Hill; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2012
Topical Treatment of Acute Otitis Media With Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora

Conditions: Acute Otitis Media With Tympanostomy Tubes.; Healthy Subjects With Tympanostomy Tubes.
Intervention: Drug: Ciprodex (0.3% ciprofloxacin/0.1% dexamethasone)
Sponsors: Alcon Research; Alcon Research
Recruiting - verified May 2012
Cognitive Neuroscience of Autism Spectrum Disorders

Conditions: Autistic Disorder; Asperger Syndrome; Mental Retardation; Child; Adult
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified July 2011
Internal Monitoring of Eye Movement in Schizophrenia

Condition: Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Eye Institute (NEI)
Recruiting - verified September 2011
The Healthy Elderly Longevity Cohort

Condition: Healthy
Intervention:
Sponsors: Scripps Translational Science Institute; Scripps Translational Science Institute
Recruiting - verified January 2012
Recording and Modulation of Neuronal Mechanisms During Operant Conditioning: a MEG Study

Condition: Central Nervous System
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2011
Cultivating Healthy Environments in Families With Type 1 Diabetes (CHEF)

Condition: Type I Diabetes
Interventions: Behavioral: Education; Device: CGM; Behavioral: Problem Solving; Behavioral: Social Learning; Behavioral: Behavior Modification
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2012
Molecular and Morphologic Characterization of Circulating Endothelial Cells

Condition: Acute Myocardial Infarction
Intervention:
Sponsors: Scripps Translational Science Institute; Scripps Translational Science Institute
Recruiting - verified January 2012
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2011
Bimatoprost Ophthalmic Solution in Increasing Eyebrow and Eyelash Growth in Patients Who Have Undergone Chemotherapy for Breast Cancer and in Healthy Participants

Conditions: Alopecia; Breast Cancer
Interventions: Drug: bimatoprost ophthalmic solution; Drug: placebo
Sponsors: University of California, Los Angeles; University of California, Los Angeles; National Cancer Institute (NCI)
Not yet recruiting - verified February 2012
Study to Assess the Effect of BMS-791325 on the Pharmacokinetics of Midazolam in Healthy Subjects

Condition: Hepatitis C
Interventions: Drug: Midazolam; Drug: BMS-791325
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb
Not yet recruiting - verified February 2012
Phase I STEBVax in Healthy Adults

Condition: Staphylococcus Enterotoxin B
Intervention: Biological: STEBVax
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified February 2012
Phase 1 Study of the Safety and Immunogenicity of a Malaria Transmission-blocking Pfs25-Pfs25 Conjugate Vaccine

Conditions: Malaria; Malaria Vaccines; Plasmodium Falciparum Malaria
Intervention: Biological: Malaria Transmission-Blocking Pfs25-Pfs25 Conjugate Vaccine
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Not yet recruiting - verified March 2011
Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects

Conditions: Parkinson Disease; Huntington Disease
Intervention: Drug: [123I]MNI-420
Sponsors: Institute for Neurodegenerative Disorders; Institute for Neurodegenerative Disorders
Recruiting - verified February 2012
Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Protocols

Conditions: Inflammatory Disease; Autoimmune Disease; Immunologic Disease; Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2012
Non-Invasive Non-Ionizing Polarized Imaging System to Assess Structure of Cervix

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified September 2011
Immune Response to an HIV DNA Plasmid Vaccine Prime Followed by Adenovirus Boost in HIV-uninfected Individuals

Condition: HIV Infections
Interventions: Biological: VRC-HIVDNA-016-00-VP; Biological: VRCHIVADV014-00-VP
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2012
Japanese Bridging Study Conducted in the United States

Condition: Hepatitis C Virus
Interventions: Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: Placebo; Drug: Placebo; Drug: Placebo; Drug: Placebo
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb
Not yet recruiting - verified February 2012
The Effect of Prolonged Fasting and Hypocaloric Diet on FGF-21 Levels

