Conditions:   Depressive Disorder, Major;   Depressive Disorder, Minor;   Dysthymic Disorder
Interventions:   Other: RESPECT-D;   Other: RESPECT-D-E (Enhanced)
Sponsors:   Dartmouth-Hitchcock Medical Center;   Dartmouth-Hitchcock Medical Center;   Johnson & Johnson
Recruiting - verified April 2012

Conditions:   Breast Cancer;   Depression;   Fatigue;   Sleep Disorders
Interventions:   Drug: metformin hydrochloride;   Genetic: DNA analysis;   Genetic: RNA analysis;   Genetic: polymerase chain reaction;   Genetic: polymorphism analysis;   Genetic: reverse transcriptase-polymerase chain reaction;   Other: enzyme-linked immunosorbent assay;   Other: laboratory biomarker analysis;   Other: questionnaire administration;   Procedure: quality-of-life assessment
Sponsors:   National Cancer Institute (NCI);   National Surgical Adjuvant Breast and Bowel Project (NSABP);   National Cancer Institute (NCI)
Recruiting - verified February 2012

Condition:   Major Depressive Disorder (MDD)
Interventions:   Drug: LY2216684;   Drug: Placebo
Sponsors:   Eli Lilly and Company;   Eli Lilly and Company
Recruiting - verified May 2012