Conditions: Metabolism; Fasting; Non-alcoholic Fatty Liver Disease (NAFLD)
Interventions: Behavioral: Fasting; Behavioral: Fasting; Behavioral: Diet
Sponsors: Beth Israel Deaconess Medical Center; Beth Israel Deaconess Medical Center
Recruiting - verified December 2011
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission Tomography

Conditions: Schizoaffective Disorder; Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified February 2012
Genotype and Phenotype Registry: Enrollment of Normal Control Subjects for Current and Future Research

Condition: Healthy
Intervention:
Sponsors: North Shore Long Island Jewish Health System; North Shore Long Island Jewish Health System
Recruiting - verified January 2012
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions: Epilepsy; Epilepsy, Temporal Lobe; Depression; Depressive Disorder, Major
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin

Conditions: Breast Cancer; Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified September 2011
Study of Biomarkers Using Blood and Tissue Samples From Patients With Colorectal Cancer or Colorectal Polyps and From Patients Without Polyps

Conditions: Colorectal Cancer; Healthy, no Evidence of Disease; Precancerous Condition
Interventions: Genetic: gene expression analysis; Genetic: polymerase chain reaction; Genetic: polymorphism analysis; Genetic: protein expression analysis; Genetic: proteomic profiling; Other: gas chromatography; Other: laboratory biomarker analysis; Other: liquid chromatography; Other: mass spectrometry; Other: questionnaire administration
Sponsors: Indiana University; Indiana University; National Cancer Institute (NCI)
Recruiting - verified May 2012
Study of Breast Tissue in Women Not Previously Diagnosed With Breast Cancer Who Are Undergoing Fine Needle Aspiration

Conditions: Breast Cancer; Healthy, no Evidence of Disease
Interventions: Procedure: Random fine need aspiration (rFNA); Other: Mammogram
Sponsors: Northwestern University; Northwestern University; National Cancer Institute (NCI)
Recruiting - verified May 2012
Fatigue in Healthy Individuals

Conditions: Healthy Volunteer; Fatigue; Depression
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Nursing Research (NINR)
Recruiting - verified January 2012
Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Conditions: Lymphohistiocytosis, Hemophagocytic; Common Variable Immunodeficiency; Severe Combined Immunodeficiency
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified January 2012
Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders

Conditions: Movement Disorder; Tourette Syndrome; Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2012
Study Evaluating Safety And Tolerability Of Meningococcal B Rlp2086 Vaccine In Healthy Adults

Condition: Meningitis, Meningococcal
Interventions: Biological: rLP2086 vaccine or control; Biological: rLP2086 vaccine or control; Biological: rLP2086 vaccine or control; Biological: rLP2086 vaccine or control
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation

Conditions: Memory Disorders; Sleep Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Cardiovascular Disease Study

Condition: Spinal Cord Injury
Interventions: Procedure: 2 hour Oral Glucose Tolerance Test; Procedure: Fat Meal Test
Sponsors: Department of Veterans Affairs; Department of Veterans Affairs; Kessler Foundation
Recruiting - verified March 2012
A Multicenter Prospective Study of Quality of Life in Adult Scoliosis

Condition: Scoliosis
Interventions: Procedure: Surgical intervention; Other: Non operative intervention
Sponsors: Washington University School of Medicine; Washington University School of Medicine; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); Northwestern University; New York University; University of Virginia; University of Louisville; Maryland Spine Center; Hospital for Special Surgery, New York; University Health Network, Toronto; Hopital du Sacre', Montreal University; Dartmouth-Hitchcock Medical Center
Recruiting - verified April 2012
Genetic Determinants of Response to Beta Blockade

Condition: Healthy
Intervention: Drug: Atenolol (β-blocker)
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified April 2012
Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone

Conditions: Blood Glucose; Lipids
Intervention:
Sponsors: Washington University School of Medicine; Washington University School of Medicine; Pfizer
Recruiting - verified March 2012
Reduced Carbohydrate vs. Fat

Condition: Obesity
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2011
Healthy Brains & Behavior: Understanding and Treating Youth Aggression

Condition: Aggression
Interventions: Behavioral: CBI; Dietary Supplement: NUT
Sponsors: University of Pennsylvania; University of Pennsylvania; Pennsylvania Department of Health
Recruiting - verified March 2012
Normal Blood, Bone Marrow and Buccal Mucosa Protocol

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified June 2011
Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

Conditions: Central Nervous System Disease; Multiple Sclerosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2011
Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors

Condition: Healthy
Intervention: Drug: Filgrastim
Sponsors: Center for International Blood and Marrow Transplant Research; Center for International Blood and Marrow Transplant Research; National Marrow Donor Program
Recruiting - verified February 2012
Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine

Condition: Tularemia
Intervention: Biological: Live Francisella Tularensis Vaccine
Sponsors: U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command
Recruiting - verified May 2012
Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults

Conditions: Cardiovascular Disease; HIV Infections
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2012
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages

Condition: Healthy Volunteers
Interventions: Drug: G-CSF; Procedure: Stem Cell Apheresis
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital
Recruiting - verified November 2011
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions

Conditions: WAGR Syndrome; Wilm's Tumor; Aniridia; Urogenital Abnormalities; Mental Retardation
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 2011
Evaluation of Assessments of Motor Performance, Physical Impairments and Functional Abilities

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified July 2011
Warfighter Head Injury Study

Condition: Head Injury
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS); Department of Defense; National Institutes of Health Clinical Center (CC); Center for Neuroscience and Regenerative Medicine (CNRM)
Recruiting - verified January 2012
Exercise and Healthy Diet or Standard Care in Patients in Remission From Stage I or Stage II Endometrial Cancer

Condition: Endometrial Cancer
Interventions: Behavioral: behavioral dietary intervention; Behavioral: exercise intervention; Other: counseling intervention; Other: educational intervention; Other: survey administration
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified December 2011
Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Normal Volunteers

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified April 2012
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

Conditions: Spasmodic Dysphonia; Focal Dystonia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2012
Computer-Assisted Self-Administration of Ethanol

Condition: Alcoholic Intoxication
Interventions: Drug: Alcohol; Procedure: Self-Administration
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified February 2012
Language Mapping in Patients With Epilepsy

Conditions: Epilepsy; Epilepsy, Temporal Lobe; Partial Epilepsy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2012
PET Imaging of Peripheral Benzodiazepine Receptors

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
A New Method for Determining Gastric Acid Output Using a Wireless Capsule

Condition: Gastrointestinal Diseases
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified July 2011
p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram

Condition: Depression
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers

Condition: Retinoblastoma
Interventions: Genetic: DNA ploidy analysis; Genetic: DNA stability analysis; Genetic: Southern blotting; Genetic: genetic linkage analysis; Genetic: loss of heterozygosity analysis; Genetic: mutation analysis; Genetic: polymorphism analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: environmental carcinogenesis study; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: evaluation of cancer risk factors; Procedure: mutation carrier screening
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012
Screening for Subjects to Participate in Studies of Blood Disorders

Conditions: Bone Marrow Transplant; Sickle Cell Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified July 2011
Bioavailability of Golden Rice Carotenoids in Humans

Condition: Healthy
Intervention: Dietary Supplement: golden rice
Sponsors: Tufts University; Tufts University
Recruiting - verified April 2012
Glycan Analysis in Diagnosing Cancer in Women With Ovarian Epithelial Cancer and in Healthy Female Participants

Condition: Ovarian Cancer
Intervention:
Sponsors: University of California, Davis; University of California, Davis; National Cancer Institute (NCI)
Recruiting - verified April 2012
Biomarkers in Exhaled Breath From Asthmatic Patients

Condition: Asthma
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified December 2011
Eating Behavior in Adolescents

Conditions: Overweight; Eating Behavior; Binge Eating
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 2011
Mirror Therapy for Phantom Limb Pain

Conditions: Phantom Limb Pain; Amputee
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified March 2012
PET Imaging of P-glycoprotein Function Using [11C]dLop

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
Studies of Skin Microbes in Healthy People and in People With Skin Conditions

Conditions: Atopic Dermatitis; Eczema; Ichthyosis Vulgaris
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified July 2011
PET Imaging of Cannabinoid CB1 Receptors Using [11C]MePPEP

Condition: Healthy
Intervention: Drug: [11C]MePPEP
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
Relationship of HHV-6B Virus to Seizures and Brain Injury

Conditions: Epilepsy; HHV6B Infection
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Women's Health Research Registry

Condition: Healthy
Intervention: Other: No Intervention
Sponsors: Cedars-Sinai Medical Center; Cedars-Sinai Medical Center
Recruiting - verified March 2012
Cardiac Magnetic Resonance Imaging (MRI) Normal Reference Control Group Testing

Condition: Healthy
Intervention: Other: Cardiac MRI
Sponsors: Cedars-Sinai Medical Center; Cedars-Sinai Medical Center
Recruiting - verified March 2012
Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine

Condition: Eastern Equine Encephalitis
Intervention: Biological: Inactivated, Dried, TSI-GSD 104, EEE
Sponsors: U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command
Recruiting - verified May 2012
Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine

Condition: Venezuelan Equine Encephalomyelitis
Intervention: Biological: VEE TC-83
Sponsors: U.S. Army Medical Research and Materiel Command; U.S. Army Medical Research and Materiel Command
Recruiting - verified May 2012
Visual Motor Coordination

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Eye Institute (NEI)
Recruiting - verified August 2011
Calibrating Imaging Techniques to Study Blood Flow

Condition: Healthy Volunteers Only
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 2011
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203

Conditions: Healthy; Glutamate Receptor; mGlur5 Protein; Excitatory Amino Acid Receptors; Drug Kinetics; PET Scan
Intervention: Drug: [18F]SP203
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified August 2011
PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28

Conditions: Neurocysticercosis; Healthy
Intervention: Drug: [C-11]PBR28
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified January 2011
Pancreatic Cancer Genetic Epidemiology (PACGENE) Study

Condition: Pancreatic Cancer
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified April 2012
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures

Condition: Obesity
Intervention: Procedure: Exposure to Cold Temperature
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified August 2011
Preparing the Personal Physician for Practice (P4)

Condition: Healthy
Intervention: Other: Evaluating Educational Models
Sponsors: Christiana Care Health Services; Christiana Care Health Services
Recruiting - verified February 2012
Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions: Psycogenic Movement Disorders; Non-Epileptic Seizures
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Normative High-frequency MEG Database for Children

Condition: Healthy
Intervention:
Sponsors: Children's Hospital Medical Center, Cincinnati; Children's Hospital Medical Center, Cincinnati; University of Cincinnati
Recruiting - verified February 2012
Brain Changes in Blepharospasm

Conditions: Dystonia; Focal Dystonia; Cerebellar Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Study to Evaluate Immune Responses in Neurologically Normal Cancer Patients

Condition: Healthy
Intervention:
Sponsors: Rockefeller University; Rockefeller University
Recruiting - verified January 2012
Effect of Diet on Vascular Disease in Pre-Menopausal Women

Conditions: Cardiovascular Diseases; Vascular Disease; Inflammation; Insulin; Triglycerides
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified June 2011
Dry Eye in Women With Turner Syndrome and Women With Premature Ovarian Failure

Conditions: Turner Syndrome; Ovarian Failure, Premature; Sex Chromosome Aberrations; Menopause; Perimenopause
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Eye Institute (NEI)
Recruiting - verified October 2009
Collection of Lung Fluid and Tissue Samples for Research

Conditions: Mycobacterium Infections, Atypical; Granulomatous Disease, Chronic; Job's Syndrome; Influenza, Human
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2011
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)

Conditions: HIV-Dementia; HIV-Associated Cognitive Motor Complex; AIDS Encephalopathy; AIDS Dementia Complex; AIDS-Related Dementia Complex; HIV Infections; Healthy
Intervention: Drug: [11C]PBR28
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified August 2011
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2011
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2011
Changes in Breast Density and Breast Cancer Risk in Women With Breast Cancer and in Healthy Women

Condition: Breast Cancer
Interventions: Other: physiologic testing; Other: screening questionnaire administration; Procedure: breast imaging study; Procedure: radiomammography; Procedure: study of high risk factors
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified February 2012
The Role of Serotonin in Seizures

Condition: Epilepsy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified September 2011
Effect of EGCG on the Body's Response to Insulin

Conditions: Hypertension; Obesity; Type 2 Diabetes; Insulin Resistance
Interventions: Drug: Dietary Supplement: epigallocatechin 3-gallate (EGCG); Procedure: hyperinsulinemic isoglycemic glucose clamp; Procedure: insulin-stimulated brachial artery blood flow; Procedure: assess capillary recruitment in forearm skeletal muscle
Sponsors: University of Maryland; University of Maryland; Office of Dietary Supplements (ODS); National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified December 2011
Brain Peripheral Benzodiazepine Receptors in Patients With Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified August 2011
Spaced Versus Massed Skill Learning

Condition: Healthy Volunteer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2011
Physical and Behavioral Traits of Overweight and Obese Adults

Conditions: Morbid Obesity; Diabetes Mellitus Type 2; Insulin Resistance; Obstructive Sleep Apnea; Mood Disorders
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2012
Detecting a Reward Signal in the Motor Cortex

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2011
Growth of Airways and Lung Tissues in Premature and Healthy Infants

Conditions: Infant, Premature; Bronchopulmonary Dysplasia; Asthma
Intervention:
Sponsors: Indiana University; Indiana University School of Medicine; National Institutes of Health (NIH)
Recruiting - verified March 2012
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28

Condition: Healthy
Intervention: Drug: [C-11]PRB28
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified March 2012
Blood Collection In Healthy Adult Volunteers To Obtain Serum For Use In Serum Bactericidal Activity Assay Development

Condition: Healthy Subjects
Intervention: Procedure: Blood Collection
Sponsors: Pfizer; Pfizer
Recruiting - verified April 2012
Immune Cell Response to Stimuli

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified June 2011
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

Conditions: Depressive Disorder, Major; Bipolar Disorder; Panic Disorder; Stress Disorders, Post-Traumatic
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

Conditions: Major Depressive Disorder; Healthy
Interventions: Procedure: PET scan; Drug: Rolipram
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease

Conditions: Mycobacteria, Atypical; Cystic Fibrosis; Ciliary Disorders; Pseudohypoaldosteronism; Bronchiectasis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2011
Endocrine and Psychological Evaluation of Adopted Children

Condition: Psychosocial Adjustment
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 2011
Development of Computer-aided Detection and Diagnosis From Imaging Techniques

Condition: Diagnostic Imaging
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified August 2011
Collection and Distribution of Blood Samples From Healthy Donors for In Vitro Research at the NCI Frederick Cancer Research and Development Center

Condition: Samples
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified August 2011
An Evaluation of Safety and Efficacy of Escalating Doses of AMD3100 to Mobilize CD34+ Cells in Healthy Volunteers

Condition: Stem Cell Mobilization
Intervention: Drug: AMD3100
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2012
Long-Term Motor Learning in Focal Hand Dystonia

Condition: Focal Hand Dystonia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Long-Term Improvement in Motor Learning by Transcranial Direct Current Stimulation

Condition: Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS); Department of Defense; Center for Neuroscience and Regenerative Medicine (CNRM); National Institutes of Health Clinical Center (CC)
Recruiting - verified November 2011
Thyroid and Fat Tissue Metabolism

Condition: Healthy Volunteers
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2012
Stem Cell Collection

Condition: Stem Cells
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
Positron Emission Tomography (PET) Imaging in People With Gaucher Mutations

Conditions: Glucocerebrosidase Mutations; Gaucher Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified June 2011
Clinical and Immunological Investigations of Subtypes of Autism

Condition: Autism
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Body Weight Regulation in Patients With Narcolepsy

Condition: Narcolepsy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2011
Screening for Studies on Autism Spectrum Disorders

Condition: Autism Spectrum Disorders
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Reference Values for Plasma Catechols

Condition: Catecholamine
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2011
Moving a Paralyzed Hand Through Use of a Brain-Computer Interface

Condition: Stroke
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS); Center for Neuroscience and Regenerative Medicine (CNRM)
Recruiting - verified September 2011
Identification and Analysis of Immunomodulatory Molecules in Patients With Hematologic Disorders and Healthy Volunteers

Conditions: Hematologic Diseases; Healthy Volunteers
Intervention: Genetic: Isolation of genomic DNA
Sponsors: The University of Texas Health Science Center at San Antonio; The University of Texas Health Science Center at San Antonio; Department of Veterans Affairs
Recruiting - verified March 2012
Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)

Condition: Focus Groups
Intervention:
Sponsors: University of California, San Francisco; University of California, San Francisco
Recruiting - verified May 2012
Movement-Related Brain Networks Involved in Hand Dystonia

Condition: Dystonia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2011
Analysis of Lyme Disease Lesions

Conditions: Erythema Migrans Lesions; Erythema Migrans
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2012
Training for Diagnosing Neurological Disorders

Condition: Nervous System Diseases
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified June 2011
Evaluation of Patients With Immune Function Abnormalities

Condition: Immune System Diseases
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Dose-Response of Gonadal Steroids and Bone Turnover in Men

Condition: Healthy Volunteers
Interventions: Drug: Testosterone; Drug: Testosterone; Drug: Anastrazole; Drug: Goserelin acetate
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Institute on Aging (NIA); Solvay Pharmaceuticals; AstraZeneca
Recruiting - verified April 2012
MRS Measurement of Glutamate and GABA Metabolism in Brain

Condition: Healthy
Intervention: Procedure: Magnetic Resonance Spectroscopy
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Brain Changes in Children and Adolescents With Behavioral Problems

Conditions: Attention Deficit Disorder With Hyperactivity; Mental Disorders Diagnosed in Childhood; Conduct Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified November 2011
Hormonal Causes of Menstrual-Related Mood Disorders

Conditions: Mood Disorders; Premenstrual Syndrome; PMS; PMDD; Depression; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders

Condition: Depressive Disorder, Major
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Collection of Peripheral Blood and Bone Marrow From Healthy Donors for Use in In Vitro Research

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2012
Event Related Potentials in Infants and Adults

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 2011
Procurement and Analysis of Specimens From Individuals With Pulmonary Fibrosis

Condition: Pulmonary Fibrosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Human Genome Research Institute (NHGRI)
Recruiting - verified August 2011
G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers

Condition: Healthy
Intervention: Drug: AMD3100
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified November 2011
Dutasteride to Treat Women With Menstrually Related Mood Disorders

Conditions: Premenstrual Syndrome; PMS; Healthy; Depression
Interventions: Drug: Dutasteride; Drug: Placebo oral capsule
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified April 2012
AMD3100 to Mobilize Stem Cells for Donation

Conditions: Healthy; Blood Component Removal
Intervention: Drug: AMD3100
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified August 2011
The Effect of Ethanol on Brain Activity

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified September 2011
Pelvic Pain in Women With Endometriosis

Conditions: Endometriosis; Pelvic Pain; Healthy; Tubal Ligation
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified April 2012
Urinary Vitamin C Loss in Diabetic Subjects

Condition: Diabetes Mellitus
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified October 2011
Apheresis and Specimen Collection Procedures to Obtain Plasma, Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens for Research Studies

Condition: Blood Component Removal
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
The Effects of Estrogen Withdrawal on Mood Symptoms in Women

Conditions: Perimenopausal Depression; Post Menopausal; Healthy; Depression
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
The Psychobiology of Childhood Temperament

Conditions: Mood Disorders; Anxiety Disorders; Adolescents
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified August 2011
Gene Message (mRNA) Analysis of Granulocytes

Condition: Neutropenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2012
Genetic Factors in Age-Related Macular Degeneration

Condition: Macular Degeneration
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Eye Institute (NEI)
Recruiting - verified November 2011
Effects of Modafinil on Brain Function in Patients With Schizophrenia

Conditions: Schizophrenia; Schizoaffective Disorder
Interventions: Drug: Modafinil; Procedure: Functional MRI; Procedure: Neuropsychological Testing
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Screening Evaluation for Women With Postpartum Depression

Conditions: Postpartum Depression; Depression
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies

Conditions: Mood Disorders; Healthy; Unipolar Depression; Bipolar Depression
Intervention: Drug: Transderm Scopolamine
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified July 2011
Expectation of Unpleasant Events in Anxiety Disorders

Condition: Anxiety Disorders
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified December 2011
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities

Conditions: Healthy; Pituitary Disease; Thyroid Disease
Intervention: Drug: TRH (Thyrotropin Releasing Hormone)
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2012
Study of Families With Twins or Siblings Discordant for Rheumatic Disorders

Conditions: Rheumatic Diseases; Rheumatoid Arthritis; Systemic Lupus Erythematosus; Scleroderma; Dermatomyositis; Myositis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified November 2011
Infant's Examination and Manipulation of Objects

Conditions: Healthy; Infant
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified June 2011
MRI Study of Musculoskeletal Function

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified March 2012
Natural History of Anthrax: a Study of Primary Infected, Recovered, and Exposed Individuals (SPoRE); and Evaluation of AVA-Vaccinated Recipients

Condition: Anthrax
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Brain Changes in Fear

Condition: Anxiety Disorders
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified March 2012
Psychopharmacology of Fear-Potentiated Startle in Humans

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified February 2012
Clinical Trial of Tolcapone for Cognition in Schizophrenia

Condition: Schizophrenia
Intervention: Drug: Tolcapone
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified February 2012
Study of Heart Transplant Rejection

Condition: Heart Transplantation
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2012
The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time

Condition: Neck Pain
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified March 2012
Study of Proteins Associated With Complex Regional Pain Syndrome

Conditions: Complex Regional Pain Syndromes; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Nursing Research (NINR)
Recruiting - verified February 2012
Stem Cell Collection for Adult Volunteers

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2012
Cell Lines From High-Risk Breast Tissue

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified July 2011
Brain Anatomy in Dystonia

Conditions: Dystonia; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
Blood Component Collection From Patients With Rheumatic Disease and Healthy Volunteers

Conditions: Rheumatic Diseases; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Recruiting - verified January 2012
Screening Protocol for HIV Vaccine Studies

Conditions: HIV Seronegativity; HIV Infections
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified August 2011
Magnetic Resonance Spectroscopy to Evaluate Tourette's Syndrome

Condition: Tourette Syndrome
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2012
High-Risk Breast Duct Epithelium

Conditions: Breast Neoplasms; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified January 2012
Morbidity After Diagnosis and Treatment of Breast Cancer Patients

Condition: Breast Cancer
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified March 2012
Effects of Arousal and Stress in Anxiety

Condition: Anxiety Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified January 2012
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder

Conditions: Mood Disorder; Bipolar Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

Conditions: Mood Disorder; Anxiety Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH); Suburban Hospital
Recruiting - verified October 2011
PET Scanning in Parkinson's Disease

Condition: Parkinson's Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Study of Taste Deficits

Conditions: Taste Disorder; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified July 2011
Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes

Conditions: Depression; Mood Disorder; Anxiety Disorder; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Adult and Juvenile Myositis

Conditions: Dermatomyositis; Polymyositis; Idiopathic Inflammatory Myopathy; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified September 2011
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

Conditions: Healthy; Sickle Cell Anemia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified July 2011
Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

Conditions: Healthy; Bipolar Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified January 2012
Comparison of Immune Response in Normal Volunteers and Patients With Helminth Infections

Conditions: Healthy; Helminthiasis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Study of New Magnetic Resonance Imaging Methods of the Brain

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified December 2011
Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

Conditions: Bipolar Disorder; Healthy; Mood Disorder; Parkinson's Disease; Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Hereditary Deficits in Auditory Processing Leading to Language Impairment

Conditions: Auditory Perceptual Disorder; Language Delay; Language Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified December 2011
The Development of Categorization

Conditions: Cognition Disorder; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified May 2011
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children

Conditions: Autoimmune Disease; Congenital Adrenal Hyperplasia; Healthy; Mental Disorder Diagnosed in Childhood; Neurologic Manifestations
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified September 2011
Whole Blood and Blood Component Collection for Research

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified February 2012
Salivary Evaluation in Normal Volunteers

Conditions: Healthy; Salivary Gland Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified June 2011
The Body's Affect on Vitamin C

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2012
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

Conditions: Graft vs Host Disease; Healthy; Lymphopenia
Intervention: Drug: G-CSF
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified October 2011
Screening Evaluation for Studies of the National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Conditions: Alcoholic Intoxication; Alcoholism; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified June 2011
Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings

Conditions: Healthy; Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified July 2011
Study of New Magnetic Resonance Methods

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified September 2011
Studies of Frontal Lobe Brain Functioning in Schizophrenia

Conditions: Healthy; Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified July 2011
Perimenopause-Related Mood and Behavioral Disorders

Conditions: Depression; Healthy; Perimenopausal Depression
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia

Conditions: Healthy; Schizophrenia
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified October 2011
Studies of Blood Flow to the Brain During Thought

Conditions: Cognition Disorder; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Mental Health (NIMH)
Recruiting - verified June 2011
Inflammatory Responses in Normal Volunteers and Patients With Abnormal Immune Responses

Conditions: Healthy; Inflammation; Vasculitis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2011
Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Conditions: Abetalipoproteinemia; Atherosclerosis; Healthy; Inborn Errors Lipid Metabolism
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified December 2011
Human Movement Database

Conditions: Healthy; Movement Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified December 2011
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics

Conditions: Alcoholism; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified September 2011
Sample Collections From the Airways of Asthmatic Patients

Conditions: Asthma; Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified October 2011
Genetic Analysis of Immune Disorders

Conditions: Healthy; Immunologic Deficiency Syndrome; Job's Syndrome; Severe Combined Immunodeficiency
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2011
Comparing Magnetic Resonance Imaging/Spectroscopy Techniques

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified September 2011
Magnetic Resonance Imaging (MRI) of Normal Volunteers

Condition: Healthy
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Recruiting - verified May 2012
Central Mechanisms in Speech Motor Control Studied With H215O PET

Conditions: Communication Disorder; Healthy; Stuttering; Tourette Syndrome; Voice Disorder
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified November 2011
Use of G-CSF to Obtain Blood Cell Precursors

Conditions: Chronic Granulomatous Disease; Healthy; Immunologic Disease; Leukocyte Adhesion Deficiency Syndrome; Severe Combined Immunodeficiency
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified July 2011
The Acquisition of Blood and Skin Samples From Normal Volunteers to Support Research Activities on Dermatologic Diseases

Conditions: Healthy; Skin Disease
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified May 2012
Evaluation of Lyme Disease: Clinical, Microbiological and Immunological Characteristics

Conditions: Chronic Disease; Healthy; Lyme Arthritis; Lyme Disease; Multiple Sclerosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2011
Segmental Bronchoalveolar Lavage

Conditions: Asthma; Pulmonary Fibrosis
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2012

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